BETHUNE DAVID R

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2004-10-06	2004-10-05	Tolmar Therapeutics Inc (atrx)	PlS Planned sale	42,583 +33.7% 248.59 US$1,436,525	42,583 +33.7%	248.59	US$1,436,525
2004-07-06	2004-07-06	Tolmar Therapeutics Inc (atrx)	PlS Planned sale	13,946 +14.4% 434.97 US$2,178,031	13,946 +14.4%	434.97	US$2,178,031
2004-05-10	2004-05-05	Tolmar Therapeutics Inc (atrx)	S Sale	57,458 -7.1% 253.10 US$3,553,406	57,458 -7.1%	253.10	US$3,553,406