United States Biotechnology & Medical Research

Prime Medicine Inc (PRME)

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Prime Medicine Inc. experienced significant insider trading activity throughout mid-2025. Major institutional investors and executives executed substantial buy orders on August 1, 2025, following a series of planned purchases by David R. Liu during June. These acquisitions represent the most recent market movements by company insiders, reflecting notable capital deployment within the organization.
Ticker: PRME Exchange: NMS
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
4.3
GV 2021 GP, L.L.C. Large shareholder
Transaction date
Purchase
Price
343.82
Quantity 60,175 +11.0%
Value US$3,533,428
3.3
NELSEN ROBERT Non-Executive Director Large shareholder
Transaction date
Purchase
Price
229.54
Quantity 6,658 +29.4%
Value US$168,381
Liu David R. Large shareholder
Transaction date
Planned purchase
Price
2.52
Quantity 21,000 +0.1%
Value US$52,830
Liu David R. Large shareholder
Transaction date
Planned purchase
Price
2.16
Quantity 21,000 +0.1%
Value US$45,402
Liu David R. Large shareholder
Transaction date
Planned purchase
Price
1.49
Quantity 21,000 +0.1%
Value US$31,196
Liu David R. Large shareholder
Transaction date
Planned purchase
Price
1.60
Quantity 21,000 +0.1%
Value US$33,590
3.4
LEE ANN L. Chief Technical Officer Officer
Transaction date
Purchase
Price
1.13
Quantity 100,000 +inf%
Value US$113,000
3.4
Reine Allan Chief Executive Officer Executive Director
Transaction date
Purchase
Price
1.18
Quantity 125,000 +inf%
Value US$147,150
3.4
Brudnick Richard Chief Business Officer Officer
Transaction date
Purchase
Price
1.19
Quantity 20,000 +inf%
Value US$23,790
3.3
NELSEN ROBERT Non-Executive Director Large shareholder
Transaction date
Purchase
Price
6.25
Quantity 3,200,000 +inf%
Value US$20,000,000
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.97
Quantity 19,003 -100.0%
Value US$284,496
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
15.06
Quantity 37,405 -100.0%
Value US$563,248
Alphabet Holdings LLC 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
14.91
Quantity 522,561
Value US$7,791,385
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
15.02
Quantity 6,532 -100.0%
Value US$98,109
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.92
Quantity 66,659 -100.0%
Value US$994,326
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.87
Quantity 28,960 -100.0%
Value US$430,684
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
15.13
Quantity 28,100 -100.0%
Value US$425,102
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.98
Quantity 16,031 -100.0%
Value US$240,151
Alphabet Holdings LLC 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
14.49
Quantity 159,596
Value US$2,312,542
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.48
Quantity 15,672 -100.0%
Value US$226,984
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
15.74
Quantity 5,000 -100.0%
Value US$78,686
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
16.92
Quantity 15,000 -100.0%
Value US$253,870
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
17.02
Quantity 29,975 -100.0%
Value US$510,166
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
16.70
Quantity 22,434 -100.0%
Value US$374,612
Alphabet Holdings LLC 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
16.11
Quantity 88,081
Value US$1,418,985
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.75
Quantity 471 -100.0%
Value US$6,949
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.35
Quantity 44,752 -99.0%
Value US$642,245
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.65
Quantity 16,633 -100.0%
Value US$227,004
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.70
Quantity 16,805 -100.0%
