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United States Biotechnology & Medical Research

Lyra Therapeutics Inc (LYRA)

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The most recent insider trading activity occurred on January 27, 2026, with a proposed sale of shares by Maria Palasis. Prior to this, on January 6, 2026, Maria Palasis and Jason Cavalier engaged in planned and proposed sales. Significant selling activity was also noted from PERCEPTIVE ADVISORS LLC in November 2025.
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Ticker: LYRA Exchange: NMS
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
Palasis Maria
Officer; Director
1 sale — total 3,248 USD
Proposed sale 27 Jan 2026
Value US$3,504,813.87 | Price 161.90 | Shares 64,805
Planned sale 6 Jan 2026
Value US$29,831.36 | Price 66.17 | Shares 13,753
Proposed sale 6 Jan 2026
Value US$3,028,912.64 | Price 499.93 | Shares 72,713
Planned sale 6 Jan 2026
Value US$2,586.92 | Price 3.36 | Shares 769
Sale 13 Nov 2025
Value US$12,531.02 | Price 3.90 | Shares 3,213
Sale 13 Nov 2025
Value US$111,531.16 | Price 3.90 | Shares 28,597
Sale 12 Nov 2025
Value US$3,584.45 | Price 4.06 | Shares 883
Sale 12 Nov 2025
Value US$31,915.00 | Price 4.06 | Shares 7,862
Sale 11 Nov 2025
Value US$2,316.94 | Price 4.31 | Shares 537
Sale 11 Nov 2025
Value US$20,636.73 | Price 4.31 | Shares 4,783
Sale 10 Nov 2025
Value US$8,484.89 | Price 4.54 | Shares 1,869
Sale 10 Nov 2025
Value US$75,510.49 | Price 4.54 | Shares 16,633
Sale 7 Nov 2025
Value US$9,460.17 | Price 4.75 | Shares 1,993
Sale 7 Nov 2025
Value US$84,234.94 | Price 4.75 | Shares 17,746
Sale 6 Nov 2025
Value US$16,819.14 | Price 5.18 | Shares 3,247
Sale 6 Nov 2025
Value US$149,709.47 | Price 5.18 | Shares 28,902
Proposed sale 14 Oct 2025
Value US$3,881.06 | Price 7.23 | Shares 537
Planned sale 10 Jul 2025
Value US$13,944.15 | Price 8.91 | Shares 1,565
Proposed sale 10 Jul 2025
Value US$13,944.93 | Price 8.91 | Shares 1,565
Planned sale 10 Jul 2025
Value US$6,094.44 | Price 8.91 | Shares 684
Proposed sale 25 Apr 2025
Value US$14,929.50 | Price 0.10 | Shares 145,370
Proposed sale 9 Apr 2025
Value US$3,545.20 | Price 0.09 | Shares 39,567
Buy 10 Nov 2023
Value US$74,095.00 | Price 2.96 | Shares 25,000
Buy 31 May 2023
Value US$2,924,777.16 | Price 2.43 | Shares 1,203,612
Buy 31 May 2023
Value US$481,008.78 | Price 2.43 | Shares 197,946
Buy 31 May 2023
Value US$981,374.94 | Price 2.43 | Shares 403,858
Buy 31 May 2023
Value US$2,924,777.16 | Price 2.43 | Shares 1,203,612
Buy 31 May 2023
Value US$481,008.78 | Price 2.43 | Shares 197,946
Buy 31 May 2023
