Birchler Brian

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PS: Planned sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value	Details
2025-04-17	2025-04-16	Ionis Pharmaceuticals Inc (IONS)	S Sale	680 -1.2% 28.37 USD 19,292	680 -1.2%	28.37	USD 19,292
2025-01-17	2025-01-16	Ionis Pharmaceuticals Inc (IONS)	S Sale	5,400 -8.9% 32.70 USD 176,580	5,400 -8.9%	32.70	USD 176,580
2024-04-17	2024-04-16	Ionis Pharmaceuticals Inc (IONS)	S Sale	905 -1.9% 41.66 USD 37,698	905 -1.9%	41.66	USD 37,698
2024-01-18	2024-01-17	Ionis Pharmaceuticals Inc (IONS)	S Sale	4,497 -9.2% 50.42 USD 226,725	4,497 -9.2%	50.42	USD 226,725
2023-04-19	2023-04-18	Ionis Pharmaceuticals Inc (IONS)	S Sale	672 -1.8% 36.50 USD 24,530	672 -1.8%	36.50	USD 24,530