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United States Biotechnology & Medical Research

Tyra Biosciences Inc (TYRA)

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Over the last 90 days, Tyra Biosciences Inc. has seen significant insider selling, with a net value of approximately -$528,506. The majority of transactions were sales, totaling over $13.6 million. Notably, a large proposed sale of $10 million by NEXTECH VI ONCOLOGY SCSP occurred on June 1, 2026. Director Gilla Kaplan also engaged in substantial selling.
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Ticker: TYRA Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
NEXTECH VI ONCOLOGY SCSP
Shareholder
1 sale — total 10,023,000 USD
Proposed sale 1 Jun 2026
Value US$3,976,419.40 | Price 319.74 | Shares 61,532
Proposed sale 12 May 2026
Value US$979,041.53 | Price 294.92 | Shares 18,101
Proposed sale 13 Apr 2026
Value US$285,000.00 | Price 35.63 | Shares 8,000
Proposed sale 26 Mar 2026
Value US$2,007,152.61 | Price 37.75 | Shares 53,172
Sale 25 Mar 2026
Value US$528,506.16 | Price 36.97 | Shares 14,295
Proposed sale 25 Mar 2026
Value US$528,506.16 | Price 36.97 | Shares 14,295
Proposed sale 12 Mar 2026
Value US$283,000.00 | Price 35.38 | Shares 8,000
Planned sale 12 Feb 2026
Value US$195,928.68 | Price 33.37 | Shares 5,872
Planned sale 12 Feb 2026
Value US$67,035.83 | Price 31.50 | Shares 2,128
Proposed sale 12 Feb 2026
Value US$262,000.00 | Price 32.75 | Shares 8,000
Planned sale 12 Jan 2026
Value US$29,575.17 | Price 29.08 | Shares 1,017
Planned sale 12 Jan 2026
Value US$198,610.49 | Price 28.44 | Shares 6,983
Proposed sale 12 Jan 2026
Value US$232,000.00 | Price 29.00 | Shares 8,000
Planned sale 19 Dec 2025
Value US$250,000.00 | Price 25.00 | Shares 10,000
Planned sale 12 Dec 2025
Value US$181,159.20 | Price 22.64 | Shares 8,000
Proposed sale 12 Dec 2025
Value US$180,000.00 | Price 22.50 | Shares 8,000
Planned sale 21 Nov 2025
Value US$5,000,026.49 | Price 20.25 | Shares 246,871
Proposed sale 21 Nov 2025
Value US$5,394,291.00 | Price 21.00 | Shares 256,871
Planned sale 19 Nov 2025
Value US$815,296.91 | Price 16.32 | Shares 49,956
Planned sale 18 Nov 2025
Value US$1,215,626.52 | Price 16.07 | Shares 75,633
Proposed sale 18 Nov 2025
Value US$2,000,000.00 | Price 16.05 | Shares 124,589
Proposed sale 17 Nov 2025
Value US$320,000.00 | Price 15.94 | Shares 20,072
Planned sale 17 Nov 2025
Value US$25,606.95 | Price 17.07 | Shares 1,500
Planned sale 17 Nov 2025
Value US$299,191.21 | Price 16.11 | Shares 18,572
Planned sale 14 Nov 2025
Value US$1,765,488.81 | Price 16.02 | Shares 110,228
Proposed sale 14 Nov 2025
Value US$1,380,000.00 | Price 15.98 | Shares 86,339
Planned sale 13 Nov 2025
Value US$17,780.00 | Price 16.00 | Shares 1,111
Proposed sale 13 Nov 2025
Value US$400,000.00 | Price 16.00 | Shares 25,000
Sale 18 Jun 2025
Value US$93,596.09 | Price 9.78 | Shares 9,568
Proposed sale 18 Jun 2025
Value US$93,596.09 | Price 9.78 | Shares 9,568
Sale 17 Jun 2025
Value US$103.50 | Price 10.35 | Shares 10
Proposed sale 17 Jun 2025
