2023-01-26 |
2023-01-24 |
PS
Planned sale
|
Fong James K
EVP & Chief Commercial Officer
Officer
|
100,000
-96.6%
6.00
600,000
USD
|
100,000
-96.6%
|
6.00
|
600,000
USD
|
|
2023-01-26 |
2023-01-24 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
2,117
-6.7%
6.01
12,723
USD
|
2,117
-6.7%
|
6.01
|
12,723
USD
|
|
2023-01-26 |
2023-01-24 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
83,200
-73.9%
6.00
499,200
USD
|
83,200
-73.9%
|
6.00
|
499,200
USD
|
|
2023-01-03 |
2023-01-03 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
27,021
-61.2%
6.01
162,423
USD
|
27,021
-61.2%
|
6.01
|
162,423
USD
|
|
2023-01-03 |
2023-01-03 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
84,683
-74.2%
6.01
509,224
USD
|
84,683
-74.2%
|
6.01
|
509,224
USD
|
|
2023-01-03 |
2022-12-30 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
1,047
-5.8%
6.01
6,292
USD
|
1,047
-5.8%
|
6.01
|
6,292
USD
|
|
2023-01-03 |
2022-12-30 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
800
-4.5%
6.01
4,804
USD
|
800
-4.5%
|
6.01
|
4,804
USD
|
|
2023-01-03 |
2022-12-30 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
12,000
-41.2%
6.00
72,000
USD
|
12,000
-41.2%
|
6.00
|
72,000
USD
|
|
2023-01-03 |
2022-12-30 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
4,400
-13.0%
6.01
26,444
USD
|
4,400
-13.0%
|
6.01
|
26,444
USD
|
|
2023-01-03 |
2022-12-30 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
700
-2.3%
6.01
4,204
USD
|
700
-2.3%
|
6.01
|
4,204
USD
|
|
2023-01-03 |
2022-12-30 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
12,000
-29.0%
6.00
72,000
USD
|
12,000
-29.0%
|
6.00
|
72,000
USD
|
|
2023-01-03 |
2022-12-29 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
13,174
-43.8%
6.00
79,044
USD
|
13,174
-43.8%
|
6.00
|
79,044
USD
|
|
2023-01-03 |
2022-12-29 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
13,800
-33.1%
6.00
82,800
USD
|
13,800
-33.1%
|
6.00
|
82,800
USD
|
|
2022-11-14 |
2022-11-10 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
2,700
-8.8%
6.04
16,308
USD
|
2,700
-8.8%
|
6.04
|
16,308
USD
|
|
2022-11-14 |
2022-11-10 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
5,800
-16.0%
6.03
34,974
USD
|
5,800
-16.0%
|
6.03
|
34,974
USD
|
|
2022-11-14 |
2022-11-10 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
16,396
-31.1%
6.02
98,704
USD
|
16,396
-31.1%
|
6.02
|
98,704
USD
|
|
2022-11-14 |
2022-11-10 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
100
-0.2%
6.02
602
USD
|
100
-0.2%
|
6.02
|
602
USD
|
|
2022-11-14 |
2022-11-10 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
26,700
-33.6%
6.01
160,467
USD
|
26,700
-33.6%
|
6.01
|
160,467
USD
|
|
2022-11-14 |
2022-11-10 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
200
-0.3%
6.01
1,201
USD
|
200
-0.3%
|
6.01
|
1,201
USD
|
|
2022-11-14 |
2022-11-10 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
136,408
-63.1%
6.00
818,448
USD
|
136,408
-63.1%
|
6.00
|
818,448
USD
|
|
2022-11-14 |
2022-11-09 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
300
-1.1%
6.02
1,805
USD
|
300
-1.1%
|
6.02
|
1,805
USD
|
|
2022-11-14 |
2022-11-09 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
7,596
-21.2%
6.01
45,652
USD
|
7,596
-21.2%
|
6.01
|
45,652
USD
|
|
2022-11-14 |
2022-11-09 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
46,100
-56.3%
6.00
276,600
USD
|
46,100
-56.3%
|
6.00
|
276,600
USD
|
|
2022-11-10 |
2022-11-08 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
4,500
-100.0%
5.70
25,660
USD
|
4,500
-100.0%
|
5.70
|
25,660
USD
|
|
2022-11-10 |
2022-11-08 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
36,942
-89.1%
5.65
208,578
USD
|
36,942
-89.1%
|
5.65
|
208,578
USD
|
|
2022-11-10 |
2022-11-08 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
