Madrigal Pharmaceuticals, Inc. (MDGL)

Madrigal Pharmaceuticals experienced significant insider selling over the past quarter, totaling over $41 million. Key executives, including CEO William Sibold and Director Paul Friedman, executed multiple planned divestments. Despite a positive earnings report in July, the stock price declined 17.1% recently, reflecting broader market pressure while leadership reduced equity holdings.
Ticker: MDGL Exchange: NSM


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Insider trades have triggered activity signals for Madrigal Pharmaceuticals, Inc.. Upgrade to see score, net flow, insiders and the full signal context.

Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
2.5
PAUL FRIEDMAN Director Non-Executive Director
Transaction date
Proposed sale
Price
365.89
Quantity 80,281
Value US$414,118
2.7
Sibold William John President and CEO Executive Director
Transaction date
Planned sale
Price
462.12
Quantity 80,638 +36.4%
Value US$1,486,083
2.7
Sibold William John President and CEO Executive Director
Transaction date
Planned sale
Price
131.88
Quantity 11,311 -30.9%
Value US$3,744,060
2.7
Sibold William John President and CEO Executive Director
Transaction date
Planned sale
Price
544.02
Quantity 1,539 -0.8%
Value US$837,253
2.7
Sibold William John President and CEO Executive Director
Transaction date
Planned sale
Price
542.60
Quantity 1,202 -0.6%
Value US$652,209
2.7
Sibold William John President and CEO Executive Director
Transaction date
Planned sale
Price
541.64
Quantity 368 -0.2%
Value US$199,324
2.7
Sibold William John President and CEO Executive Director
Transaction date
Planned sale
Price
540.59
Quantity 687 -0.3%
Value US$371,382
2.7
Sibold William John President and CEO Executive Director
Transaction date
Planned sale
Price
537.62
Quantity 160 -0.1%
Value US$86,019
2.7
Sibold William John President and CEO Executive Director
Transaction date
Planned sale
Price
535.94
Quantity 218 -0.1%
Value US$116,836
2.7
Sibold William John President and CEO Executive Director
Transaction date
Planned sale
Price
534.06
Quantity 106 -0.1%
Value US$56,611
2.7
Sibold William John President and CEO Executive Director
Transaction date
Planned sale
Price
533.09
Quantity 60 -0.0%
Value US$31,985
2.7
WILLIAM SIBOLD Director; Officer Executive Director
Transaction date
Proposed sale
Price
533.12
Quantity 5,221
Value US$2,783,420
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
542.55
Quantity 160 -0.1%
Value US$86,808
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
541.65
Quantity 362 -0.2%
Value US$196,079
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
540.19
Quantity 505 -0.2%
Value US$272,796
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
539.03
Quantity 215 -0.1%
Value US$115,891
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
538.30
Quantity 520 -0.3%
Value US$279,914
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
537.17
Quantity 640 -0.3%
Value US$343,791
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
536.11
Quantity 1,040 -0.5%
Value US$557,557
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
535.27
Quantity 644 -0.3%
Value US$344,715
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
534.20
Quantity 396 -0.2%
Value US$211,542
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
533.09
Quantity 512 -0.2%
Value US$272,944
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
531.99
Quantity 368 -0.2%
Value US$195,772
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
530.23
Quantity 522 -0.2%
Value US$276,781
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
529.27
Quantity 347 -0.2%
Value US$183,656
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
527.88
Quantity 131 -0.1%
Value US$69,152
2.7
William John Sibold Officer and Director Executive Director
Transaction date
Proposed sale
Price
534.16
Quantity 6,362
Value US$3,398,326
1.7
Kelley Shannon T General Counsel Officer
Transaction date
Sale
Price
514.97
Quantity 664 -5.5%
Value US$341,940
1.7
Shannon Kelley Officer Officer
Transaction date
Proposed sale
Price
507.56
Quantity 664
Value US$337,020
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
555.05
Quantity 280 -0.1%
Value US$155,414
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
550.72
Quantity 1 -0.0%
Value US$551
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
550.01
Quantity 153 -0.1%
Value US$84,152
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
548.87
Quantity 47 -0.0%
Value US$25,797
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
547.70
Quantity 680 -0.3%
Value US$372,435
