United States Biotechnology & Medical Research

Eton Pharmaceuticals Inc (ETON)

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Over the past 90 days, Eton Pharmaceuticals Inc. has seen significant insider selling, with a net value of approximately $14.5 million across 22 transactions. Notable activity includes sales by Opaleye Management Inc., CEO Sean Brynjelsen, and other officers. These transactions follow a 93.4% stock price increase, occurring after the company's May 2026 earnings report.
Ticker: ETON Exchange: NMS
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Eton Pharmaceuticals Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Trades
Sale 14 Jul 2026
Value US$745,156.19 | Price 420.31 | Shares 85,171 (-0.9%)
Sale 14 Jul 2026
Value US$1,007,512.77 | Price 110.41 | Shares 80,760 (+0.9%)
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-07-16 2026-07-14 S Sale
3.4
Opaleye Management Inc.
Large shareholder
85,171 -0.9%
420.31
US$745,156 		85,171 -0.9% 420.31 US$745,156
2026-07-16 2026-07-14 S Sale
3.4
Opaleye Management Inc.
Large shareholder
80,760 +0.9%
110.41
US$1,007,513 		80,760 +0.9% 110.41 US$1,007,513
2026-07-07 2026-07-07 S Sale
3.4
Opaleye Management Inc.
Large shareholder
81,685 -22.5%
67.60
US$944,043 		81,685 -22.5% 67.60 US$944,043
2026-07-07 2026-07-07 S Sale
3.4
Opaleye Management Inc.
Large shareholder
20,000 -0.7%
38.37
US$767,456 		20,000 -0.7% 38.37 US$767,456
2026-07-07 2026-07-06 S Sale
3.4
Opaleye Management Inc.
Large shareholder
10,000 -0.4%
38.00
US$380,000 		10,000 -0.4% 38.00 US$380,000
2026-07-07 2026-07-02 S Sale
3.4
Opaleye Management Inc.
Large shareholder
25,000 -29.4%
37.39
US$934,628 		25,000 -29.4% 37.39 US$934,628
2026-07-07 2026-07-02 S Sale
3.4
Opaleye Management Inc.
Large shareholder
65,000 -2.3%
37.39
US$2,430,032 		65,000 -2.3% 37.39 US$2,430,032
2026-06-26 2026-06-26 PrS Proposed sale
1.6
Gruber James R.

Officer

Officer
251,818
35.70
US$8,990,000 		251,818 35.70 US$8,990,000
2026-06-25 2026-06-25 PrS Proposed sale
1.6
Gruber James R.

Officer

Officer
25,000
35.01
US$875,251 		25,000 35.01 US$875,251
2026-06-23 2026-06-23 PrS Proposed sale
1.6
Gruber James R.

Officer

Officer
25,000
33.23
US$830,874 		25,000 33.23 US$830,874
2026-06-17 2026-06-17 S Sale
Adams Jennifer McKie
Non-Executive Director
50,000 -100.0%
32.48
US$1,623,795 		50,000 -100.0% 32.48 US$1,623,795
2026-06-17 2026-06-17 PrS Proposed sale
Adams Jennifer McKie

Director

Non-Executive Director
50,000
32.37
US$1,618,500 		50,000 32.37 US$1,618,500
2026-06-02 2026-06-02 PrS Proposed sale
1.6
Gruber James R.

Officer

Officer
3,117
27.00
US$84,163 		3,117 27.00 US$84,163
2026-05-29 2026-05-28 S Sale
2.8
BRYNJELSEN SEAN

President & CEO

Executive Director
148 -0.0%
32.67
US$4,835 		148 -0.0% 32.67 US$4,835
2026-05-29 2026-05-28 S Sale
2.8
BRYNJELSEN SEAN

President & CEO

Executive Director
119,852 -12.6%
31.88
US$3,820,882 		119,852 -12.6% 31.88 US$3,820,882
2026-05-28 2026-05-28 PrS Proposed sale
2.8
BRYNJELSEN SEAN

