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United States Biotechnology & Medical Research

Spero Therapeutics Inc (SPRO)

Track

Recent insider trading at Spero Therapeutics Inc. shows a net sell-off of $63,352.39 over the last 90 days, primarily driven by executive sales. This activity occurred against a backdrop of a 9.3% stock price decrease over the past 90 days. No buy transactions were recorded.
Stock chart
Ticker: SPRO Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
Rajavelu Esther
See Remarks
1 sale — total 63,352 USD
Sale 4 May 2026
Value US$900,718.31 | Price 495.73 | Shares 74,789
Sale 6 Feb 2026
Value US$2,291,416.31 | Price 231.70 | Shares 98,478
Sale 6 Feb 2026
Value US$1,532,051.79 | Price 49.46 | Shares 87,845
Sale 6 Feb 2026
Value US$44,018.72 | Price 2.36 | Shares 18,652
Sale 4 Feb 2026
Value US$7,775.04 | Price 2.24 | Shares 3,471
Sale 3 Feb 2026
Value US$51,839.36 | Price 2.14 | Shares 24,224
Sale 2 Feb 2026
Value US$41,560.20 | Price 2.20 | Shares 18,891
Sale 2 Feb 2026
Value US$40,572.40 | Price 2.20 | Shares 18,442
Sale 2 Feb 2026
Value US$40,572.40 | Price 2.20 | Shares 18,442
Sale 7 Nov 2025
Value US$95,439.90 | Price 2.37 | Shares 40,270
Sale 28 Aug 2025
Value US$12,946.84 | Price 1.97 | Shares 6,572
Sale 28 Aug 2025
Value US$3,339.15 | Price 1.97 | Shares 1,695
Sale 5 Feb 2025
Value US$19,437.60 | Price 0.78 | Shares 24,920
Sale 5 Feb 2025
Value US$21,561.54 | Price 0.78 | Shares 27,643
Sale 5 Feb 2025
Value US$3,099.72 | Price 0.78 | Shares 3,974
Sale 5 Feb 2025
Value US$16,137.42 | Price 0.78 | Shares 20,689
Sale 5 Feb 2025
Value US$82,998.24 | Price 0.78 | Shares 106,408
Sale 5 Feb 2025
Value US$33,373.08 | Price 0.78 | Shares 42,786
Sale 5 Feb 2025
Value US$4,788.42 | Price 0.78 | Shares 6,139
Sale 5 Feb 2025
Value US$43,102.80 | Price 0.78 | Shares 55,260
Sale 5 Feb 2025
Value US$10,888.02 | Price 0.78 | Shares 13,959
Sale 8 Nov 2024
Value US$22,418.50 | Price 1.30 | Shares 17,245
Sale 7 Nov 2024
Value US$30,589.81 | Price 1.31 | Shares 23,351
Sale 27 Aug 2024
Value US$2,987.55 | Price 1.35 | Shares 2,213
Sale 27 Aug 2024
Value US$7,981.20 | Price 1.35 | Shares 5,912
Sale 27 Aug 2024
Value US$3,721.95 | Price 1.35 | Shares 2,757
Sale 5 Aug 2024
Value US$23,109.71 | Price 1.31 | Shares 17,641
Sale 2 Aug 2024
Value US$19,536.00 | Price 1.32 | Shares 14,800
Proposed sale 5 Feb 2024
Value US$65,466.02 | Price 1.45 | Shares 45,093
Planned sale 5 Feb 2024
Value US$65,384.85 | Price 1.45 | Shares 45,093
Sale 2 Feb 2024
Value US$38,462.75 | Price 1.37 | Shares 28,075
Sale 2 Feb 2024
Value US$42,120.56 | Price 1.36 | Shares 30,971
Sale 2 Feb 2024
Value US$42,334.37 | Price 1.37 | Shares 30,901
Sale 2 Feb 2024
Value US$87,399.15 | Price 1.37 | Shares 63,795
Sale 2 Feb 2024
Value US$42,341.22 | Price 1.37 | Shares 30,906
