|
2012-07-13 |
2012-07-13 |
S
Venta
|
ORBIMED ADVISORS LLC
Gran accionista
|
14 989
-22.0%
246,88
4.627.799 US$
|
14 989
-22.0%
|
246,88
|
4.627.799 US$
|
|
|
2012-07-13 |
2012-07-13 |
S
Venta
|
ORBIMED ADVISORS LLC
Gran accionista
|
67 353
-38.0%
398,80
4.394.510 US$
|
67 353
-38.0%
|
398,80
|
4.394.510 US$
|
|
|
2012-07-13 |
2012-07-12 |
S
Venta
|
ORBIMED ADVISORS LLC
Gran accionista
|
99 422
+14.8%
46,32
2.375.975 US$
|
99 422
+14.8%
|
46,32
|
2.375.975 US$
|
|
|
2012-07-13 |
2012-07-12 |
S
Venta
|
ORBIMED ADVISORS LLC
Gran accionista
|
218 624
-6.0%
2,85
622.991 US$
|
218 624
-6.0%
|
2,85
|
622.991 US$
|
|
|
2012-07-13 |
2012-07-11 |
S
Venta
|
ORBIMED ADVISORS LLC
Gran accionista
|
4 792
-12.2%
2,90
13.891 US$
|
4 792
-12.2%
|
2,90
|
13.891 US$
|
|
|
2012-07-13 |
2012-07-11 |
S
Venta
|
ORBIMED ADVISORS LLC
Gran accionista
|
503 144
-12.2%
2,90
1.458.514 US$
|
503 144
-12.2%
|
2,90
|
1.458.514 US$
|
|
|
2012-03-16 |
2012-03-16 |
S
Venta
|
WAITE CHARLES P JR
Consejero no ejecutivo
Gran accionista
|
450 000
-24.4%
2,92
1.316.070 US$
|
450 000
-24.4%
|
2,92
|
1.316.070 US$
|
|
|
2012-03-16 |
2012-03-16 |
S
Venta
|
OVP VENTURE PARTNERS VI LP
Gran accionista
|
450 000
-24.4%
2,92
1.316.070 US$
|
450 000
-24.4%
|
2,92
|
1.316.070 US$
|
|
|
2012-03-16 |
2012-03-15 |
S
Venta
|
WAITE CHARLES P JR
Consejero no ejecutivo
Gran accionista
|
165 059
-8.2%
2,89
477.136 US$
|
165 059
-8.2%
|
2,89
|
477.136 US$
|
|
|
2012-03-16 |
2012-03-15 |
S
Venta
|
OVP VENTURE PARTNERS VI LP
Gran accionista
|
165 059
-8.2%
2,89
477.136 US$
|
165 059
-8.2%
|
2,89
|
477.136 US$
|
|
|
2012-03-16 |
2012-03-14 |
S
Venta
|
WAITE CHARLES P JR
Consejero no ejecutivo
Gran accionista
|
142 941
-6.6%
3,09
441.359 US$
|
142 941
-6.6%
|
3,09
|
441.359 US$
|
|
|
2012-03-16 |
2012-03-14 |
S
Venta
|
OVP VENTURE PARTNERS VI LP
Gran accionista
|
142 941
-6.6%
3,09
441.359 US$
|
142 941
-6.6%
|
3,09
|
441.359 US$
|
|
|
2012-03-15 |
2012-03-13 |
S
Venta
|
WAITE CHARLES P JR
Consejero no ejecutivo
Gran accionista
|
275 000
-11.3%
3,20
879.588 US$
|
275 000
-11.3%
|
3,20
|
879.588 US$
|
|
|
2012-03-15 |
2012-03-13 |
S
Venta
|
OVP VENTURE PARTNERS VI LP
Gran accionista
|
275 000
-11.3%
3,20
879.588 US$
|
275 000
-11.3%
|
3,20
|
879.588 US$
|
|
|
2011-12-16 |
2011-12-14 |
B
Compra
|
SENYEI ANDREW E
Consejero no ejecutivo
Gran accionista
|
100 000
+99.0%
3,05
305.000 US$
|
100 000
+99.0%
|
3,05
|
305.000 US$
|
|
|
2011-12-16 |
2011-12-14 |
S
Venta
|
OVP VENTURE PARTNERS VI LP
Gran accionista
|
100 000
-4.0%
3,05
305.000 US$
|
100 000
-4.0%
|
3,05
|
305.000 US$
|
|
|
2011-12-16 |
2011-12-14 |
B
Compra
|
Enterprise Partners Management LLC
Gran accionista
|
100 000
+99.0%
3,05
305.000 US$
|
100 000
+99.0%
|
3,05
|
305.000 US$
|
|
|
2011-12-16 |
2011-12-14 |
S
Venta
|
WAITE CHARLES P JR
Consejero no ejecutivo
Gran accionista
|
100 000
-4.0%
3,05
305.000 US$
|
100 000
-4.0%
|
3,05
|
305.000 US$
|
|
|
2011-12-13 |
2011-12-09 |
S
Venta
|
OVP VENTURE PARTNERS VI LP
Gran accionista
|
21 400
-0.8%
3,00
64.224 US$
|
21 400
-0.8%
|
3,00
|
64.224 US$
|
|
|
2011-12-13 |
2011-12-09 |
S
Venta
|
WAITE CHARLES P JR
Consejero no ejecutivo
Gran accionista
|
21 400
-0.8%
3,00
64.224 US$
|
21 400
-0.8%
|
