|
2026-03-31 |
2026-03-31 |
S
Sale
|
Non-Executive Director
|
61,192
+12.2%
34.80
US$1,042,476
|
61,192
+12.2%
|
34.80
|
US$1,042,476
|
|
|
2026-03-31 |
2026-03-31 |
PrS
Proposed sale
|
Director
Non-Executive Director
|
80,323
219.00
US$171,725
|
80,323
|
219.00
|
US$171,725
|
|
|
2026-01-22 |
2026-01-22 |
PrS
Proposed sale
|
Director
Non-Executive Director
|
5,918
36.72
US$24,498
|
5,918
|
36.72
|
US$24,498
|
|
|
2026-01-22 |
2026-01-22 |
S
Sale
|
Non-Executive Director
|
3,500,000
-38.9%
36.40
US$127,400,000
|
3,500,000
-38.9%
|
36.40
|
US$127,400,000
|
|
|
2025-12-30 |
2025-12-26 |
S
Sale
|
Chief Financial Officer
Officer
|
77,000
-36.9%
38.68
US$2,978,360
|
77,000
-36.9%
|
38.68
|
US$2,978,360
|
|
|
2025-12-30 |
2025-12-26 |
S
Sale
|
Chief Medical Officer
Officer
|
82,642
-38.2%
38.70
US$3,198,245
|
82,642
-38.2%
|
38.70
|
US$3,198,245
|
|
|
2025-12-30 |
2025-12-26 |
S
Sale
|
Chief Scientific Officer
Officer
|
90,000
-39.1%
38.74
US$3,486,600
|
90,000
-39.1%
|
38.74
|
US$3,486,600
|
|
|
2025-12-30 |
2025-12-26 |
S
Sale
|
Chief Legal Officer
Officer
|
65,000
-37.3%
38.70
US$2,515,500
|
65,000
-37.3%
|
38.70
|
US$2,515,500
|
|
|
2025-12-29 |
2025-12-26 |
PrS
Proposed sale
|
Officer
Officer
|
82,642
38.70
US$3,198,435
|
82,642
|
38.70
|
US$3,198,435
|
|
|
2025-12-29 |
2025-12-26 |
PrS
Proposed sale
|
Officer
Officer
|
90,000
38.74
US$3,486,276
|
90,000
|
38.74
|
US$3,486,276
|
|
|
2025-12-29 |
2025-12-26 |
PrS
Proposed sale
|
Officer
Officer
|
77,000
38.68
US$2,978,322
|
77,000
|
38.68
|
US$2,978,322
|
|
|
2025-12-29 |
2025-12-26 |
PrS
Proposed sale
|
Officer
Officer
|
65,000
38.70
US$2,515,175
|
65,000
|
38.70
|
US$2,515,175
|
|
|
2025-07-14 |
2025-07-10 |
B
Purchase
|
Non-Executive Director
|
2,777,777
+44.6%
9.00
US$24,999,993
|
2,777,777
+44.6%
|
9.00
|
US$24,999,993
|
|
|
2025-01-15 |
2025-01-14 |
PP
Planned purchase
|
Chief Commercial Officer
Officer
|
43,750
+2085.3%
7.60
US$332,412
|
43,750
+2085.3%
|
7.60
|
US$332,412
|
|
|
2023-06-13 |
2023-06-09 |
B
Purchase
|
Large shareholder
|
800,000
+32.4%
12.00
US$9,600,000
|
800,000
+32.4%
|
12.00
|
US$9,600,000
|
|
|
2022-06-21 |
2022-06-16 |
B
Purchase
|
Large shareholder
|
1,200,000
+94.3%
8.25
US$9,900,000
|
1,200,000
+94.3%
|
8.25
|
US$9,900,000
|
|
|
2021-04-28 |
2021-04-26 |
S
Sale
|
Chief Financial Officer
Officer
|
17,813
-82.3%
8.86
US$157,823
|
17,813
-82.3%
|
8.86
|
US$157,823
|
|
|
2020-08-18 |
2020-08-18 |
B
Purchase
|
Large shareholder
|
101,000
+2.4%
2.62
US$264,620
|
101,000
+2.4%
|
2.62
|
US$264,620
|
|
|
2020-08-18 |
2020-08-17 |
B
Purchase
|
Large shareholder
|
250,000
+6.2%
2.57
US$642,500
|
250,000
+6.2%
|
2.57
|
US$642,500
|
|
|
2020-08-18 |
2020-08-14 |
B
Purchase
|
Large shareholder
|
100,000
+2.6%
2.30
US$230,000
|
100,000
+2.6%
|
2.30
|
US$230,000
|
|
|
2020-10-08 |