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
547.08
Quantity 269 -0.1%
Value US$147,164
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
545.71
Quantity 275 -0.1%
Value US$150,070
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
544.71
Quantity 545 -0.3%
Value US$296,869
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
543.79
Quantity 110 -0.1%
Value US$59,817
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
542.75
Quantity 140 -0.1%
Value US$75,984
2.7
William Sibold Officer and Director Executive Director
Transaction date
Proposed sale
Price
553.48
Quantity 2,500
Value US$1,383,700
1.7
Soergel David Chief Medical Officer Officer
Transaction date
Planned sale
Price
495.74
Quantity 1,042 -9.4%
Value US$516,561
1.7
DAVID SOERGEL Officer Officer
Transaction date
Proposed sale
Price
497.27
Quantity 1,042
Value US$518,155
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
519.98
Quantity 80 -0.4%
Value US$41,598
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
518.76
Quantity 782 -3.4%
Value US$405,669
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
517.59
Quantity 1,497 -6.1%
Value US$774,835
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
516.87
Quantity 723 -2.9%
Value US$373,694
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
515.92
Quantity 657 -2.6%
Value US$338,961
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
514.67
Quantity 343 -1.3%
Value US$176,532
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
512.97
Quantity 40 -0.2%
Value US$20,519
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
512.50
Quantity 439 -1.7%
Value US$224,988
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
511.40
Quantity 610 -2.2%
Value US$311,952
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
510.36
Quantity 151 -0.6%
Value US$77,064
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
508.24
Quantity 320 -1.2%
Value US$162,637
3.5
Levy Richard S Non-Executive Director
Transaction date
Planned sale
Price
506.68
Quantity 40 -0.1%
Value US$20,267
3.5
RICHARD LEVY Director Non-Executive Director
Transaction date
Proposed sale
Price
513.59
Quantity 5,682
Value US$2,918,218
1.7
David Soergel Officer Officer
Transaction date
Proposed sale
Price
523.69
Quantity 844
Value US$441,994
1.7
Soergel David Chief Medical Officer Officer
Transaction date
Sale
Price
515.90
Quantity 844 -7.1%
Value US$435,420
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Planned sale
Price
437.65
Quantity 40 -0.3%
Value US$17,506
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Planned sale
Price
436.69
Quantity 80 -0.6%
Value US$34,935
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Planned sale
Price
435.32
Quantity 80 -0.6%
Value US$34,825
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Planned sale
Price
434.20
Quantity 160 -1.2%
Value US$69,472
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Planned sale
Price
432.56
Quantity 116 -0.9%
Value US$50,176
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Planned sale
Price
430.90
Quantity 120 -0.9%
Value US$51,708
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Planned sale
Price
429.58
Quantity 40 -0.3%
Value US$17,183
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Planned sale
Price
429.00
Quantity 160 -1.2%
Value US$68,639
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Planned sale
Price
427.85
Quantity 80 -0.6%
Value US$34,228
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Planned sale
Price
426.86
Quantity 420 -3.0%
Value US$179,283
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Planned sale
Price
425.08
Quantity 40 -0.3%
Value US$17,003
2.4
Dier Mardi EVP and CFO Officer
Transaction date
Sale
Price
431.94
Quantity 646 -4.5%
Value US$279,033
2.4
Mardi Dier Officer Officer
Transaction date
Proposed sale
Price
439.34
Quantity 646
Value US$283,814
2.7
Sibold William John President and CEO Executive Director
Transaction date
Sale
Price
431.94
Quantity 1,663 -1.0%
Value US$718,316
2.7
William Sibold Officer and Director Executive Director
Transaction date
Proposed sale
Price
439.34
Quantity 1,663
Value US$730,622
1.7
Kelley Shannon T General Counsel Officer
Transaction date
Sale
Price
431.94
Quantity 360 -2.9%
Value US$155,498
1.7
Shannon Kelley Officer Officer
Transaction date
Proposed sale
Price
439.34
Quantity 360
Value US$158,162
2.8
Huntsman Carole Chief Commercial Officer Officer
Transaction date
Sale
Price
431.94
Quantity 419 -3.2%
Value US$180,983
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value
Number of shares Price Value Details
2026-09-28 2026-09-28 PrS Proposed sale

