United States Biotechnology & Medical Research

Sionna Therapeutics, Inc. (SION)

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Sionna Therapeutics Inc. has experienced significant selling activity, with insiders offloading over $40 million in shares recently. Major stakeholders, including RA Capital and OrbiMed, executed multiple planned divestments. This trend coincides with a sharp 81.5% decline in stock value over the past quarter, following a slight miss in the latest earnings report.
Ticker: SION Exchange: NMS
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Sionna Therapeutics, Inc.. Upgrade to see score, net flow, insiders and the full signal context.

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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
184.45
Quantity 77,657 -21.6%
Value US$1,334,021
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
299.42
Quantity 65,179 +19.6%
Value US$2,885,193
RA Capital Healthcare Fund, L.P. Director; 10% Stockholder Non-Executive Director Large shareholder
Transaction date
Proposed sale
Price
158.90
Quantity 30,826
Value US$969,997
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Planned sale
Price
44.86
Quantity 85,918 -3.4%
Value US$3,854,281
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Planned sale
Price
44.86
Quantity 85,918 -3.4%
Value US$3,854,281
Fitzpatrick Jennifer Chief Legal Officer Officer
Transaction date
Planned sale
Price
43.60
Quantity 10,250 -100.0%
Value US$446,862
JENNIFER FITZPATRICK Officer Officer
Transaction date
Proposed sale
Price
43.99
Quantity 10,250
Value US$450,898
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Planned sale
Price
45.50
Quantity 115,844 -4.3%
Value US$5,270,902
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Planned sale
Price
45.50
Quantity 115,844 -4.3%
Value US$5,270,902
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Planned sale
Price
44.49
Quantity 101 -0.0%
Value US$4,493
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Planned sale
Price
44.49
Quantity 101 -0.0%
Value US$4,493
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Planned sale
Price
46.22
Quantity 184,639 -6.5%
Value US$8,534,015
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Planned sale
Price
46.22
Quantity 184,639 -6.5%
Value US$8,534,015
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Planned sale
Price
44.58
Quantity 59,767 -2.0%
Value US$2,664,413
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Planned sale
Price
44.58
Quantity 59,767 -2.0%
Value US$2,664,413
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Planned sale
Price
44.61
Quantity 48,546 -1.6%
Value US$2,165,637
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Planned sale
Price
44.61
Quantity 48,546 -1.6%
Value US$2,165,637
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Planned sale
Price
44.52
Quantity 2,948 -0.1%
Value US$131,245
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Planned sale
Price
44.52
Quantity 2,948 -0.1%
Value US$131,245
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Planned sale
Price
44.68
Quantity 52,397 -1.7%
Value US$2,341,098
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Planned sale
Price
44.68
Quantity 52,397 -1.7%
Value US$2,341,098
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Planned sale
Price
45.34
Quantity 226,906 -7.0%
Value US$10,287,918
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Planned sale
Price
45.34
Quantity 226,906 -7.0%
Value US$10,287,918
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Planned sale
Price
44.64
Quantity 235,863 -6.8%
Value US$10,528,924
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Planned sale
Price
44.64
Quantity 235,863 -6.8%
Value US$10,528,924
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Planned sale
Price
44.51
Quantity 47,814 -1.4%
Value US$2,128,201
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Planned sale
Price
44.51
Quantity 47,814 -1.4%
Value US$2,128,201
Fitzpatrick Jennifer Chief Legal Officer Officer
Transaction date
Planned sale
Price
33.86
Quantity 10,250 -100.0%
Value US$347,019
JENNIFER FITZPATRICK Officer Officer
Transaction date
Proposed sale
Price
34.57
Quantity 10,250
Value US$354,342
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Sale
Price
44.58
Quantity 29,063 -0.8%
Value US$1,295,629
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Sale
Price
44.58
Quantity 29,063 -0.8%
Value US$1,295,629
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Sale
Price
44.58
Quantity 29,063 -0.8%
Value US$1,295,629
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Sale
Price
44.58
Quantity 29,063 -0.8%
Value US$1,295,629
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Sale
Price
44.57
Quantity 1,890 -0.1%
Value US$84,237
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Sale
Price
