Baroldi Joseph

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PS: Planned sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value	Details
2025-04-17	2025-04-16	Ionis Pharmaceuticals Inc (IONS)	S Sale	3,928 -11.0% 28.40 USD 111,555	3,928 -11.0%	28.40	USD 111,555
2025-01-17	2025-01-16	Ionis Pharmaceuticals Inc (IONS)	S Sale	1,029 -25.1% 32.70 USD 33,648	1,029 -25.1%	32.70	USD 33,648
2025-01-17	2025-01-16	Ionis Pharmaceuticals Inc (IONS)	S Sale	3,401 -12.0% 32.70 USD 111,213	3,401 -12.0%	32.70	USD 111,213
2024-04-17	2024-04-16	Ionis Pharmaceuticals Inc (IONS)	S Sale	4,006 -16.9% 41.60 USD 166,641	4,006 -16.9%	41.60	USD 166,641
2024-01-18	2024-01-17	Ionis Pharmaceuticals Inc (IONS)	S Sale	564 -25.6% 50.42 USD 28,435	564 -25.6%	50.42	USD 28,435
2024-01-18	2024-01-17	Ionis Pharmaceuticals Inc (IONS)	S Sale	1,460 -10.2% 50.42 USD 73,609	1,460 -10.2%	50.42	USD 73,609
2023-04-19	2023-04-18	Ionis Pharmaceuticals Inc (IONS)	S Sale	3,880 -26.8% 36.50 USD 141,631	3,880 -26.8%	36.50	USD 141,631
2023-01-19	2023-01-18	Ionis Pharmaceuticals Inc (IONS)	S Sale	375 -30.6% 39.79 USD 14,920	375 -30.6%	39.79	USD 14,920