Sale 13 Sep 2023
Value US$50,159.92 | Price 1.27 | Shares 39,496
Planned sale 29 Aug 2023
Value US$5,411.90 | Price 1.30 | Shares 4,163
Proposed sale 29 Aug 2023
Value US$5,411.90 | Price 1.30 | Shares 4,163
Sale 28 Aug 2023
Value US$2,336.04 | Price 1.26 | Shares 1,854
Sale 28 Aug 2023
Value US$11,390.40 | Price 1.26 | Shares 9,040
Sale 28 Aug 2023
Value US$2,336.04 | Price 1.26 | Shares 1,854
Sale 28 Aug 2023
Value US$2,336.04 | Price 1.26 | Shares 1,854
Sale 3 Feb 2023
Value US$22,237.66 | Price 1.81 | Shares 12,286
Sale 2 Feb 2023
Value US$6,312.84 | Price 1.86 | Shares 3,394
Sale 2 Feb 2023
Value US$6,312.84 | Price 1.86 | Shares 3,394
Planned sale 2 Feb 2023
Value US$17,372.36 | Price 1.83 | Shares 9,504
Sale 22 Sep 2022
Value US$1,274,308.89 | Price 2.25 | Shares 566,284
Sale 22 Sep 2022
Value US$3,005,302.65 | Price 2.25 | Shares 1,335,512
Planned sale 29 Aug 2022
Value US$5,377.99 | Price 0.89 | Shares 6,017
Buy 26 Apr 2022
Value US$207,970.84 | Price 5.24 | Shares 39,727
Buy 14 Mar 2022
Value US$61,053.76 | Price 7.63 | Shares 8,006
Buy 14 Mar 2022
Value US$119,743.45 | Price 7.63 | Shares 15,702
Buy 28 Feb 2022
Value US$143,930.55 | Price 9.53 | Shares 15,104
Buy 28 Feb 2022
Value US$283,296.56 | Price 9.53 | Shares 29,729
Buy 18 Feb 2022
Value US$137,038.89 | Price 9.24 | Shares 14,828
Buy 31 Jan 2022
Value US$1,448,262.50 | Price 11.59 | Shares 125,000
Buy 24 Jan 2022
Value US$17,418.07 | Price 10.89 | Shares 1,599
Buy 18 Jan 2022
Value US$601,963.97 | Price 12.41 | Shares 48,488
Buy 10 Jan 2022
Value US$114,608.64 | Price 12.93 | Shares 8,867
Buy 31 Dec 2021
Value US$1,969,025.00 | Price 15.75 | Shares 125,000
Buy 30 Dec 2021
Value US$788,610.00 | Price 15.77 | Shares 50,000
Buy 29 Dec 2021
Value US$1,105,262.82 | Price 14.64 | Shares 75,493
Buy 29 Oct 2021
Value US$2,630,175.00 | Price 17.53 | Shares 150,000
Buy 30 Sep 2021
Value US$2,509,173.13 | Price 18.65 | Shares 134,543
Buy 31 Aug 2021
Value US$920,660.13 | Price 18.93 | Shares 48,645
Buy 30 Aug 2021
Value US$786,858.78 | Price 17.87 | Shares 44,042
Sale 8 Feb 2021
Value US$65,215.20 | Price 21.74 | Shares 3,000
Sale 4 Feb 2021
Value US$648,254.57 | Price 18.99 | Shares 34,144
Sale 3 Feb 2021
Value US$557,100.76 | Price 18.98 | Shares 29,354
Sale 2 Feb 2021
Value US$433,771.15 | Price 18.99 | Shares 22,841
Sale 1 Feb 2021
Value US$262,860.86 | Price 19.24 | Shares 13,661
Sale 17 Dec 2020
Value US$4,703,225.00 | Price 18.81 | Shares 250,000
Planned sale 16 Dec 2020
Value US$228,000.00 | Price 19.00 | Shares 12,000
Sale 16 Dec 2020
Value US$278,034.54 | Price 18.62 | Shares 14,933
Sale 9 Nov 2020
Value US$1,734,071.06 | Price 13.77 | Shares 125,900
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-05-06 2026-05-04 S Sale
2.7
Rajavelu Esther

