United States Biotechnology & Medical Research

Applied Therapeutics Inc (APLT)

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Ticker: APLT Exchange: NMS
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Sale 16 Dec 2025
Value US$4,114,318.69 | Price 203.00 | Shares 79,537 (+36.3%)
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2025-12-18 2025-12-16 S Sale
2.0
Kanter Stacy J.
Non-Executive Director
79,537 +36.3%
203.00
US$4,114,319 		79,537 +36.3% 203.00 US$4,114,319
2025-12-16 2025-12-16 PrS Proposed sale
2.0
Stacy J. Kanter

Director

Non-Executive Director
59,308
296.59
US$2,471,509 		59,308 296.59 US$2,471,509
2025-03-06 2025-03-04 S Sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
82,220 +5.4%
131.88
US$4,125,548 		82,220 +5.4% 131.88 US$4,125,548
2025-03-06 2025-03-04 S Sale
3.6
Chinoporos Constantine

See Remarks

Officer
447 -0.2%
0.44
US$197 		447 -0.2% 0.44 US$197
2025-03-06 2025-03-04 S Sale
4.2
Funtleyder Leslie D.

See Remarks

Executive Director
14,502 -3.6%
0.44
US$6,381 		14,502 -3.6% 0.44 US$6,381
2025-02-07 2025-02-06 S Sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
86,078 -8.7%
0.61
US$52,508 		86,078 -8.7% 0.61 US$52,508
2025-02-07 2025-02-06 S Sale
3.6
Chinoporos Constantine

See Remarks

Officer
28,117 -9.4%
0.61
US$17,151 		28,117 -9.4% 0.61 US$17,151
2025-02-07 2025-02-06 S Sale
4.2
Funtleyder Leslie D.

See Remarks

Executive Director
22,950 -5.4%
0.61
US$14,000 		22,950 -5.4% 0.61 US$14,000
2024-08-23 2024-08-22 S Sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
22,681 -2.2%
5.83
US$132,230 		22,681 -2.2% 5.83 US$132,230
2024-08-23 2024-08-22 S Sale
4.2
Funtleyder Leslie D.

Chief Financial Officer

Executive Director
13,530 -4.6%
5.83
US$78,880 		13,530 -4.6% 5.83 US$78,880
2024-08-14 2024-08-14 S Sale
2.7
Shendelman Shoshana

President and CEO

Executive Director
119,591 -2.5%
5.93
US$709,175 		119,591 -2.5% 5.93 US$709,175
2024-08-14 2024-08-13 S Sale
2.7
Shendelman Shoshana

President and CEO

Executive Director
357,423 -6.9%
6.18
US$2,208,874 		357,423 -6.9% 6.18 US$2,208,874
2024-08-14 2024-08-12 S Sale
2.7
Shendelman Shoshana

President and CEO

Executive Director
300,000 -5.5%
5.98
US$1,794,000 		300,000 -5.5% 5.98 US$1,794,000
2024-08-09 2024-08-12 PrS Proposed sale
2.7
Shendelman Shoshana

Officer; President and Chief Executive Officer

Officer
1,000,000
6.21
US$6,210,000 		1,000,000 6.21 US$6,210,000
2024-06-10 2024-06-06 S Sale
2.7
Shendelman Shoshana

President and CEO

Executive Director Large shareholder
61,795 -1.6%
4.32
US$266,954 		61,795 -1.6% 4.32 US$266,954
2024-06-10 2024-06-06 S Sale
4.2
Funtleyder Leslie D.

Chief Financial Officer

Executive Director
16,980 -5.5%
4.32
US$73,354 		16,980 -5.5% 4.32 US$73,354
2024-06-10 2024-06-06 S Sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
22,003 -2.1%
4.32
US$95,053 		22,003 -2.1% 4.32 US$95,053
2024-06-06 2024-06-05 S Sale
1.8
ALEXANDRIA REAL ESTATE EQUITIES, INC.
Large shareholder
150,000 -2.5%
4.24
US$636,000 		150,000 -2.5% 4.24 US$636,000
2024-06-05 2024-06-05 PrS Proposed sale
ALEXANDRIA VENTURE INVESTMENTS LLC

10% Stockholder

Large shareholder
150,000
4.24
US$636,000 		150,000 4.24 US$636,000
2024-06-06 2024-06-04 S Sale
1.8
ALEXANDRIA REAL ESTATE EQUITIES, INC.
Large shareholder
150,000 -2.4%
4.21
US$631,500 		150,000 -2.4% 4.21 US$631,500
2024-06-04 2024-06-04 PrS Proposed sale
ALEXANDRIA VENTURE INVESTMENTS LLC

10% Stockholder

Large shareholder
150,000
4.20
US$630,000 		150,000 4.20 US$630,000
2024-05-17 2024-05-17 PrS Proposed sale
3.0
Hansard Adam

Officer

Officer
115,777
4.04
US$467,739 		115,777 4.04 US$467,739
2024-05-16 2024-05-16 PrS Proposed sale
3.0
Hansard Adam

Officer

Officer
179,425
4.20
US$753,585 		179,425 4.20 US$753,585
2024-03-18 2024-03-14 S Sale
3.0
Hansard Adam

Chief Commercial Officer

Officer
48,871 -6.3%
5.39
US$263,415 		48,871 -6.3% 5.39 US$263,415
2024-03-18 2024-03-14 S Sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
110,804 -9.7%
5.39
US$597,234 		110,804 -9.7% 5.39 US$597,234
2024-03-18 2024-03-14 S Sale
4.2
Funtleyder Leslie D.