3,00
|
64.224 US$
|
|
|
2011-12-09 |
2011-12-08 |
S
Venta
|
WAITE CHARLES P JR
Consejero no ejecutivo
Gran accionista
|
24 525
-1.0%
3,00
73.685 US$
|
24 525
-1.0%
|
3,00
|
73.685 US$
|
|
|
2011-12-09 |
2011-12-08 |
S
Venta
|
OVP VENTURE PARTNERS VI LP
Gran accionista
|
24 525
-1.0%
3,00
73.685 US$
|
24 525
-1.0%
|
3,00
|
73.685 US$
|
|
|
2011-12-08 |
2011-12-07 |
S
Venta
|
WAITE CHARLES P JR
Consejero no ejecutivo
Gran accionista
|
55 420
-2.1%
3,09
171.342 US$
|
55 420
-2.1%
|
3,09
|
171.342 US$
|
|
|
2011-12-08 |
2011-12-07 |
S
Venta
|
OVP VENTURE PARTNERS VI LP
Gran accionista
|
55 420
-2.1%
3,09
171.342 US$
|
55 420
-2.1%
|
3,09
|
171.342 US$
|
|
|
2011-12-08 |
2011-12-06 |
S
Venta
|
WAITE CHARLES P JR
Consejero no ejecutivo
Gran accionista
|
42 575
-1.6%
3,13
133.170 US$
|
42 575
-1.6%
|
3,13
|
133.170 US$
|
|
|
2011-12-08 |
2011-12-06 |
S
Venta
|
OVP VENTURE PARTNERS VI LP
Gran accionista
|
42 575
-1.6%
3,13
133.170 US$
|
42 575
-1.6%
|
3,13
|
133.170 US$
|
|
|
2011-09-22 |
2011-09-21 |
Por favor
Venta prevista
|
REID CLIFFORD A
Chief Executive Officer
Consejero ejecutivo
|
8 000
-100.0%
6,81
54.441 US$
|
8 000
-100.0%
|
6,81
|
54.441 US$
|
|
|
2011-09-22 |
2011-09-20 |
Por favor
Venta prevista
|
REID CLIFFORD A
Chief Executive Officer
Consejero ejecutivo
|
8 000
-100.0%
7,30
58.367 US$
|
8 000
-100.0%
|
7,30
|
58.367 US$
|
|
|
2011-08-12 |
2011-08-08 |
B
Compra
|
RAFFEL KEITH
SVP & Chief Commercial Officer
Oficial
|
10 000
+inf%
7,94
79.364 US$
|
10 000
+inf%
|
7,94
|
79.364 US$
|
|
|
2011-05-31 |
2011-05-26 |
B
Compra
|
DONDERO JAMES D
Gran accionista
|
10 623
+0.4%
12,50
132.788 US$
|
10 623
+0.4%
|
12,50
|
132.788 US$
|
|
|
2010-11-16 |
2010-11-16 |
B
Compra
|
ORBIMED ADVISORS LLC
Gran accionista
|
5 687
+17.0%
9,00
51.183 US$
|
5 687
+17.0%
|
9,00
|
51.183 US$
|
|
|
2010-11-16 |
2010-11-16 |
B
Compra
|
ORBIMED ADVISORS LLC
Gran accionista
|
597 091
+17.0%
9,00
5.373.819 US$
|
597 091
+17.0%
|
9,00
|
5.373.819 US$
|
|
|
2010-11-16 |
2010-11-16 |
B
Compra
|
Prospect Venture Partners III L P
Gran accionista
|
333 333
+12.5%
9,00
2.999.997 US$
|
333 333
+12.5%
|
9,00
|
2.999.997 US$
|
|
|
2010-11-16 |
2010-11-16 |
B
Compra
|
ENTERPRISE PARTNERS V L P
Gran accionista
|
111 111
+20.0%
9,00
999.999 US$
|
111 111
+20.0%
|
9,00
|
999.999 US$
|
|
|
2010-11-16 |
2010-11-16 |
B
Compra
|
BARKAS ALEXANDER E
Consejero no ejecutivo
Gran accionista
|
333 333
+12.5%
9,00
2.999.997 US$
|
333 333
+12.5%
|
9,00
|
2.999.997 US$
|
|
|
2010-11-16 |
2010-11-16 |
B
Compra
|
SENYEI ANDREW E
Consejero no ejecutivo
Gran accionista
|
111 111
+20.0%
9,00
999.999 US$
|
111 111
+20.0%
|
9,00
|
999.999 US$
|
|
|
2010-11-16 |
2010-11-16 |
B
Compra
|
ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP
Gran accionista
|
17 124
+17.0%
9,00
154.116 US$
|
17 124
+17.0%
|
9,00
|
154.116 US$
|
|
|
2010-11-16 |
2010-11-16 |
B
Compra
|
ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP
Gran accionista
|
39 386
+17.0%
9,00
354.474 US$
|
39 386
+17.0%
|
9,00
|
354.474 US$
|
|
|
2010-11-16 |
2010-11-16 |
B
Compra
|
ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP
Gran accionista
|
546 268
+17.0%
9,00
4.916.412 US$
|
546 268
+17.0%
|
9,00
|
4.916.412 US$
|
|