United States Biotechnology & Medical Research

Lyra Therapeutics Inc (LYRA)

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Ticker: LYRA Exchange: NMS
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Palasis Maria Officer; Director Executive Director
Transaction date
Proposed sale
Price
161.90
Quantity 64,805
Value US$3,504,814
Palasis Maria President & CEO Executive Director
Transaction date
Planned sale
Price
66.17
Quantity 13,753 -5.1%
Value US$29,831
Cavalier Jason Chief Financial Officer Officer
Transaction date
Planned sale
Price
469.47
Quantity 57,659 -35.9%
Value US$4,754,584
Palasis Maria Officer; Director Executive Director
Transaction date
Proposed sale
Price
3.36
Quantity 1,702
Value US$5,725
2.7
PERCEPTIVE ADVISORS LLC Large shareholder
Transaction date
Sale
Price
3.90
Quantity 28,597 -18.6%
Value US$111,531
Palasis Maria Officer; Director Executive Director
Transaction date
Proposed sale
Price
7.23
Quantity 537
Value US$3,881
Palasis Maria President & CEO Executive Director
Transaction date
Planned sale
Price
8.91
Quantity 1,565 -0.1%
Value US$13,944
Cavalier Jason Chief Financial Officer Officer
Transaction date
Planned sale
Price
8.91
Quantity 684 -0.1%
Value US$6,094
Palasis Maria Officer; Director Executive Director
Transaction date
Proposed sale
Price
8.91
Quantity 1,565
Value US$13,945
3.3
Waksal Harlan Officer; Director Executive Director
Transaction date
Proposed sale
Price
0.10
Quantity 145,370
Value US$14,930
Palasis Maria Officer; Director Executive Director
Transaction date
Proposed sale
Price
0.09
Quantity 39,567
Value US$3,545
3.3
Waksal Harlan Executive Chair Executive Director
Transaction date
Purchase
Price
2.96
Quantity 25,000 +10.6%
Value US$74,095
3.2
NBVM GP, LLC Large shareholder
Transaction date
Purchase
Price
2.43
Quantity 1,203,612 +91.3%
Value US$2,924,777
3.2
NBVM GP, LLC Large shareholder
Transaction date
Purchase
Price
2.43
Quantity 197,946 +21.8%
Value US$481,009
3.2
NBVM GP, LLC Large shareholder
Transaction date
Purchase
Price
2.43
Quantity 403,858 +21.8%
Value US$981,375
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Purchase
Price
2.43
Quantity 1,203,612 +91.3%
Value US$2,924,777
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Purchase
Price
2.43
Quantity 197,946 +21.8%
Value US$481,009
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Purchase
Price
2.43
Quantity 403,858 +21.8%
Value US$981,375
2.7
PERCEPTIVE ADVISORS LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
2.49
Quantity 3,610,832 +45.9%
Value US$8,999,999
2.6
MERRIFIELD C ANN Non-Executive Director
Transaction date
Purchase
Price
5.05
Quantity 4,000 +54.6%
Value US$20,200
2.6
MERRIFIELD C ANN Non-Executive Director
Transaction date
Purchase
Price
5.00
Quantity 328 +4.7%
Value US$1,640
2.6
MERRIFIELD C ANN Non-Executive Director
Transaction date
Purchase
Price
4.81
Quantity 3,500 +100.0%
Value US$16,846
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Purchase
Price
4.22
Quantity 118,483 +inf%
Value US$499,998
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Purchase
Price
4.22
Quantity 765,010 +138.3%
Value US$3,228,342
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Purchase
Price
4.22
Quantity 527,806 +138.3%
Value US$2,227,341
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Purchase
Price
4.22
Quantity 1,076,851 +138.3%
Value US$4,544,311
2.7
PERCEPTIVE ADVISORS LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
4.22
Quantity 5,924,170 +306.3%
Value US$24,999,997
3.2
NBVM GP, LLC Large shareholder
Transaction date
Purchase
Price
4.22
Quantity 765,010 +138.3%
Value US$3,228,342
3.2
NBVM GP, LLC Large shareholder
Transaction date
Purchase
Price
4.22
Quantity 527,806 +138.3%
Value US$2,227,341
3.2
NBVM GP, LLC Large shareholder
Transaction date
Purchase
Price
4.22
Quantity 1,076,851 +138.3%
Value US$4,544,311
3.3
Waksal Harlan Executive Chair Executive Director
Transaction date
Purchase
Price
4.22
Quantity 236,966 +inf%
Value US$999,997
2.6
MERRIFIELD C ANN Non-Executive Director
Transaction date
Purchase
Price
8.97
Quantity 3,500 +inf%
Value US$31,395
2.8
snyderman nancy lynn MD Non-Executive Director
Transaction date
Purchase
Price
9.72
Quantity 1,025 +inf%
Value US$9,963
2.7
PERCEPTIVE ADVISORS LLC Non-Executive Director Large shareholder
Transaction date
Purchase
Price
16.00
Quantity 625,000 +47.7%
Value US$10,000,000
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Purchase
Price
16.00
Quantity 75,000 +15.7%
Value US$1,200,000
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Purchase
Price
16.00
Quantity 57,561 +17.8%
Value US$920,976
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Purchase
Price
16.00
Quantity 117,439 +17.8%
Value US$1,879,024
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Sale
Price
16.00
Quantity 7,255 -1.5%
Value US$116,080
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Sale
Price
16.00
Quantity 5,568 -1.7%
Value US$89,088
3.4
ANDERSON EDWARD T Non-Executive Director Large shareholder
Transaction date
Sale
Price
16.00
Quantity 11,360 -1.7%
Value US$181,760
3.2
NBVM GP, LLC Large shareholder
Transaction date
Purchase
Price
16.00
Quantity 75,000 +15.7%
Value US$1,200,000
3.2
NBVM GP, LLC Large shareholder
Transaction date
Purchase
Price
16.00
Quantity 57,561 +17.8%
Value US$920,976
3.2
NBVM GP, LLC Large shareholder
Transaction date
Purchase
Price
16.00
Quantity 117,439 +17.8%
Value US$1,879,024
3.2
NBVM GP, LLC Large shareholder
Transaction date
Sale
Price
16.00
Quantity 7,255 -1.5%
Value US$116,080
3.2
NBVM GP, LLC Large shareholder
Transaction date
Sale
Price
16.00
Quantity 5,568 -1.7%
Value US$89,088
3.2
NBVM GP, LLC Large shareholder
Transaction date
Sale
Price
16.00
Quantity 11,360 -1.7%
Value US$181,760
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-01-27 2026-01-27 PrS Proposed sale
Palasis Maria

