Liu David R.

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2025-07-01	2025-06-30	Prime Medicine Inc (PRME)	PP Planned purchase	28,135 -24.2% 283.69 US$4,555,140	28,135 -24.2%	283.69	US$4,555,140
2025-06-23	2025-06-23	Prime Medicine Inc (PRME)	PP Planned purchase	17,082 -44.3% 90.96 US$3,428,827	17,082 -44.3%	90.96	US$3,428,827
2025-06-16	2025-06-16	Prime Medicine Inc (PRME)	PP Planned purchase	60,390 +9.7% 320.89 US$2,388,562	60,390 +9.7%	320.89	US$2,388,562
2025-06-12	2025-06-11	Prime Medicine Inc (PRME)	PP Planned purchase	21,000 +0.1% 1.60 US$33,590	21,000 +0.1%	1.60	US$33,590