United States Biotechnology & Medical Research

Spero Therapeutics Inc (SPRO)

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Spero Therapeutics Inc. has seen no insider trading activity within the last three months. The most recent transactions occurred on May 4, 2026, involving sales by Esther Rajavelu. Prior to this, multiple executives executed various sell orders throughout early 2026 and late 2025, reflecting a consistent pattern of divestment by company leadership.
Ticker: SPRO Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
2.9
Rajavelu Esther See Remarks Officer
Transaction date
Sale
Price
495.73
Quantity 74,789 -2.2%
Value US$900,718
2.9
Rajavelu Esther See Remarks Officer
Transaction date
Sale
Price
231.70
Quantity 98,478 +11.7%
Value US$2,291,416
2.9
Rajavelu Esther See Remarks Officer
Transaction date
Sale
Price
49.46
Quantity 87,845 +1.5%
Value US$1,532,052
2.3
Keutzer Timothy Chief Operating Officer Officer
Transaction date
Sale
Price
2.36
Quantity 18,652 -2.5%
Value US$44,019
2.3
Keutzer Timothy Chief Operating Officer Officer
Transaction date
Sale
Price
2.24
Quantity 3,471 -0.5%
Value US$7,775
2.3
Keutzer Timothy Chief Operating Officer Officer
Transaction date
Sale
Price
2.14
Quantity 24,224 -3.1%
Value US$51,839
2.3
Keutzer Timothy Chief Operating Officer Officer
Transaction date
Sale
Price
2.20
Quantity 18,891 -2.3%
Value US$41,560
2.9
Rajavelu Esther See Remarks Officer
Transaction date
Sale
Price
2.20
Quantity 18,442 -1.6%
Value US$40,572
2.9
Rajavelu Esther See Remarks Officer
Transaction date
Sale
Price
2.20
Quantity 18,442 -1.6%
Value US$40,572
2.9
Rajavelu Esther See Remarks Officer
Transaction date
Sale
Price
2.37
Quantity 40,270 -4.4%
Value US$95,440
2.4
Mahadevia Ankit Non-Executive Director
Transaction date
Sale
Price
1.97
Quantity 6,572 -0.9%
Value US$12,947
2.3
Keutzer Timothy Chief Operating Officer Officer
Transaction date
Sale
Price
1.97
Quantity 1,695 -0.2%
Value US$3,339
2.3
Keutzer Timothy Chief Operating Officer Officer
Transaction date
Sale
Price
0.78
Quantity 24,920 -3.3%
Value US$19,438
2.3
Keutzer Timothy Chief Operating Officer Officer
Transaction date
Sale
Price
0.78
Quantity 27,643 -3.5%
Value US$21,562
2.3
Keutzer Timothy Chief Operating Officer Officer
Transaction date
Sale
Price
0.78
Quantity 3,974 -0.5%
Value US$3,100
2.9
Rajavelu Esther CFO & CBO Officer
Transaction date
Sale
Price
0.78
Quantity 20,689 -2.8%
Value US$16,137
2.7
Shukla Sath CEO & President Officer
Transaction date
Sale
Price
0.78
Quantity 106,408 -5.8%
Value US$82,998
2.7
Shukla Sath CEO & President Officer
Transaction date
Sale
Price
0.78
Quantity 42,786 -2.3%
Value US$33,373
2.7
Shukla Sath CEO & President Officer
Transaction date
Sale
Price
0.78
Quantity 6,139 -0.3%
Value US$4,788
2.4
Mahadevia Ankit Non-Executive Director
Transaction date
Sale
Price
0.78
Quantity 55,260 -7.4%
Value US$43,103
2.4
Mahadevia Ankit Non-Executive Director
Transaction date
Sale
Price
0.78
Quantity 13,959 -1.8%
Value US$10,888
2.9
Rajavelu Esther CFO & CBO Officer
Transaction date
Sale
Price
1.30
Quantity 17,245 -4.3%
Value US$22,418
2.9
Rajavelu Esther CFO & CBO Officer
Transaction date
Sale