Officer; Director

Executive Director
64,805
161.90
US$3,504,814 		64,805 161.90 US$3,504,814
2026-01-08 2026-01-06 PlS Planned sale
Palasis Maria

President & CEO

Executive Director
13,753 -5.1%
66.17
US$29,831 		13,753 -5.1% 66.17 US$29,831
2026-01-08 2026-01-06 PlS Planned sale
Cavalier Jason

Chief Financial Officer

Officer
57,659 -35.9%
469.47
US$4,754,584 		57,659 -35.9% 469.47 US$4,754,584
2026-01-06 2026-01-06 PrS Proposed sale
Palasis Maria

Officer; Director

Executive Director
1,702
3.36
US$5,725 		1,702 3.36 US$5,725
2025-11-13 2025-11-13 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
3,213 -18.6%
3.90
US$12,531 		3,213 -18.6% 3.90 US$12,531
2025-11-13 2025-11-13 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
28,597 -18.6%
3.90
US$111,531 		28,597 -18.6% 3.90 US$111,531
2025-11-13 2025-11-12 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
883 -4.9%
4.06
US$3,584 		883 -4.9% 4.06 US$3,584
2025-11-13 2025-11-12 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
7,862 -4.9%
4.06
US$31,915 		7,862 -4.9% 4.06 US$31,915
2025-11-13 2025-11-11 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
537 -2.9%
4.31
US$2,317 		537 -2.9% 4.31 US$2,317
2025-11-13 2025-11-11 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
4,783 -2.9%
4.31
US$20,637 		4,783 -2.9% 4.31 US$20,637
2025-11-10 2025-11-10 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
1,869 -9.1%
4.54
US$8,485 		1,869 -9.1% 4.54 US$8,485
2025-11-10 2025-11-10 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
16,633 -9.1%
4.54
US$75,510 		16,633 -9.1% 4.54 US$75,510
2025-11-10 2025-11-07 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
1,993 -8.8%
4.75
US$9,460 		1,993 -8.8% 4.75 US$9,460
2025-11-10 2025-11-07 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
17,746 -8.9%
4.75
US$84,235 		17,746 -8.9% 4.75 US$84,235
2025-11-10 2025-11-06 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
3,247 -12.6%
5.18
US$16,819 		3,247 -12.6% 5.18 US$16,819
2025-11-10 2025-11-06 S Sale
2.7
PERCEPTIVE ADVISORS LLC
Large shareholder
28,902 -12.6%
5.18
US$149,709 		28,902 -12.6% 5.18 US$149,709
2025-10-14 2025-10-14 PrS Proposed sale
Palasis Maria

Officer; Director

Executive Director
537
7.23
US$3,881 		537 7.23 US$3,881
2025-07-14 2025-07-10 PlS Planned sale
Palasis Maria

