United States Biotechnology & Medical Research

Upstream Bio Inc (UPB)

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Upstream Bio Inc. executives conducted multiple share sales on June 16, 2026. These transactions involved the CEO, CFO, and other senior leadership members. No insider trading activity has occurred within the last three months, as the most recent recorded divestments date back to mid-June.
Ticker: UPB Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Upstream Bio Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
2.5
Sutherland Everett Rand Chief Executive Officer Executive Director
Transaction date
Sale
Price
424.31
Quantity 15,198 -33.7%
Value US$2,176,482
2.5
Houghton Adam Chief Business Officer Officer
Transaction date
Sale
Price
127.05
Quantity 87,455 +11.2%
Value US$4,385,354
2.4
Deykin Aaron Chief Medical Officer Officer
Transaction date
Sale
Price
75.77
Quantity 14,545 -15.2%
Value US$4,655,810
2.5
Ambrose Allison General Counsel Officer
Transaction date
Sale
Price
5.49
Quantity 1,000 -3.0%
Value US$100,000
1.7
GRAY MICHAEL CFO and COO Officer
Transaction date
Sale
Price
5.49
Quantity 1,000 -3.0%
Value US$100,000
2.5
Houghton Adam Chief Business Officer Officer
Transaction date
Sale
Price
6.10
Quantity 700 -2.9%
Value US$4,270
2.4
Deykin Aaron Chief Medical Officer Officer
Transaction date
Planned sale
Price
6.10
Quantity 895 -2.6%
Value US$5,460
2.5
Ambrose Allison General Counsel Officer
Transaction date
Sale
Price
6.10
Quantity 477 -2.9%
Value US$2,910
2.5
Sutherland Everett Rand Chief Executive Officer Executive Director
Transaction date
Sale
Price
6.10
Quantity 2,095 -2.9%
Value US$12,780
1.7
GRAY MICHAEL CFO and COO Officer
Transaction date
Sale
Price
6.10
Quantity 853 -2.9%
Value US$5,203
1.7
GRAY MICHAEL CFO and COO Officer
Transaction date
Sale
Price
9.29
Quantity 852 -2.8%
Value US$7,915
2.4
Deykin Aaron Chief Medical Officer Officer
Transaction date
Sale
Price
9.29
Quantity 894 -2.7%
Value US$8,305
2.5
Sutherland Everett Rand Chief Executive Officer Executive Director
Transaction date
Sale
Price
9.29
Quantity 2,093 -2.8%
Value US$19,444
2.5
Ambrose Allison General Counsel Officer
Transaction date
Sale
Price
9.29
Quantity 475 -2.8%
Value US$4,413
2.5
Houghton Adam Chief Business Officer Officer
Transaction date
Sale
Price
9.29
Quantity 699 -2.8%
Value US$6,494
2.6
ORBIMED ADVISORS LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 660,000 +16.9%
Value US$11,220,000
2.6
ORBIMED ADVISORS LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 165,000 +16.9%
Value US$2,805,000
AI Upstream LLC Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 1,175,000 +inf%
Value US$19,975,000
Chimovits Erez Non-Executive Director Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 660,000 +16.9%
Value US$11,220,000
Chimovits Erez Non-Executive Director Large shareholder
Transaction date
Purchase
Price
17.00
Quantity 165,000 +16.9%
Value US$2,805,000
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-09-17 2026-09-16 S Sale
2.5
Sutherland Everett Rand

Chief Executive Officer

Executive Director
15,198 -33.7%
424.31
US$2,176,482 		15,198 -33.7% 424.31 US$2,176,482
2026-09-17 2026-09-16 S Sale
2.5
Houghton Adam

Chief Business Officer

Officer
87,455 +11.2%
127.05
US$4,385,354 		87,455 +11.2% 127.05 US$4,385,354
2026-09-17 2026-09-16 S Sale
2.4
Deykin Aaron

Chief Medical Officer

Officer
14,545 -15.2%
75.77
US$4,655,810 		14,545 -15.2% 75.77 US$4,655,810
2026-09-17 2026-09-16 S Sale
2.5
Ambrose Allison

General Counsel

Officer
1,000 -3.0%
5.49
US$100,000 		1,000 -3.0% 5.49 US$100,000
2026-09-17 2026-09-16 S Sale
1.7
GRAY MICHAEL

CFO and COO

Officer
1,000 -3.0%
5.49
US$100,000 		1,000 -3.0% 5.49 US$100,000
2026-06-17 2026-06-16 S Sale
2.5
Houghton Adam

Chief Business Officer

Officer
700 -2.9%
6.10
US$4,270 		700 -2.9% 6.10 US$4,270
2026-06-17 2026-06-16 PlS Planned sale
2.4
Deykin Aaron

Chief Medical Officer

Officer
895 -2.6%
6.10
US$5,460 		895 -2.6% 6.10 US$5,460
2026-06-17 2026-06-16 S Sale
2.5
Ambrose Allison

General Counsel

Officer
477 -2.9%
6.10
US$2,910 		477 -2.9% 6.10 US$2,910
2026-06-17 2026-06-16 S Sale
2.5
Sutherland Everett Rand

Chief Executive Officer

Executive Director
2,095 -2.9%
6.10
US$12,780 		2,095 -2.9% 6.10 US$12,780
2026-06-17 2026-06-16 S Sale
1.7
GRAY MICHAEL

CFO and COO

Officer
853 -2.9%
6.10
US$5,203 		853 -2.9% 6.10 US$5,203
2026-03-17 2026-03-16 S Sale
1.7
GRAY MICHAEL

CFO and COO

Officer
852 -2.8%
9.29
US$7,915 		852 -2.8% 9.29 US$7,915
2026-03-17 2026-03-16 S Sale
2.4
Deykin Aaron

Chief Medical Officer

Officer
894 -2.7%
9.29
US$8,305 		894 -2.7% 9.29 US$8,305
2026-03-17 2026-03-16 S Sale
2.5
Sutherland Everett Rand

Chief Executive Officer

Executive Director
2,093 -2.8%
9.29
US$19,444 		2,093 -2.8% 9.29 US$19,444
2026-03-17 2026-03-16 S Sale
2.5
Ambrose Allison

General Counsel

Officer
475 -2.8%
9.29
US$4,413 		475 -2.8% 9.29 US$4,413
2026-03-17 2026-03-16 S Sale
2.5
Houghton Adam

Chief Business Officer

Officer
699 -2.8%
9.29
US$6,494 		699 -2.8% 9.29 US$6,494
2024-10-17 2024-10-15 B Purchase
2.6
ORBIMED ADVISORS LLC
Non-Executive Director Large shareholder
660,000 +16.9%
17.00
US$11,220,000 		660,000 +16.9% 17.00 US$11,220,000
2024-10-17 2024-10-15 B Purchase
2.6
ORBIMED ADVISORS LLC
Non-Executive Director Large shareholder
165,000 +16.9%
17.00
US$2,805,000 		165,000 +16.9% 17.00 US$2,805,000
2024-10-17 2024-10-15 B Purchase
AI Upstream LLC
Large shareholder
1,175,000 +inf%
17.00
US$19,975,000 		1,175,000 +inf% 17.00 US$19,975,000
2024-10-17 2024-10-15 B Purchase
Chimovits Erez
Non-Executive Director Large shareholder
660,000 +16.9%
17.00
US$11,220,000 		660,000 +16.9% 17.00 US$11,220,000
2024-10-17 2024-10-15 B Purchase
Chimovits Erez
Non-Executive Director Large shareholder
165,000 +16.9%
17.00
US$2,805,000 		165,000 +16.9% 17.00 US$2,805,000
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