Value US$981,374.94 | Price 2.43 | Shares 403,858
Buy 31 May 2023
Value US$8,999,998.76 | Price 2.49 | Shares 3,610,832
Buy 10 Jun 2022
Value US$20,200.00 | Price 5.05 | Shares 4,000
Buy 16 May 2022
Value US$1,640.00 | Price 5.00 | Shares 328
Buy 13 May 2022
Value US$16,845.50 | Price 4.81 | Shares 3,500
Buy 12 Apr 2022
Value US$499,998.26 | Price 4.22 | Shares 118,483
Buy 12 Apr 2022
Value US$3,228,342.20 | Price 4.22 | Shares 765,010
Buy 12 Apr 2022
Value US$2,227,341.32 | Price 4.22 | Shares 527,806
Buy 12 Apr 2022
Value US$4,544,311.22 | Price 4.22 | Shares 1,076,851
Buy 12 Apr 2022
Value US$24,999,997.40 | Price 4.22 | Shares 5,924,170
Buy 12 Apr 2022
Value US$3,228,342.20 | Price 4.22 | Shares 765,010
Buy 12 Apr 2022
Value US$2,227,341.32 | Price 4.22 | Shares 527,806
Buy 12 Apr 2022
Value US$4,544,311.22 | Price 4.22 | Shares 1,076,851
Buy 12 Apr 2022
Value US$999,996.52 | Price 4.22 | Shares 236,966
Buy 17 Jun 2021
Value US$31,394.65 | Price 8.97 | Shares 3,500
Buy 16 Dec 2020
Value US$9,963.00 | Price 9.72 | Shares 1,025
Buy 5 May 2020
Value US$10,000,000.00 | Price 16.00 | Shares 625,000
Buy 5 May 2020
Value US$2,480,000.00 | Price 16.00 | Shares 155,000
Sale 5 May 2020
Value US$270,544.00 | Price 16.00 | Shares 16,909
Buy 5 May 2020
Value US$6,608.00 | Price 16.00 | Shares 413
Buy 5 May 2020
Value US$9,648.00 | Price 16.00 | Shares 603
Buy 5 May 2020
Value US$18,816.00 | Price 16.00 | Shares 1,176
Buy 5 May 2020
Value US$964,928.00 | Price 16.00 | Shares 60,308
Sale 5 May 2020
Value US$1,024.00 | Price 16.00 | Shares 64
Sale 5 May 2020
Value US$1,504.00 | Price 16.00 | Shares 94
Sale 5 May 2020
Value US$2,912.00 | Price 16.00 | Shares 182
Sale 5 May 2020
Value US$149,344.00 | Price 16.00 | Shares 9,334
Buy 5 May 2020
Value US$1,200,000.00 | Price 16.00 | Shares 75,000
Buy 5 May 2020
Value US$920,976.00 | Price 16.00 | Shares 57,561
Buy 5 May 2020
Value US$1,879,024.00 | Price 16.00 | Shares 117,439
Sale 5 May 2020
Value US$116,080.00 | Price 16.00 | Shares 7,255
Sale 5 May 2020
Value US$89,088.00 | Price 16.00 | Shares 5,568
Sale 5 May 2020
Value US$181,760.00 | Price 16.00 | Shares 11,360
Buy 5 May 2020
Value US$1,200,000.00 | Price 16.00 | Shares 75,000
Buy 5 May 2020
Value US$920,976.00 | Price 16.00 | Shares 57,561
Buy 5 May 2020
Value US$1,879,024.00 | Price 16.00 | Shares 117,439
Sale 5 May 2020
Value US$116,080.00 | Price 16.00 | Shares 7,255
Sale 5 May 2020
Value US$89,088.00 | Price 16.00 | Shares 5,568
Sale 5 May 2020
Value US$181,760.00 | Price 16.00 | Shares 11,360
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-01-27 2026-01-27 PrS Proposed sale
Palasis Maria

