United States Biotechnology & Medical Research

Prime Medicine Inc (PRME)

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Prime Medicine Inc. experienced significant insider trading activity throughout 2025, with the most recent transactions occurring on August 1. Multiple entities and individuals executed substantial buy orders during this period. These acquisitions represent the latest recorded movements, as no further activity has been reported within the last three months.
Ticker: PRME Exchange: NMS
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
4.3
GV 2021 GP, L.L.C. Large shareholder
Transaction date
Purchase
Price
343.82
Quantity 60,175 +11.0%
Value US$3,533,428
3.3
NELSEN ROBERT Non-Executive Director Large shareholder
Transaction date
Purchase
Price
229.54
Quantity 6,658 +29.4%
Value US$168,381
Liu David R. Large shareholder
Transaction date
Planned purchase
Price
2.52
Quantity 21,000 +0.1%
Value US$52,830
Liu David R. Large shareholder
Transaction date
Planned purchase
Price
2.16
Quantity 21,000 +0.1%
Value US$45,402
Liu David R. Large shareholder
Transaction date
Planned purchase
Price
1.49
Quantity 21,000 +0.1%
Value US$31,196
Liu David R. Large shareholder
Transaction date
Planned purchase
Price
1.60
Quantity 21,000 +0.1%
Value US$33,590
3.4
LEE ANN L. Chief Technical Officer Officer
Transaction date
Purchase
Price
1.13
Quantity 100,000 +inf%
Value US$113,000
3.4
Reine Allan Chief Executive Officer Executive Director
Transaction date
Purchase
Price
1.18
Quantity 125,000 +inf%
Value US$147,150
3.4
Brudnick Richard Chief Business Officer Officer
Transaction date
Purchase
Price
1.19
Quantity 20,000 +inf%
Value US$23,790
3.3
NELSEN ROBERT Non-Executive Director Large shareholder
Transaction date
Purchase
Price
6.25
Quantity 3,200,000 +inf%
Value US$20,000,000
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.97
Quantity 19,003 -100.0%
Value US$284,496
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
15.06
Quantity 37,405 -100.0%
Value US$563,248
Alphabet Holdings LLC 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
14.91
Quantity 522,561
Value US$7,791,385
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
15.02
Quantity 6,532 -100.0%
Value US$98,109
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.92
Quantity 66,659 -100.0%
Value US$994,326
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.87
Quantity 28,960 -100.0%
Value US$430,684
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
15.13
Quantity 28,100 -100.0%
Value US$425,102
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.98
Quantity 16,031 -100.0%
Value US$240,151
Alphabet Holdings LLC 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
14.49
Quantity 159,596
Value US$2,312,542
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.48
Quantity 15,672 -100.0%
Value US$226,984
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
15.74
Quantity 5,000 -100.0%
Value US$78,686
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
16.92
Quantity 15,000 -100.0%
Value US$253,870
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
17.02
Quantity 29,975 -100.0%
Value US$510,166
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
16.70
Quantity 22,434 -100.0%
Value US$374,612
Alphabet Holdings LLC 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
16.11
Quantity 88,081
Value US$1,418,985
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.75
Quantity 471 -100.0%
Value US$6,949
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.35
Quantity 44,752 -99.0%
Value US$642,245
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.65
Quantity 16,633 -100.0%
Value US$227,004
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.70
Quantity 16,805 -100.0%