Chief Financial Officer

Executive Director
28,727 -8.5%
5.39
US$154,839 		28,727 -8.5% 5.39 US$154,839
2024-03-18 2024-03-14 S Sale
2.7
Shendelman Shoshana

President and CEO

Executive Director Large shareholder
318,573 -7.7%
5.39
US$1,717,108 		318,573 -7.7% 5.39 US$1,717,108
2023-12-05 2023-12-01 B Purchase
2.0
Kanter Stacy J.
Non-Executive Director
30,000 +90.9%
2.18
US$65,367 		30,000 +90.9% 2.18 US$65,367
2023-12-01 2023-11-30 S Sale
2.7
Shendelman Shoshana

President and CEO

Executive Director Large shareholder
3,968 -0.2%
1.97
US$7,817 		3,968 -0.2% 1.97 US$7,817
2023-12-01 2023-11-30 S Sale
3.0
Hansard Adam

Chief Commercial Officer

Officer
965 -0.3%
1.97
US$1,901 		965 -0.3% 1.97 US$1,901
2023-12-01 2023-11-30 S Sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
1,583 -0.2%
1.97
US$3,119 		1,583 -0.2% 1.97 US$3,119
2023-11-06 2023-11-03 S Sale
1.8
ALEXANDRIA REAL ESTATE EQUITIES, INC.
Large shareholder
143,450 -2.5%
2.31
US$331,370 		143,450 -2.5% 2.31 US$331,370
2023-11-03 2023-11-03 PrS Proposed sale
ALEXANDRIA VENTURE INVESTMENTS LLC

10% Stockholder

Large shareholder
143,450
2.30
US$329,935 		143,450 2.30 US$329,935
2023-11-06 2023-11-02 S Sale
1.8
ALEXANDRIA REAL ESTATE EQUITIES, INC.
Large shareholder
103,808 -1.8%
2.32
US$240,835 		103,808 -1.8% 2.32 US$240,835
2023-11-02 2023-11-02 PrS Proposed sale
ALEXANDRIA VENTURE INVESTMENTS LLC

10% Stockholder

Large shareholder
103,808
2.32
US$240,874 		103,808 2.32 US$240,874
2023-11-02 2023-11-01 S Sale
1.8
ALEXANDRIA REAL ESTATE EQUITIES, INC.
Large shareholder
172,742 -2.9%
2.36
US$407,671 		172,742 -2.9% 2.36 US$407,671
2023-11-01 2023-11-01 PrS Proposed sale
ALEXANDRIA VENTURE INVESTMENTS LLC

10% Stockholder

Large shareholder
172,742
2.36
US$407,671 		172,742 2.36 US$407,671
2023-11-02 2023-10-31 S Sale
1.8
ALEXANDRIA REAL ESTATE EQUITIES, INC.
Large shareholder
155,000 -2.5%
2.41
US$373,550 		155,000 -2.5% 2.41 US$373,550
2023-10-31 2023-10-31 PrS Proposed sale
ALEXANDRIA VENTURE INVESTMENTS LLC

10% Stockholder

Large shareholder
155,000
2.41
US$373,550 		155,000 2.41 US$373,550
2023-09-29 2023-09-27 S Sale
3.0
Hansard Adam

Chief Commercial Officer

Officer
9,720 -2.5%
2.70
US$26,244 		9,720 -2.5% 2.70 US$26,244
2023-09-29 2023-09-27 S Sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
10,932 -1.6%
2.70
US$29,516 		10,932 -1.6% 2.70 US$29,516
2023-09-29 2023-09-27 S Sale
2.7
Shendelman Shoshana

President and CEO

Executive Director Large shareholder
115,632 -4.3%
2.70
US$312,206 		115,632 -4.3% 2.70 US$312,206
2023-01-13 2023-01-11 S Sale
2.7
Shendelman Shoshana

President and CEO

Executive Director Large shareholder
15,870 -2.1%
0.91
US$14,442 		15,870 -2.1% 0.91 US$14,442
2023-01-13 2023-01-11 S Sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
6,053 -3.8%
0.91
US$5,508 		6,053 -3.8% 0.91 US$5,508
2023-01-13 2023-01-11 S Sale
3.0
Hansard Adam

Chief Commercial Officer

Officer
4,495 -4.6%
0.91
US$4,090 		4,495 -4.6% 0.91 US$4,090
2022-10-14 2022-10-14 B Purchase
2.7
Shendelman Shoshana