Price
1.31
Quantity 23,351 -5.6%
Value US$30,590
2.3
Keutzer Timothy Chief Operating Officer Officer
Transaction date
Sale
Price
1.35
Quantity 2,213 -0.4%
Value US$2,988
2.4
Mahadevia Ankit Non-Executive Director
Transaction date
Sale
Price
1.35
Quantity 5,912 -0.8%
Value US$7,981
2.7
Shukla Sath CEO & President Officer
Transaction date
Sale
Price
1.35
Quantity 2,757 -0.2%
Value US$3,722
2.7
Shukla Sath CEO and President Officer
Transaction date
Sale
Price
1.31
Quantity 17,641 -1.5%
Value US$23,110
2.7
Shukla Sath CEO and President Officer
Transaction date
Sale
Price
1.32
Quantity 14,800 -1.3%
Value US$19,536
2.7
SATYAVRAT SHUKLA Officer; Director Executive Director
Transaction date
Proposed sale
Price
1.45
Quantity 45,093
Value US$65,466
2.7
Shukla Sath CEO and President Executive Director
Transaction date
Planned sale
Price
1.45
Quantity 45,093 -3.7%
Value US$65,385
1.8
HAMED KAMAL Chief Medical Officer Officer
Transaction date
Sale
Price
1.37
Quantity 28,075 -3.4%
Value US$38,463
2.3
Keutzer Timothy Chief Operating Officer Officer
Transaction date
Sale
Price
1.36
Quantity 30,971 -5.5%
Value US$42,121
2.7
Shukla Sath CEO and President Executive Director
Transaction date
Sale
Price
1.37
Quantity 30,901 -2.5%
Value US$42,334
2.4
Mahadevia Ankit Non-Executive Director
Transaction date
Sale
Price
1.37
Quantity 63,795 -7.9%
Value US$87,399
1.9
JOSEPH TAMARA L Chief Legal Officer Officer
Transaction date
Sale
Price
1.37
Quantity 30,906 -5.5%
Value US$42,341
1.8
HAMED KAMAL Chief Medical Officer Officer
Transaction date
Sale
Price
1.27
Quantity 39,496 -6.4%
Value US$50,160
2.7
Shukla Sath CEO and President Executive Director
Transaction date
Planned sale
Price
1.30
Quantity 4,163 -0.7%
Value US$5,412
2.7
SATYAVRAT SHUKLA Officer Officer
Transaction date
Proposed sale
Price
1.30
Quantity 4,163
Value US$5,412
1.9
JOSEPH TAMARA L Chief Legal Officer Officer
Transaction date
Sale
Price
1.26
Quantity 1,854 -0.6%
Value US$2,336
2.4
Mahadevia Ankit Non-Executive Director
Transaction date
Sale
Price
1.26
Quantity 9,040 -1.1%
Value US$11,390
2.7
Shukla Sath CEO and President Executive Director
Transaction date
Sale
Price
1.26
Quantity 1,854 -0.3%
Value US$2,336
2.3
Keutzer Timothy Chief Development Officer Officer
Transaction date
Sale
Price
1.26
Quantity 1,854 -0.6%
Value US$2,336
2.4
Mahadevia Ankit CEO and President Executive Director
Transaction date
Sale
Price
1.81
Quantity 12,286 -1.5%
Value US$22,238
1.9
JOSEPH TAMARA L Chief Legal Officer Officer
Transaction date
Sale
Price
1.86
Quantity 3,394 -1.0%
Value US$6,313
2.3
Keutzer Timothy Chief Operating Officer Officer
Transaction date
Sale
Price
1.86
Quantity 3,394 -1.0%
Value US$6,313
2.7
Shukla Sath Chief Financial Officer Officer
Transaction date
Planned sale
Price
1.83
Quantity 9,504 -3.0%
Value US$17,372
2.7
Shukla Sath Chief Financial Officer Officer
Transaction date
Planned sale
Price
0.89
Quantity 6,017 -9.7%
Value US$5,378
Larkin Cristina Chief Operating Officer Officer
Transaction date
Planned sale
Price
19.00
Quantity 12,000 -88.9%
Value US$228,000
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-05-06 2026-05-04 S Sale
2.9
Rajavelu Esther

