|
2025-10-31 |
2025-10-29 |
S
Sale
|
See Remarks below
Officer
|
76,594
+46.9%
491.19
US$3,382,866
|
76,594
+46.9%
|
491.19
|
US$3,382,866
|
|
|
2025-04-03 |
2025-04-02 |
S
Sale
|
See Remarks below
Officer
|
69,430
-5.0%
497.91
US$4,489,002
|
69,430
-5.0%
|
497.91
|
US$4,489,002
|
|
|
2025-02-04 |
2025-02-03 |
S
Sale
|
See Remarks below
Officer
|
37,667
+25.9%
311.00
US$2,849,106
|
37,667
+25.9%
|
311.00
|
US$2,849,106
|
|
|
2024-10-30 |
2024-10-29 |
S
Sale
|
Head of Finance
Officer
|
79
-0.5%
1.40
US$111
|
79
-0.5%
|
1.40
|
US$111
|
|
|
2024-04-22 |
2024-04-19 |
PrS
Proposed sale
|
Affiliate
|
88,293
1.83
US$161,576
|
88,293
|
1.83
|
US$161,576
|
|
|
2024-04-04 |
2024-04-02 |
S
Sale
|
Head of Finance
Officer
|
188
-1.2%
1.73
US$325
|
188
-1.2%
|
1.73
|
US$325
|
|
|
2024-04-04 |
2024-04-02 |
S
Sale
|
Chief Operating Officer
Officer
|
372
-1.1%
1.73
US$644
|
372
-1.1%
|
1.73
|
US$644
|
|
|
2024-03-21 |
2024-03-21 |
PrS
Proposed sale
|
Affiliate
|
6,868
1.73
US$11,881
|
6,868
|
1.73
|
US$11,881
|
|
|
2023-04-05 |
2023-04-03 |
S
Sale
|
Chief Operating Officer
Officer
|
6,438
-7.9%
0.58
US$3,707
|
6,438
-7.9%
|
0.58
|
US$3,707
|
|
|
2023-04-05 |
2023-04-03 |
PlS
Planned sale
|
See Remarks
Executive Director
|
19,042
-6.9%
0.58
US$10,964
|
19,042
-6.9%
|
0.58
|
US$10,964
|
|
|
2023-04-05 |
2023-04-03 |
PlS
Planned sale
|
Chief Financial Officer
Officer
|
2,553
-5.2%
0.58
US$1,470
|
2,553
-5.2%
|
0.58
|
US$1,470
|
|
|
2022-05-25 |
2022-05-24 |
B
Purchase
|
Chief Financial Officer
Officer
|
9,500
+31.7%
1.12
US$10,640
|
9,500
+31.7%
|
1.12
|
US$10,640
|
|
|
2022-04-06 |
2022-04-04 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
2,650
-3.2%
2.45
US$6,482
|
2,650
-3.2%
|
2.45
|
US$6,482
|
|
|
2022-04-06 |
2022-04-04 |
PlS
Planned sale
|
See Remarks
Executive Director
|
8,894
-3.1%
2.45
US$21,754
|
8,894
-3.1%
|
2.45
|
US$21,754
|
|
|
2019-12-16 |
2019-12-13 |
B
Purchase
|
Shea Richard P
Non-Executive Director
|
7,500
+inf%
2.74
US$20,550
|
7,500
+inf%
|
2.74
|
US$20,550
|
|
|
2019-02-14 |
2019-02-13 |
PlS
Planned sale
|
Chief Scientific Officer
Officer
|
5,849
-10.8%
9.75
US$57,028
|
5,849
-10.8%
|
9.75
|
US$57,028
|
|
|
2019-02-14 |
2019-02-12 |
PlS
Planned sale
|
Chief Scientific Officer
Officer
|
3,151
-5.5%
9.75
US$30,722
|
3,151
-5.5%
|
9.75
|
US$30,722
|
|
|
2018-10-19 |
2018-10-18 |
PlS
Planned sale
|
Miller Paul Francis
Chief Scientific Officer
Officer
|
3,000
-5.0%
9.77
US$29,296
|
3,000
-5.0%
|
9.77
|
US$29,296
|
|
|
2018-09-19 |
2018-09-18 |
PlS
Planned sale
|
Miller Paul Francis
Chief Scientific Officer
Officer
|
3,000
-4.8%
13.05
US$39,163
|
3,000
-4.8%
|
13.05
|
US$39,163
|
|
|
2018-09-07 |
2018-09-05 |
PlS
Planned sale
|
Miller Paul Francis
Chief Scientific Officer
Officer
|
3,000
-4.5%
12.55
US$37,635
|
3,000
-4.5%
|
12.55
|
US$37,635
|
|
|
2018-08-31 |
2018-08-30 |
PlS
Planned sale
