|
2018-09-20 |
2018-09-19 |
V
Vente
|
Froehlich Juergen Kurt
Chief Medical Officer
Dirigeant
|
38 252
-38.9%
283,02
4 557 753 $US
|
38 252
-38.9%
|
283,02
|
4 557 753 $US
|
|
|
2018-01-31 |
2018-01-29 |
V
Vente
|
Froehlich Juergen Kurt
Chief Medical Officer
Dirigeant
|
73 873
-9.9%
210,22
505 084 $US
|
73 873
-9.9%
|
210,22
|
505 084 $US
|
|
|
2017-04-06 |
2017-04-04 |
PlS
Vente planifiée
|
Froehlich Juergen Kurt
Chief Medical Officer
|
55 443
+7.1%
56,92
2 468 225 $US
|
55 443
+7.1%
|
56,92
|
2 468 225 $US
|
|
|
2016-10-05 |
2016-10-04 |
PlS
Vente planifiée
|
Froehlich Juergen Kurt
Chief Medical Officer
Dirigeant
|
423
-0.5%
6,76
2 859 $US
|
423
-0.5%
|
6,76
|
2 859 $US
|
|
|
2016-06-23 |
2016-06-21 |
PlS
Vente planifiée
|
Froehlich Juergen Kurt
Chief Medical Officer
Dirigeant
|
333
-0.4%
4,45
1 482 $US
|
333
-0.4%
|
4,45
|
1 482 $US
|
|
|
2013-12-16 |
2013-12-13 |
V
Vente
|
THOMPSON VIRGIL
Administrateur non-exécutif
|
3 340
-0.3%
0,17
568 $US
|
3 340
-0.3%
|
0,17
|
568 $US
|
|
|
2013-08-29 |
2013-08-27 |
A
Achat
|
First Eagle Investment Management, LLC
Actionnaire important
|
40 322 580
0,12
5 000 000 $US
|
40 322 580
|
0,12
|
5 000 000 $US
|
|
|
2012-12-13 |
2012-12-11 |
A
Achat
|
First Eagle Investment Management, LLC
Actionnaire important
|
41 666 667
+57.6%
0,12
5 000 000 $US
|
41 666 667
+57.6%
|
0,12
|
5 000 000 $US
|
|
|
2011-07-11 |
2011-07-07 |
A
Achat
|
First Eagle Value in Biotechnology Master Fund, Ltd.
See Footnote below
Actionnaire important
|
10 625 000
+17.5%
0,19
2 018 750 $US
|
10 625 000
+17.5%
|
0,19
|
2 018 750 $US
|
|
|
2010-11-09 |
2010-11-05 |
V
Vente
|
NOVO NORDISK A S
Actionnaire important
|
401 469
-1.5%
0,17
68 691 $US
|
401 469
-1.5%
|
0,17
|
68 691 $US
|
|
|
2010-11-05 |
2010-11-04 |
V
Vente
|
NOVO NORDISK A S
Actionnaire important
|
225 000
-0.8%
0,17
38 182 $US
|
225 000
-0.8%
|
0,17
|
38 182 $US
|
|
|
2010-11-04 |
2010-11-03 |
V
Vente
|
NOVO NORDISK A S
Actionnaire important
|
250 000
-0.9%
0,16
40 750 $US
|
250 000
-0.9%
|
0,16
|
40 750 $US
|
|
|
2010-11-03 |
2010-11-02 |
V
Vente
|
NOVO NORDISK A S
Actionnaire important
|
256 675
-0.9%
0,16
42 249 $US
|
256 675
-0.9%
|
0,16
|
42 249 $US
|
|
|
2010-11-02 |
2010-11-01 |
V
Vente
|
NOVO NORDISK A S
Actionnaire important
|
236 406
-0.9%
0,17
39 031 $US
|
236 406
-0.9%
|
0,17
|
39 031 $US
|
|
|
2010-06-22 |
2010-06-18 |
A
Achat
|
First Eagle Value in Biotechnology Master Fund, Ltd.
See Remarks.
