AI Upstream LLC

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value	Details
2024-10-17	2024-10-15	Upstream Bio Inc (UPB)	B Purchase	68,099 -24.9% 269.51 US$2,495,276	68,099 -24.9%	269.51	US$2,495,276