Officer; Director

Executive Director
64,805
161.90
US$3,504,814 		64,805 161.90 US$3,504,814
2026-01-08 2026-01-06 PlS Planned sale
Palasis Maria

President & CEO

Executive Director
13,753 -5.1%
66.17
US$29,831 		13,753 -5.1% 66.17 US$29,831
2026-01-08 2026-01-06 PlS Planned sale
Cavalier Jason

Chief Financial Officer

Officer
57,659 -35.9%
469.47
US$4,754,584 		57,659 -35.9% 469.47 US$4,754,584
2026-01-06 2026-01-06 PrS Proposed sale
Palasis Maria

Officer; Director

Executive Director
1,702
3.36
US$5,725 		1,702 3.36 US$5,725
2025-11-13 2025-11-13 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
3,213 -18.6%
3.90
US$12,531 		3,213 -18.6% 3.90 US$12,531
2025-11-13 2025-11-13 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
28,597 -18.6%
3.90
US$111,531 		28,597 -18.6% 3.90 US$111,531
2025-11-13 2025-11-12 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
883 -4.9%
4.06
US$3,584 		883 -4.9% 4.06 US$3,584
2025-11-13 2025-11-12 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
7,862 -4.9%
4.06
US$31,915 		7,862 -4.9% 4.06 US$31,915
2025-11-13 2025-11-11 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
537 -2.9%
4.31
US$2,317 		537 -2.9% 4.31 US$2,317
2025-11-13 2025-11-11 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
4,783 -2.9%
4.31
US$20,637 		4,783 -2.9% 4.31 US$20,637
2025-11-10 2025-11-10 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
1,869 -9.1%
4.54
US$8,485 		1,869 -9.1% 4.54 US$8,485
2025-11-10 2025-11-10 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
16,633 -9.1%
4.54
US$75,510 		16,633 -9.1% 4.54 US$75,510
2025-11-10 2025-11-07 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
1,993 -8.8%
4.75
US$9,460 		1,993 -8.8% 4.75 US$9,460
2025-11-10 2025-11-07 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
17,746 -8.9%
4.75
US$84,235 		17,746 -8.9% 4.75 US$84,235
2025-11-10 2025-11-06 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
3,247 -12.6%
5.18
US$16,819 		3,247 -12.6% 5.18 US$16,819
2025-11-10 2025-11-06 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
28,902 -12.6%
5.18
US$149,709 		28,902 -12.6% 5.18 US$149,709
2025-10-14 2025-10-14 PrS Proposed sale
Palasis Maria

Officer; Director

Executive Director
537
7.23
US$3,881 		537 7.23 US$3,881
2025-07-14 2025-07-10 PlS Planned sale
Palasis Maria

President & CEO

Executive Director
1,565 -0.1%
8.91
US$13,944 		1,565 -0.1% 8.91 US$13,944
2025-07-14 2025-07-10 PlS Planned sale
Cavalier Jason

Chief Financial Officer

Officer
684 -0.1%
8.91
US$6,094 		684 -0.1% 8.91 US$6,094
2025-07-10 2025-07-10 PrS Proposed sale
Palasis Maria

Officer; Director

Executive Director
1,565
8.91
US$13,945 		1,565 8.91 US$13,945
2025-04-25 2025-04-25 PrS Proposed sale
3.3
Waksal Harlan

Officer; Director

Executive Director
145,370
0.10
US$14,930 		145,370 0.10 US$14,930
2025-04-09 2025-04-09 PrS Proposed sale
Palasis Maria

Officer; Director

Executive Director
39,567
0.09
US$3,545 		39,567 0.09 US$3,545
2023-11-13 2023-11-10 B Purchase
3.3
Waksal Harlan