Actionnaire important
|
19 433 408
+52.4%
0,12
2 300 916 $US
|
19 433 408
+52.4%
|
0,12
|
2 300 916 $US
|
|
|
2008-10-31 |
2008-10-29 |
V
Vente
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
5 600 000
-83.8%
0,25
1 400 000 $US
|
5 600 000
-83.8%
|
0,25
|
1 400 000 $US
|
|
|
2008-10-23 |
2008-10-21 |
A
Achat
|
TANG KEVIN C
Actionnaire important
|
10 000
+0.2%
0,24
2 400 $US
|
10 000
+0.2%
|
0,24
|
2 400 $US
|
|
|
2008-10-22 |
2008-10-20 |
A
Achat
|
TANG KEVIN C
Actionnaire important
|
17 000
+0.3%
0,24
4 080 $US
|
17 000
+0.3%
|
0,24
|
4 080 $US
|
|
|
2008-10-15 |
2008-10-13 |
A
Achat
|
TANG KEVIN C
Actionnaire important
|
25 000
+0.5%
0,24
6 000 $US
|
25 000
+0.5%
|
0,24
|
6 000 $US
|
|
|
2008-10-14 |
2008-10-10 |
A
Achat
|
TANG KEVIN C
Actionnaire important
|
45 000
+0.8%
0,24
10 602 $US
|
45 000
+0.8%
|
0,24
|
10 602 $US
|
|
|
2008-10-08 |
2008-10-06 |
V
Vente
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
1 000 000
-13.0%
0,35
350 000 $US
|
1 000 000
-13.0%
|
0,35
|
350 000 $US
|
|
|
2008-06-06 |
2008-06-05 |
A
Achat
|
GONDA IGOR
Chief Executive Officer
Administrateur exécutif
|
15 000
+30.6%
0,75
11 250 $US
|
15 000
+30.6%
|
0,75
|
11 250 $US
|
|
|
2008-04-10 |
2008-04-04 |
A
Achat
|
BARKER FRANK H
Administrateur non-exécutif
|
5 000
+14.3%
1,05
5 250 $US
|
5 000
+14.3%
|
1,05
|
5 250 $US
|
|
|
2008-04-10 |
2008-04-03 |
A
Achat
|
BARKER FRANK H
Administrateur non-exécutif
|
15 000
+75.0%
1,05
15 750 $US
|
15 000
+75.0%
|
1,05
|
15 750 $US
|
|
|
2008-04-10 |
2008-04-02 |
A
Achat
|
BARKER FRANK H
Administrateur non-exécutif
|
20 000
+inf%
1,05
20 900 $US
|
20 000
+inf%
|
1,05
|
20 900 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
19 550
+0.3%
1,45
28 348 $US
|
19 550
+0.3%
|
1,45
|
28 348 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
500
+0.0%
1,41
705 $US
|
500
+0.0%
|
1,41
|
705 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
15 130
+0.2%
1,40
21 182 $US
|
15 130
+0.2%
|
1,40
|
21 182 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
500
+0.0%
1,39
695 $US
|
500
+0.0%
|
1,39
|
695 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
11 000
+0.1%
1,38
15 180 $US
|
11 000
+0.1%
|
1,38
|
15 180 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
3 200
+0.0%
1,36
4 352 $US
|
3 200
+0.0%
|
1,36
|
4 352 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
63 120
+0.8%
1,35
85 212 $US
|
63 120
+0.8%
|
1,35
|
85 212 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
16 000
+0.2%
1,34
21 440 $US
|
16 000
+0.2%
|
1,34
|
21 440 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
41 600
+0.6%
1,33
55 328 $US
|
41 600
+0.6%
|
1,33
|
55 328 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
7 500
+0.1%
1,32
9 900 $US
|
7 500
+0.1%
|
1,32
|
9 900 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
3 500
+0.0%
1,31
4 585 $US
|
3 500
+0.0%
|
1,31
|
4 585 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
3 000
+0.0%
1,29
3 870 $US
|
3 000
+0.0%
|
1,29
|
3 870 $US
|
|
|
2008-01-16 |
2008-01-15 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
7 000
+0.1%
1,28
8 960 $US
|
7 000
+0.1%
|
1,28
|
8 960 $US
|
|
|
2007-11-05 |
2007-11-01 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