Value US$103.50 | Price 10.35 | Shares 10
Proposed sale 16 Jun 2025
Value US$70,725.91 | Price 10.38 | Shares 6,814
Buy 16 Jun 2025
Value US$119,665.69 | Price 10.13 | Shares 11,813
Sale 16 Jun 2025
Value US$70,725.91 | Price 10.38 | Shares 6,814
Buy 13 Jun 2025
Value US$1,225,703.40 | Price 10.20 | Shares 120,167
Sale 13 Jun 2025
Value US$154,582.50 | Price 10.31 | Shares 15,000
Proposed sale 13 Jun 2025
Value US$154,582.50 | Price 10.31 | Shares 15,000
Buy 12 Jun 2025
Value US$319,331.40 | Price 10.20 | Shares 31,307
Sale 12 Jun 2025
Value US$309,255.00 | Price 10.31 | Shares 30,000
Proposed sale 12 Jun 2025
Value US$309,255.00 | Price 10.31 | Shares 30,000
Buy 9 Jun 2025
Value US$1,904,001.50 | Price 10.19 | Shares 186,850
Buy 5 Jun 2025
Value US$2,141,873.36 | Price 10.04 | Shares 213,334
Buy 4 Jun 2025
Value US$9,609,430.32 | Price 9.63 | Shares 997,864
Sale 5 Feb 2025
Value US$48,315.22 | Price 13.76 | Shares 3,511
Sale 5 Feb 2025
Value US$26,008.48 | Price 13.76 | Shares 1,890
Proposed sale 5 Feb 2025
Value US$1,650,000.00 | Price 13.75 | Shares 120,000
Proposed sale 5 Feb 2025
Value US$1,546,875.00 | Price 13.75 | Shares 112,500
Sale 23 Jan 2025
Value US$78,466.08 | Price 16.26 | Shares 4,825
Proposed sale 22 Jan 2025
Value US$292,235.66 | Price 15.71 | Shares 18,597
Sale 21 Jan 2025
Value US$65,335.86 | Price 16.36 | Shares 3,993
Sale 17 Jan 2025
Value US$7,560.45 | Price 16.40 | Shares 461
Sale 17 Jan 2025
Value US$210,052.48 | Price 16.40 | Shares 12,808
Sale 16 Jan 2025
Value US$13,599.64 | Price 16.29 | Shares 835
Sale 16 Jan 2025
Value US$113,096.93 | Price 16.29 | Shares 6,944
Proposed sale 9 Dec 2024
Value US$159,000.00 | Price 15.90 | Shares 10,000
Proposed sale 5 Dec 2024
Value US$75,000.00 | Price 15.00 | Shares 5,000
Proposed sale 2 Dec 2024
Value US$80,000.00 | Price 16.00 | Shares 5,000
Sale 25 Nov 2024
Value US$9,530.65 | Price 16.84 | Shares 566
Sale 25 Nov 2024
Value US$79,242.45 | Price 16.84 | Shares 4,706
Proposed sale 20 Nov 2024
Value US$154,700.00 | Price 15.47 | Shares 10,000
Proposed sale 14 Nov 2024
Value US$161,105.58 | Price 15.94 | Shares 10,107
Buy 8 Nov 2024
Value US$19,836,066.25 | Price 16.25 | Shares 1,220,681
Sale 7 Nov 2024
Value US$41,061.22 | Price 17.32 | Shares 2,371
Sale 7 Nov 2024
Value US$341,512.93 | Price 17.32 | Shares 19,720
Sale 6 Nov 2024
Value US$96,783.94 | Price 17.18 | Shares 5,635
Sale 6 Nov 2024
Value US$804,775.23 | Price 17.18 | Shares 46,856
Sale 5 Nov 2024
Value US$18,881.11 | Price 16.77 | Shares 1,126
Sale 5 Nov 2024
Value US$157,068.67 | Price 16.77 | Shares 9,367
Sale 4 Nov 2024
Value US$1,972.70 | Price 17.01 | Shares 116
Sale 4 Nov 2024
Value US$16,325.76 | Price 17.01 | Shares 960
Sale 1 Nov 2024
Value US$1,252.64 | Price 17.16 | Shares 73
Sale 1 Nov 2024
Value US$47,614.78 | Price 16.54 | Shares 2,878
Sale 1 Nov 2024
Value US$10,364.28 | Price 17.16 | Shares 604
Sale 1 Nov 2024
Value US$396,039.85 | Price 16.54 | Shares 23,938
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-06-01 2026-06-01 PrS Proposed sale
NEXTECH VI ONCOLOGY SCSP