See Remarks

Officer
74,789 -2.2%
495.73
US$900,718 		74,789 -2.2% 495.73 US$900,718
2026-02-09 2026-02-06 S Sale
2.9
Rajavelu Esther

See Remarks

Officer
98,478 +11.7%
231.70
US$2,291,416 		98,478 +11.7% 231.70 US$2,291,416
2026-02-09 2026-02-06 S Sale
2.9
Rajavelu Esther

See Remarks

Officer
87,845 +1.5%
49.46
US$1,532,052 		87,845 +1.5% 49.46 US$1,532,052
2026-02-09 2026-02-06 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
18,652 -2.5%
2.36
US$44,019 		18,652 -2.5% 2.36 US$44,019
2026-02-05 2026-02-04 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
3,471 -0.5%
2.24
US$7,775 		3,471 -0.5% 2.24 US$7,775
2026-02-05 2026-02-03 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
24,224 -3.1%
2.14
US$51,839 		24,224 -3.1% 2.14 US$51,839
2026-02-05 2026-02-02 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
18,891 -2.3%
2.20
US$41,560 		18,891 -2.3% 2.20 US$41,560
2026-02-04 2026-02-02 S Sale
2.9
Rajavelu Esther

See Remarks

Officer
18,442 -1.6%
2.20
US$40,572 		18,442 -1.6% 2.20 US$40,572
2026-02-04 2026-02-02 S Sale
2.9
Rajavelu Esther

See Remarks

Officer
18,442 -1.6%
2.20
US$40,572 		18,442 -1.6% 2.20 US$40,572
2025-11-12 2025-11-07 S Sale
2.9
Rajavelu Esther

See Remarks

Officer
40,270 -4.4%
2.37
US$95,440 		40,270 -4.4% 2.37 US$95,440
2025-09-03 2025-08-28 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
6,572 -0.9%
1.97
US$12,947 		6,572 -0.9% 1.97 US$12,947
2025-09-03 2025-08-28 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
1,695 -0.2%
1.97
US$3,339 		1,695 -0.2% 1.97 US$3,339
2025-02-05 2025-02-05 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
24,920 -3.3%
0.78
US$19,438 		24,920 -3.3% 0.78 US$19,438
2025-02-05 2025-02-05 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
27,643 -3.5%
0.78
US$21,562 		27,643 -3.5% 0.78 US$21,562
2025-02-05 2025-02-05 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
3,974 -0.5%
0.78
US$3,100 		3,974 -0.5% 0.78 US$3,100
2025-02-05 2025-02-05 S Sale
2.9
Rajavelu Esther

CFO & CBO

Officer
20,689 -2.8%
0.78
US$16,137 		20,689 -2.8% 0.78 US$16,137
2025-02-05 2025-02-05 S Sale
2.7
Shukla Sath

CEO & President

Officer
106,408 -5.8%
0.78
US$82,998 		106,408 -5.8% 0.78 US$82,998
2025-02-05 2025-02-05 S Sale
2.7
Shukla Sath

CEO & President

Officer
42,786 -2.3%
0.78
US$33,373 		42,786 -2.3% 0.78 US$33,373
2025-02-05 2025-02-05 S Sale
2.7
Shukla Sath

CEO & President

Officer
6,139 -0.3%
0.78
US$4,788 		6,139 -0.3% 0.78 US$4,788
2025-02-05 2025-02-05 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
55,260 -7.4%
0.78
US$43,103 		55,260 -7.4% 0.78 US$43,103
2025-02-05 2025-02-05 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
13,959 -1.8%
0.78
US$10,888 		13,959 -1.8% 0.78 US$10,888
2024-11-12 2024-11-08 S Sale
2.9
Rajavelu Esther

CFO & CBO

Officer
17,245 -4.3%
1.30
US$22,418 		17,245 -4.3% 1.30 US$22,418
2024-11-12 2024-11-07 S Sale
2.9
Rajavelu Esther

CFO & CBO

Officer
23,351 -5.6%
1.31
US$30,590 		23,351 -5.6% 1.31 US$30,590
2024-08-29 2024-08-27 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
2,213 -0.4%
1.35
US$2,988 		2,213 -0.4% 1.35 US$2,988
2024-08-29 2024-08-27 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
5,912 -0.8%
1.35
US$7,981 		5,912 -0.8% 1.35 US$7,981
2024-08-29 2024-08-27 S Sale
2.7
Shukla Sath

CEO & President

Officer
2,757 -0.2%
1.35
US$3,722 		2,757 -0.2% 1.35 US$3,722
2024-08-06 2024-08-05 S Sale
2.7
Shukla Sath

