United States Biotechnology & Medical Research

Ionis Pharmaceuticals Inc (IONS)

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Over the past 90 days, Ionis Pharmaceuticals saw 36 insider trading transactions. While insiders executed significant planned and proposed sales totaling approximately $56.7 million, Michael R. Hayden made notable purchases of $1.06 million in late July. These activities follow the company's recent earnings report, which showed a 35.78% earnings beat amid a 31.4% stock price decline.
Ticker: IONS Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Ionis Pharmaceuticals Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Top insiders
Trades
Buy 31 Jul 2026
Value US$1,490,098.76 | Price 143.88 | Shares 39,761 (-17.3%)
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-07-31 2026-07-31 B Purchase
3.1
Hayden Michael R
Non-Executive Director
39,761 -17.3%
143.88
US$1,490,099 		39,761 -17.3% 143.88 US$1,490,099
2026-07-31 2026-07-30 B Purchase
3.1
Hayden Michael R
Non-Executive Director
21,494 +42.1%
76.66
US$2,255,742 		21,494 +42.1% 76.66 US$2,255,742
2026-07-09 2026-07-07 PlS Planned sale
3.9
BENNETT C FRANK

EVP, Chief Scientific Officer

Officer
52,657 +11.5%
396.09
US$1,930,724 		52,657 +11.5% 396.09 US$1,930,724
2026-07-09 2026-07-07 PlS Planned sale
3.9
BENNETT C FRANK

EVP, Chief Scientific Officer

Officer
5,536 -6.9%
83.58
US$462,693 		5,536 -6.9% 83.58 US$462,693
2026-07-09 2026-07-07 PlS Planned sale
2.0
Kordasiewicz Holly B.

EVP, Chief Development Officer

Officer
362 -1.6%
84.30
US$30,517 		362 -1.6% 84.30 US$30,517
2026-07-09 2026-07-07 PlS Planned sale
Diaz Allene M.
Non-Executive Director
10,111 -72.6%
85.42
US$863,637 		10,111 -72.6% 85.42 US$863,637
2026-07-07 2026-07-07 PrS Proposed sale
Diaz Allene M.

Director

Non-Executive Director
10,111
85.42
US$863,637 		10,111 85.42 US$863,637
2026-07-07 2026-07-07 PrS Proposed sale
2.0
Kordasiewicz Holly B.

Officer

Officer
1,287
84.30
US$108,494 		1,287 84.30 US$108,494
2026-07-07 2026-07-07 PrS Proposed sale
3.9
BENNETT C FRANK

Officer

Officer
67,386
84.95
US$5,724,724 		67,386 84.95 US$5,724,724
2026-07-06 2026-07-01 PlS Planned sale
1.5
KLEIN JOSEPH III
Non-Executive Director
11,419 -50.9%
79.04
US$902,551 		11,419 -50.9% 79.04 US$902,551
2026-07-06 2026-07-01 PlS Planned sale
1.5
KLEIN JOSEPH III
Non-Executive Director
99 -0.4%
79.45
US$7,866 		99 -0.4% 79.45 US$7,866
2026-07-01 2026-07-01 PrS Proposed sale
1.5
KLEIN JOSEPH III

Director

Non-Executive Director
11,518
79.04
US$910,417 		11,518 79.04 US$910,417
2026-06-30 2026-06-26 PlS Planned sale
3.7
Schneider Eugene

EVP, Chf Clinical Develop Ofcr

Officer
26,000 -25.2%
81.05
US$2,107,196 		26,000 -25.2% 81.05 US$2,107,196
2026-06-30 2026-06-26 PlS Planned sale
3.3
Baroldi Joseph

EVP, Chief Business Officer

Officer
5,635 -54.7%
80.16
US$451,699 		5,635 -54.7% 80.16 US$451,699
2026-06-30 2026-06-26 PlS Planned sale
3.8
O'NEIL PATRICK R.

EVP CLO & General Counsel

Officer
3,069 -4.8%
80.00
US$245,520 		3,069 -4.8% 80.00 US$245,520
2026-06-26 2026-06-26 PlS Planned sale
3.7
Monia Brett P

Chief Executive Officer

Executive Director
50,000 -16.9%
80.59
US$4,029,500 		50,000 -16.9% 80.59 US$4,029,500
2026-06-26 2026-06-26 PrS Proposed sale
Baroldi Mariana

Member of immediate family of any of the foregoing
5,635
80.16
US$451,699 		5,635 80.16 US$451,699
2026-06-26 2026-06-26 PrS Proposed sale
3.8
O'NEIL PATRICK R.