Shareholder
61,532
319.74
US$3,976,419 		61,532 319.74 US$3,976,419
2026-05-12 2026-05-12 PrS Proposed sale
3.2
Daniel Bensen

Officer

Officer
18,101
294.92
US$979,042 		18,101 294.92 US$979,042
2026-04-13 2026-04-13 PrS Proposed sale
3.2
Daniel Bensen

Officer

Officer
63,462
220.04
US$2,123,843 		63,462 220.04 US$2,123,843
2026-03-26 2026-03-26 PrS Proposed sale
1.1
GILLA KAPLAN

Director

Non-Executive Director
53,172
37.75
US$2,007,153 		53,172 37.75 US$2,007,153
2026-03-27 2026-03-25 S Sale
1.1
KAPLAN GILLA
Non-Executive Director
14,295 -33.6%
36.97
US$528,506 		14,295 -33.6% 36.97 US$528,506
2026-03-25 2026-03-25 PrS Proposed sale
1.1
GILLA KAPLAN

Director

Non-Executive Director
14,295
36.97
US$528,506 		14,295 36.97 US$528,506
2026-03-12 2026-03-12 PrS Proposed sale
3.2
Daniel Bensen

Officer

Officer
8,000
35.38
US$283,000 		8,000 35.38 US$283,000
2026-02-13 2026-02-12 PlS Planned sale
3.2
Bensen Daniel

Chief Discovery Officer

Officer
5,872 -3.8%
33.37
US$195,929 		5,872 -3.8% 33.37 US$195,929
2026-02-13 2026-02-12 PlS Planned sale
3.2
Bensen Daniel

Chief Discovery Officer

Officer
2,128 -1.4%
31.50
US$67,036 		2,128 -1.4% 31.50 US$67,036
2026-02-12 2026-02-12 PrS Proposed sale
3.2
Daniel Bensen

Officer

Officer
8,000
32.75
US$262,000 		8,000 32.75 US$262,000
2026-01-20 2026-01-12 PlS Planned sale
3.2
Bensen Daniel

Chief Discovery Officer

Officer
1,017 -0.7%
29.08
US$29,575 		1,017 -0.7% 29.08 US$29,575
2026-01-20 2026-01-12 PlS Planned sale
3.2
Bensen Daniel

Chief Discovery Officer

Officer
6,983 -4.3%
28.44
US$198,610 		6,983 -4.3% 28.44 US$198,610
2026-01-12 2026-01-12 PrS Proposed sale
3.2
Daniel Bensen

Officer

Officer
8,000
29.00
US$232,000 		8,000 29.00 US$232,000
2025-12-19 2025-12-19 PlS Planned sale
2.8
MORE ROBERT J
Non-Executive Director
10,000 -0.3%
25.00
US$250,000 		10,000 -0.3% 25.00 US$250,000
2025-12-16 2025-12-12 PlS Planned sale
3.2
Bensen Daniel

Chief Discovery Officer

Officer
8,000 -4.7%
22.64
US$181,159 		8,000 -4.7% 22.64 US$181,159
2025-12-12 2025-12-12 PrS Proposed sale
3.2
Daniel Bensen

Officer

Officer
8,000
22.50
US$180,000 		8,000 22.50 US$180,000
2025-11-25 2025-11-21 PlS Planned sale
2.8
MORE ROBERT J
Non-Executive Director
246,871 -6.1%
20.25
US$5,000,026 		246,871 -6.1% 20.25 US$5,000,026
2025-11-21 2025-11-21 PrS Proposed sale
Alta Partners NextGen Fund II, L.P.