50,058
-54.7%
5.53
276,781
USD
|
50,058
-54.7%
|
5.53
|
276,781
USD
|
|
2022-10-06 |
2022-10-04 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
609
-3.5%
6.27
3,818
USD
|
609
-3.5%
|
6.27
|
3,818
USD
|
|
2022-10-06 |
2022-10-04 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
100
-0.6%
6.26
626
USD
|
100
-0.6%
|
6.26
|
626
USD
|
|
2022-10-06 |
2022-10-04 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
1,400
-7.6%
6.25
8,750
USD
|
1,400
-7.6%
|
6.25
|
8,750
USD
|
|
2022-10-03 |
2022-10-03 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
300
-1.7%
6.25
1,875
USD
|
300
-1.7%
|
6.25
|
1,875
USD
|
|
2022-10-03 |
2022-09-30 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
139,841
-89.2%
6.05
845,549
USD
|
139,841
-89.2%
|
6.05
|
845,549
USD
|
|
2022-10-03 |
2022-09-29 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
100
-0.6%
6.01
601
USD
|
100
-0.6%
|
6.01
|
601
USD
|
|
2022-10-03 |
2022-09-29 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
800
-4.5%
6.00
4,800
USD
|
800
-4.5%
|
6.00
|
4,800
USD
|
|
2022-09-20 |
2022-09-16 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
22,592
-57.2%
6.02
136,004
USD
|
22,592
-57.2%
|
6.02
|
136,004
USD
|
|
2022-09-14 |
2022-09-12 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
242,300
-89.7%
6.43
1,557,989
USD
|
242,300
-89.7%
|
6.43
|
1,557,989
USD
|
|
2022-08-16 |
2022-08-16 |
B
Purchase
|
Craig Adam R
President and CEO
Executive Director
|
5,000
+21.9%
5.50
27,500
USD
|
5,000
+21.9%
|
5.50
|
27,500
USD
|
|
2022-08-11 |
2022-08-09 |
S
Sale
|
BVF PARTNERS L P/IL
Non-Executive Director
Major owner
|
1,289,434
-99.5%
6.12
7,891,336
USD
|
1,289,434
-99.5%
|
6.12
|
7,891,336
USD
|
|
2022-08-11 |
2022-08-09 |
S
Sale
|
BVF PARTNERS L P/IL
Non-Executive Director
Major owner
|
469,040
-95.9%
6.12
2,870,525
USD
|
469,040
-95.9%
|
6.12
|
2,870,525
USD
|
|
2022-08-11 |
2022-08-09 |
S
Sale
|
BVF PARTNERS L P/IL
Non-Executive Director
Major owner
|
2,890,723
-94.5%
6.12
17,691,225
USD
|
2,890,723
-94.5%
|
6.12
|
17,691,225
USD
|
|
2022-08-11 |
2022-08-09 |
S
Sale
|
BVF PARTNERS L P/IL
Non-Executive Director
Major owner
|
3,850,803
-94.2%
6.12
23,566,914
USD
|
3,850,803
-94.2%
|
6.12
|
23,566,914
USD
|
|
2022-07-11 |
2022-07-07 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
1,100
-100.0%
6.55
7,205
USD
|
1,100
-100.0%
|
6.55
|
7,205
USD
|
|
2022-07-11 |
2022-07-07 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
400
-26.7%
6.54
2,616
USD
|
400
-26.7%
|
6.54
|
2,616
USD
|
|
2022-07-11 |
2022-07-07 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
400
-21.1%
6.53
2,612
USD
|
400
-21.1%
|
6.53
|
2,612
USD
|
|
2022-07-11 |
2022-07-07 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
3,321
-63.6%
6.52
21,653
USD
|
3,321
-63.6%
|
6.52
|
21,653
USD
|
|
2022-07-11 |
2022-07-07 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
5,900
-53.1%
6.51
38,409
USD
|
5,900
-53.1%
|
6.51
|
38,409
USD
|
|
2022-07-11 |
2022-07-07 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
9,000
-44.7%
6.50
58,500
USD
|
9,000
-44.7%
|
6.50
|
58,500
USD
|
|
2022-07-06 |
2022-07-06 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
18,223
-44.4%
6.11
111,343
USD
|
18,223
-44.4%
|
6.11
|
111,343
USD
|
|
2022-07-07 |
2022-07-05 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
3,331
-14.2%
6.23
20,737
USD
|
3,331
-14.2%
|
6.23
|
20,737
USD
|
|
2022-07-07 |
2022-07-05 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
27,506
-54.0%
6.14
168,895
USD
|
27,506
-54.0%
|
6.14
|
168,895
USD
|
|
2022-07-07 |
2022-07-05 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
51,963
-50.5%
6.05
314,439
USD
|
51,963
-50.5%
|
6.05
|
314,439
USD
|
|
2022-07-07 |
2022-07-05 |
PS
Planned sale
|
Metzger Michael A
