REARDAN DAYTON T

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2004-05-05	2004-05-03	Open Orphan PLC (ORPH)	PlS Planned sale	55,450 +46.9% 73.05 US$4,804,957	55,450 +46.9%	73.05	US$4,804,957
2004-05-05	2004-05-03	Open Orphan PLC (ORPH)	PlS Planned sale	20,305 -10.4% 422.43 US$303,618	20,305 -10.4%	422.43	US$303,618
2004-05-05	2004-05-03	Open Orphan PLC (ORPH)	PlS Planned sale	2,176 +11.2% 79.48 US$3,095,967	2,176 +11.2%	79.48	US$3,095,967
2004-05-03	2004-04-30	Open Orphan PLC (ORPH)	PlS Planned sale	2,400 -16.2% 11.10 US$26,640	2,400 -16.2%	11.10	US$26,640
2004-05-03	2004-04-29	Open Orphan PLC (ORPH)	PlS Planned sale	200 -1.3% 11.09 US$2,218	200 -1.3%	11.09	US$2,218