Affiliate
256,871
21.00
US$5,394,291 		256,871 21.00 US$5,394,291
2025-11-19 2025-11-19 PlS Planned sale
3.2
Bensen Daniel

Chief Operating Officer

Officer
49,956 -22.6%
16.32
US$815,297 		49,956 -22.6% 16.32 US$815,297
2025-11-19 2025-11-18 PlS Planned sale
3.2
Bensen Daniel

Chief Operating Officer

Officer
75,633 -25.5%
16.07
US$1,215,627 		75,633 -25.5% 16.07 US$1,215,627
2025-11-18 2025-11-18 PrS Proposed sale
3.2
Daniel Bensen

Officer

Officer
124,589
16.05
US$2,000,000 		124,589 16.05 US$2,000,000
2025-11-17 2025-11-17 PrS Proposed sale
3.2
Daniel Bensen

Officer

Officer
20,072
15.94
US$320,000 		20,072 15.94 US$320,000
2025-11-17 2025-11-17 PlS Planned sale
3.2
Bensen Daniel

Chief Operating Officer

Officer
1,500 -0.5%
17.07
US$25,607 		1,500 -0.5% 17.07 US$25,607
2025-11-17 2025-11-17 PlS Planned sale
3.2
Bensen Daniel

Chief Operating Officer

Officer
18,572 -5.9%
16.11
US$299,191 		18,572 -5.9% 16.11 US$299,191
2025-11-17 2025-11-14 PlS Planned sale
3.2
Bensen Daniel

Chief Operating Officer

Officer
110,228 -25.8%
16.02
US$1,765,489 		110,228 -25.8% 16.02 US$1,765,489
2025-11-14 2025-11-14 PrS Proposed sale
3.2
Daniel Bensen

Officer

Officer
86,339
15.98
US$1,380,000 		86,339 15.98 US$1,380,000
2025-11-17 2025-11-13 PlS Planned sale
3.2
Bensen Daniel

Chief Operating Officer

Officer
1,111 -0.3%
16.00
US$17,780 		1,111 -0.3% 16.00 US$17,780
2025-11-13 2025-11-13 PrS Proposed sale
3.2
Daniel Bensen

Officer

Officer
25,000
16.00
US$400,000 		25,000 16.00 US$400,000
2025-06-20 2025-06-18 S Sale
1.1
KAPLAN GILLA
Non-Executive Director
9,568 -25.3%
9.78
US$93,596 		9,568 -25.3% 9.78 US$93,596
2025-06-18 2025-06-18 PrS Proposed sale
1.1
GILLA KAPLAN

Director

Non-Executive Director
9,568
9.78
US$93,596 		9,568 9.78 US$93,596
2025-06-20 2025-06-17 S Sale
1.1
KAPLAN GILLA
Non-Executive Director
10 -0.0%
10.35
US$104 		10 -0.0% 10.35 US$104
2025-06-17 2025-06-17 PrS Proposed sale
1.1
GILLA KAPLAN

Director

Non-Executive Director
10
10.35
US$104 		10 10.35 US$104
2025-06-16 2025-06-16 PrS Proposed sale
1.1
GILLA KAPLAN

Director

Non-Executive Director
6,814
10.38
US$70,726 		6,814 10.38 US$70,726
2025-06-16 2025-06-16 B Purchase
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
11,813 +0.1%
10.13
US$119,666 		11,813 +0.1% 10.13 US$119,666
2025-06-16 2025-06-16 S Sale
1.1
KAPLAN GILLA
Non-Executive Director
6,814 -15.3%
10.38
US$70,726 		6,814 -15.3% 10.38 US$70,726
2025-06-16 2025-06-13 B Purchase
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
120,167 +1.2%
10.20
US$1,225,703 		120,167 +1.2% 10.20 US$1,225,703
2025-06-16 2025-06-13 S Sale
1.1
KAPLAN GILLA
Non-Executive Director
15,000 -25.2%
10.31
US$154,582 		15,000 -25.2% 10.31 US$154,582
2025-06-13 2025-06-13 PrS Proposed sale
1.1
GILLA KAPLAN