Value US$230,240
Alphabet Holdings LLC 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
13.67
Quantity 71,263
Value US$974,165
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.70
Quantity 12,602 -100.0%
Value US$172,603
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.38
Quantity 23,161 -100.0%
Value US$309,973
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.66
Quantity 7,900 -100.0%
Value US$107,920
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.74
Quantity 43,939 -100.0%
Value US$647,648
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.13
Quantity 87,922 -100.0%
Value US$1,242,092
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.88
Quantity 63,212 -100.0%
Value US$877,066
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.06
Quantity 14,022 -100.0%
Value US$183,171
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.01
Quantity 13,076 -0.1%
Value US$170,100
Alphabet Holdings LLC 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
13.02
Quantity 260,156
Value US$3,387,231
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
12.77
Quantity 15,000 -0.1%
Value US$191,600
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
12.59
Quantity 50,649 -0.5%
Value US$637,676
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
12.74
Quantity 157,952 -1.4%
Value US$2,012,087
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
12.72
Quantity 27,290 -0.2%
Value US$347,222
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.79
Quantity 4,807 -0.0%
Value US$66,290
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
12.98
Quantity 21,819 -0.2%
Value US$283,243
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.03
Quantity 87,397 -0.8%
Value US$1,225,804
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.08
Quantity 321,238 -2.8%
Value US$4,522,613
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.13
Quantity 100,772 -0.9%
Value US$1,423,727
GV 2019, L.P. 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
14.32
Quantity 1,121,197
Value US$16,055,541
3.3
NELSEN ROBERT Non-Executive Director Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 400,000 +7.0%
Value US$6,800,000
3.3
NELSEN ROBERT Non-Executive Director Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 400,000 +7.0%
Value US$6,800,000
2.4
Cahill Thomas Non-Executive Director
Transaction date
Purchase
Price
17.00
Quantity 400,000 +8.2%
Value US$6,800,000
2.6
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 800,000 +7.5%
Value US$13,600,000
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2025-08-05 2025-08-01 B Purchase
4.3
GV 2021 GP, L.L.C.
Large shareholder
60,175 +11.0%
343.82
US$3,533,428 		60,175 +11.0% 343.82 US$3,533,428
2025-08-01 2025-08-01 B Purchase
3.3
NELSEN ROBERT
Non-Executive Director Large shareholder
6,658 +29.4%
229.54
US$168,381 		6,658 +29.4% 229.54 US$168,381
2025-08-01 2025-08-01 B Purchase
3.7
ARCH Venture Partners XII, LLC
Large shareholder
65,787 -23.2%
313.46
US$512,085 		65,787 -23.2% 313.46 US$512,085
2025-08-01 2025-08-01 B Purchase
3.4
ARCH Venture Partners X, LLC
Large shareholder
3,030,300 +94.7%
3.30
US$9,999,990 		3,030,300 +94.7% 3.30 US$9,999,990
2025-07-01 2025-06-30 PP Planned purchase
Liu David R.
Large shareholder
21,000 +0.1%
2.52
US$52,830 		21,000 +0.1% 2.52 US$52,830
2025-06-23 2025-06-23 PP Planned purchase
Liu David R.
Large shareholder
21,000 +0.1%
2.16
US$45,402 		21,000 +0.1% 2.16 US$45,402
2025-06-16 2025-06-16 PP Planned purchase
Liu David R.
Large shareholder
21,000 +0.1%
1.49
US$31,196 		21,000 +0.1% 1.49 US$31,196
2025-06-12 2025-06-11 PP Planned purchase
Liu David R.
Large shareholder
21,000 +0.1%
1.60
US$33,590 		21,000 +0.1% 1.60 US$33,590
2025-05-22 2025-05-21 B Purchase
3.4
LEE ANN L.

