United States Biotechnology & Medical Research

Upstream Bio Inc (UPB)

Track

Over the past 90 days, Upstream Bio Inc. insiders have exclusively engaged in selling activity, with five transactions totaling approximately $25,162 in net value. Key executives, including the CEO, CFO, and CBO, participated in these sales. This activity follows a period of significant stock price decline, with the shares currently trading near their 52-week low.
Ticker: UPB Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Upstream Bio Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Top insiders
Trades
Sale 16 Jun 2026
Value US$3,236,454.96 | Price 232.01 | Shares 36,812 (-10.9%)
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-06-17 2026-06-16 S Sale
2.5
Houghton Adam

Chief Business Officer

Officer
36,812 -10.9%
232.01
US$3,236,455 		36,812 -10.9% 232.01 US$3,236,455
2026-06-17 2026-06-16 PlS Planned sale
2.4
Deykin Aaron

Chief Medical Officer

Officer
70,051 +7.4%
398.46
US$4,862,839 		70,051 +7.4% 398.46 US$4,862,839
2026-06-17 2026-06-16 S Sale
2.5
Ambrose Allison

General Counsel

Officer
49,480 -4.5%
183.86
US$1,962,710 		49,480 -4.5% 183.86 US$1,962,710
2026-06-17 2026-06-16 S Sale
2.5
Sutherland Everett Rand

Chief Executive Officer

Executive Director
2,095 -2.9%
6.10
US$12,780 		2,095 -2.9% 6.10 US$12,780
2026-06-17 2026-06-16 S Sale
1.7
GRAY MICHAEL

CFO and COO

Officer
853 -2.9%
6.10
US$5,203 		853 -2.9% 6.10 US$5,203
2026-03-17 2026-03-16 S Sale
1.7
GRAY MICHAEL

CFO and COO

Officer
852 -2.8%
9.29
US$7,915 		852 -2.8% 9.29 US$7,915
2026-03-17 2026-03-16 S Sale
2.4
Deykin Aaron

Chief Medical Officer

Officer
894 -2.7%
9.29
US$8,305 		894 -2.7% 9.29 US$8,305
2026-03-17 2026-03-16 S Sale
2.5
Sutherland Everett Rand

Chief Executive Officer

Executive Director
2,093 -2.8%
9.29
US$19,444 		2,093 -2.8% 9.29 US$19,444
2026-03-17 2026-03-16 S Sale
2.5
Ambrose Allison

General Counsel

Officer
475 -2.8%
9.29
US$4,413 		475 -2.8% 9.29 US$4,413
2026-03-17 2026-03-16 S Sale
2.5
Houghton Adam

Chief Business Officer

Officer
699 -2.8%
9.29
US$6,494 		699 -2.8% 9.29 US$6,494
2024-10-17 2024-10-15 B Purchase
2.6
ORBIMED ADVISORS LLC
Non-Executive Director Large shareholder
660,000 +16.9%
17.00
US$11,220,000 		660,000 +16.9% 17.00 US$11,220,000
2024-10-17 2024-10-15 B Purchase
2.6
ORBIMED ADVISORS LLC
Non-Executive Director Large shareholder
165,000 +16.9%
17.00
US$2,805,000 		165,000 +16.9% 17.00 US$2,805,000
2024-10-17 2024-10-15 B Purchase
AI Upstream LLC
Large shareholder
1,175,000 +inf%
17.00
US$19,975,000 		1,175,000 +inf% 17.00 US$19,975,000
2024-10-17 2024-10-15 B Purchase
Chimovits Erez
Non-Executive Director Large shareholder
660,000 +16.9%
17.00
US$11,220,000 		660,000 +16.9% 17.00 US$11,220,000
2024-10-17 2024-10-15 B Purchase
Chimovits Erez
Non-Executive Director Large shareholder
165,000 +16.9%
17.00
US$2,805,000 		165,000 +16.9% 17.00 US$2,805,000
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