WARDELL WILLIAM M

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value	Details
2004-07-02	2004-06-30	Open Orphan PLC (ORPH)	PlS Planned sale	63,082 -25.8% 495.76 US$1,696,321	63,082 -25.8%	495.76	US$1,696,321
2004-05-13	2004-05-11	Open Orphan PLC (ORPH)	PlS Planned sale	69,741 -37.5% 466.18 US$835,502	69,741 -37.5%	466.18	US$835,502