Director

Non-Executive Director
120,000
32.40
US$3,888,000 		120,000 32.40 US$3,888,000
2026-05-27 2026-05-27 S Sale
1.4
Krempa David

Chief Business Officer

Officer
19,679 -43.8%
31.47
US$619,375 		19,679 -43.8% 31.47 US$619,375
2026-05-27 2026-05-26 S Sale
1.4
Krempa David

Chief Business Officer

Officer
37,524 -59.8%
31.49
US$1,181,732 		37,524 -59.8% 31.49 US$1,181,732
2026-05-27 2026-05-22 S Sale
1.4
Krempa David

Chief Business Officer

Officer
519 -2.0%
35.00
US$18,165 		519 -2.0% 35.00 US$18,165
2026-05-27 2026-05-22 S Sale
1.4
Krempa David

Chief Business Officer

Officer
9,315 -26.6%
33.88
US$315,594 		9,315 -26.6% 33.88 US$315,594
2026-05-27 2026-05-22 S Sale
1.4
Krempa David

Chief Business Officer

Officer
32,963 -48.4%
33.22
US$1,095,057 		32,963 -48.4% 33.22 US$1,095,057
2026-05-22 2026-05-22 PrS Proposed sale
1.4
Krempa David

Officer

Officer
100,000
35.00
US$3,500,000 		100,000 35.00 US$3,500,000
2026-01-14 2026-01-14 PrS Proposed sale
1.4
Krempa David

Officer

Officer
1,942
15.62
US$30,334 		1,942 15.62 US$30,334
2026-01-14 2026-01-14 PrS Proposed sale
1.6
Gruber James R.

Officer

Officer
2,293
15.47
US$35,484 		2,293 15.47 US$35,484
2026-01-14 2026-01-14 PrS Proposed sale
2.8
BRYNJELSEN SEAN

Officer; Director; 10% Stockholder

Executive Director Large shareholder
5,015
15.39
US$77,182 		5,015 15.39 US$77,182
2025-12-12 2025-12-12 PrS Proposed sale
1.6
Gruber James R.

Officer

Officer
5,450
16.88
US$91,996 		5,450 16.88 US$91,996
2025-12-12 2025-12-12 PrS Proposed sale
2.8
BRYNJELSEN SEAN

Officer; Director; 10% Stockholder

Executive Director Large shareholder
8,035
16.88
US$135,631 		8,035 16.88 US$135,631
2025-12-12 2025-12-12 PrS Proposed sale
Erdogan-Trinkaus Ipek

Officer

Officer
99
16.91
US$1,674 		99 16.91 US$1,674
2025-12-12 2025-12-12 PrS Proposed sale
1.4
Krempa David

Officer

Officer
7,545
16.88
US$127,360 		7,545 16.88 US$127,360
2025-08-20 2025-08-20 S Sale
1.6
Gruber James R.

Chief Financial Officer

Officer
2,631 -1.3%
16.02
US$42,149 		2,631 -1.3% 16.02 US$42,149
2025-08-20 2025-08-19 S Sale
1.6
Gruber James R.

Chief Financial Officer

Officer
39,082 -16.0%
16.16
US$631,565 		39,082 -16.0% 16.16 US$631,565
2025-08-19 2025-08-18 PrS Proposed sale
1.6
Gruber James R.

Officer

Officer
41,713
16.61
US$692,645 		41,713 16.61 US$692,645
2025-06-16 2025-06-16 S Sale
1.4
Krempa David

Chief Business Officer

Officer
10,223 -1.6%
14.73
US$150,585 		10,223 -1.6% 14.73 US$150,585
2025-06-16 2025-06-13 S Sale
1.4
Krempa David

Chief Business Officer

Officer
6,800 -1.1%
14.77
US$100,436 		6,800 -1.1% 14.77 US$100,436
2025-06-16 2025-06-12 S Sale
1.4
Krempa David

