|
2018-09-20 |
2018-09-19 |
S
Sale
|
Froehlich Juergen Kurt
Chief Medical Officer
Officer
|
306
-0.3%
1.20
USD 367
|
306
-0.3%
|
1.20
|
USD 367
|
|
|
2018-01-31 |
2018-01-29 |
S
Sale
|
Froehlich Juergen Kurt
Chief Medical Officer
Officer
|
17,011
-15.8%
1.53
USD 26,027
|
17,011
-15.8%
|
1.53
|
USD 26,027
|
|
|
2017-04-06 |
2017-04-04 |
PS
Planned sale
|
Froehlich Juergen Kurt
Chief Medical Officer
|
3,765
-4.2%
1.51
USD 5,685
|
3,765
-4.2%
|
1.51
|
USD 5,685
|
|
|
2016-10-05 |
2016-10-04 |
PS
Planned sale
|
Froehlich Juergen Kurt
Chief Medical Officer
Officer
|
423
-0.5%
6.76
USD 2,859
|
423
-0.5%
|
6.76
|
USD 2,859
|
|
|
2016-06-23 |
2016-06-21 |
PS
Planned sale
|
Froehlich Juergen Kurt
Chief Medical Officer
Officer
|
333
-0.4%
4.45
USD 1,482
|
333
-0.4%
|
4.45
|
USD 1,482
|
|
|
2013-12-16 |
2013-12-13 |
S
Sale
|
THOMPSON VIRGIL
Non-Executive Director
|
3,340
-0.3%
0.17
USD 568
|
3,340
-0.3%
|
0.17
|
USD 568
|
|
|
2013-08-29 |
2013-08-27 |
B
Purchase
|
First Eagle Investment Management, LLC
Large shareholder
|
40,322,580
0.12
USD 5,000,000
|
40,322,580
|
0.12
|
USD 5,000,000
|
|
|
2012-12-13 |
2012-12-11 |
B
Purchase
|
First Eagle Investment Management, LLC
Large shareholder
|
41,666,667
+57.6%
0.12
USD 5,000,000
|
41,666,667
+57.6%
|
0.12
|
USD 5,000,000
|
|
|
2011-07-11 |
2011-07-07 |
B
Purchase
|
First Eagle Value in Biotechnology Master Fund, Ltd.
See Footnote below
Large shareholder
|
10,625,000
+17.5%
0.19
USD 2,018,750
|
10,625,000
+17.5%
|
0.19
|
USD 2,018,750
|
|
|
2010-11-09 |
2010-11-05 |
S
Sale
|
NOVO NORDISK A S
Large shareholder
|
401,469
-1.5%
0.17
USD 68,691
|
401,469
-1.5%
|
0.17
|
USD 68,691
|
|
|
2010-11-05 |
2010-11-04 |
S
Sale
|
NOVO NORDISK A S
Large shareholder
|
225,000
-0.8%
0.17
USD 38,183
|
225,000
-0.8%
|
0.17
|
USD 38,183
|
|
|
2010-11-04 |
2010-11-03 |
S
Sale
|
NOVO NORDISK A S
Large shareholder
|
250,000
-0.9%
0.16
USD 40,750
|
250,000
-0.9%
|
0.16
|
USD 40,750
|
|
|
2010-11-03 |
2010-11-02 |
S
Sale
|
NOVO NORDISK A S
Large shareholder
|
256,675
-0.9%
0.16
USD 42,249
|
256,675
-0.9%
|
0.16
|
USD 42,249
|
|
|
2010-11-02 |
2010-11-01 |
S
Sale
|
NOVO NORDISK A S
Large shareholder
|
236,406
-0.9%
0.17
USD 39,031
|
236,406
-0.9%
|
0.17
|
USD 39,031
|
|
|
2010-06-22 |
2010-06-18 |
B
Purchase
|
First Eagle Value in Biotechnology Master Fund, Ltd.
See Remarks.