Officer

Officer
3,069
80.00
US$245,520 		3,069 80.00 US$245,520
2026-06-26 2026-06-26 PrS Proposed sale
3.7
Schneider Eugene

Officer

Officer
47,884
81.05
US$3,880,807 		47,884 81.05 US$3,880,807
2026-06-26 2026-06-25 PlS Planned sale
3.7
Monia Brett P

Chief Executive Officer

Executive Director
21,072 -7.9%
78.49
US$1,653,941 		21,072 -7.9% 78.49 US$1,653,941
2026-06-26 2026-06-25 PlS Planned sale
3.7
Swayze Eric

EVP Research

Officer
10,602 -32.8%
79.18
US$839,492 		10,602 -32.8% 79.18 US$839,492
2026-06-25 2026-06-25 PrS Proposed sale
3.7
Swayze Eric

Officer

Officer
10,602
79.16
US$839,287 		10,602 79.16 US$839,287
2026-06-26 2026-06-24 PlS Planned sale
3.7
Monia Brett P

Chief Executive Officer

Executive Director
14,565 -5.6%
78.41
US$1,142,082 		14,565 -5.6% 78.41 US$1,142,082
2026-06-16 2026-06-15 PlS Planned sale
1.5
BERTHELSEN SPENCER R
Non-Executive Director
8,000 -4.9%
73.49
US$587,920 		8,000 -4.9% 73.49 US$587,920
2026-06-15 2026-06-15 PrS Proposed sale
1.5
BERTHELSEN SPENCER R

Director

Non-Executive Director
8,000
73.49
US$587,920 		8,000 73.49 US$587,920
2026-06-16 2026-06-12 PlS Planned sale
2.0
Kordasiewicz Holly B.

EVP, Chief Development Officer

Officer
19,842 -46.9%
74.05
US$1,469,306 		19,842 -46.9% 74.05 US$1,469,306
2026-06-16 2026-06-12 PlS Planned sale
2.0
Kordasiewicz Holly B.

EVP, Chief Development Officer

Officer
41,004 -49.2%
73.09
US$2,997,122 		41,004 -49.2% 73.09 US$2,997,122
2026-06-12 2026-06-12 PrS Proposed sale
2.0
Kordasiewicz Holly B.

Officer

Officer
60,846
73.41
US$4,466,425 		60,846 73.41 US$4,466,425
2026-06-03 2026-06-01 PlS Planned sale
1.5
BERTHELSEN SPENCER R
Non-Executive Director
8,000 -4.9%
75.67
US$605,360 		8,000 -4.9% 75.67 US$605,360
2026-06-01 2026-06-01 PrS Proposed sale
1.5
BERTHELSEN SPENCER R

Director

Non-Executive Director
8,000
75.67
US$605,360 		8,000 75.67 US$605,360
2026-05-15 2026-05-14 PlS Planned sale
3.7
Monia Brett P

Chief Executive Officer

Executive Director
3,220 -1.3%
78.68
US$253,347 		3,220 -1.3% 78.68 US$253,347
2026-05-15 2026-05-13 PlS Planned sale
3.7
Monia Brett P

Chief Executive Officer

Executive Director
1,316 -0.5%
78.01
US$102,665 		1,316 -0.5% 78.01 US$102,665
2026-05-13 2026-05-13 PrS Proposed sale
3.7
Monia Brett P

Officer

Officer
100,000
78.01
US$7,801,300 		100,000 78.01 US$7,801,300
2026-05-06 2026-05-04 PlS Planned sale
LOSCALZO JOSEPH
Non-Executive Director
17,781 -32.9%
75.58
US$1,343,934 		17,781 -32.9% 75.58 US$1,343,934
2026-05-06 2026-05-04 PlS Planned sale
LOSCALZO JOSEPH
Non-Executive Director
59,508 -52.4%
74.90
US$4,457,292 		59,508 -52.4% 74.90 US$4,457,292
2026-05-04 2026-05-04 PrS Proposed sale
LOSCALZO JOSEPH