Value US$230,240
Alphabet Holdings LLC 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
13.67
Quantity 71,263
Value US$974,165
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.70
Quantity 12,602 -100.0%
Value US$172,603
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.38
Quantity 23,161 -100.0%
Value US$309,973
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.66
Quantity 7,900 -100.0%
Value US$107,920
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.74
Quantity 43,939 -100.0%
Value US$647,648
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.13
Quantity 87,922 -100.0%
Value US$1,242,092
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.88
Quantity 63,212 -100.0%
Value US$877,066
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.06
Quantity 14,022 -100.0%
Value US$183,171
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.01
Quantity 13,076 -0.1%
Value US$170,100
Alphabet Holdings LLC 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
13.02
Quantity 260,156
Value US$3,387,231
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
12.77
Quantity 15,000 -0.1%
Value US$191,600
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
12.59
Quantity 50,649 -0.5%
Value US$637,676
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
12.74
Quantity 157,952 -1.4%
Value US$2,012,087
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
12.72
Quantity 27,290 -0.2%
Value US$347,222
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
13.79
Quantity 4,807 -0.0%
Value US$66,290
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
12.98
Quantity 21,819 -0.2%
Value US$283,243
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.03
Quantity 87,397 -0.8%
Value US$1,225,804
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.08
Quantity 321,238 -2.8%
Value US$4,522,613
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Planned sale
Price
14.13
Quantity 100,772 -0.9%
Value US$1,423,727
GV 2019, L.P. 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
14.32
Quantity 1,121,197
Value US$16,055,541
3.3
NELSEN ROBERT Non-Executive Director Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 400,000 +7.0%
Value US$6,800,000
3.3
NELSEN ROBERT Non-Executive Director Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 400,000 +7.0%
Value US$6,800,000
2.4
Cahill Thomas Non-Executive Director
Transaction date
Purchase
Price
17.00
Quantity 400,000 +8.2%
Value US$6,800,000
2.0
GV 2019 GP, L.L.C. Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 800,000 +7.5%
Value US$13,600,000
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2025-08-05 2025-08-01 B Purchase
4.3
GV 2021 GP, L.L.C.
Large shareholder
60,175 +11.0%
343.82
US$3,533,428 		60,175 +11.0% 343.82 US$3,533,428
2025-08-01 2025-08-01 B Purchase
3.3
NELSEN ROBERT
Non-Executive Director Large shareholder
6,658 +29.4%
229.54
US$168,381 		6,658 +29.4% 229.54 US$168,381
2025-08-01 2025-08-01 B Purchase
3.7
ARCH Venture Partners XII, LLC
Large shareholder
65,787 -23.2%
313.46
US$512,085 		65,787 -23.2% 313.46 US$512,085
2025-08-01 2025-08-01 B Purchase
3.4
ARCH Venture Partners X, LLC
Large shareholder
3,030,300 +94.7%
3.30
US$9,999,990 		3,030,300 +94.7% 3.30 US$9,999,990
2025-07-01 2025-06-30 PP Planned purchase
Liu David R.
Large shareholder
21,000 +0.1%
2.52
US$52,830 		21,000 +0.1% 2.52 US$52,830
2025-06-23 2025-06-23 PP Planned purchase
Liu David R.
Large shareholder
21,000 +0.1%
2.16
US$45,402 		21,000 +0.1% 2.16 US$45,402
2025-06-16 2025-06-16 PP Planned purchase
Liu David R.
Large shareholder
21,000 +0.1%
1.49
US$31,196 		21,000 +0.1% 1.49 US$31,196
2025-06-12 2025-06-11 PP Planned purchase
Liu David R.
Large shareholder
21,000 +0.1%
1.60
US$33,590 		21,000 +0.1% 1.60 US$33,590
2025-05-22 2025-05-21 B Purchase
3.4
LEE ANN L.