Executive Chair

Executive Director
25,000 +10.6%
2.96
US$74,095 		25,000 +10.6% 2.96 US$74,095
2023-06-02 2023-05-31 B Purchase
3.2
NBVM GP, LLC
Large shareholder
1,203,612 +91.3%
2.43
US$2,924,777 		1,203,612 +91.3% 2.43 US$2,924,777
2023-06-02 2023-05-31 B Purchase
3.2
NBVM GP, LLC
Large shareholder
197,946 +21.8%
2.43
US$481,009 		197,946 +21.8% 2.43 US$481,009
2023-06-02 2023-05-31 B Purchase
3.2
NBVM GP, LLC
Large shareholder
403,858 +21.8%
2.43
US$981,375 		403,858 +21.8% 2.43 US$981,375
2023-06-02 2023-05-31 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
1,203,612 +91.3%
2.43
US$2,924,777 		1,203,612 +91.3% 2.43 US$2,924,777
2023-06-02 2023-05-31 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
197,946 +21.8%
2.43
US$481,009 		197,946 +21.8% 2.43 US$481,009
2023-06-02 2023-05-31 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
403,858 +21.8%
2.43
US$981,375 		403,858 +21.8% 2.43 US$981,375
2023-06-02 2023-05-31 B Purchase
2.7
PERCEPTIVE ADVISORS LLC
Non-Executive Director Large shareholder
3,610,832 +45.9%
2.49
US$8,999,999 		3,610,832 +45.9% 2.49 US$8,999,999
2022-06-13 2022-06-10 B Purchase
2.6
MERRIFIELD C ANN
Non-Executive Director
4,000 +54.6%
5.05
US$20,200 		4,000 +54.6% 5.05 US$20,200
2022-05-17 2022-05-16 B Purchase
2.6
MERRIFIELD C ANN
Non-Executive Director
328 +4.7%
5.00
US$1,640 		328 +4.7% 5.00 US$1,640
2022-05-17 2022-05-13 B Purchase
2.6
MERRIFIELD C ANN
Non-Executive Director
3,500 +100.0%
4.81
US$16,846 		3,500 +100.0% 4.81 US$16,846
2022-04-14 2022-04-12 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
118,483 +inf%
4.22
US$499,998 		118,483 +inf% 4.22 US$499,998
2022-04-14 2022-04-12 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
765,010 +138.3%
4.22
US$3,228,342 		765,010 +138.3% 4.22 US$3,228,342
2022-04-14 2022-04-12 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
527,806 +138.3%
4.22
US$2,227,341 		527,806 +138.3% 4.22 US$2,227,341
2022-04-14 2022-04-12 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
1,076,851 +138.3%
4.22
US$4,544,311 		1,076,851 +138.3% 4.22 US$4,544,311
2022-04-14 2022-04-12 B Purchase
2.7
PERCEPTIVE ADVISORS LLC
Non-Executive Director Large shareholder
5,924,170 +306.3%
4.22
US$24,999,997 		5,924,170 +306.3% 4.22 US$24,999,997
2022-04-14 2022-04-12 B Purchase
3.2
NBVM GP, LLC
Large shareholder
765,010 +138.3%
4.22
US$3,228,342 		765,010 +138.3% 4.22 US$3,228,342
2022-04-14 2022-04-12 B Purchase
3.2
NBVM GP, LLC
Large shareholder
527,806 +138.3%
4.22
US$2,227,341 		527,806 +138.3% 4.22 US$2,227,341
2022-04-14 2022-04-12 B Purchase
3.2
NBVM GP, LLC
Large shareholder
1,076,851 +138.3%
4.22
US$4,544,311 		1,076,851 +138.3% 4.22 US$4,544,311
2022-04-13 2022-04-12 B Purchase
3.3
Waksal Harlan