See Remarks

Officer
74,789 -2.2%
495.73
US$900,718 		74,789 -2.2% 495.73 US$900,718
2026-02-09 2026-02-06 S Sale
2.7
Rajavelu Esther

See Remarks

Officer
98,478 +11.7%
231.70
US$2,291,416 		98,478 +11.7% 231.70 US$2,291,416
2026-02-09 2026-02-06 S Sale
2.7
Rajavelu Esther

See Remarks

Officer
87,845 +1.5%
49.46
US$1,532,052 		87,845 +1.5% 49.46 US$1,532,052
2026-02-09 2026-02-06 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
18,652 -2.5%
2.36
US$44,019 		18,652 -2.5% 2.36 US$44,019
2026-02-05 2026-02-04 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
3,471 -0.5%
2.24
US$7,775 		3,471 -0.5% 2.24 US$7,775
2026-02-05 2026-02-03 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
24,224 -3.1%
2.14
US$51,839 		24,224 -3.1% 2.14 US$51,839
2026-02-05 2026-02-02 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
18,891 -2.3%
2.20
US$41,560 		18,891 -2.3% 2.20 US$41,560
2026-02-04 2026-02-02 S Sale
2.7
Rajavelu Esther

See Remarks

Officer
18,442 -1.6%
2.20
US$40,572 		18,442 -1.6% 2.20 US$40,572
2026-02-04 2026-02-02 S Sale
2.7
Rajavelu Esther

See Remarks

Officer
18,442 -1.6%
2.20
US$40,572 		18,442 -1.6% 2.20 US$40,572
2025-11-12 2025-11-07 S Sale
2.7
Rajavelu Esther

See Remarks

Officer
40,270 -4.4%
2.37
US$95,440 		40,270 -4.4% 2.37 US$95,440
2025-09-03 2025-08-28 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
6,572 -0.9%
1.97
US$12,947 		6,572 -0.9% 1.97 US$12,947
2025-09-03 2025-08-28 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
1,695 -0.2%
1.97
US$3,339 		1,695 -0.2% 1.97 US$3,339
2025-02-05 2025-02-05 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
24,920 -3.3%
0.78
US$19,438 		24,920 -3.3% 0.78 US$19,438
2025-02-05 2025-02-05 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
27,643 -3.5%
0.78
US$21,562 		27,643 -3.5% 0.78 US$21,562
2025-02-05 2025-02-05 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
3,974 -0.5%
0.78
US$3,100 		3,974 -0.5% 0.78 US$3,100
2025-02-05 2025-02-05 S Sale
2.7
Rajavelu Esther

CFO & CBO

Officer
20,689 -2.8%
0.78
US$16,137 		20,689 -2.8% 0.78 US$16,137
2025-02-05 2025-02-05 S Sale
2.7
Shukla Sath

CEO & President

Officer
106,408 -5.8%
0.78
US$82,998 		106,408 -5.8% 0.78 US$82,998
2025-02-05 2025-02-05 S Sale
2.7
Shukla Sath

CEO & President

Officer
42,786 -2.3%
0.78
US$33,373 		42,786 -2.3% 0.78 US$33,373
2025-02-05 2025-02-05 S Sale
2.7
Shukla Sath

CEO & President

Officer
6,139 -0.3%
0.78
US$4,788 		6,139 -0.3% 0.78 US$4,788
2025-02-05 2025-02-05 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
55,260 -7.4%
0.78
US$43,103 		55,260 -7.4% 0.78 US$43,103
2025-02-05 2025-02-05 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
13,959 -1.8%
0.78
US$10,888 		13,959 -1.8% 0.78 US$10,888
2024-11-12 2024-11-08 S Sale
2.7
Rajavelu Esther

CFO & CBO

Officer
17,245 -4.3%
1.30
US$22,418 		17,245 -4.3% 1.30 US$22,418
2024-11-12 2024-11-07 S Sale
2.7
Rajavelu Esther

CFO & CBO

Officer
23,351 -5.6%
1.31
US$30,590 		23,351 -5.6% 1.31 US$30,590
2024-08-29 2024-08-27 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
2,213 -0.4%
1.35
US$2,988 		2,213 -0.4% 1.35 US$2,988
2024-08-29 2024-08-27 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
5,912 -0.8%
1.35
US$7,981 		5,912 -0.8% 1.35 US$7,981
2024-08-29 2024-08-27 S Sale
2.7
Shukla Sath

CEO & President

Officer
2,757 -0.2%
1.35
US$3,722 		2,757 -0.2% 1.35 US$3,722
2024-08-06 2024-08-05 S Sale
2.7
Shukla Sath