CEO and President

Officer
17,641 -1.5%
1.31
US$23,110 		17,641 -1.5% 1.31 US$23,110
2024-08-06 2024-08-02 S Sale
2.7
Shukla Sath

CEO and President

Officer
14,800 -1.3%
1.32
US$19,536 		14,800 -1.3% 1.32 US$19,536
2024-02-05 2024-02-05 PrS Proposed sale
2.7
SATYAVRAT SHUKLA

Officer; Director

Executive Director
45,093
1.45
US$65,466 		45,093 1.45 US$65,466
2024-02-05 2024-02-05 PlS Planned sale
2.7
Shukla Sath

CEO and President

Executive Director
45,093 -3.7%
1.45
US$65,385 		45,093 -3.7% 1.45 US$65,385
2024-02-05 2024-02-02 S Sale
1.8
HAMED KAMAL

Chief Medical Officer

Officer
28,075 -3.4%
1.37
US$38,463 		28,075 -3.4% 1.37 US$38,463
2024-02-05 2024-02-02 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
30,971 -5.5%
1.36
US$42,121 		30,971 -5.5% 1.36 US$42,121
2024-02-05 2024-02-02 S Sale
2.7
Shukla Sath

CEO and President

Executive Director
30,901 -2.5%
1.37
US$42,334 		30,901 -2.5% 1.37 US$42,334
2024-02-05 2024-02-02 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
63,795 -7.9%
1.37
US$87,399 		63,795 -7.9% 1.37 US$87,399
2024-02-05 2024-02-02 S Sale
1.9
JOSEPH TAMARA L

Chief Legal Officer

Officer
30,906 -5.5%
1.37
US$42,341 		30,906 -5.5% 1.37 US$42,341
2023-09-15 2023-09-13 S Sale
1.8
HAMED KAMAL

Chief Medical Officer

Officer
39,496 -6.4%
1.27
US$50,160 		39,496 -6.4% 1.27 US$50,160
2023-08-30 2023-08-29 PlS Planned sale
2.7
Shukla Sath

CEO and President

Executive Director
4,163 -0.7%
1.30
US$5,412 		4,163 -0.7% 1.30 US$5,412
2023-08-29 2023-08-29 PrS Proposed sale
2.7
SATYAVRAT SHUKLA

Officer

Officer
4,163
1.30
US$5,412 		4,163 1.30 US$5,412
2023-08-30 2023-08-28 S Sale
1.9
JOSEPH TAMARA L

Chief Legal Officer

Officer
1,854 -0.6%
1.26
US$2,336 		1,854 -0.6% 1.26 US$2,336
2023-08-30 2023-08-28 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
9,040 -1.1%
1.26
US$11,390 		9,040 -1.1% 1.26 US$11,390
2023-08-30 2023-08-28 S Sale
2.7
Shukla Sath

CEO and President

Executive Director
1,854 -0.3%
1.26
US$2,336 		1,854 -0.3% 1.26 US$2,336
2023-08-30 2023-08-28 S Sale
2.3
Keutzer Timothy

Chief Development Officer

Officer
1,854 -0.6%
1.26
US$2,336 		1,854 -0.6% 1.26 US$2,336
2023-02-06 2023-02-03 S Sale
2.4
Mahadevia Ankit

CEO and President

Executive Director
12,286 -1.5%
1.81
US$22,238 		12,286 -1.5% 1.81 US$22,238
2023-02-03 2023-02-02 S Sale
1.9
JOSEPH TAMARA L

Chief Legal Officer

Officer
3,394 -1.0%
1.86
US$6,313 		3,394 -1.0% 1.86 US$6,313
2023-02-03 2023-02-02 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
3,394 -1.0%
1.86
US$6,313 		3,394 -1.0% 1.86 US$6,313
2023-02-03 2023-02-02 PlS Planned sale
2.7
Shukla Sath

Chief Financial Officer

Officer
9,504 -3.0%
1.83
US$17,372 		9,504 -3.0% 1.83 US$17,372
2022-09-26 2022-09-22 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
566,284 -14.2%
2.25
US$1,274,309 		566,284 -14.2% 2.25 US$1,274,309
2022-09-26 2022-09-22 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
1,335,512 -25.1%
2.25
US$3,005,303 		1,335,512 -25.1% 2.25 US$3,005,303
2022-08-30 2022-08-29 PlS Planned sale
2.7
Shukla Sath