President & CEO

Executive Director
1,565 -0.1%
8.91
US$13,944 		1,565 -0.1% 8.91 US$13,944
2025-07-14 2025-07-10 PlS Planned sale
Cavalier Jason

Chief Financial Officer

Officer
684 -0.1%
8.91
US$6,094 		684 -0.1% 8.91 US$6,094
2025-07-10 2025-07-10 PrS Proposed sale
Palasis Maria

Officer; Director

Executive Director
1,565
8.91
US$13,945 		1,565 8.91 US$13,945
2025-04-25 2025-04-25 PrS Proposed sale
3.3
Waksal Harlan

Officer; Director

Executive Director
145,370
0.10
US$14,930 		145,370 0.10 US$14,930
2025-04-09 2025-04-09 PrS Proposed sale
Palasis Maria

Officer; Director

Executive Director
39,567
0.09
US$3,545 		39,567 0.09 US$3,545
2023-11-13 2023-11-10 B Purchase
3.3
Waksal Harlan

Executive Chair

Executive Director
25,000 +10.6%
2.96
US$74,095 		25,000 +10.6% 2.96 US$74,095
2023-06-02 2023-05-31 B Purchase
3.2
NBVM GP, LLC
Large shareholder
1,203,612 +91.3%
2.43
US$2,924,777 		1,203,612 +91.3% 2.43 US$2,924,777
2023-06-02 2023-05-31 B Purchase
3.2
NBVM GP, LLC
Large shareholder
197,946 +21.8%
2.43
US$481,009 		197,946 +21.8% 2.43 US$481,009
2023-06-02 2023-05-31 B Purchase
3.2
NBVM GP, LLC
Large shareholder
403,858 +21.8%
2.43
US$981,375 		403,858 +21.8% 2.43 US$981,375
2023-06-02 2023-05-31 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
1,203,612 +91.3%
2.43
US$2,924,777 		1,203,612 +91.3% 2.43 US$2,924,777
2023-06-02 2023-05-31 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
197,946 +21.8%
2.43
US$481,009 		197,946 +21.8% 2.43 US$481,009
2023-06-02 2023-05-31 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
403,858 +21.8%
2.43
US$981,375 		403,858 +21.8% 2.43 US$981,375
2023-06-02 2023-05-31 B Purchase
2.7
PERCEPTIVE ADVISORS LLC
Non-Executive Director Large shareholder
3,610,832 +45.9%
2.49
US$8,999,999 		3,610,832 +45.9% 2.49 US$8,999,999
2022-06-13 2022-06-10 B Purchase
2.6
MERRIFIELD C ANN
Non-Executive Director
4,000 +54.6%
5.05
US$20,200 		4,000 +54.6% 5.05 US$20,200
2022-05-17 2022-05-16 B Purchase
2.6
MERRIFIELD C ANN
Non-Executive Director
328 +4.7%
5.00
US$1,640 		328 +4.7% 5.00 US$1,640
2022-05-17 2022-05-13 B Purchase
2.6
MERRIFIELD C ANN
Non-Executive Director
3,500 +100.0%
4.81
US$16,846 		3,500 +100.0% 4.81 US$16,846
2022-04-14 2022-04-12 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
118,483 +inf%
4.22
US$499,998 		118,483 +inf% 4.22 US$499,998
2022-04-14 2022-04-12 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
765,010 +138.3%
4.22
US$3,228,342 		765,010 +138.3% 4.22 US$3,228,342
2022-04-14 2022-04-12 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
527,806 +138.3%
4.22
US$2,227,341 		527,806 +138.3% 4.22 US$2,227,341
2022-04-14 2022-04-12 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
1,076,851 +138.3%
4.22
US$4,544,311 		1,076,851 +138.3% 4.22 US$4,544,311
2022-04-14 2022-04-12 B Purchase
2.7
PERCEPTIVE ADVISORS LLC
Non-Executive Director Large shareholder
5,924,170 +306.3%
4.22
US$24,999,997 		5,924,170 +306.3% 4.22 US$24,999,997
2022-04-14 2022-04-12 B Purchase
3.2
NBVM GP, LLC
Large shareholder
765,010 +138.3%
4.22
US$3,228,342 		765,010 +138.3% 4.22 US$3,228,342
2022-04-14 2022-04-12 B Purchase
3.2
NBVM GP, LLC
Large shareholder
527,806 +138.3%
4.22
US$2,227,341 		527,806 +138.3% 4.22 US$2,227,341
2022-04-14 2022-04-12 B Purchase
3.2
NBVM GP, LLC
Large shareholder
1,076,851 +138.3%
4.22
US$4,544,311 		1,076,851 +138.3% 4.22 US$4,544,311
2022-04-13 2022-04-12 B Purchase
3.3
Waksal Harlan