44.57
Quantity 1,890 -0.1%
Value US$84,237
3.0
TPG GP A, LLC Large shareholder
Transaction date
Sale
Price
40.00
Quantity 250,000 -3.7%
Value US$10,000,000
Rise Fund Sling, L.P. Stockholder Large shareholder
Transaction date
Proposed sale
Price
41.77
Quantity 195,667
Value US$8,173,011
Rise Fund Sling II, L.P. Stockholder Large shareholder
Transaction date
Proposed sale
Price
41.77
Quantity 54,333
Value US$2,269,489
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Sale
Price
44.55
Quantity 33,356 -0.9%
Value US$1,486,010
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Sale
Price
44.55
Quantity 33,356 -0.9%
Value US$1,486,010
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Sale
Price
44.49
Quantity 875 -0.0%
Value US$38,929
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Sale
Price
44.49
Quantity 875 -0.0%
Value US$38,929
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Sale
Price
44.49
Quantity 100 -0.0%
Value US$4,449
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Sale
Price
44.49
Quantity 100 -0.0%
Value US$4,449
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Sale
Price
44.50
Quantity 900 -0.0%
Value US$40,050
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Sale
Price
44.50
Quantity 900 -0.0%
Value US$40,050
Fitzpatrick Jennifer Chief Legal Officer Officer
Transaction date
Planned sale
Price
40.52
Quantity 10,250 -100.0%
Value US$415,330
JENNIFER R FITZPATRICK Officer Officer
Transaction date
Proposed sale
Price
40.88
Quantity 10,250
Value US$419,020
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Sale
Price
44.49
Quantity 1,600 -0.0%
Value US$71,184
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Sale
Price
44.49
Quantity 1,600 -0.0%
Value US$71,184
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Sale
Price
44.60
Quantity 11,890 -0.3%
Value US$530,294
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Sale
Price
44.60
Quantity 11,890 -0.3%
Value US$530,294
2.6
ORBIMED ADVISORS LLC Non-Executive Director
Transaction date
Sale
Price
44.54
Quantity 94,583 -2.6%
Value US$4,212,727
3.0
Thompson Peter A. Non-Executive Director
Transaction date
Sale
Price
44.54
Quantity 94,583 -2.6%
Value US$4,212,727
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
39.50
Quantity 7,609 -4.6%
Value US$300,556
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
39.50
Quantity 6,440 -0.3%
Value US$254,380
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
39.50
Quantity 9,924 -1.5%
Value US$391,998
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
39.50
Quantity 1,210 -0.0%
Value US$47,795
RA Capital Nexus Fund III, L.P. Director; 10% Stockholder Non-Executive Director Large shareholder
Transaction date
Proposed sale
Price
43.66
Quantity 6,440
Value US$281,170
RA Capital Healthcare Fund LP Director; 10% Stockholder Non-Executive Director Large shareholder
Transaction date
Proposed sale
Price
43.66
Quantity 1,210
Value US$52,829
RA Capital Nexus Fund, L.P. Director; 10% Stockholder Non-Executive Director Large shareholder
Transaction date
Proposed sale
Price
43.66
Quantity 9,924
Value US$433,282
BLACKWELL PARTNERS LLC - SERIES A Director; 10% Stockholder Non-Executive Director Large shareholder
Transaction date
Proposed sale
Price
43.66
Quantity 7,609
Value US$332,209
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
40.50
Quantity 604 -0.4%
Value US$24,462
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
40.50
Quantity 512 -0.0%
Value US$20,736
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
40.50
Quantity 788 -0.1%
Value US$31,914
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
40.50
Quantity 96 -0.0%
Value US$3,888
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
39.89
Quantity 947 -0.6%
Value US$37,776
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
39.89
Quantity 801 -0.0%
Value US$31,952
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
39.89
Quantity 1,235 -0.2%
Value US$49,264
2.9
RA CAPITAL MANAGEMENT, L.P. Non-Executive Director Large shareholder
Transaction date
Sale
Price
39.89
Quantity 150 -0.0%
Value US$5,984
RA Capital Nexus Fund III, L.P. Director; 10% Stockholder Non-Executive Director Large shareholder
Transaction date
Proposed sale
Price
38.94
Quantity 1,313
Value US$51,128
RA Capital Nexus Fund, L.P. Director; 10% Stockholder Non-Executive Director Large shareholder
Transaction date
Proposed sale
Price
38.94
Quantity 2,023
Value US$78,776
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-09-21 2026-09-17 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
77,657 -21.6%
184.45
US$1,334,021 		77,657 -21.6% 184.45 US$1,334,021
2026-09-21 2026-09-17 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
65,179 +19.6%
299.42
US$2,885,193 		65,179 +19.6% 299.42 US$2,885,193
2026-09-17 2026-09-17 PrS Proposed sale
RA Capital Healthcare Fund, L.P.