Chief Financial Officer

Officer
6,017 -9.7%
0.89
US$5,378 		6,017 -9.7% 0.89 US$5,378
2022-04-28 2022-04-26 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
39,727 +0.8%
5.24
US$207,971 		39,727 +0.8% 5.24 US$207,971
2022-03-16 2022-03-14 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
8,006 +0.2%
7.63
US$61,054 		8,006 +0.2% 7.63 US$61,054
2022-03-16 2022-03-14 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
15,702 +0.3%
7.63
US$119,743 		15,702 +0.3% 7.63 US$119,743
2022-03-02 2022-02-28 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
15,104 +0.3%
9.53
US$143,931 		15,104 +0.3% 9.53 US$143,931
2022-03-02 2022-02-28 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
29,729 +0.6%
9.53
US$283,297 		29,729 +0.6% 9.53 US$283,297
2022-02-23 2022-02-18 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
14,828 +0.3%
9.24
US$137,039 		14,828 +0.3% 9.24 US$137,039
2022-02-01 2022-01-31 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
125,000 +2.5%
11.59
US$1,448,262 		125,000 +2.5% 11.59 US$1,448,262
2022-01-26 2022-01-24 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
1,599 +0.0%
10.89
US$17,418 		1,599 +0.0% 10.89 US$17,418
2022-01-20 2022-01-18 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
48,488 +1.0%
12.41
US$601,964 		48,488 +1.0% 12.41 US$601,964
2022-01-12 2022-01-10 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
8,867 +0.2%
12.93
US$114,609 		8,867 +0.2% 12.93 US$114,609
2022-01-03 2021-12-31 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
125,000 +2.6%
15.75
US$1,969,025 		125,000 +2.6% 15.75 US$1,969,025
2022-01-03 2021-12-30 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
50,000 +1.0%
15.77
US$788,610 		50,000 +1.0% 15.77 US$788,610
2022-01-03 2021-12-29 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
75,493 +1.6%
14.64
US$1,105,263 		75,493 +1.6% 14.64 US$1,105,263
2021-11-02 2021-10-29 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
150,000 +3.3%
17.53
US$2,630,175 		150,000 +3.3% 17.53 US$2,630,175
2021-10-04 2021-09-30 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
134,543 +3.0%
18.65
US$2,509,173 		134,543 +3.0% 18.65 US$2,509,173
2021-09-01 2021-08-31 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
48,645 +1.1%
18.93
US$920,660 		48,645 +1.1% 18.93 US$920,660
2021-09-01 2021-08-30 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
44,042 +1.0%
17.87
US$786,859 		44,042 +1.0% 17.87 US$786,859
2021-02-10 2021-02-08 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
3,000 -0.1%
21.74
US$65,215 		3,000 -0.1% 21.74 US$65,215
2021-02-04 2021-02-04 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
34,144 -0.9%
18.99
US$648,255 		34,144 -0.9% 18.99 US$648,255
2021-02-04 2021-02-03 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
29,354 -0.8%
18.98
US$557,101 		29,354 -0.8% 18.98 US$557,101
2021-02-04 2021-02-02 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
22,841 -0.6%
18.99
US$433,771 		22,841 -0.6% 18.99 US$433,771
2021-02-04 2021-02-01 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
13,661 -0.3%
19.24
US$262,861 		13,661 -0.3% 19.24 US$262,861
2020-12-18 2020-12-17 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
250,000 -6.0%
18.81
US$4,703,225 		250,000 -6.0% 18.81 US$4,703,225
2020-12-18 2020-12-16 PlS Planned sale
Larkin Cristina

Chief Operating Officer

Officer
12,000 -88.9%
19.00
US$228,000 		12,000 -88.9% 19.00 US$228,000
2020-12-18 2020-12-16 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
14,933 -0.4%
18.62
US$278,035 		14,933 -0.4% 18.62 US$278,035
2020-11-10 2020-11-09 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
125,900 -2.9%
13.77
US$1,734,071 		125,900 -2.9% 13.77 US$1,734,071
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