Director

Non-Executive Director
54,321
80.00
US$4,345,680 		54,321 80.00 US$4,345,680
2026-05-05 2026-05-01 PlS Planned sale
1.5
KLEIN JOSEPH III
Non-Executive Director
1,431 -11.5%
74.45
US$106,534 		1,431 -11.5% 74.45 US$106,534
2026-05-05 2026-05-01 PlS Planned sale
1.5
KLEIN JOSEPH III
Non-Executive Director
8,680 -41.1%
73.35
US$636,704 		8,680 -41.1% 73.35 US$636,704
2026-04-30 2026-04-28 PlS Planned sale
3.3
Baroldi Joseph

EVP, Chief Business Officer

Officer
1,626 -3.5%
71.79
US$116,727 		1,626 -3.5% 71.79 US$116,727
2026-04-28 2026-04-28 PrS Proposed sale
3.3
Baroldi Joseph

Officer

Officer
1,626
71.79
US$116,727 		1,626 71.79 US$116,727
2026-04-17 2026-04-16 S Sale
2.6
Birchler Brian

EVP, Corp and Development Ops

Officer
973 -1.4%
75.04
US$73,016 		973 -1.4% 75.04 US$73,016
2026-04-17 2026-04-16 S Sale
2.6
Jenne Kyle

EVP, Chf GL Pdt Str Ofcr

Officer
4,902 -17.1%
75.17
US$368,488 		4,902 -17.1% 75.17 US$368,488
2026-04-17 2026-04-16 S Sale
3.3
Baroldi Joseph

EVP, Chief Business Officer

Officer
5,619 -10.8%
74.56
US$418,953 		5,619 -10.8% 74.56 US$418,953
2026-04-16 2026-04-16 PrS Proposed sale
2.6
Jenne Kyle

Officer

Officer
4,902
75.40
US$369,600 		4,902 75.40 US$369,600
2026-04-16 2026-04-16 PrS Proposed sale
2.6
Birchler Brian

Officer

Officer
973
75.40
US$73,362 		973 75.40 US$73,362
2026-04-16 2026-04-16 PrS Proposed sale
3.3
Baroldi Joseph

Officer

Officer
5,619
75.40
US$423,660 		5,619 75.40 US$423,660
2026-04-17 2026-04-15 PlS Planned sale
3.8
PARSHALL B LYNNE
Non-Executive Director
534 -1.0%
76.97
US$41,102 		534 -1.0% 76.97 US$41,102
2026-04-17 2026-04-15 PlS Planned sale
3.8
PARSHALL B LYNNE
Non-Executive Director
4,466 -7.9%
76.19
US$340,265 		4,466 -7.9% 76.19 US$340,265
2026-04-02 2026-04-02 PlS Planned sale
2.6
Devers Shannon L.

EVP, Chief Human Resources Ofc

Officer
6,193 -27.5%
74.05
US$458,613 		6,193 -27.5% 74.05 US$458,613
2026-04-02 2026-04-01 PlS Planned sale
1.5
KLEIN JOSEPH III
Non-Executive Director
2,216 -16.7%
75.95
US$168,314 		2,216 -16.7% 75.95 US$168,314
2026-04-02 2026-04-01 PlS Planned sale
1.5
KLEIN JOSEPH III
Non-Executive Director
20,105 -60.3%
75.50
US$1,517,988 		20,105 -60.3% 75.50 US$1,517,988
2026-03-24 2026-03-19 PrS Proposed sale
3.7
Schneider Eugene

Officer

Officer
5,812
70.97
US$412,486 		5,812 70.97 US$412,486
2026-03-23 2026-03-19 PlS Planned sale
3.7
Schneider Eugene

EVP, Chf Clinical Develop Ofcr

Officer
5,812 -8.3%
70.97
US$412,486 		5,812 -8.3% 70.97 US$412,486
2026-03-19 2026-03-19 PrS Proposed sale
3.7
Schneider Eugene

Officer

Officer
5,812
70.97
US$412,486 		5,812 70.97 US$412,486
2026-03-18 2026-03-17 PlS Planned sale
3.6
HOUGEN ELIZABETH L

EVP, Finance & CFO

Officer
10,172 -11.0%
73.21
US$744,662 		10,172 -11.0% 73.21 US$744,662
2026-03-18 2026-03-16 PlS Planned sale
3.6
HOUGEN ELIZABETH L

EVP, Finance & CFO

Officer
9,440 -9.2%
72.77
US$686,902 		9,440 -9.2% 72.77 US$686,902
2026-03-18 2026-03-16 PlS Planned sale
3.6
HOUGEN ELIZABETH L