Chief Technical Officer

Officer
100,000 +inf%
1.13
US$113,000 		100,000 +inf% 1.13 US$113,000
2025-05-22 2025-05-21 B Purchase
3.4
Reine Allan

Chief Executive Officer

Executive Director
125,000 +inf%
1.18
US$147,150 		125,000 +inf% 1.18 US$147,150
2025-05-22 2025-05-20 B Purchase
3.4
Brudnick Richard

Chief Business Officer

Officer
20,000 +inf%
1.19
US$23,790 		20,000 +inf% 1.19 US$23,790
2024-02-20 2024-02-15 B Purchase
3.3
NELSEN ROBERT
Non-Executive Director Large shareholder
3,200,000 +inf%
6.25
US$20,000,000 		3,200,000 +inf% 6.25 US$20,000,000
2024-02-20 2024-02-15 B Purchase
3.4
ARCH Venture Partners X, LLC
Large shareholder
3,200,000 +inf%
6.25
US$20,000,000 		3,200,000 +inf% 6.25 US$20,000,000
2024-02-20 2024-02-15 B Purchase
3.7
ARCH Venture Partners XII, LLC
Large shareholder
3,200,000 +inf%
6.25
US$20,000,000 		3,200,000 +inf% 6.25 US$20,000,000
2023-06-22 2023-06-21 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
19,003 -100.0%
14.97
US$284,496 		19,003 -100.0% 14.97 US$284,496
2023-06-22 2023-06-20 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
37,405 -100.0%
15.06
US$563,248 		37,405 -100.0% 15.06 US$563,248
2023-06-20 2023-06-20 PrS Proposed sale
Alphabet Holdings LLC

10% Stockholder

Large shareholder
522,561
14.91
US$7,791,385 		522,561 14.91 US$7,791,385
2023-06-20 2023-06-16 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
6,532 -100.0%
15.02
US$98,109 		6,532 -100.0% 15.02 US$98,109
2023-06-20 2023-06-15 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
66,659 -100.0%
14.92
US$994,326 		66,659 -100.0% 14.92 US$994,326
2023-06-15 2023-06-14 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
28,960 -100.0%
14.87
US$430,684 		28,960 -100.0% 14.87 US$430,684
2023-06-15 2023-06-13 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
28,100 -100.0%
15.13
US$425,102 		28,100 -100.0% 15.13 US$425,102
2023-06-13 2023-06-12 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
16,031 -100.0%
14.98
US$240,151 		16,031 -100.0% 14.98 US$240,151
2023-06-12 2023-06-12 PrS Proposed sale
Alphabet Holdings LLC

10% Stockholder

Large shareholder
159,596
14.49
US$2,312,542 		159,596 14.49 US$2,312,542
2023-06-13 2023-06-09 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
15,672 -100.0%
14.48
US$226,984 		15,672 -100.0% 14.48 US$226,984
2023-06-09 2023-06-08 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
5,000 -100.0%
15.74
US$78,686 		5,000 -100.0% 15.74 US$78,686
2023-06-09 2023-06-07 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
15,000 -100.0%
16.92
US$253,870 		15,000 -100.0% 16.92 US$253,870
2023-06-07 2023-06-06 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
29,975 -100.0%
17.02
US$510,166 		29,975 -100.0% 17.02 US$510,166
2023-06-07 2023-06-05 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
22,434 -100.0%
16.70
US$374,612 		22,434 -100.0% 16.70 US$374,612
2023-06-05 2023-06-05 PrS Proposed sale
Alphabet Holdings LLC

10% Stockholder

Large shareholder
88,081
16.11
US$1,418,985 		88,081 16.11 US$1,418,985
2023-06-02 2023-06-01 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
471 -100.0%
14.75
US$6,949 		471 -100.0% 14.75 US$6,949
2023-06-02 2023-06-01 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
44,752 -99.0%
14.35
US$642,245 		44,752 -99.0% 14.35 US$642,245
2023-06-02 2023-05-31 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
16,633 -100.0%
13.65
US$227,004 		16,633 -100.0% 13.65 US$227,004
2023-05-31 2023-05-30 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
16,805 -100.0%
13.70
US$230,240 		16,805 -100.0% 13.70 US$230,240
2023-05-30 2023-05-30 PrS Proposed sale
Alphabet Holdings LLC