Director

Non-Executive Director
80,281
365.89
US$414,118
80,281 365.89 US$414,118
2026-09-11 2026-09-11 PlS Planned sale

President and CEO

Executive Director
80,638 +36.4%
462.12
US$1,486,083
80,638 +36.4% 462.12 US$1,486,083
2026-09-11 2026-09-11 PlS Planned sale

President and CEO

Executive Director
11,311 -30.9%
131.88
US$3,744,060
11,311 -30.9% 131.88 US$3,744,060
2026-09-11 2026-09-11 PlS Planned sale

President and CEO

Executive Director
1,539 -0.8%
544.02
US$837,253
1,539 -0.8% 544.02 US$837,253
2026-09-11 2026-09-11 PlS Planned sale

President and CEO

Executive Director
1,202 -0.6%
542.60
US$652,209
1,202 -0.6% 542.60 US$652,209
2026-09-11 2026-09-11 PlS Planned sale

President and CEO

Executive Director
368 -0.2%
541.64
US$199,324
368 -0.2% 541.64 US$199,324
2026-09-11 2026-09-11 PlS Planned sale

President and CEO

Executive Director
687 -0.3%
540.59
US$371,382
687 -0.3% 540.59 US$371,382
2026-09-11 2026-09-11 PlS Planned sale

President and CEO

Executive Director
160 -0.1%
537.62
US$86,019
160 -0.1% 537.62 US$86,019
2026-09-11 2026-09-11 PlS Planned sale

President and CEO

Executive Director
218 -0.1%
535.94
US$116,836
218 -0.1% 535.94 US$116,836
2026-09-11 2026-09-11 PlS Planned sale

President and CEO

Executive Director
106 -0.1%
534.06
US$56,611
106 -0.1% 534.06 US$56,611
2026-09-11 2026-09-11 PlS Planned sale

President and CEO

Executive Director
60 -0.0%
533.09
US$31,985
60 -0.0% 533.09 US$31,985
2026-09-11 2026-09-11 PrS Proposed sale

Director; Officer

Executive Director
5,221
533.12
US$2,783,420
5,221 533.12 US$2,783,420
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
160 -0.1%
542.55
US$86,808
160 -0.1% 542.55 US$86,808
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
362 -0.2%
541.65
US$196,079
362 -0.2% 541.65 US$196,079
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
505 -0.2%
540.19
US$272,796
505 -0.2% 540.19 US$272,796
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
215 -0.1%
539.03
US$115,891
215 -0.1% 539.03 US$115,891
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
520 -0.3%
538.30
US$279,914
520 -0.3% 538.30 US$279,914
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
640 -0.3%
537.17
US$343,791
640 -0.3% 537.17 US$343,791
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
1,040 -0.5%
536.11
US$557,557
1,040 -0.5% 536.11 US$557,557
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
644 -0.3%
535.27
US$344,715
644 -0.3% 535.27 US$344,715
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
396 -0.2%
534.20
US$211,542
396 -0.2% 534.20 US$211,542
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
512 -0.2%
533.09
US$272,944
512 -0.2% 533.09 US$272,944
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
368 -0.2%
531.99
US$195,772
368 -0.2% 531.99 US$195,772
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
522 -0.2%
530.23
US$276,781
522 -0.2% 530.23 US$276,781
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
347 -0.2%
529.27
US$183,656
347 -0.2% 529.27 US$183,656
2026-09-11 2026-09-09 S Sale