Executive Chair

Executive Director
236,966 +inf%
4.22
US$999,997 		236,966 +inf% 4.22 US$999,997
2021-06-22 2021-06-17 B Purchase
2.6
MERRIFIELD C ANN
Non-Executive Director
3,500 +inf%
8.97
US$31,395 		3,500 +inf% 8.97 US$31,395
2020-12-17 2020-12-16 B Purchase
2.5
snyderman nancy lynn MD
Non-Executive Director
1,025 +inf%
9.72
US$9,963 		1,025 +inf% 9.72 US$9,963
2020-05-29 2020-05-05 B Purchase
2.7
PERCEPTIVE ADVISORS LLC
Non-Executive Director Large shareholder
625,000 +47.7%
16.00
US$10,000,000 		625,000 +47.7% 16.00 US$10,000,000
2020-05-15 2020-05-05 B Purchase
1.2
Soleus Private Equity GP I, LLC
Large shareholder
155,000 +inf%
16.00
US$2,480,000 		155,000 +inf% 16.00 US$2,480,000
2020-05-15 2020-05-05 S Sale
1.2
Soleus Private Equity GP I, LLC
Large shareholder
16,909 -3.6%
16.00
US$270,544 		16,909 -3.6% 16.00 US$270,544
2020-05-06 2020-05-05 B Purchase
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
413 +6.0%
16.00
US$6,608 		413 +6.0% 16.00 US$6,608
2020-05-06 2020-05-05 B Purchase
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
603 +6.0%
16.00
US$9,648 		603 +6.0% 16.00 US$9,648
2020-05-06 2020-05-05 B Purchase
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
1,176 +6.0%
16.00
US$18,816 		1,176 +6.0% 16.00 US$18,816
2020-05-06 2020-05-05 B Purchase
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
60,308 +6.0%
16.00
US$964,928 		60,308 +6.0% 16.00 US$964,928
2020-05-06 2020-05-05 S Sale
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
64 -0.9%
16.00
US$1,024 		64 -0.9% 16.00 US$1,024
2020-05-06 2020-05-05 S Sale
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
94 -0.9%
16.00
US$1,504 		94 -0.9% 16.00 US$1,504
2020-05-06 2020-05-05 S Sale
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
182 -0.9%
16.00
US$2,912 		182 -0.9% 16.00 US$2,912
2020-05-06 2020-05-05 S Sale
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
9,334 -0.9%
16.00
US$149,344 		9,334 -0.9% 16.00 US$149,344
2020-05-06 2020-05-05 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
75,000 +15.7%
16.00
US$1,200,000 		75,000 +15.7% 16.00 US$1,200,000
2020-05-06 2020-05-05 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
57,561 +17.8%
16.00
US$920,976 		57,561 +17.8% 16.00 US$920,976
2020-05-06 2020-05-05 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
117,439 +17.8%
16.00
US$1,879,024 		117,439 +17.8% 16.00 US$1,879,024
2020-05-06 2020-05-05 S Sale
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
7,255 -1.5%
16.00
US$116,080 		7,255 -1.5% 16.00 US$116,080
2020-05-06 2020-05-05 S Sale
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
5,568 -1.7%
16.00
US$89,088 		5,568 -1.7% 16.00 US$89,088
2020-05-06 2020-05-05 S Sale
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
11,360 -1.7%
16.00
US$181,760 		11,360 -1.7% 16.00 US$181,760
2020-05-06 2020-05-05 B Purchase
3.2
NBVM GP, LLC
Large shareholder
75,000 +15.7%
16.00
US$1,200,000 		75,000 +15.7% 16.00 US$1,200,000
2020-05-06 2020-05-05 B Purchase
3.2
NBVM GP, LLC
Large shareholder
57,561 +17.8%
16.00
US$920,976 		57,561 +17.8% 16.00 US$920,976
2020-05-06 2020-05-05 B Purchase
3.2
NBVM GP, LLC
Large shareholder
117,439 +17.8%
16.00
US$1,879,024 		117,439 +17.8% 16.00 US$1,879,024
2020-05-06 2020-05-05 S Sale
3.2
NBVM GP, LLC
Large shareholder
7,255 -1.5%
16.00
US$116,080 		7,255 -1.5% 16.00 US$116,080
2020-05-06 2020-05-05 S Sale
3.2
NBVM GP, LLC
Large shareholder
5,568 -1.7%
16.00
US$89,088 		5,568 -1.7% 16.00 US$89,088
2020-05-06 2020-05-05 S Sale
3.2
NBVM GP, LLC
Large shareholder
11,360 -1.7%
16.00
US$181,760 		11,360 -1.7% 16.00 US$181,760
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