CEO and President

Officer
17,641 -1.5%
1.31
US$23,110 		17,641 -1.5% 1.31 US$23,110
2024-08-06 2024-08-02 S Sale
2.7
Shukla Sath

CEO and President

Officer
14,800 -1.3%
1.32
US$19,536 		14,800 -1.3% 1.32 US$19,536
2024-02-05 2024-02-05 PrS Proposed sale
2.7
SATYAVRAT SHUKLA

Officer; Director

Executive Director
45,093
1.45
US$65,466 		45,093 1.45 US$65,466
2024-02-05 2024-02-05 PlS Planned sale
2.7
Shukla Sath

CEO and President

Executive Director
45,093 -3.7%
1.45
US$65,385 		45,093 -3.7% 1.45 US$65,385
2024-02-05 2024-02-02 S Sale
1.8
HAMED KAMAL

Chief Medical Officer

Officer
28,075 -3.4%
1.37
US$38,463 		28,075 -3.4% 1.37 US$38,463
2024-02-05 2024-02-02 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
30,971 -5.5%
1.36
US$42,121 		30,971 -5.5% 1.36 US$42,121
2024-02-05 2024-02-02 S Sale
2.7
Shukla Sath

CEO and President

Executive Director
30,901 -2.5%
1.37
US$42,334 		30,901 -2.5% 1.37 US$42,334
2024-02-05 2024-02-02 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
63,795 -7.9%
1.37
US$87,399 		63,795 -7.9% 1.37 US$87,399
2024-02-05 2024-02-02 S Sale
1.9
JOSEPH TAMARA L

Chief Legal Officer

Officer
30,906 -5.5%
1.37
US$42,341 		30,906 -5.5% 1.37 US$42,341
2023-09-15 2023-09-13 S Sale
1.8
HAMED KAMAL

Chief Medical Officer

Officer
39,496 -6.4%
1.27
US$50,160 		39,496 -6.4% 1.27 US$50,160
2023-08-30 2023-08-29 PlS Planned sale
2.7
Shukla Sath

CEO and President

Executive Director
4,163 -0.7%
1.30
US$5,412 		4,163 -0.7% 1.30 US$5,412
2023-08-29 2023-08-29 PrS Proposed sale
2.7
SATYAVRAT SHUKLA

Officer

Officer
4,163
1.30
US$5,412 		4,163 1.30 US$5,412
2023-08-30 2023-08-28 S Sale
1.9
JOSEPH TAMARA L

Chief Legal Officer

Officer
1,854 -0.6%
1.26
US$2,336 		1,854 -0.6% 1.26 US$2,336
2023-08-30 2023-08-28 S Sale
2.4
Mahadevia Ankit
Non-Executive Director
9,040 -1.1%
1.26
US$11,390 		9,040 -1.1% 1.26 US$11,390
2023-08-30 2023-08-28 S Sale
2.7
Shukla Sath

CEO and President

Executive Director
1,854 -0.3%
1.26
US$2,336 		1,854 -0.3% 1.26 US$2,336
2023-08-30 2023-08-28 S Sale
2.3
Keutzer Timothy

Chief Development Officer

Officer
1,854 -0.6%
1.26
US$2,336 		1,854 -0.6% 1.26 US$2,336
2023-02-06 2023-02-03 S Sale
2.4
Mahadevia Ankit

CEO and President

Executive Director
12,286 -1.5%
1.81
US$22,238 		12,286 -1.5% 1.81 US$22,238
2023-02-03 2023-02-02 S Sale
1.9
JOSEPH TAMARA L

Chief Legal Officer

Officer
3,394 -1.0%
1.86
US$6,313 		3,394 -1.0% 1.86 US$6,313
2023-02-03 2023-02-02 S Sale
2.3
Keutzer Timothy

Chief Operating Officer

Officer
3,394 -1.0%
1.86
US$6,313 		3,394 -1.0% 1.86 US$6,313
2023-02-03 2023-02-02 PlS Planned sale
2.7
Shukla Sath

Chief Financial Officer

Officer
9,504 -3.0%
1.83
US$17,372 		9,504 -3.0% 1.83 US$17,372
2022-09-26 2022-09-22 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
566,284 -14.2%
2.25
US$1,274,309 		566,284 -14.2% 2.25 US$1,274,309
2022-09-26 2022-09-22 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
1,335,512 -25.1%
2.25
US$3,005,303 		1,335,512 -25.1% 2.25 US$3,005,303
2022-08-30 2022-08-29 PlS Planned sale
2.7
Shukla Sath