Director; 10% Stockholder

Non-Executive Director Large shareholder
30,826
158.90
US$969,997 		30,826 158.90 US$969,997
2026-07-09 2026-07-07 PlS Planned sale
3.0
Thompson Peter A.
Non-Executive Director
85,918 -3.4%
44.86
US$3,854,281 		85,918 -3.4% 44.86 US$3,854,281
2026-07-09 2026-07-07 PlS Planned sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
85,918 -3.4%
44.86
US$3,854,281 		85,918 -3.4% 44.86 US$3,854,281
2026-07-07 2026-07-06 PlS Planned sale
Fitzpatrick Jennifer

Chief Legal Officer

Officer
10,250 -100.0%
43.60
US$446,862 		10,250 -100.0% 43.60 US$446,862
2026-07-06 2026-07-06 PrS Proposed sale
JENNIFER FITZPATRICK

Officer

Officer
10,250
43.99
US$450,898 		10,250 43.99 US$450,898
2026-07-02 2026-06-30 PlS Planned sale
3.0
Thompson Peter A.
Non-Executive Director
115,844 -4.3%
45.50
US$5,270,902 		115,844 -4.3% 45.50 US$5,270,902
2026-07-02 2026-06-30 PlS Planned sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
115,844 -4.3%
45.50
US$5,270,902 		115,844 -4.3% 45.50 US$5,270,902
2026-06-01 2026-05-29 PrS Proposed sale
2.6
OrbiMed Private Investments VIII, LP

Shareholder
210,876
42.82
US$9,029,710 		210,876 42.82 US$9,029,710
2026-05-29 2026-05-29 PrS Proposed sale
2.6
OrbiMed Private Investments VIII, LP

Shareholder
1,082,480
42.80
US$46,330,144 		1,082,480 42.80 US$46,330,144
2026-05-29 2026-05-27 PlS Planned sale
3.0
Thompson Peter A.
Non-Executive Director
101 -0.0%
44.49
US$4,493 		101 -0.0% 44.49 US$4,493
2026-05-29 2026-05-27 PlS Planned sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
101 -0.0%
44.49
US$4,493 		101 -0.0% 44.49 US$4,493
2026-05-11 2026-05-11 PlS Planned sale
3.0
Thompson Peter A.
Non-Executive Director
184,639 -6.5%
46.22
US$8,534,015 		184,639 -6.5% 46.22 US$8,534,015
2026-05-11 2026-05-11 PlS Planned sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
184,639 -6.5%
46.22
US$8,534,015 		184,639 -6.5% 46.22 US$8,534,015
2026-05-11 2026-05-08 PlS Planned sale
3.0
Thompson Peter A.
Non-Executive Director
59,767 -2.0%
44.58
US$2,664,413 		59,767 -2.0% 44.58 US$2,664,413
2026-05-11 2026-05-08 PlS Planned sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
59,767 -2.0%
44.58
US$2,664,413 		59,767 -2.0% 44.58 US$2,664,413
2026-05-11 2026-05-07 PlS Planned sale
3.0
Thompson Peter A.
Non-Executive Director
48,546 -1.6%
44.61
US$2,165,637 		48,546 -1.6% 44.61 US$2,165,637
2026-05-11 2026-05-07 PlS Planned sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
48,546 -1.6%
44.61
US$2,165,637 		48,546 -1.6% 44.61 US$2,165,637
2026-04-21 2026-04-18 PlS Planned sale
3.0
Thompson Peter A.
Non-Executive Director
2,948 -0.1%
44.52
US$131,245 		2,948 -0.1% 44.52 US$131,245
2026-04-21 2026-04-18 PlS Planned sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
2,948 -0.1%
44.52
US$131,245 		2,948 -0.1% 44.52 US$131,245
2026-04-21 2026-04-17 PlS Planned sale
3.0
Thompson Peter A.
Non-Executive Director
52,397 -1.7%
44.68
US$2,341,098 		52,397 -1.7% 44.68 US$2,341,098
2026-04-21 2026-04-17 PlS Planned sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
52,397 -1.7%
44.68
US$2,341,098 		52,397 -1.7% 44.68 US$2,341,098
2026-04-16 2026-04-16 PlS Planned sale
3.0
Thompson Peter A.
Non-Executive Director
226,906 -7.0%
45.34
US$10,287,918 		226,906 -7.0% 45.34 US$10,287,918
2026-04-16 2026-04-16 PlS Planned sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
226,906 -7.0%
45.34
US$10,287,918 		226,906 -7.0% 45.34 US$10,287,918
2026-04-16 2026-04-15 PlS Planned sale
3.0
Thompson Peter A.
Non-Executive Director
235,863 -6.8%
44.64
US$10,528,924 		235,863 -6.8% 44.64 US$10,528,924
2026-04-16 2026-04-15 PlS Planned sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
235,863 -6.8%
44.64
US$10,528,924 		235,863 -6.8% 44.64 US$10,528,924
2026-04-16 2026-04-14 PlS Planned sale
3.0
Thompson Peter A.
Non-Executive Director
47,814 -1.4%
44.51
US$2,128,201 		47,814 -1.4% 44.51 US$2,128,201
2026-04-16 2026-04-14 PlS Planned sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
47,814 -1.4%
44.51
US$2,128,201 		47,814 -1.4% 44.51 US$2,128,201
2026-03-06 2026-03-05 PlS Planned sale
Fitzpatrick Jennifer