|
Miller Paul Francis
Chief Scientific Officer
Officer
|
1,342
-2.0%
9.76
US$13,092
|
1,342
-2.0%
|
9.76
|
US$13,092
|
|
|
2018-08-31 |
2018-08-29 |
PlS
Planned sale
|
Miller Paul Francis
Chief Scientific Officer
Officer
|
1,658
-2.4%
9.77
US$16,198
|
1,658
-2.4%
|
9.77
|
US$16,198
|
|
|
2018-07-19 |
2018-07-18 |
PlS
Planned sale
|
Miller Paul Francis
Chief Scientific Officer
Officer
|
3,000
-4.2%
11.01
US$33,022
|
3,000
-4.2%
|
11.01
|
US$33,022
|
|
|
2018-06-21 |
2018-06-20 |
PlS
Planned sale
|
Miller Paul Francis
Chief Scientific Officer
Officer
|
1,000
-1.4%
9.75
US$9,750
|
1,000
-1.4%
|
9.75
|
US$9,750
|
|
|
2018-06-21 |
2018-06-20 |
PlS
Planned sale
|
Miller Paul Francis
Chief Scientific Officer
Officer
|
1,054
-1.4%
9.80
US$10,329
|
1,054
-1.4%
|
9.80
|
US$10,329
|
|
|
2018-06-21 |
2018-06-19 |
PlS
Planned sale
|
Miller Paul Francis
Chief Scientific Officer
Officer
|
946
-1.3%
9.75
US$9,224
|
946
-1.3%
|
9.75
|
US$9,224
|
|
|
2016-11-15 |
2016-11-11 |
PlS
Planned sale
|
Irvin Jon
Vice President, Finance
Officer
|
150
-1.9%
1.45
US$218
|
150
-1.9%
|
1.45
|
US$218
|
|
|
2016-11-02 |
2016-11-01 |
PlS
Planned sale
|
Vice President, Finance
Officer
|
280
-3.4%
1.28
US$359
|
280
-3.4%
|
1.28
|
US$359
|
|
|
2016-10-12 |
2016-10-11 |
PlS
Planned sale
|
Irvin Jon
Vice President, Finance
Officer
|
150
-1.8%
1.83
US$274
|
150
-1.8%
|
1.83
|
US$274
|
|
|
2016-10-05 |
2016-10-03 |
PlS
Planned sale
|
Vice President, Finance
Officer
|
250
-2.9%
1.93
US$481
|
250
-2.9%
|
1.93
|
US$481
|
|
|
2015-10-07 |
2015-10-06 |
B
Purchase
|
PFIZER INC
Large shareholder
|
714,285
+46.4%
7.00
US$4,999,995
|
714,285
+46.4%
|
7.00
|
US$4,999,995
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
Sofinnova Venture Partners VIII, L.P.
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
BASKETT FOREST
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
KOLLURI KRISHNA KITTU
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
Viswanathan Ravi
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
BARRIS PETER J
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
POWELL MICHAEL
Non-Executive Director
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
Sonsini Peter W.
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
Weller Harry R
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
KERINS PATRICK J
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
SANDELL SCOTT D
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
New Enterprise Associates 14, L.P.
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
MOTT DAVID M
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
Florence Anthony A. Jr.
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|
|
2015-10-06 |
2015-10-06 |
B
Purchase
|
BARRETT M JAMES
Large shareholder
|
857,142
+40.5%
7.00
US$5,999,994
|
857,142
+40.5%
|
7.00
|
US$5,999,994
|
|