Executive Chair

Executive Director
236,966 +inf%
4.22
US$999,997 		236,966 +inf% 4.22 US$999,997
2021-06-22 2021-06-17 B Purchase
2.6
MERRIFIELD C ANN
Non-Executive Director
3,500 +inf%
8.97
US$31,395 		3,500 +inf% 8.97 US$31,395
2020-12-17 2020-12-16 B Purchase
2.8
snyderman nancy lynn MD
Non-Executive Director
1,025 +inf%
9.72
US$9,963 		1,025 +inf% 9.72 US$9,963
2020-05-29 2020-05-05 B Purchase
2.7
PERCEPTIVE ADVISORS LLC
Non-Executive Director Large shareholder
625,000 +47.7%
16.00
US$10,000,000 		625,000 +47.7% 16.00 US$10,000,000
2020-05-15 2020-05-05 B Purchase
1.2
Soleus Private Equity GP I, LLC
Large shareholder
155,000 +inf%
16.00
US$2,480,000 		155,000 +inf% 16.00 US$2,480,000
2020-05-15 2020-05-05 S Sale
1.2
Soleus Private Equity GP I, LLC
Large shareholder
16,909 -3.6%
16.00
US$270,544 		16,909 -3.6% 16.00 US$270,544
2020-05-06 2020-05-05 B Purchase
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
413 +6.0%
16.00
US$6,608 		413 +6.0% 16.00 US$6,608
2020-05-06 2020-05-05 B Purchase
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
603 +6.0%
16.00
US$9,648 		603 +6.0% 16.00 US$9,648
2020-05-06 2020-05-05 B Purchase
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
1,176 +6.0%
16.00
US$18,816 		1,176 +6.0% 16.00 US$18,816
2020-05-06 2020-05-05 B Purchase
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
60,308 +6.0%
16.00
US$964,928 		60,308 +6.0% 16.00 US$964,928
2020-05-06 2020-05-05 S Sale
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
64 -0.9%
16.00
US$1,024 		64 -0.9% 16.00 US$1,024
2020-05-06 2020-05-05 S Sale
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
94 -0.9%
16.00
US$1,504 		94 -0.9% 16.00 US$1,504
2020-05-06 2020-05-05 S Sale
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
182 -0.9%
16.00
US$2,912 		182 -0.9% 16.00 US$2,912
2020-05-06 2020-05-05 S Sale
1.5
Polaris Venture Management Co. V, L.L.C.
Large shareholder
9,334 -0.9%
16.00
US$149,344 		9,334 -0.9% 16.00 US$149,344
2020-05-06 2020-05-05 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
75,000 +15.7%
16.00
US$1,200,000 		75,000 +15.7% 16.00 US$1,200,000
2020-05-06 2020-05-05 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
57,561 +17.8%
16.00
US$920,976 		57,561 +17.8% 16.00 US$920,976
2020-05-06 2020-05-05 B Purchase
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
117,439 +17.8%
16.00
US$1,879,024 		117,439 +17.8% 16.00 US$1,879,024
2020-05-06 2020-05-05 S Sale
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
7,255 -1.5%
16.00
US$116,080 		7,255 -1.5% 16.00 US$116,080
2020-05-06 2020-05-05 S Sale
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
5,568 -1.7%
16.00
US$89,088 		5,568 -1.7% 16.00 US$89,088
2020-05-06 2020-05-05 S Sale
3.4
ANDERSON EDWARD T
Non-Executive Director Large shareholder
11,360 -1.7%
16.00
US$181,760 		11,360 -1.7% 16.00 US$181,760
2020-05-06 2020-05-05 B Purchase
3.2
NBVM GP, LLC
Large shareholder
75,000 +15.7%
16.00
US$1,200,000 		75,000 +15.7% 16.00 US$1,200,000
2020-05-06 2020-05-05 B Purchase
3.2
NBVM GP, LLC
Large shareholder
57,561 +17.8%
16.00
US$920,976 		57,561 +17.8% 16.00 US$920,976
2020-05-06 2020-05-05 B Purchase
3.2
NBVM GP, LLC
Large shareholder
117,439 +17.8%
16.00
US$1,879,024 		117,439 +17.8% 16.00 US$1,879,024
2020-05-06 2020-05-05 S Sale
3.2
NBVM GP, LLC
Large shareholder
7,255 -1.5%
16.00
US$116,080 		7,255 -1.5% 16.00 US$116,080
2020-05-06 2020-05-05 S Sale
3.2
NBVM GP, LLC
Large shareholder
5,568 -1.7%
16.00
US$89,088 		5,568 -1.7% 16.00 US$89,088
2020-05-06 2020-05-05 S Sale
3.2
NBVM GP, LLC
Large shareholder
11,360 -1.7%
16.00
US$181,760 		11,360 -1.7% 16.00 US$181,760
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