Director

Non-Executive Director
15,000
10.31
US$154,582 		15,000 10.31 US$154,582
2025-06-16 2025-06-12 B Purchase
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
31,307 +0.3%
10.20
US$319,331 		31,307 +0.3% 10.20 US$319,331
2025-06-16 2025-06-12 S Sale
1.1
KAPLAN GILLA
Non-Executive Director
30,000 -33.5%
10.31
US$309,255 		30,000 -33.5% 10.31 US$309,255
2025-06-12 2025-06-12 PrS Proposed sale
1.1
GILLA KAPLAN

Director

Non-Executive Director
30,000
10.31
US$309,255 		30,000 10.31 US$309,255
2025-06-11 2025-06-09 B Purchase
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
186,850 +1.9%
10.19
US$1,904,002 		186,850 +1.9% 10.19 US$1,904,002
2025-06-06 2025-06-05 B Purchase
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
213,334 +2.2%
10.04
US$2,141,873 		213,334 +2.2% 10.04 US$2,141,873
2025-06-06 2025-06-04 B Purchase
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
997,864 +11.5%
9.63
US$9,609,430 		997,864 +11.5% 9.63 US$9,609,430
2025-02-07 2025-02-05 S Sale
4.0
Kjellson Nina S
Non-Executive Director
3,511 -0.8%
13.76
US$48,315 		3,511 -0.8% 13.76 US$48,315
2025-02-07 2025-02-05 S Sale
4.0
Kjellson Nina S
Non-Executive Director
1,890 -0.1%
13.76
US$26,008 		1,890 -0.1% 13.76 US$26,008
2025-02-05 2025-02-05 PrS Proposed sale
2.0
Canaan XI, LP

Director

Non-Executive Director
120,000
13.75
US$1,650,000 		120,000 13.75 US$1,650,000
2025-02-05 2025-02-05 PrS Proposed sale
Canaan 2020 Plus Co-Investment LP - Series 7

Director

Non-Executive Director
112,500
13.75
US$1,546,875 		112,500 13.75 US$1,546,875
2025-01-27 2025-01-23 S Sale
4.0
Kjellson Nina S
Non-Executive Director
4,825 -0.1%
16.26
US$78,466 		4,825 -0.1% 16.26 US$78,466
2025-01-22 2025-01-22 PrS Proposed sale
Subramony Siddarth

Director

Non-Executive Director
18,597
15.71
US$292,236 		18,597 15.71 US$292,236
2025-01-21 2025-01-21 S Sale
4.0
Kjellson Nina S
Non-Executive Director
3,993 -0.1%
16.36
US$65,336 		3,993 -0.1% 16.36 US$65,336
2025-01-21 2025-01-17 S Sale
4.0
Kjellson Nina S
Non-Executive Director
461 -0.1%
16.40
US$7,560 		461 -0.1% 16.40 US$7,560
2025-01-21 2025-01-17 S Sale
4.0
Kjellson Nina S
Non-Executive Director
12,808 -0.3%
16.40
US$210,052 		12,808 -0.3% 16.40 US$210,052
2025-01-21 2025-01-16 S Sale
4.0
Kjellson Nina S
Non-Executive Director
835 -0.2%
16.29
US$13,600 		835 -0.2% 16.29 US$13,600
2025-01-21 2025-01-16 S Sale
4.0
Kjellson Nina S
Non-Executive Director
6,944 -0.2%
16.29
US$113,097 		6,944 -0.2% 16.29 US$113,097
2024-12-09 2024-12-09 PrS Proposed sale
Tada Hiroomi