Chief Business Officer

Officer
16,977 -2.6%
14.92
US$253,297 		16,977 -2.6% 14.92 US$253,297
2025-06-12 2025-06-12 PrS Proposed sale
1.4
Krempa David

Officer

Officer
40,000
15.00
US$600,000 		40,000 15.00 US$600,000
2025-06-12 2025-06-10 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
2,930 +3.6%
15.82
US$46,364 		2,930 +3.6% 15.82 US$46,364
2025-06-12 2025-06-10 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
5,000 +0.2%
15.82
US$79,120 		5,000 +0.2% 15.82 US$79,120
2025-06-05 2025-06-05 S Sale
2.8
BRYNJELSEN SEAN

President & CEO

Executive Director Large shareholder
70,000 -2.4%
16.81
US$1,176,700 		70,000 -2.4% 16.81 US$1,176,700
2025-06-05 2025-06-04 S Sale
2.8
BRYNJELSEN SEAN

President & CEO

Executive Director Large shareholder
70,000 -2.3%
17.00
US$1,190,000 		70,000 -2.3% 17.00 US$1,190,000
2025-06-05 2025-06-03 S Sale
2.8
BRYNJELSEN SEAN

President & CEO

Executive Director Large shareholder
400 -0.0%
19.02
US$7,608 		400 -0.0% 19.02 US$7,608
2025-06-05 2025-06-03 S Sale
2.8
BRYNJELSEN SEAN

President & CEO

Executive Director Large shareholder
8,655 -0.3%
18.38
US$159,079 		8,655 -0.3% 18.38 US$159,079
2025-06-05 2025-06-03 S Sale
2.8
BRYNJELSEN SEAN

President & CEO

Executive Director Large shareholder
60,945 -2.0%
17.38
US$1,059,224 		60,945 -2.0% 17.38 US$1,059,224
2025-06-03 2025-06-03 PrS Proposed sale
2.8
BRYNJELSEN SEAN

Officer; Director; 10% Stockholder

Executive Director Large shareholder
210,000
18.00
US$3,780,000 		210,000 18.00 US$3,780,000
2024-10-25 2024-10-23 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
10,000 +0.4%
7.98
US$79,814 		10,000 +0.4% 7.98 US$79,814
2024-10-08 2024-10-08 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
3,970 +5.1%
7.03
US$27,906 		3,970 +5.1% 7.03 US$27,906
2024-10-08 2024-10-08 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
30,000 +1.1%
7.03
US$210,876 		30,000 +1.1% 7.03 US$210,876
2024-10-08 2024-10-07 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
1,248 +1.6%
7.22
US$9,015 		1,248 +1.6% 7.22 US$9,015
2024-10-08 2024-10-07 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
10,000 +0.4%
7.22
US$72,235 		10,000 +0.4% 7.22 US$72,235
2024-10-08 2024-10-04 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
1,852 +2.5%
6.77
US$12,540 		1,852 +2.5% 6.77 US$12,540
2024-10-08 2024-10-04 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
15,000 +0.6%
6.77
US$101,565 		15,000 +0.6% 6.77 US$101,565
2024-09-12 2024-09-11 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
5,000 +7.1%
4.75
US$23,750 		5,000 +7.1% 4.75 US$23,750
2024-09-12 2024-09-11 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
45,000 +1.7%
4.75
US$213,750 		45,000 +1.7% 4.75 US$213,750
2024-09-12 2024-09-10 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
7,500 +12.0%
4.65
US$34,875 		7,500 +12.0% 4.65 US$34,875
2024-09-12 2024-09-10 B Purchase
3.4
Opaleye Management Inc.
Large shareholder
50,000 +1.9%
4.65
US$232,500 		50,000 +1.9% 4.65 US$232,500
2022-09-23 2022-09-22 B Purchase
2.8
BRYNJELSEN SEAN