Non-Executive Director
|
8,700
-7.8%
5.98
51,996
USD
|
8,700
-7.8%
|
5.98
|
51,996
USD
|
|
2022-07-06 |
2022-07-05 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
27,000
-54.2%
6.00
162,000
USD
|
27,000
-54.2%
|
6.00
|
162,000
USD
|
|
2022-07-06 |
2022-07-01 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
27,000
-54.2%
6.00
162,000
USD
|
27,000
-54.2%
|
6.00
|
162,000
USD
|
|
2022-06-17 |
2022-06-17 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
50,000
-87.1%
6.25
312,505
USD
|
50,000
-87.1%
|
6.25
|
312,505
USD
|
|
2022-06-17 |
2022-06-17 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
10,000
-57.5%
6.00
60,000
USD
|
10,000
-57.5%
|
6.00
|
60,000
USD
|
|
2022-06-16 |
2022-06-14 |
PS
Planned sale
|
KIRSKE DAVID
EVP, Chief Financial Officer
Officer
|
10,000
-57.5%
5.50
55,000
USD
|
10,000
-57.5%
|
5.50
|
55,000
USD
|
|
2022-06-03 |
2022-06-03 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
18,223
-52.2%
6.01
109,520
USD
|
18,223
-52.2%
|
6.01
|
109,520
USD
|
|
2022-06-03 |
2022-06-02 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
27,000
-61.8%
6.00
162,000
USD
|
27,000
-61.8%
|
6.00
|
162,000
USD
|
|
2022-06-03 |
2022-06-01 |
PS
Planned sale
|
Craig Adam R
President and CEO
Executive Director
|
27,000
-61.8%
6.00
162,000
USD
|
27,000
-61.8%
|
6.00
|
162,000
USD
|
|
2021-12-02 |
2021-12-02 |
B
Purchase
|
Craig Adam R
President and CEO
Executive Director
|
2,178
+19.2%
1.53
3,321
USD
|
2,178
+19.2%
|
1.53
|
3,321
USD
|
|
2021-12-02 |
2021-12-02 |
B
Purchase
|
Craig Adam R
President and CEO
Executive Director
|
1,322
+13.2%
1.52
2,016
USD
|
1,322
+13.2%
|
1.52
|
2,016
USD
|
|
2021-04-05 |
2021-04-01 |
B
Purchase
|
BVF PARTNERS L P/IL
Non-Executive Director
Major owner
|
5,171
+1.1%
2.50
12,928
USD
|
5,171
+1.1%
|
2.50
|
12,928
USD
|
|
2021-04-05 |
2021-04-01 |
B
Purchase
|
BVF PARTNERS L P/IL
Non-Executive Director
Major owner
|
950,016
+45.0%
2.50
2,375,040
USD
|
950,016
+45.0%
|
2.50
|
2,375,040
USD
|
|
2021-04-05 |
2021-04-01 |
B
Purchase
|
BVF PARTNERS L P/IL
Non-Executive Director
Major owner
|
1,044,813
+34.4%
2.50
2,612,033
USD
|
1,044,813
+34.4%
|
2.50
|
2,612,033
USD
|
|
2021-01-11 |
2021-01-07 |
S
Sale
|
ORBIMED ADVISORS LLC
Major owner
|
2,000,000
-21.0%
3.50
7,000,000
USD
|
2,000,000
-21.0%
|
3.50
|
7,000,000
USD
|
|
2018-02-12 |
2018-02-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
699,225
+117.2%
3.00
2,097,675
USD
|
699,225
+117.2%
|
3.00
|
2,097,675
USD
|
|
2018-02-12 |
2018-02-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
483,708
+inf%
3.00
1,451,124
USD
|
483,708
+inf%
|
3.00
|
1,451,124
USD
|
|
2018-02-12 |
2018-02-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
2,109,280
+inf%
3.00
6,327,840
USD
|
2,109,280
+inf%
|
3.00
|
6,327,840
USD
|
|
2018-02-12 |
2018-02-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Major owner
|
3,041,120
+inf%
3.00
9,123,360
USD
|
3,041,120
+inf%
|
3.00
|
9,123,360
USD
|
|
2017-10-02 |
2017-09-29 |
S
Sale
|
LOVE RICHARD L
Non-Executive Director
|
976
-1.3%
3.20
3,123
USD
|
976
-1.3%
|
3.20
|
3,123
USD
|
|
2017-10-02 |
2017-09-28 |
S
Sale
|
LOVE RICHARD L
Non-Executive Director
|
200
-0.3%
3.25
650
USD
|
200
-0.3%
|
3.25
|
650
USD
|
|
2017-10-02 |
2017-09-28 |
S
Sale
|
LOVE RICHARD L
Non-Executive Director
|
477
-0.6%
3.24
1,545
USD
|
477
-0.6%
|
3.24
|
1,545
USD
|
|
2017-10-02 |
2017-09-28 |
S
Sale
|
LOVE RICHARD L
Non-Executive Director
|
200
-0.3%
3.24
647
USD
|
200
-0.3%
|
3.24
|
647
USD
|
|
2017-10-02 |
2017-09-28 |
S
Sale
|
LOVE RICHARD L
Non-Executive Director
|
1,600
-2.1%
3.23
5,168
USD
|
1,600
-2.1%
|
3.23
|
5,168
USD
|
|
2017-10-02 |
2017-09-28 |
S
Sale
|
LOVE RICHARD L
Non-Executive Director
|
1,675
-2.1%
3.23
5,410
USD
|
1,675
-2.1%
|
3.23
|
5,410
USD
|
|