Chief Legal Officer

Officer
10,250 -100.0%
33.86
US$347,019 		10,250 -100.0% 33.86 US$347,019
2026-03-05 2026-03-05 PrS Proposed sale
JENNIFER FITZPATRICK

Officer

Officer
10,250
34.57
US$354,342 		10,250 34.57 US$354,342
2026-02-04 2026-02-03 S Sale
3.0
Thompson Peter A.
Non-Executive Director
29,063 -0.8%
44.58
US$1,295,629 		29,063 -0.8% 44.58 US$1,295,629
2026-02-04 2026-02-03 S Sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
29,063 -0.8%
44.58
US$1,295,629 		29,063 -0.8% 44.58 US$1,295,629
2026-02-04 2026-02-03 S Sale
3.0
Thompson Peter A.
Non-Executive Director
29,063 -0.8%
44.58
US$1,295,629 		29,063 -0.8% 44.58 US$1,295,629
2026-02-04 2026-02-03 S Sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
29,063 -0.8%
44.58
US$1,295,629 		29,063 -0.8% 44.58 US$1,295,629
2026-02-04 2026-02-02 S Sale
3.0
Thompson Peter A.
Non-Executive Director
1,890 -0.1%
44.57
US$84,237 		1,890 -0.1% 44.57 US$84,237
2026-02-04 2026-02-02 S Sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
1,890 -0.1%
44.57
US$84,237 		1,890 -0.1% 44.57 US$84,237
2026-01-26 2026-01-22 S Sale
3.0
TPG GP A, LLC
Large shareholder
250,000 -3.7%
40.00
US$10,000,000 		250,000 -3.7% 40.00 US$10,000,000
2026-01-22 2026-01-22 PrS Proposed sale
Rise Fund Sling, L.P.

Stockholder

Large shareholder
195,667
41.77
US$8,173,011 		195,667 41.77 US$8,173,011
2026-01-22 2026-01-22 PrS Proposed sale
Rise Fund Sling II, L.P.

Stockholder

Large shareholder
54,333
41.77
US$2,269,489 		54,333 41.77 US$2,269,489
2025-12-29 2025-12-24 S Sale
3.0
Thompson Peter A.
Non-Executive Director
33,356 -0.9%
44.55
US$1,486,010 		33,356 -0.9% 44.55 US$1,486,010
2025-12-29 2025-12-24 S Sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
33,356 -0.9%
44.55
US$1,486,010 		33,356 -0.9% 44.55 US$1,486,010
2025-12-19 2025-12-19 S Sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
875 -0.0%
44.49
US$38,929 		875 -0.0% 44.49 US$38,929
2025-12-19 2025-12-19 S Sale
3.0
Thompson Peter A.
Non-Executive Director
875 -0.0%
44.49
US$38,929 		875 -0.0% 44.49 US$38,929
2025-12-19 2025-12-18 S Sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
100 -0.0%
44.49
US$4,449 		100 -0.0% 44.49 US$4,449
2025-12-19 2025-12-18 S Sale
3.0
Thompson Peter A.
Non-Executive Director
100 -0.0%
44.49
US$4,449 		100 -0.0% 44.49 US$4,449
2025-12-19 2025-12-17 S Sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
900 -0.0%
44.50
US$40,050 		900 -0.0% 44.50 US$40,050
2025-12-19 2025-12-17 S Sale
3.0
Thompson Peter A.
Non-Executive Director
900 -0.0%
44.50
US$40,050 		900 -0.0% 44.50 US$40,050
2025-12-09 2025-12-05 PlS Planned sale
Fitzpatrick Jennifer

Chief Legal Officer

Officer
10,250 -100.0%
40.52
US$415,330 		10,250 -100.0% 40.52 US$415,330
2025-12-05 2025-12-05 PrS Proposed sale
JENNIFER R FITZPATRICK

