Canada Biotechnology & Medical Research

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ZYUS Life Sciences Corp (ZYUS)

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Ticker: ZYUS Exchange: CVE

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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Trades

Knowles, John Lewis

Director of Issuer

1 purchase — total 50,000 CAD

Buy 27 Jun 2025

Value CA$1,615,457.95 | Price 149.27 | Shares 51,349

Zettl, Brenton Harold

Director or Senior Officer of 10% Security Holder

1 purchase — total 200,000 CAD

Buy 27 Jun 2025

Value CA$3,459,952.39 | Price 273.98 | Shares 22,588

Brownlee, Wayne Richard

Director of Issuer

1 purchase — total 250,000 CAD

Buy 27 Jun 2025

Value CA$249,999.78 | Price 0.67 | Shares 373,134

Hyshka, John Michael

Senior Officer of Issuer

1 purchase — total 900 CAD

Buy 6 Dec 2024

Value CA$900.00 | Price 0.90 | Shares 1,000

Knowles, John Lewis

Director of Issuer

1 purchase — total 149,999 CAD

Buy 26 Aug 2024

Value CA$149,999.30 | Price 0.95 | Shares 157,894

Hoyt, Richard

Director of Issuer

1 purchase — total 149,999 CAD

Buy 26 Aug 2024

Value CA$149,999.30 | Price 0.95 | Shares 157,894

Brownlee, Wayne Richard

Director of Issuer

1 purchase — total 499,999 CAD

Buy 26 Aug 2024

Value CA$499,999.25 | Price 0.95 | Shares 526,315

Zettl, Brenton Harold

Director or Senior Officer of 10% Security Holder

1 purchase — total 169,280 CAD

Buy 29 Jan 2024

Value CA$169,280.00 | Price 0.92 | Shares 184,000

102042227 Saskatchewan Ltd.

10% Security Holder of Issuer

1 sale — total 169,280 CAD

Sale 29 Jan 2024

Value CA$169,280.00 | Price 0.92 | Shares 184,000

Hyshka, John Michael

Senior Officer of Issuer

1 purchase — total 1,469 CAD

Buy 18 Dec 2023

Value CA$1,468.50 | Price 0.89 | Shares 1,650

Hyshka, John Michael

Senior Officer of Issuer

1 purchase — total 618 CAD

Buy 28 Sep 2023

Value CA$618.00 | Price 1.03 | Shares 600

Hyshka, John Michael

Senior Officer of Issuer

1 purchase — total 909 CAD

Buy 27 Sep 2023

Value CA$909.00 | Price 1.01 | Shares 900

Hyshka, John Michael

Senior Officer of Issuer

1 purchase — total 1,530 CAD

Buy 19 Sep 2023

Value CA$1,530.00 | Price 1.02 | Shares 1,500

Detlefsen, Michael Erik

Director of Issuer

1 sale — total 10,304 CAD

Sale 25 May 2022

Value CA$10,304.00 | Price 0.74 | Shares 14,000

Detlefsen, Michael Erik

Director of Issuer

1 sale — total 9,100 CAD

Sale 2 Jul 2020

Value CA$9,100.00 | Price 1.30 | Shares 7,000

Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Insider and/or position	Nb. shares Price Value	Number of shares	Price	Value
2025-07-02	2025-06-27	B Purchase	0.8 Knowles, John Lewis Director of Issuer Non-Executive Director	51,349 -3.5% 149.27 CA$1,615,458	51,349 -3.5%	149.27	CA$1,615,458
2025-06-30	2025-06-27	B Purchase	3.0 Zettl, Brenton Harold Director or Senior Officer of 10% Security Holder	22,588 +0.6% 273.98 CA$3,459,952	22,588 +0.6%	273.98	CA$3,459,952
2025-06-30	2025-06-27	B Purchase	0.8 Brownlee, Wayne Richard Director of Issuer Non-Executive Director	90,564 +49.8% 67.28 CA$3,955,745	90,564 +49.8%	67.28	CA$3,955,745
2024-12-13	2024-12-06	B Purchase	2.3 Hyshka, John Michael Senior Officer of Issuer Officer	1,000 +10.7% 0.90 CA$900	1,000 +10.7%	0.90	CA$900
2024-09-10	2024-08-26	B Purchase	0.8 Knowles, John Lewis Director of Issuer Non-Executive Director	157,894 +53.6% 0.95 CA$149,999	157,894 +53.6%	0.95	CA$149,999
2024-08-28	2024-08-26	B Purchase	0.8 Hoyt, Richard Director of Issuer Non-Executive Director	157,894 +104.5% 0.95 CA$149,999	157,894 +104.5%	0.95	CA$149,999
2024-08-27	2024-08-26	B Purchase	0.8 Brownlee, Wayne Richard Director of Issuer Non-Executive Director	526,315 +16.2% 0.95 CA$499,999	526,315 +16.2%	0.95	CA$499,999
2024-01-31	2024-01-29	B Purchase	3.0 Zettl, Brenton Harold Director or Senior Officer of 10% Security Holder	184,000 0.92 CA$169,280	184,000	0.92	CA$169,280
2024-01-31	2024-01-29	S Sale	0.8 102042227 Saskatchewan Ltd. 10% Security Holder of Issuer Large shareholder	184,000 -0.5% 0.92 CA$169,280	184,000 -0.5%	0.92	CA$169,280
2023-12-19	2023-12-18	B Purchase	2.3 Hyshka, John Michael Senior Officer of Issuer Officer	1,650 +21.4% 0.89 CA$1,468	1,650 +21.4%	0.89	CA$1,468
2023-09-29	2023-09-28	B Purchase	2.3 Hyshka, John Michael Senior Officer of Issuer Officer	600 +9.2% 1.03 CA$618	600 +9.2%	1.03	CA$618
2023-09-29	2023-09-27	B Purchase	2.3 Hyshka, John Michael Senior Officer of Issuer Officer	900 +19.1% 1.01 CA$909	900 +19.1%	1.01	CA$909
2023-09-22	2023-09-19	B Purchase	2.3 Hyshka, John Michael Senior Officer of Issuer Officer	1,500 +46.9% 1.02 CA$1,530	1,500 +46.9%	1.02	CA$1,530
2023-01-04	2022-05-25	S Sale	3.4 Detlefsen, Michael Erik Director of Issuer Non-Executive Director	14,000 -12.4% 0.74 CA$10,304	14,000 -12.4%	0.74	CA$10,304
2023-02-01	2020-07-02	S Sale	3.4 Detlefsen, Michael Erik Director of Issuer Non-Executive Director	7,000 1.30 CA$9,100	7,000	1.30	CA$9,100