President and CEO

Executive Director Large shareholder
50,000 +7.0%
0.65
US$32,250 		50,000 +7.0% 0.65 US$32,250
2022-10-13 2022-10-13 B Purchase
2.7
Shendelman Shoshana

President and CEO

Executive Director Large shareholder
73,256 +11.4%
0.56
US$40,891 		73,256 +11.4% 0.56 US$40,891
2022-10-12 2022-10-12 B Purchase
2.7
Shendelman Shoshana

President and CEO

Executive Director Large shareholder
38,153 +6.3%
0.52
US$19,943 		38,153 +6.3% 0.52 US$19,943
2022-06-29 2022-06-27 B Purchase
1.8
ALEXANDRIA REAL ESTATE EQUITIES, INC.
Large shareholder
2,065,000 +82.9%
1.00
US$2,065,000 		2,065,000 +82.9% 1.00 US$2,065,000
2022-06-29 2022-06-27 B Purchase
1.8
ALEXANDRIA REAL ESTATE EQUITIES, INC.
Large shareholder
1,435,000 +152.0%
1.00
US$1,435,000 		1,435,000 +152.0% 1.00 US$1,435,000
2022-05-18 2022-05-16 S Sale
3.1
Mahadevan Chids

See Remarks

Officer
905 -8.5%
1.65
US$1,493 		905 -8.5% 1.65 US$1,493
2022-03-23 2022-03-23 B Purchase
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
30,000 +22.9%
1.97
US$59,100 		30,000 +22.9% 1.97 US$59,100
2022-03-23 2022-03-22 B Purchase
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
21,961 +20.2%
1.98
US$43,483 		21,961 +20.2% 1.98 US$43,483
2022-03-23 2022-03-21 B Purchase
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
12,548 +13.0%
1.85
US$23,214 		12,548 +13.0% 1.85 US$23,214
2021-09-14 2021-09-14 B Purchase
2.7
Shendelman Shoshana

President and CEO

Executive Director Large shareholder
9,300 +2.6%
14.49
US$134,740 		9,300 +2.6% 14.49 US$134,740
2021-09-14 2021-09-13 B Purchase
2.7
Shendelman Shoshana

President and CEO

Executive Director Large shareholder
701 +0.2%
14.69
US$10,298 		701 +0.2% 14.69 US$10,298
2021-06-10 2021-06-08 S Sale
3.0
Silberstein Charles

Chief Financial Officer

Officer
5,047 -5.4%
21.42
US$108,107 		5,047 -5.4% 21.42 US$108,107
2021-06-07 2021-06-07 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
260 -100.0%
21.38
US$5,559 		260 -100.0% 21.38 US$5,559
2021-06-07 2021-06-07 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
200 -43.5%
20.43
US$4,086 		200 -43.5% 20.43 US$4,086
2021-06-07 2021-06-04 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
460 -100.0%
19.65
US$9,039 		460 -100.0% 19.65 US$9,039
2021-06-07 2021-06-03 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
460 -100.0%
19.66
US$9,044 		460 -100.0% 19.66 US$9,044
2021-05-28 2021-05-26 S Sale
3.0
Hansard Adam

Chief Commercial Officer

Officer
2,894 -7.9%
18.35
US$53,105 		2,894 -7.9% 18.35 US$53,105
2021-04-30 2021-04-30 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
460 -100.0%
18.32
US$8,427 		460 -100.0% 18.32 US$8,427
2021-04-30 2021-04-29 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
460 -100.0%
18.28
US$8,409 		460 -100.0% 18.28 US$8,409
2021-04-30 2021-04-28 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
300 -100.0%
18.92
US$5,676 		300 -100.0% 18.92 US$5,676
2021-04-30 2021-04-28 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
1,340 -81.7%
18.33
US$24,562 		1,340 -81.7% 18.33 US$24,562
2021-03-30 2021-03-30 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
460 -100.0%
18.43
US$8,478 		460 -100.0% 18.43 US$8,478
2021-03-30 2021-03-29 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
465 -100.0%
18.53
US$8,616 		465 -100.0% 18.53 US$8,616
2021-03-30 2021-03-26 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
465 -100.0%
19.68
US$9,151 		465 -100.0% 19.68 US$9,151
2021-03-15 2021-03-15 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
465 -100.0%
19.61
US$9,119 		465 -100.0% 19.61 US$9,119
2021-03-15 2021-03-12 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
465 -100.0%
19.38
US$9,012 		465 -100.0% 19.38 US$9,012
2021-03-15 2021-03-11 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
465 -100.0%
18.48
US$8,593 		465 -100.0% 18.48 US$8,593
2021-02-25 2021-02-25 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
1,295 -100.0%
23.20
US$30,044 		1,295 -100.0% 23.20 US$30,044
2021-02-25 2021-02-24 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
600 -100.0%
24.57
US$14,742 		600 -100.0% 24.57 US$14,742
2021-02-25 2021-02-24 PlS Planned sale
3.1
Perfetti Riccardo

Chief Medical Officer

Officer
1,525 -71.8%
23.71
US$36,158 		1,525 -71.8% 23.71 US$36,158
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