President and CEO

Executive Director
131 -0.1%
527.88
US$69,152
131 -0.1% 527.88 US$69,152
2026-09-09 2026-09-09 PrS Proposed sale

Officer and Director

Executive Director
6,362
534.16
US$3,398,326
6,362 534.16 US$3,398,326
2026-08-20 2026-08-17 S Sale

General Counsel

Officer
664 -5.5%
514.97
US$341,940
664 -5.5% 514.97 US$341,940
2026-08-20 2026-08-17 PrS Proposed sale

Officer

Officer
664
507.56
US$337,020
664 507.56 US$337,020
2026-07-20 2026-07-20 S Sale

President and CEO

Executive Director
280 -0.1%
555.05
US$155,414
280 -0.1% 555.05 US$155,414
2026-07-20 2026-07-20 S Sale

President and CEO

Executive Director
1 -0.0%
550.72
US$551
1 -0.0% 550.72 US$551
2026-07-20 2026-07-20 S Sale

President and CEO

Executive Director
153 -0.1%
550.01
US$84,152
153 -0.1% 550.01 US$84,152
2026-07-20 2026-07-20 S Sale

President and CEO

Executive Director
47 -0.0%
548.87
US$25,797
47 -0.0% 548.87 US$25,797
2026-07-20 2026-07-20 S Sale

President and CEO

Executive Director
680 -0.3%
547.70
US$372,435
680 -0.3% 547.70 US$372,435
2026-07-20 2026-07-20 S Sale

President and CEO

Executive Director
269 -0.1%
547.08
US$147,164
269 -0.1% 547.08 US$147,164
2026-07-20 2026-07-20 S Sale

President and CEO

Executive Director
275 -0.1%
545.71
US$150,070
275 -0.1% 545.71 US$150,070
2026-07-20 2026-07-20 S Sale

President and CEO

Executive Director
545 -0.3%
544.71
US$296,869
545 -0.3% 544.71 US$296,869
2026-07-20 2026-07-20 S Sale

President and CEO

Executive Director
110 -0.1%
543.79
US$59,817
110 -0.1% 543.79 US$59,817
2026-07-20 2026-07-20 S Sale

President and CEO

Executive Director
140 -0.1%
542.75
US$75,984
140 -0.1% 542.75 US$75,984
2026-07-20 2026-07-20 PrS Proposed sale

Officer and Director

Executive Director
2,500
553.48
US$1,383,700
2,500 553.48 US$1,383,700
2026-06-01 2026-06-01 PlS Planned sale

Chief Medical Officer

Officer
1,042 -9.4%
495.74
US$516,561
1,042 -9.4% 495.74 US$516,561
2026-06-01 2026-06-01 PrS Proposed sale

Officer

Officer
1,042
497.27
US$518,155
1,042 497.27 US$518,155
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
80 -0.4%
519.98
US$41,598
80 -0.4% 519.98 US$41,598
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
782 -3.4%
518.76
US$405,669
782 -3.4% 518.76 US$405,669
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
1,497 -6.1%
517.59
US$774,835
1,497 -6.1% 517.59 US$774,835
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
723 -2.9%
516.87
US$373,694
723 -2.9% 516.87 US$373,694
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
657 -2.6%
515.92
US$338,961
657 -2.6% 515.92 US$338,961
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
343 -1.3%
514.67
US$176,532
343 -1.3% 514.67 US$176,532
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
40 -0.2%
512.97
US$20,519
40 -0.2% 512.97 US$20,519
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
439 -1.7%
512.50
US$224,988
439 -1.7% 512.50 US$224,988
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
610 -2.2%
511.40
US$311,952
610 -2.2% 511.40 US$311,952
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
151 -0.6%
510.36
US$77,064
151 -0.6% 510.36 US$77,064
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
320 -1.2%
508.24
US$162,637
320 -1.2% 508.24 US$162,637
2026-05-22 2026-05-22 PlS Planned sale Non-Executive Director
40 -0.1%
506.68
US$20,267
40 -0.1% 506.68 US$20,267
2026-05-22 2026-05-22 PrS Proposed sale