Officer

Officer
10,000
15.90
US$159,000 		10,000 15.90 US$159,000
2024-12-05 2024-12-05 PrS Proposed sale
Tada Hiroomi

Officer

Officer
5,000
15.00
US$75,000 		5,000 15.00 US$75,000
2024-12-02 2024-12-02 PrS Proposed sale
Tada Hiroomi

Officer

Officer
5,000
16.00
US$80,000 		5,000 16.00 US$80,000
2024-11-26 2024-11-25 S Sale
4.0
Kjellson Nina S
Non-Executive Director
566 -0.1%
16.84
US$9,531 		566 -0.1% 16.84 US$9,531
2024-11-26 2024-11-25 S Sale
4.0
Kjellson Nina S
Non-Executive Director
4,706 -0.1%
16.84
US$79,242 		4,706 -0.1% 16.84 US$79,242
2024-11-20 2024-11-20 PrS Proposed sale
Tada Hiroomi

Officer

Officer
10,000
15.47
US$154,700 		10,000 15.47 US$154,700
2024-11-14 2024-11-14 PrS Proposed sale
Tada Hiroomi

Officer

Officer
10,107
15.94
US$161,106 		10,107 15.94 US$161,106
2024-11-13 2024-11-08 B Purchase
2.9
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director Large shareholder
1,220,681 +16.3%
16.25
US$19,836,066 		1,220,681 +16.3% 16.25 US$19,836,066
2024-11-08 2024-11-07 S Sale
4.0
Kjellson Nina S
Non-Executive Director
2,371 -0.5%
17.32
US$41,061 		2,371 -0.5% 17.32 US$41,061
2024-11-08 2024-11-07 S Sale
4.0
Kjellson Nina S
Non-Executive Director
19,720 -0.5%
17.32
US$341,513 		19,720 -0.5% 17.32 US$341,513
2024-11-08 2024-11-06 S Sale
4.0
Kjellson Nina S
Non-Executive Director
5,635 -1.2%
17.18
US$96,784 		5,635 -1.2% 17.18 US$96,784
2024-11-08 2024-11-06 S Sale
4.0
Kjellson Nina S
Non-Executive Director
46,856 -1.2%
17.18
US$804,775 		46,856 -1.2% 17.18 US$804,775
2024-11-06 2024-11-05 S Sale
4.0
Kjellson Nina S
Non-Executive Director
1,126 -0.2%
16.77
US$18,881 		1,126 -0.2% 16.77 US$18,881
2024-11-06 2024-11-05 S Sale
4.0
Kjellson Nina S
Non-Executive Director
9,367 -0.2%
16.77
US$157,069 		9,367 -0.2% 16.77 US$157,069
2024-11-06 2024-11-04 S Sale
4.0
Kjellson Nina S
Non-Executive Director
116 -0.0%
17.01
US$1,973 		116 -0.0% 17.01 US$1,973
2024-11-06 2024-11-04 S Sale
4.0
Kjellson Nina S
Non-Executive Director
960 -0.0%
17.01
US$16,326 		960 -0.0% 17.01 US$16,326
2024-11-01 2024-11-01 S Sale
4.0
Kjellson Nina S
Non-Executive Director
73 -0.0%
17.16
US$1,253 		73 -0.0% 17.16 US$1,253
2024-11-01 2024-11-01 S Sale
4.0
Kjellson Nina S
Non-Executive Director
2,878 -0.6%
16.54
US$47,615 		2,878 -0.6% 16.54 US$47,615
2024-11-01 2024-11-01 S Sale
4.0
Kjellson Nina S
Non-Executive Director
604 -0.0%
17.16
US$10,364 		604 -0.0% 17.16 US$10,364
2024-11-01 2024-11-01 S Sale
4.0
Kjellson Nina S
Non-Executive Director
23,938 -0.6%
16.54
US$396,040 		23,938 -0.6% 16.54 US$396,040
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