|
2012-07-13 |
2012-07-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
14,989
-22.0%
246.88
US$4,627,799
|
14,989
-22.0%
|
246.88
|
US$4,627,799
|
|
|
2012-07-13 |
2012-07-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
67,353
-38.0%
398.80
US$4,394,510
|
67,353
-38.0%
|
398.80
|
US$4,394,510
|
|
|
2012-07-13 |
2012-07-12 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
99,422
+14.8%
46.32
US$2,375,975
|
99,422
+14.8%
|
46.32
|
US$2,375,975
|
|
|
2012-07-13 |
2012-07-12 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
218,624
-6.0%
2.85
US$622,991
|
218,624
-6.0%
|
2.85
|
US$622,991
|
|
|
2012-07-13 |
2012-07-11 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
4,792
-12.2%
2.90
US$13,891
|
4,792
-12.2%
|
2.90
|
US$13,891
|
|
|
2012-07-13 |
2012-07-11 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
503,144
-12.2%
2.90
US$1,458,514
|
503,144
-12.2%
|
2.90
|
US$1,458,514
|
|
|
2012-03-16 |
2012-03-16 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
450,000
-24.4%
2.92
US$1,316,070
|
450,000
-24.4%
|
2.92
|
US$1,316,070
|
|
|
2012-03-16 |
2012-03-16 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
450,000
-24.4%
2.92
US$1,316,070
|
450,000
-24.4%
|
2.92
|
US$1,316,070
|
|
|
2012-03-16 |
2012-03-15 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
165,059
-8.2%
2.89
US$477,136
|
165,059
-8.2%
|
2.89
|
US$477,136
|
|
|
2012-03-16 |
2012-03-15 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
165,059
-8.2%
2.89
US$477,136
|
165,059
-8.2%
|
2.89
|
US$477,136
|
|
|
2012-03-16 |
2012-03-14 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
142,941
-6.6%
3.09
US$441,359
|
142,941
-6.6%
|
3.09
|
US$441,359
|
|
|
2012-03-16 |
2012-03-14 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
142,941
-6.6%
3.09
US$441,359
|
142,941
-6.6%
|
3.09
|
US$441,359
|
|
|
2012-03-15 |
2012-03-13 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
275,000
-11.3%
3.20
US$879,588
|
275,000
-11.3%
|
3.20
|
US$879,588
|
|
|
2012-03-15 |
2012-03-13 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
275,000
-11.3%
3.20
US$879,588
|
275,000
-11.3%
|
3.20
|
US$879,588
|
|
|
2011-12-16 |
2011-12-14 |
B
Purchase
|
SENYEI ANDREW E
Non-Executive Director
Large shareholder
|
100,000
+99.0%
3.05
US$305,000
|
100,000
+99.0%
|
3.05
|
US$305,000
|
|
|
2011-12-16 |
2011-12-14 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
100,000
-4.0%
3.05
US$305,000
|
100,000
-4.0%
|
3.05
|
US$305,000
|
|
|
2011-12-16 |
2011-12-14 |
B
Purchase
|
Enterprise Partners Management LLC
Large shareholder
|
100,000
+99.0%
3.05
US$305,000
|
100,000
+99.0%
|
3.05
|
US$305,000
|
|
|
2011-12-16 |
2011-12-14 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
100,000
-4.0%
3.05
US$305,000
|
100,000
-4.0%
|
3.05
|
US$305,000
|
|
|
2011-12-13 |
2011-12-09 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
21,400
-0.8%
3.00
US$64,224
|
21,400
-0.8%
|
3.00
|
US$64,224
|
|
|
2011-12-13 |
2011-12-09 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
21,400
-0.8%
3.00
US$64,224
|
21,400
-0.8%
|
3.00
|
US$64,224
|
|
|
2011-12-09 |
2011-12-08 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
24,525
-1.0%
3.00
US$73,685
|
24,525
-1.0%
|
3.00
|
US$73,685
|
|
|
2011-12-09 |
2011-12-08 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
24,525
-1.0%
3.00
US$73,685
|
24,525
-1.0%
|
3.00
|
US$73,685
|
|
|
2011-12-08 |
2011-12-07 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
55,420
-2.1%
3.09
US$171,342
|
55,420
-2.1%
|
3.09
|
US$171,342
|
|
|
2011-12-08 |
2011-12-07 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
55,420
-2.1%
3.09
US$171,342
|
55,420
-2.1%
|
3.09
|
US$171,342
|
|
|
2011-12-08 |
2011-12-06 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
42,575
-1.6%
3.13
US$133,170
|
42,575
-1.6%
|
3.13
|
US$133,170
|
|
|
2011-12-08 |
2011-12-06 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
42,575
-1.6%
3.13
US$133,170
|
42,575
-1.6%
|
3.13
|
US$133,170
|
|
|
2011-09-22 |
2011-09-21 |
PlS
Planned sale
|
REID CLIFFORD A
Chief Executive Officer
Executive Director
|
8,000
-100.0%
6.81
US$54,441
|
8,000
-100.0%
|
6.81
|
US$54,441
|
|
|
2011-09-22 |
2011-09-20 |
PlS
Planned sale
|
REID CLIFFORD A
Chief Executive Officer
Executive Director
|
8,000
-100.0%
7.30
US$58,367
|
8,000
-100.0%
|
7.30
|
US$58,367
|
|
|
2011-08-12 |
2011-08-08 |
B
Purchase
|
RAFFEL KEITH
SVP & Chief Commercial Officer
Officer
|
10,000
+inf%
7.94
US$79,364
|
10,000
+inf%
|
7.94
|
US$79,364
|
|
|
2011-05-31 |
2011-05-26 |
B
Purchase
|
DONDERO JAMES D
Large shareholder
|
10,623
+0.4%
12.50
US$132,788
|
10,623
+0.4%
|
12.50
|
US$132,788
|
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
5,687
+17.0%
9.00
US$51,183
|
5,687
+17.0%
|
9.00
|
US$51,183
|
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
597,091
+17.0%
9.00
US$5,373,819
|
597,091
+17.0%
|
9.00
|
US$5,373,819
|
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
Prospect Venture Partners III L P
Large shareholder
|
333,333
+12.5%
9.00
US$2,999,997
|
333,333
+12.5%
|
9.00
|
US$2,999,997
|
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ENTERPRISE PARTNERS V L P
Large shareholder
|
111,111
+20.0%
9.00
US$999,999
|
111,111
+20.0%
|
9.00
|
US$999,999
|
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
BARKAS ALEXANDER E
Non-Executive Director
Large shareholder
|
333,333
+12.5%
9.00
US$2,999,997
|
333,333
+12.5%
|
9.00
|
US$2,999,997
|
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
SENYEI ANDREW E
Non-Executive Director
Large shareholder
|
111,111
+20.0%
9.00
US$999,999
|
111,111
+20.0%
|
9.00
|
US$999,999
|
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP
Large shareholder
|
17,124
+17.0%
9.00
US$154,116
|
17,124
+17.0%
|
9.00
|
US$154,116
|
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP
Large shareholder
|
39,386
+17.0%
9.00
US$354,474
|
39,386
+17.0%
|
9.00
|
US$354,474
|
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP
Large shareholder
|
546,268
+17.0%
9.00
US$4,916,412
|
546,268
+17.0%
|
9.00
|
US$4,916,412
|
|