10% Stockholder

Large shareholder
71,263
13.67
US$974,165 		71,263 13.67 US$974,165
2023-05-31 2023-05-26 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
12,602 -100.0%
13.70
US$172,603 		12,602 -100.0% 13.70 US$172,603
2023-05-26 2023-05-25 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
23,161 -100.0%
13.38
US$309,973 		23,161 -100.0% 13.38 US$309,973
2023-05-26 2023-05-24 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
7,900 -100.0%
13.66
US$107,920 		7,900 -100.0% 13.66 US$107,920
2023-05-24 2023-05-23 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
43,939 -100.0%
14.74
US$647,648 		43,939 -100.0% 14.74 US$647,648
2023-05-24 2023-05-22 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
87,922 -100.0%
14.13
US$1,242,092 		87,922 -100.0% 14.13 US$1,242,092
2023-05-22 2023-05-19 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
63,212 -100.0%
13.88
US$877,066 		63,212 -100.0% 13.88 US$877,066
2023-05-22 2023-05-18 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
14,022 -100.0%
13.06
US$183,171 		14,022 -100.0% 13.06 US$183,171
2023-05-22 2023-05-18 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
13,076 -0.1%
13.01
US$170,100 		13,076 -0.1% 13.01 US$170,100
2023-05-18 2023-05-18 PrS Proposed sale
Alphabet Holdings LLC

10% Stockholder

Large shareholder
260,156
13.02
US$3,387,231 		260,156 13.02 US$3,387,231
2023-05-18 2023-05-17 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
15,000 -0.1%
12.77
US$191,600 		15,000 -0.1% 12.77 US$191,600
2023-05-18 2023-05-16 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
50,649 -0.5%
12.59
US$637,676 		50,649 -0.5% 12.59 US$637,676
2023-05-16 2023-05-15 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
157,952 -1.4%
12.74
US$2,012,087 		157,952 -1.4% 12.74 US$2,012,087
2023-05-16 2023-05-12 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
27,290 -0.2%
12.72
US$347,222 		27,290 -0.2% 12.72 US$347,222
2023-05-12 2023-05-11 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
4,807 -0.0%
13.79
US$66,290 		4,807 -0.0% 13.79 US$66,290
2023-05-12 2023-05-11 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
21,819 -0.2%
12.98
US$283,243 		21,819 -0.2% 12.98 US$283,243
2023-05-12 2023-05-10 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
87,397 -0.8%
14.03
US$1,225,804 		87,397 -0.8% 14.03 US$1,225,804
2023-05-10 2023-05-09 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
321,238 -2.8%
14.08
US$4,522,613 		321,238 -2.8% 14.08 US$4,522,613
2023-05-10 2023-05-08 PlS Planned sale
2.0
GV 2019 GP, L.L.C.
Large shareholder
100,772 -0.9%
14.13
US$1,423,727 		100,772 -0.9% 14.13 US$1,423,727
2023-05-08 2023-05-08 PrS Proposed sale
GV 2019, L.P.

10% Stockholder

Large shareholder
1,121,197
14.32
US$16,055,541 		1,121,197 14.32 US$16,055,541
2022-10-26 2022-10-24 B Purchase
3.4
ARCH Venture Partners X, LLC
Large shareholder
400,000 +7.0%
17.00
US$6,800,000 		400,000 +7.0% 17.00 US$6,800,000
2022-10-26 2022-10-24 B Purchase
3.4
ARCH Venture Partners X, LLC
Large shareholder
400,000 +7.0%
17.00
US$6,800,000 		400,000 +7.0% 17.00 US$6,800,000
2022-10-26 2022-10-24 B Purchase
3.3
NELSEN ROBERT
Non-Executive Director Large shareholder
400,000 +7.0%
17.00
US$6,800,000 		400,000 +7.0% 17.00 US$6,800,000
2022-10-26 2022-10-24 B Purchase
3.3
NELSEN ROBERT
Non-Executive Director Large shareholder
400,000 +7.0%
17.00
US$6,800,000 		400,000 +7.0% 17.00 US$6,800,000
2022-10-26 2022-10-24 B Purchase
2.4
Cahill Thomas
Non-Executive Director
400,000 +8.2%
17.00
US$6,800,000 		400,000 +8.2% 17.00 US$6,800,000
2022-10-26 2022-10-24 B Purchase
2.0
GV 2019 GP, L.L.C.
Large shareholder
800,000 +7.5%
17.00
US$13,600,000 		800,000 +7.5% 17.00 US$13,600,000
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