United States Biotechnology & Medical Research

Upstream Bio Inc (UPB)

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In the last 90 days, Upstream Bio Inc. saw net insider selling totaling $46,571, with five executives selling shares. This activity occurred despite a 13.6% stock price increase over the past 90 days. The company's last earnings report showed a slight beat of 1.32%.
Stock chart
Ticker: UPB Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
GRAY MICHAEL
CFO and COO
1 sale — total 7,915 USD
Sale 16 Mar 2026
Value US$691,260.35 | Price 39.09 | Shares 18,841
Sale 16 Mar 2026
Value US$2,553,311.14 | Price 290.78 | Shares 50,483
Sale 16 Mar 2026
Value US$19,443.97 | Price 9.29 | Shares 2,093
Sale 16 Mar 2026
Value US$4,412.75 | Price 9.29 | Shares 475
Sale 16 Mar 2026
Value US$6,493.71 | Price 9.29 | Shares 699
Buy 15 Oct 2024
Value US$11,220,000.00 | Price 17.00 | Shares 660,000
Buy 15 Oct 2024
Value US$2,805,000.00 | Price 17.00 | Shares 165,000
Buy 15 Oct 2024
Value US$19,975,000.00 | Price 17.00 | Shares 1,175,000
Buy 15 Oct 2024
Value US$11,220,000.00 | Price 17.00 | Shares 660,000
Buy 15 Oct 2024
Value US$2,805,000.00 | Price 17.00 | Shares 165,000
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-03-17 2026-03-16 S Sale
1.2
GRAY MICHAEL

CFO and COO

Officer
18,841 +35.9%
39.09
US$691,260 		18,841 +35.9% 39.09 US$691,260
2026-03-17 2026-03-16 S Sale
Deykin Aaron

Chief Medical Officer

Officer
50,483 -30.9%
290.78
US$2,553,311 		50,483 -30.9% 290.78 US$2,553,311
2026-03-17 2026-03-16 S Sale
Sutherland Everett Rand

Chief Executive Officer

Executive Director
19,316 +23.9%
42.73
US$33,443 		19,316 +23.9% 42.73 US$33,443
2026-03-17 2026-03-16 S Sale
Ambrose Allison

General Counsel

Officer
475 -2.8%
9.29
US$4,413 		475 -2.8% 9.29 US$4,413
2026-03-17 2026-03-16 S Sale
Houghton Adam

Chief Business Officer

Officer
699 -2.8%
9.29
US$6,494 		699 -2.8% 9.29 US$6,494
2024-10-17 2024-10-15 B Purchase
2.6
ORBIMED ADVISORS LLC
Non-Executive Director Large shareholder
660,000 +16.9%
17.00
US$11,220,000 		660,000 +16.9% 17.00 US$11,220,000
2024-10-17 2024-10-15 B Purchase
2.6
ORBIMED ADVISORS LLC
Non-Executive Director Large shareholder
165,000 +16.9%
17.00
US$2,805,000 		165,000 +16.9% 17.00 US$2,805,000
2024-10-17 2024-10-15 B Purchase
AI Upstream LLC
Large shareholder
1,175,000 +inf%
17.00
US$19,975,000 		1,175,000 +inf% 17.00 US$19,975,000
2024-10-17 2024-10-15 B Purchase
Chimovits Erez
Non-Executive Director Large shareholder
660,000 +16.9%
17.00
US$11,220,000 		660,000 +16.9% 17.00 US$11,220,000
2024-10-17 2024-10-15 B Purchase
Chimovits Erez
Non-Executive Director Large shareholder
165,000 +16.9%
17.00
US$2,805,000 		165,000 +16.9% 17.00 US$2,805,000
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