EVP, Finance & CFO

Officer
205,608 -66.8%
72.38
US$14,882,113 		205,608 -66.8% 72.38 US$14,882,113
2026-03-16 2026-03-16 PrS Proposed sale
3.6
HOUGEN ELIZABETH L

Officer

Officer
225,200
72.31
US$16,284,212 		225,200 72.31 US$16,284,212
2026-03-11 2026-03-10 PlS Planned sale
2.6
Jenne Kyle

EVP, Chf GL Pdt Str Ofcr

Officer
16,086 -57.9%
76.30
US$1,227,362 		16,086 -57.9% 76.30 US$1,227,362
2026-03-11 2026-03-10 PlS Planned sale
2.6
Jenne Kyle

EVP, Chf GL Pdt Str Ofcr

Officer
21,191 -43.3%
75.50
US$1,599,963 		21,191 -43.3% 75.50 US$1,599,963
2026-03-11 2026-03-10 PlS Planned sale
3.7
Monia Brett P

Chief Executive Officer

Executive Director
17,591 -6.8%
76.34
US$1,342,909 		17,591 -6.8% 76.34 US$1,342,909
2026-03-11 2026-03-10 PlS Planned sale
3.7
Monia Brett P

Chief Executive Officer

Executive Director
16,512 -6.0%
75.47
US$1,246,235 		16,512 -6.0% 75.47 US$1,246,235
2026-03-10 2026-03-10 PrS Proposed sale
2.6
Jenne Kyle

Director

Non-Executive Director
58,253
75.57
US$4,402,296 		58,253 75.57 US$4,402,296
2026-03-11 2026-03-09 PlS Planned sale
3.8
O'NEIL PATRICK R.

EVP CLO & General Counsel

Officer
10,148 -14.0%
75.25
US$763,662 		10,148 -14.0% 75.25 US$763,662
2026-03-11 2026-03-09 PlS Planned sale
3.7
Monia Brett P

Chief Executive Officer

Executive Director
1,684 -0.7%
75.58
US$127,282 		1,684 -0.7% 75.58 US$127,282
2026-03-11 2026-03-09 PlS Planned sale
3.7
Monia Brett P

Chief Executive Officer

Executive Director
117,604 -32.5%
75.26
US$8,850,642 		117,604 -32.5% 75.26 US$8,850,642
2026-03-11 2026-03-09 PlS Planned sale
3.7
Monia Brett P

Chief Executive Officer

Executive Director
7,382 -2.0%
74.11
US$547,087 		7,382 -2.0% 74.11 US$547,087
2026-03-09 2026-03-09 PrS Proposed sale
3.8
O'NEIL PATRICK R.

Officer

Officer
13,217
75.25
US$994,612 		13,217 75.25 US$994,612
2026-03-05 2026-03-04 PlS Planned sale
3.3
Baroldi Joseph

EVP, Chief Business Officer

Officer
201 -4.4%
80.00
US$16,080 		201 -4.4% 80.00 US$16,080
2026-03-05 2026-03-04 PlS Planned sale
3.3
Baroldi Joseph

EVP, Chief Business Officer

Officer
238 -5.2%
80.00
US$19,040 		238 -5.2% 80.00 US$19,040
2026-03-05 2026-03-04 PlS Planned sale
LOSCALZO JOSEPH
Non-Executive Director
200 -0.5%
80.00
US$16,000 		200 -0.5% 80.00 US$16,000
2026-03-31 2026-03-03 PrS Proposed sale
Diaz Allene M.

Director

Non-Executive Director
68,800
79.50
US$5,469,600 		68,800 79.50 US$5,469,600
2026-03-05 2026-03-03 PlS Planned sale
3.3
Baroldi Joseph

EVP, Chief Business Officer

Officer
36 -0.8%
81.01
US$2,916 		36 -0.8% 81.01 US$2,916
2026-03-05 2026-03-03 PlS Planned sale
3.3
Baroldi Joseph

EVP, Chief Business Officer

Officer
2,088 -32.3%
80.41
US$167,892 		2,088 -32.3% 80.41 US$167,892
2026-03-05 2026-03-03 PlS Planned sale
3.3
Baroldi Joseph

EVP, Chief Business Officer

Officer
4,096 -9.0%
79.36
US$325,059 		4,096 -9.0% 79.36 US$325,059
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