635 000
+9.3%
1,40
889 000 $US
|
635 000
+9.3%
|
1,40
|
889 000 $US
|
|
|
2007-09-13 |
2007-09-13 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
110 800
+1.6%
1,38
152 904 $US
|
110 800
+1.6%
|
1,38
|
152 904 $US
|
|
|
2007-09-13 |
2007-09-11 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
300 000
+4.7%
1,40
420 000 $US
|
300 000
+4.7%
|
1,40
|
420 000 $US
|
|
|
2007-03-28 |
2007-03-01 |
A
Achat
|
RA CAPITAL MANAGEMENT, LLC
Actionnaire important
|
89 010
+1.4%
1,40
124 614 $US
|
89 010
+1.4%
|
1,40
|
124 614 $US
|
|
|
2007-01-30 |
2007-01-25 |
A
Achat
|
OTULANA BABTUNDE A
VP of Clincal Affairs
Dirigeant
|
5 000
+165.6%
0,95
4 750 $US
|
5 000
+165.6%
|
0,95
|
4 750 $US
|
|
|
2007-01-30 |
2007-01-25 |
A
Achat
|
GONDA IGOR
Chief Executive Officer
Administrateur exécutif
|
20 000
+67.5%
0,95
19 000 $US
|
20 000
+67.5%
|
0,95
|
19 000 $US
|
|
|
2004-03-08 |
2004-03-04 |
V
Vente
|
PERRY MARK W
Actionnaire important
|
2 941
-100.0%
2,71
7 970 $US
|
2 941
-100.0%
|
2,71
|
7 970 $US
|
|
|
2004-02-24 |
2004-02-20 |
V
Vente
|
NEWHALL CHARLES W III
Actionnaire important
|
10 247
-100.0%
2,35
24 091 $US
|
10 247
-100.0%
|
2,35
|
24 091 $US
|
|
|
2004-02-24 |
2004-02-20 |
V
Vente
|
KRAMLICH C RICHARD
Actionnaire important
|
10 247
-100.0%
2,35
24 091 $US
|
10 247
-100.0%
|
2,35
|
24 091 $US
|
|
|
2004-02-24 |
2004-02-20 |
V
Vente
|
PERRY MARK W
Actionnaire important
|
10 247
-100.0%
2,35
24 091 $US
|
10 247
-100.0%
|
2,35
|
24 091 $US
|
|
|
2004-02-24 |
2004-02-20 |
V
Vente
|
NEHRA JOHN M
|
10 247
-100.0%
2,35
24 091 $US
|
10 247
-100.0%
|
2,35
|
24 091 $US
|
|
|
2004-02-24 |
2004-02-20 |
V
Vente
|
DORMAN NANCY L
Actionnaire important
|
10 247
-100.0%
2,35
24 091 $US
|
10 247
-100.0%
|
2,35
|
24 091 $US
|
|
|
2004-02-24 |
2004-02-20 |
V
Vente
|
MCCONNELL THOMAS C
Actionnaire important
|
10 247
-100.0%
2,35
24 091 $US
|
10 247
-100.0%
|
2,35
|
24 091 $US
|
|
|
2004-02-24 |
2004-02-20 |
V
Vente
|
BARRIS PETER J
Actionnaire important
|
10 247
-100.0%
2,35
24 091 $US
|
10 247
-100.0%
|
2,35
|
24 091 $US
|
|
|
2004-02-24 |
2004-02-20 |
V
Vente
|
KASE RONALD H
|
10 247
-100.0%
2,35
24 091 $US
|
10 247
-100.0%
|
2,35
|
24 091 $US
|
|
|
2004-02-24 |
2004-02-20 |
V
Vente
|
ALSOP STEWART II
Actionnaire important
|
10 247
-100.0%
2,35
24 091 $US
|
10 247
-100.0%
|
2,35
|
24 091 $US
|
|
|
2004-02-24 |
2004-02-20 |
V
Vente
|
MORRIS PETER
Actionnaire important
|
10 247
-100.0%
2,35
24 091 $US
|
10 247
-100.0%
|
2,35
|
24 091 $US
|
|
|
2004-02-03 |
2004-01-07 |
V
Vente
|
TRAINOR III EUGENE A
Actionnaire important
|
109
-100.0%
2,08
227 $US
|
109
-100.0%
|
2,08
|
227 $US
|
|
|
2004-02-03 |
2004-01-07 |
V
Vente
|
TRAINOR III EUGENE A
Actionnaire important
|
109
-100.0%
2,08
227 $US
|
109
-100.0%
|
2,08
|
227 $US
|
|
|
2004-02-03 |
2004-01-07 |
V
Vente
|
TRAINOR III EUGENE A
Actionnaire important
|
218
-100.0%
2,08
453 $US
|
218
-100.0%
|
2,08
|
453 $US
|
|
|
2004-02-03 |
2004-01-07 |
V
Vente
|
TRAINOR III EUGENE A
Actionnaire important
|
436
-100.0%
2,08
907 $US
|
436
-100.0%
|
2,08
|
907 $US
|
|
|
2004-01-09 |
2004-01-07 |
V
Vente
|
PERRY MARK W
Actionnaire important
|
2 000
-40.5%
2,10
4 200 $US
|
2 000
-40.5%
|
2,10
|
4 200 $US
|
|