Large shareholder
|
19,433,408
+52.4%
0.12
USD 2,300,916
|
19,433,408
+52.4%
|
0.12
|
USD 2,300,916
|
|
|
2008-10-31 |
2008-10-29 |
S
Sale
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
5,600,000
-83.8%
0.25
USD 1,400,000
|
5,600,000
-83.8%
|
0.25
|
USD 1,400,000
|
|
|
2008-10-23 |
2008-10-21 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
10,000
+0.2%
0.24
USD 2,400
|
10,000
+0.2%
|
0.24
|
USD 2,400
|
|
|
2008-10-22 |
2008-10-20 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
17,000
+0.3%
0.24
USD 4,080
|
17,000
+0.3%
|
0.24
|
USD 4,080
|
|
|
2008-10-15 |
2008-10-13 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
25,000
+0.5%
0.24
USD 6,000
|
25,000
+0.5%
|
0.24
|
USD 6,000
|
|
|
2008-10-14 |
2008-10-10 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
45,000
+0.8%
0.24
USD 10,602
|
45,000
+0.8%
|
0.24
|
USD 10,602
|
|
|
2008-10-08 |
2008-10-06 |
S
Sale
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
1,000,000
-13.0%
0.35
USD 350,000
|
1,000,000
-13.0%
|
0.35
|
USD 350,000
|
|
|
2008-06-06 |
2008-06-05 |
B
Purchase
|
GONDA IGOR
Chief Executive Officer
Executive Director
|
15,000
+30.6%
0.75
USD 11,250
|
15,000
+30.6%
|
0.75
|
USD 11,250
|
|
|
2008-04-10 |
2008-04-04 |
B
Purchase
|
BARKER FRANK H
Non-Executive Director
|
5,000
+14.3%
1.05
USD 5,250
|
5,000
+14.3%
|
1.05
|
USD 5,250
|
|
|
2008-04-10 |
2008-04-03 |
B
Purchase
|
BARKER FRANK H
Non-Executive Director
|
15,000
+75.0%
1.05
USD 15,750
|
15,000
+75.0%
|
1.05
|
USD 15,750
|
|
|
2008-04-10 |
2008-04-02 |
B
Purchase
|
BARKER FRANK H
Non-Executive Director
|
20,000
+inf%
1.05
USD 20,900
|
20,000
+inf%
|
1.05
|
USD 20,900
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
19,550
+0.3%
1.45
USD 28,348
|
19,550
+0.3%
|
1.45
|
USD 28,348
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
500
+0.0%
1.41
USD 705
|
500
+0.0%
|
1.41
|
USD 705
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
15,130
+0.2%
1.40
USD 21,182
|
15,130
+0.2%
|
1.40
|
USD 21,182
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
500
+0.0%
1.39
USD 695
|
500
+0.0%
|
1.39
|
USD 695
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
11,000
+0.1%
1.38
USD 15,180
|
11,000
+0.1%
|
1.38
|
USD 15,180
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
3,200
+0.0%
1.36
USD 4,352
|
3,200
+0.0%
|
1.36
|
USD 4,352
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
63,120
+0.8%
1.35
USD 85,212
|
63,120
+0.8%
|
1.35
|
USD 85,212
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
16,000
+0.2%
1.34
USD 21,440
|
16,000
+0.2%
|
1.34
|
USD 21,440
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
41,600
+0.6%
1.33
USD 55,328
|
41,600
+0.6%
|
1.33
|
USD 55,328
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
7,500
+0.1%
1.32
USD 9,900
|
7,500
+0.1%
|
1.32
|
USD 9,900
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
3,500
+0.0%
1.31
USD 4,585
|
3,500
+0.0%
|
1.31
|
USD 4,585
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
3,000
+0.0%
1.29
USD 3,870
|
3,000
+0.0%
|
1.29
|
USD 3,870
|
|
|
2008-01-16 |
2008-01-15 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
7,000
+0.1%
1.28
USD 8,960
|
7,000
+0.1%
|
1.28
|
USD 8,960
|
|
|
2007-11-05 |