Chief Technical Officer

Officer
100,000 +inf%
1.13
US$113,000 		100,000 +inf% 1.13 US$113,000
2025-05-22 2025-05-21 B Purchase
3.4
Reine Allan

Chief Executive Officer

Executive Director
125,000 +inf%
1.18
US$147,150 		125,000 +inf% 1.18 US$147,150
2025-05-22 2025-05-20 B Purchase
3.4
Brudnick Richard

Chief Business Officer

Officer
20,000 +inf%
1.19
US$23,790 		20,000 +inf% 1.19 US$23,790
2024-02-20 2024-02-15 B Purchase
3.3
NELSEN ROBERT
Non-Executive Director Large shareholder
3,200,000 +inf%
6.25
US$20,000,000 		3,200,000 +inf% 6.25 US$20,000,000
2024-02-20 2024-02-15 B Purchase
3.4
ARCH Venture Partners X, LLC
Large shareholder
3,200,000 +inf%
6.25
US$20,000,000 		3,200,000 +inf% 6.25 US$20,000,000
2024-02-20 2024-02-15 B Purchase
3.7
ARCH Venture Partners XII, LLC
Large shareholder
3,200,000 +inf%
6.25
US$20,000,000 		3,200,000 +inf% 6.25 US$20,000,000
2023-06-22 2023-06-21 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
19,003 -100.0%
14.97
US$284,496 		19,003 -100.0% 14.97 US$284,496
2023-06-22 2023-06-20 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
37,405 -100.0%
15.06
US$563,248 		37,405 -100.0% 15.06 US$563,248
2023-06-20 2023-06-20 PrS Proposed sale
Alphabet Holdings LLC

10% Stockholder

Large shareholder
522,561
14.91
US$7,791,385 		522,561 14.91 US$7,791,385
2023-06-20 2023-06-16 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
6,532 -100.0%
15.02
US$98,109 		6,532 -100.0% 15.02 US$98,109
2023-06-20 2023-06-15 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
66,659 -100.0%
14.92
US$994,326 		66,659 -100.0% 14.92 US$994,326
2023-06-15 2023-06-14 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
28,960 -100.0%
14.87
US$430,684 		28,960 -100.0% 14.87 US$430,684
2023-06-15 2023-06-13 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
28,100 -100.0%
15.13
US$425,102 		28,100 -100.0% 15.13 US$425,102
2023-06-13 2023-06-12 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
16,031 -100.0%
14.98
US$240,151 		16,031 -100.0% 14.98 US$240,151
2023-06-12 2023-06-12 PrS Proposed sale
Alphabet Holdings LLC

10% Stockholder

Large shareholder
159,596
14.49
US$2,312,542 		159,596 14.49 US$2,312,542
2023-06-13 2023-06-09 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
15,672 -100.0%
14.48
US$226,984 		15,672 -100.0% 14.48 US$226,984
2023-06-09 2023-06-08 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
5,000 -100.0%
15.74
US$78,686 		5,000 -100.0% 15.74 US$78,686
2023-06-09 2023-06-07 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
15,000 -100.0%
16.92
US$253,870 		15,000 -100.0% 16.92 US$253,870
2023-06-07 2023-06-06 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
29,975 -100.0%
17.02
US$510,166 		29,975 -100.0% 17.02 US$510,166
2023-06-07 2023-06-05 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
22,434 -100.0%
16.70
US$374,612 		22,434 -100.0% 16.70 US$374,612
2023-06-05 2023-06-05 PrS Proposed sale
Alphabet Holdings LLC

10% Stockholder

Large shareholder
88,081
16.11
US$1,418,985 		88,081 16.11 US$1,418,985
2023-06-02 2023-06-01 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
471 -100.0%
14.75
US$6,949 		471 -100.0% 14.75 US$6,949
2023-06-02 2023-06-01 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
44,752 -99.0%
14.35
US$642,245 		44,752 -99.0% 14.35 US$642,245
2023-06-02 2023-05-31 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
16,633 -100.0%
13.65
US$227,004 		16,633 -100.0% 13.65 US$227,004
2023-05-31 2023-05-30 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
16,805 -100.0%
13.70
US$230,240 		16,805 -100.0% 13.70 US$230,240
2023-05-30 2023-05-30 PrS Proposed sale
Alphabet Holdings LLC

