Aoife Brennan

Currently holds a position at Synlogic Inc

Position	Company	Period
President, Chief Executive Officer, Director	Synlogic Inc	Oct. 1, 2018 -
Interim President and Chief Executive Officer, Chief Medical Officer	Synlogic Inc	May 10, 2018 - Oct. 1, 2018
Chief Medical Officer	Synlogic Inc	Aug. 28, 2017 - May 10, 2018

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2025-07-01	2025-06-30	Climb Bio Inc (CLYM)	PlS Planned sale	65,174 -7.1% 307.31 US$4,333,479	65,174 -7.1%	307.31	US$4,333,479
2024-04-22	2024-04-19	Synlogic Inc (SYBX)	PrS Proposed sale	85,026 220.66 US$2,421,196	85,026	220.66	US$2,421,196
2024-03-21	2024-03-21	Synlogic Inc (SYBX)	PrS Proposed sale	97,492 214.25 US$159,839	97,492	214.25	US$159,839
2023-06-09	2023-06-09	FibroGen Inc (FGEN)	PrS Proposed sale	4,733 17.19 US$81,363	4,733	17.19	US$81,363
2023-06-09	2023-06-09	FibroGen Inc (FGEN)	PlS Planned sale	2,739 -8.9% 17.52 US$47,987	2,739 -8.9%	17.52	US$47,987
2023-06-09	2023-06-09	FibroGen Inc (FGEN)	PlS Planned sale	1,994 -6.1% 16.74 US$33,380	1,994 -6.1%	16.74	US$33,380
2023-04-05	2023-04-03	Synlogic Inc (SYBX)	PlS Planned sale	19,042 -6.9% 0.58 US$10,964	19,042 -6.9%	0.58	US$10,964
2022-04-06	2022-04-04	Synlogic Inc (SYBX)	PlS Planned sale	8,894 -3.1% 2.45 US$21,754	8,894 -3.1%	2.45	US$21,754