2007-11-01 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
635,000
+9.3%
1.40
USD 889,000
|
635,000
+9.3%
|
1.40
|
USD 889,000
|
|
|
2007-09-13 |
2007-09-13 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
110,800
+1.6%
1.38
USD 152,904
|
110,800
+1.6%
|
1.38
|
USD 152,904
|
|
|
2007-09-13 |
2007-09-11 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
300,000
+4.7%
1.40
USD 420,000
|
300,000
+4.7%
|
1.40
|
USD 420,000
|
|
|
2007-03-28 |
2007-03-01 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Large shareholder
|
89,010
+1.4%
1.40
USD 124,614
|
89,010
+1.4%
|
1.40
|
USD 124,614
|
|
|
2007-01-30 |
2007-01-25 |
B
Purchase
|
OTULANA BABTUNDE A
VP of Clincal Affairs
Officer
|
5,000
+165.6%
0.95
USD 4,750
|
5,000
+165.6%
|
0.95
|
USD 4,750
|
|
|
2007-01-30 |
2007-01-25 |
B
Purchase
|
GONDA IGOR
Chief Executive Officer
Executive Director
|
20,000
+67.5%
0.95
USD 19,000
|
20,000
+67.5%
|
0.95
|
USD 19,000
|
|
|
2004-03-08 |
2004-03-04 |
S
Sale
|
PERRY MARK W
Large shareholder
|
2,941
-100.0%
2.71
USD 7,970
|
2,941
-100.0%
|
2.71
|
USD 7,970
|
|
|
2004-02-24 |
2004-02-20 |
S
Sale
|
NEWHALL CHARLES W III
Large shareholder
|
10,247
-100.0%
2.35
USD 24,091
|
10,247
-100.0%
|
2.35
|
USD 24,091
|
|
|
2004-02-24 |
2004-02-20 |
S
Sale
|
KRAMLICH C RICHARD
Large shareholder
|
10,247
-100.0%
2.35
USD 24,091
|
10,247
-100.0%
|
2.35
|
USD 24,091
|
|
|
2004-02-24 |
2004-02-20 |
S
Sale
|
PERRY MARK W
Large shareholder
|
10,247
-100.0%
2.35
USD 24,091
|
10,247
-100.0%
|
2.35
|
USD 24,091
|
|
|
2004-02-24 |
2004-02-20 |
S
Sale
|
NEHRA JOHN M
|
10,247
-100.0%
2.35
USD 24,091
|
10,247
-100.0%
|
2.35
|
USD 24,091
|
|
|
2004-02-24 |
2004-02-20 |
S
Sale
|
DORMAN NANCY L
Large shareholder
|
10,247
-100.0%
2.35
USD 24,091
|
10,247
-100.0%
|
2.35
|
USD 24,091
|
|
|
2004-02-24 |
2004-02-20 |
S
Sale
|
MCCONNELL THOMAS C
Large shareholder
|
10,247
-100.0%
2.35
USD 24,091
|
10,247
-100.0%
|
2.35
|
USD 24,091
|
|
|
2004-02-24 |
2004-02-20 |
S
Sale
|
BARRIS PETER J
Large shareholder
|
10,247
-100.0%
2.35
USD 24,091
|
10,247
-100.0%
|
2.35
|
USD 24,091
|
|
|
2004-02-24 |
2004-02-20 |
S
Sale
|
KASE RONALD H
|
10,247
-100.0%
2.35
USD 24,091
|
10,247
-100.0%
|
2.35
|
USD 24,091
|
|
|
2004-02-24 |
2004-02-20 |
S
Sale
|
ALSOP STEWART II
Large shareholder
|
10,247
-100.0%
2.35
USD 24,091
|
10,247
-100.0%
|
2.35
|
USD 24,091
|
|
|
2004-02-24 |
2004-02-20 |
S
Sale
|
MORRIS PETER
Large shareholder
|
10,247
-100.0%
2.35
USD 24,091
|
10,247
-100.0%
|
2.35
|
USD 24,091
|
|
|
2004-02-03 |
2004-01-07 |
S
Sale
|
TRAINOR III EUGENE A
Large shareholder
|
109
-100.0%
2.08
USD 227
|
109
-100.0%
|
2.08
|
USD 227
|
|
|
2004-02-03 |
2004-01-07 |
S
Sale
|
TRAINOR III EUGENE A
Large shareholder
|
109
-100.0%
2.08
USD 227
|
109
-100.0%
|
2.08
|
USD 227
|
|
|
2004-02-03 |
2004-01-07 |
S
Sale
|
TRAINOR III EUGENE A
Large shareholder
|
218
-100.0%
2.08
USD 453
|
218
-100.0%
|
2.08
|
USD 453
|
|
|
2004-02-03 |
2004-01-07 |
S
Sale
|
TRAINOR III EUGENE A
Large shareholder
|
436
-100.0%
2.08
USD 907
|
436
-100.0%
|
2.08
|
USD 907
|
|
|
2004-01-09 |
2004-01-07 |
S
Sale
|
PERRY MARK W
Large shareholder
|
2,000
-40.5%
2.10
USD 4,200
|
2,000
-40.5%
|
2.10
|
USD 4,200
|
|