10% Stockholder

Large shareholder
71,263
13.67
US$974,165 		71,263 13.67 US$974,165
2023-05-31 2023-05-26 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
12,602 -100.0%
13.70
US$172,603 		12,602 -100.0% 13.70 US$172,603
2023-05-26 2023-05-25 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
23,161 -100.0%
13.38
US$309,973 		23,161 -100.0% 13.38 US$309,973
2023-05-26 2023-05-24 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
7,900 -100.0%
13.66
US$107,920 		7,900 -100.0% 13.66 US$107,920
2023-05-24 2023-05-23 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
43,939 -100.0%
14.74
US$647,648 		43,939 -100.0% 14.74 US$647,648
2023-05-24 2023-05-22 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
87,922 -100.0%
14.13
US$1,242,092 		87,922 -100.0% 14.13 US$1,242,092
2023-05-22 2023-05-19 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
63,212 -100.0%
13.88
US$877,066 		63,212 -100.0% 13.88 US$877,066
2023-05-22 2023-05-18 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
14,022 -100.0%
13.06
US$183,171 		14,022 -100.0% 13.06 US$183,171
2023-05-22 2023-05-18 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
13,076 -0.1%
13.01
US$170,100 		13,076 -0.1% 13.01 US$170,100
2023-05-18 2023-05-18 PrS Proposed sale
Alphabet Holdings LLC

10% Stockholder

Large shareholder
260,156
13.02
US$3,387,231 		260,156 13.02 US$3,387,231
2023-05-18 2023-05-17 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
15,000 -0.1%
12.77
US$191,600 		15,000 -0.1% 12.77 US$191,600
2023-05-18 2023-05-16 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
50,649 -0.5%
12.59
US$637,676 		50,649 -0.5% 12.59 US$637,676
2023-05-16 2023-05-15 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
157,952 -1.4%
12.74
US$2,012,087 		157,952 -1.4% 12.74 US$2,012,087
2023-05-16 2023-05-12 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
27,290 -0.2%
12.72
US$347,222 		27,290 -0.2% 12.72 US$347,222
2023-05-12 2023-05-11 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
4,807 -0.0%
13.79
US$66,290 		4,807 -0.0% 13.79 US$66,290
2023-05-12 2023-05-11 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
21,819 -0.2%
12.98
US$283,243 		21,819 -0.2% 12.98 US$283,243
2023-05-12 2023-05-10 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
87,397 -0.8%
14.03
US$1,225,804 		87,397 -0.8% 14.03 US$1,225,804
2023-05-10 2023-05-09 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
321,238 -2.8%
14.08
US$4,522,613 		321,238 -2.8% 14.08 US$4,522,613
2023-05-10 2023-05-08 PlS Planned sale
2.6
GV 2019 GP, L.L.C.
Large shareholder
100,772 -0.9%
14.13
US$1,423,727 		100,772 -0.9% 14.13 US$1,423,727
2023-05-08 2023-05-08 PrS Proposed sale
GV 2019, L.P.

10% Stockholder

Large shareholder
1,121,197
14.32
US$16,055,541 		1,121,197 14.32 US$16,055,541
2022-10-26 2022-10-24 B Purchase
3.4
ARCH Venture Partners X, LLC
Large shareholder
400,000 +7.0%
17.00
US$6,800,000 		400,000 +7.0% 17.00 US$6,800,000
2022-10-26 2022-10-24 B Purchase
3.4
ARCH Venture Partners X, LLC
Large shareholder
400,000 +7.0%
17.00
US$6,800,000 		400,000 +7.0% 17.00 US$6,800,000
2022-10-26 2022-10-24 B Purchase
3.3
NELSEN ROBERT
Non-Executive Director Large shareholder
400,000 +7.0%
17.00
US$6,800,000 		400,000 +7.0% 17.00 US$6,800,000
2022-10-26 2022-10-24 B Purchase
3.3
NELSEN ROBERT
Non-Executive Director Large shareholder
400,000 +7.0%
17.00
US$6,800,000 		400,000 +7.0% 17.00 US$6,800,000
2022-10-26 2022-10-24 B Purchase
2.4
Cahill Thomas
Non-Executive Director
400,000 +8.2%
17.00
US$6,800,000 		400,000 +8.2% 17.00 US$6,800,000
2022-10-26 2022-10-24 B Purchase
2.6
GV 2019 GP, L.L.C.
Large shareholder
800,000 +7.5%
17.00
US$13,600,000 		800,000 +7.5% 17.00 US$13,600,000
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