Director

Non-Executive Director
5,682
513.59
US$2,918,218
5,682 513.59 US$2,918,218
2026-05-18 2026-05-18 PrS Proposed sale

Officer

Officer
844
523.69
US$441,994
844 523.69 US$441,994
2026-05-18 2026-05-18 S Sale

Chief Medical Officer

Officer
844 -7.1%
515.90
US$435,420
844 -7.1% 515.90 US$435,420
2026-03-06 2026-03-06 PlS Planned sale

EVP and CFO

Officer
40 -0.3%
437.65
US$17,506
40 -0.3% 437.65 US$17,506
2026-03-06 2026-03-06 PlS Planned sale

EVP and CFO

Officer
80 -0.6%
436.69
US$34,935
80 -0.6% 436.69 US$34,935
2026-03-06 2026-03-06 PlS Planned sale

EVP and CFO

Officer
80 -0.6%
435.32
US$34,825
80 -0.6% 435.32 US$34,825
2026-03-06 2026-03-06 PlS Planned sale

EVP and CFO

Officer
160 -1.2%
434.20
US$69,472
160 -1.2% 434.20 US$69,472
2026-03-06 2026-03-06 PlS Planned sale

EVP and CFO

Officer
116 -0.9%
432.56
US$50,176
116 -0.9% 432.56 US$50,176
2026-03-06 2026-03-06 PlS Planned sale

EVP and CFO

Officer
120 -0.9%
430.90
US$51,708
120 -0.9% 430.90 US$51,708
2026-03-06 2026-03-06 PlS Planned sale

EVP and CFO

Officer
40 -0.3%
429.58
US$17,183
40 -0.3% 429.58 US$17,183
2026-03-06 2026-03-06 PlS Planned sale

EVP and CFO

Officer
160 -1.2%
429.00
US$68,639
160 -1.2% 429.00 US$68,639
2026-03-06 2026-03-06 PlS Planned sale

EVP and CFO

Officer
80 -0.6%
427.85
US$34,228
80 -0.6% 427.85 US$34,228
2026-03-06 2026-03-06 PlS Planned sale

EVP and CFO

Officer
420 -3.0%
426.86
US$179,283
420 -3.0% 426.86 US$179,283
2026-03-06 2026-03-06 PlS Planned sale

EVP and CFO

Officer
40 -0.3%
425.08
US$17,003
40 -0.3% 425.08 US$17,003
2026-03-06 2026-03-06 S Sale

EVP and CFO

Officer
646 -4.5%
431.94
US$279,033
646 -4.5% 431.94 US$279,033
2026-03-06 2026-03-06 PrS Proposed sale

Officer

Officer
646
439.34
US$283,814
646 439.34 US$283,814
2026-03-06 2026-03-06 S Sale

President and CEO

Executive Director
1,663 -1.0%
431.94
US$718,316
1,663 -1.0% 431.94 US$718,316
2026-03-06 2026-03-06 PrS Proposed sale

Officer and Director

Executive Director
1,663
439.34
US$730,622
1,663 439.34 US$730,622
2026-03-06 2026-03-06 S Sale

General Counsel

Officer
360 -2.9%
431.94
US$155,498
360 -2.9% 431.94 US$155,498
2026-03-06 2026-03-06 PrS Proposed sale

Officer

Officer
360
439.34
US$158,162
360 439.34 US$158,162
2026-03-06 2026-03-06 S Sale

Chief Commercial Officer

Officer
419 -3.2%
431.94
US$180,983
419 -3.2% 431.94 US$180,983