Chief Financial Officer

Officer
6,017 -9.7%
0.89
US$5,378 		6,017 -9.7% 0.89 US$5,378
2022-04-28 2022-04-26 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
39,727 +0.8%
5.24
US$207,971 		39,727 +0.8% 5.24 US$207,971
2022-03-16 2022-03-14 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
8,006 +0.2%
7.63
US$61,054 		8,006 +0.2% 7.63 US$61,054
2022-03-16 2022-03-14 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
15,702 +0.3%
7.63
US$119,743 		15,702 +0.3% 7.63 US$119,743
2022-03-02 2022-02-28 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
15,104 +0.3%
9.53
US$143,931 		15,104 +0.3% 9.53 US$143,931
2022-03-02 2022-02-28 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
29,729 +0.6%
9.53
US$283,297 		29,729 +0.6% 9.53 US$283,297
2022-02-23 2022-02-18 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
14,828 +0.3%
9.24
US$137,039 		14,828 +0.3% 9.24 US$137,039
2022-02-01 2022-01-31 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
125,000 +2.5%
11.59
US$1,448,262 		125,000 +2.5% 11.59 US$1,448,262
2022-01-26 2022-01-24 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
1,599 +0.0%
10.89
US$17,418 		1,599 +0.0% 10.89 US$17,418
2022-01-20 2022-01-18 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
48,488 +1.0%
12.41
US$601,964 		48,488 +1.0% 12.41 US$601,964
2022-01-12 2022-01-10 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
8,867 +0.2%
12.93
US$114,609 		8,867 +0.2% 12.93 US$114,609
2022-01-03 2021-12-31 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
125,000 +2.6%
15.75
US$1,969,025 		125,000 +2.6% 15.75 US$1,969,025
2022-01-03 2021-12-30 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
50,000 +1.0%
15.77
US$788,610 		50,000 +1.0% 15.77 US$788,610
2022-01-03 2021-12-29 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
75,493 +1.6%
14.64
US$1,105,263 		75,493 +1.6% 14.64 US$1,105,263
2021-11-02 2021-10-29 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
150,000 +3.3%
17.53
US$2,630,175 		150,000 +3.3% 17.53 US$2,630,175
2021-10-04 2021-09-30 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
134,543 +3.0%
18.65
US$2,509,173 		134,543 +3.0% 18.65 US$2,509,173
2021-09-01 2021-08-31 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
48,645 +1.1%
18.93
US$920,660 		48,645 +1.1% 18.93 US$920,660
2021-09-01 2021-08-30 B Purchase
1.7
Aquilo Capital Management, LLC
Large shareholder
44,042 +1.0%
17.87
US$786,859 		44,042 +1.0% 17.87 US$786,859
2021-02-10 2021-02-08 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
3,000 -0.1%
21.74
US$65,215 		3,000 -0.1% 21.74 US$65,215
2021-02-04 2021-02-04 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
34,144 -0.9%
18.99
US$648,255 		34,144 -0.9% 18.99 US$648,255
2021-02-04 2021-02-03 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
29,354 -0.8%
18.98
US$557,101 		29,354 -0.8% 18.98 US$557,101
2021-02-04 2021-02-02 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
22,841 -0.6%
18.99
US$433,771 		22,841 -0.6% 18.99 US$433,771
2021-02-04 2021-02-01 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
13,661 -0.3%
19.24
US$262,861 		13,661 -0.3% 19.24 US$262,861
2020-12-18 2020-12-17 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
250,000 -6.0%
18.81
US$4,703,225 		250,000 -6.0% 18.81 US$4,703,225
2020-12-18 2020-12-16 PlS Planned sale
Larkin Cristina

Chief Operating Officer

Officer
12,000 -88.9%
19.00
US$228,000 		12,000 -88.9% 19.00 US$228,000
2020-12-18 2020-12-16 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
14,933 -0.4%
18.62
US$278,035 		14,933 -0.4% 18.62 US$278,035
2020-11-10 2020-11-09 S Sale
1.7
Aquilo Capital Management, LLC
Large shareholder
125,900 -2.9%
13.77
US$1,734,071 		125,900 -2.9% 13.77 US$1,734,071
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