Chief Executive Officer

Executive Director
10,000 +1.0%
2.10
US$21,042 		10,000 +1.0% 2.10 US$21,042
2021-11-19 2021-11-17 S Sale
3.4
Opaleye Management Inc.
Large shareholder
25,000 -1.0%
4.67
US$116,712 		25,000 -1.0% 4.67 US$116,712
2021-11-17 2021-11-16 S Sale
3.4
Opaleye Management Inc.
Large shareholder
938 -1.1%
4.86
US$4,560 		938 -1.1% 4.86 US$4,560
2021-11-17 2021-11-16 S Sale
3.4
Opaleye Management Inc.
Large shareholder
11,500 -0.5%
4.86
US$55,912 		11,500 -0.5% 4.86 US$55,912
2021-11-17 2021-11-15 S Sale
3.4
Opaleye Management Inc.
Large shareholder
500 -0.6%
4.80
US$2,401 		500 -0.6% 4.80 US$2,401
2021-11-17 2021-11-15 S Sale
3.4
Opaleye Management Inc.
Large shareholder
2,500 -0.1%
4.80
US$12,004 		2,500 -0.1% 4.80 US$12,004
2021-11-09 2021-11-08 S Sale
3.4
Opaleye Management Inc.
Large shareholder
2,661 -3.0%
6.10
US$16,235 		2,661 -3.0% 6.10 US$16,235
2021-11-09 2021-11-08 S Sale
3.4
Opaleye Management Inc.
Large shareholder
50,000 -2.0%
6.10
US$305,050 		50,000 -2.0% 6.10 US$305,050
2021-11-09 2021-11-05 S Sale
3.4
Opaleye Management Inc.
Large shareholder
8,401 -8.6%
6.30
US$52,936 		8,401 -8.6% 6.30 US$52,936
2021-11-09 2021-11-05 S Sale
3.4
Opaleye Management Inc.
Large shareholder
159,300 -6.1%
6.30
US$1,003,765 		159,300 -6.1% 6.30 US$1,003,765
2021-11-05 2021-11-04 S Sale
3.4
Opaleye Management Inc.
Large shareholder
4,000 -3.9%
6.44
US$25,748 		4,000 -3.9% 6.44 US$25,748
2021-11-05 2021-11-04 S Sale
3.4
Opaleye Management Inc.
Large shareholder
81,700 -3.0%
6.44
US$525,903 		81,700 -3.0% 6.44 US$525,903
2021-11-05 2021-11-03 S Sale
3.4
Opaleye Management Inc.
Large shareholder
6,500 -6.0%
6.53
US$42,451 		6,500 -6.0% 6.53 US$42,451
2021-11-05 2021-11-03 S Sale
3.4
Opaleye Management Inc.
Large shareholder
110,000 -3.9%
6.53
US$718,399 		110,000 -3.9% 6.53 US$718,399
2021-10-13 2021-10-12 S Sale
3.4
Opaleye Management Inc.
Large shareholder
4,807 -3.9%
5.06
US$24,308 		4,807 -3.9% 5.06 US$24,308
2021-10-13 2021-10-12 S Sale
3.4
Opaleye Management Inc.
Large shareholder
82,500 -2.8%
5.06
US$417,178 		82,500 -2.8% 5.06 US$417,178
2021-10-13 2021-10-11 S Sale
3.4
Opaleye Management Inc.
Large shareholder
1,601 -1.4%
5.01
US$8,015 		1,601 -1.4% 5.01 US$8,015
2021-10-13 2021-10-11 S Sale
3.4
Opaleye Management Inc.
Large shareholder
32,500 -1.1%
5.01
US$162,702 		32,500 -1.1% 5.01 US$162,702
2021-10-13 2021-10-08 S Sale
3.4
Opaleye Management Inc.
Large shareholder
2,692 -2.3%
5.00
US$13,461 		2,692 -2.3% 5.00 US$13,461
2021-10-13 2021-10-08 S Sale
3.4
Opaleye Management Inc.
Large shareholder
41,000 -1.4%
5.00
US$205,008 		41,000 -1.4% 5.00 US$205,008
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