Officer

Officer
10,250
40.88
US$419,020 		10,250 40.88 US$419,020
2025-11-26 2025-11-26 S Sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
1,600 -0.0%
44.49
US$71,184 		1,600 -0.0% 44.49 US$71,184
2025-11-26 2025-11-26 S Sale
3.0
Thompson Peter A.
Non-Executive Director
1,600 -0.0%
44.49
US$71,184 		1,600 -0.0% 44.49 US$71,184
2025-11-26 2025-11-25 S Sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
11,890 -0.3%
44.60
US$530,294 		11,890 -0.3% 44.60 US$530,294
2025-11-26 2025-11-25 S Sale
3.0
Thompson Peter A.
Non-Executive Director
11,890 -0.3%
44.60
US$530,294 		11,890 -0.3% 44.60 US$530,294
2025-11-26 2025-11-24 S Sale
2.6
ORBIMED ADVISORS LLC
Non-Executive Director
94,583 -2.6%
44.54
US$4,212,727 		94,583 -2.6% 44.54 US$4,212,727
2025-11-26 2025-11-24 S Sale
3.0
Thompson Peter A.
Non-Executive Director
94,583 -2.6%
44.54
US$4,212,727 		94,583 -2.6% 44.54 US$4,212,727
2025-11-24 2025-11-24 PrS Proposed sale
2.6
OrbiMed Private Investments VIII, LP

Shareholder
1,047,770
44.38
US$46,500,033 		1,047,770 44.38 US$46,500,033
2025-11-24 2025-11-21 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
7,609 -4.6%
39.50
US$300,556 		7,609 -4.6% 39.50 US$300,556
2025-11-24 2025-11-21 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
6,440 -0.3%
39.50
US$254,380 		6,440 -0.3% 39.50 US$254,380
2025-11-24 2025-11-21 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
9,924 -1.5%
39.50
US$391,998 		9,924 -1.5% 39.50 US$391,998
2025-11-24 2025-11-21 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
1,210 -0.0%
39.50
US$47,795 		1,210 -0.0% 39.50 US$47,795
2025-11-21 2025-11-21 PrS Proposed sale
RA Capital Nexus Fund III, L.P.

Director; 10% Stockholder

Non-Executive Director Large shareholder
6,440
43.66
US$281,170 		6,440 43.66 US$281,170
2025-11-21 2025-11-21 PrS Proposed sale
RA Capital Healthcare Fund LP

Director; 10% Stockholder

Non-Executive Director Large shareholder
1,210
43.66
US$52,829 		1,210 43.66 US$52,829
2025-11-21 2025-11-21 PrS Proposed sale
RA Capital Nexus Fund, L.P.

Director; 10% Stockholder

Non-Executive Director Large shareholder
9,924
43.66
US$433,282 		9,924 43.66 US$433,282
2025-11-21 2025-11-21 PrS Proposed sale
BLACKWELL PARTNERS LLC - SERIES A

Director; 10% Stockholder

Non-Executive Director Large shareholder
7,609
43.66
US$332,209 		7,609 43.66 US$332,209
2025-11-24 2025-11-20 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
604 -0.4%
40.50
US$24,462 		604 -0.4% 40.50 US$24,462
2025-11-24 2025-11-20 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
512 -0.0%
40.50
US$20,736 		512 -0.0% 40.50 US$20,736
2025-11-24 2025-11-20 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
788 -0.1%
40.50
US$31,914 		788 -0.1% 40.50 US$31,914
2025-11-24 2025-11-20 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
96 -0.0%
40.50
US$3,888 		96 -0.0% 40.50 US$3,888
2025-11-24 2025-11-20 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
947 -0.6%
39.89
US$37,776 		947 -0.6% 39.89 US$37,776
2025-11-24 2025-11-20 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
801 -0.0%
39.89
US$31,952 		801 -0.0% 39.89 US$31,952
2025-11-24 2025-11-20 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
1,235 -0.2%
39.89
US$49,264 		1,235 -0.2% 39.89 US$49,264
2025-11-24 2025-11-20 S Sale
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
150 -0.0%
39.89
US$5,984 		150 -0.0% 39.89 US$5,984
2025-11-20 2025-11-20 PrS Proposed sale
RA Capital Nexus Fund III, L.P.

Director; 10% Stockholder

Non-Executive Director Large shareholder
1,313
38.94
US$51,128 		1,313 38.94 US$51,128
2025-11-20 2025-11-20 PrS Proposed sale
RA Capital Nexus Fund, L.P.

Director; 10% Stockholder

Non-Executive Director Large shareholder
2,023
38.94
US$78,776 		2,023 38.94 US$78,776
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