2020-05-12 |
S
Sale
|
Large shareholder
|
98,200
-3.1%
0.46
US$45,545
|
98,200
-3.1%
|
0.46
|
US$45,545
|
|
|
2020-10-08 |
2020-05-11 |
S
Sale
|
Large shareholder
|
77,719
-2.4%
0.45
US$35,160
|
77,719
-2.4%
|
0.45
|
US$35,160
|
|
|
2020-10-08 |
2020-05-11 |
S
Sale
|
Large shareholder
|
22,281
-0.7%
0.46
US$10,336
|
22,281
-0.7%
|
0.46
|
US$10,336
|
|
|
2020-10-08 |
2020-05-08 |
S
Sale
|
Large shareholder
|
100,000
-2.9%
0.46
US$46,390
|
100,000
-2.9%
|
0.46
|
US$46,390
|
|
|
2020-10-08 |
2020-05-07 |
S
Sale
|
Large shareholder
|
100,000
-2.9%
0.41
US$41,430
|
100,000
-2.9%
|
0.41
|
US$41,430
|
|
|
2020-10-08 |
2020-05-06 |
S
Sale
|
Large shareholder
|
1,800
-0.1%
0.40
US$722
|
1,800
-0.1%
|
0.40
|
US$722
|
|
|
2020-10-08 |
2020-05-05 |
S
Sale
|
Large shareholder
|
135,484
-3.7%
0.40
US$54,437
|
135,484
-3.7%
|
0.40
|
US$54,437
|
|
|
2020-10-08 |
2020-05-04 |
S
Sale
|
Large shareholder
|
4,795
-0.1%
0.40
US$1,921
|
4,795
-0.1%
|
0.40
|
US$1,921
|
|
|
2020-10-08 |
2020-05-01 |
S
Sale
|
Large shareholder
|
800
-0.0%
0.41
US$328
|
800
-0.0%
|
0.41
|
US$328
|
|
|
2020-10-08 |
2020-04-30 |
S
Sale
|
Large shareholder
|
75,994
-2.0%
0.40
US$30,557
|
75,994
-2.0%
|
0.40
|
US$30,557
|
|
|
2020-10-08 |
2020-04-29 |
S
Sale
|
Large shareholder
|
382,927
-9.4%
0.41
US$155,507
|
382,927
-9.4%
|
0.41
|
US$155,507
|
|
|
2020-10-08 |
2020-04-28 |
S
Sale
|
Large shareholder
|
15,048
-0.4%
0.41
US$6,168
|
15,048
-0.4%
|
0.41
|
US$6,168
|
|
|
2020-10-08 |
2020-04-27 |
S
Sale
|
Large shareholder
|
242,579
-5.6%
0.40
US$97,808
|
242,579
-5.6%
|
0.40
|
US$97,808
|
|
|
2020-10-08 |
2020-04-20 |
S
Sale
|
Large shareholder
|
12,606
-0.3%
0.40
US$5,050
|
12,606
-0.3%
|
0.40
|
US$5,050
|
|
|
2020-10-08 |
2020-04-17 |
S
Sale
|
Large shareholder
|
65,540
-1.5%
0.39
US$25,574
|
65,540
-1.5%
|
0.39
|
US$25,574
|
|
|
2020-10-08 |
2020-04-16 |
S
Sale
|
Large shareholder
|
600
-0.0%
0.38
US$230
|
600
-0.0%
|
0.38
|
US$230
|
|
|
2020-10-08 |
2020-04-15 |
S
Sale
|
Large shareholder
|
82,782
-1.8%
0.38
US$31,797
|
82,782
-1.8%
|
0.38
|
US$31,797
|
|
|
2020-10-08 |
2020-04-14 |
S
Sale
|
Large shareholder
|
44,006
-1.0%
0.40
US$17,602
|
44,006
-1.0%
|
0.40
|
US$17,602
|
|
|
2020-10-08 |
2020-04-14 |
S
Sale
|
Large shareholder
|
54,967
-1.2%
0.40
US$22,119
|
54,967
-1.2%
|
0.40
|
US$22,119
|
|
|
2020-10-08 |
2020-04-09 |
S
Sale
|
Large shareholder
|
420,292
-8.3%
0.33
US$138,150
|
420,292
-8.3%
|
0.33
|
US$138,150
|
|
|
2020-10-08 |
2020-04-08 |
S
Sale
|
Large shareholder
|
100
-0.0%
0.35
US$35
|
100
-0.0%
|
0.35
|
US$35
|
|
|
2020-10-08 |
2020-04-07 |
S
Sale
|
Large shareholder
|
11,400
-0.2%
0.35
US$3,990
|
11,400
-0.2%
|
0.35
|
US$3,990
|
|
|
2020-10-08 |
2020-04-06 |
S
Sale
|
Large shareholder
|
50,080
-1.0%
0.35
US$17,528
|
50,080
-1.0%
|
0.35
|
US$17,528
|
|
|
2019-03-26 |
2019-03-25 |
PlS
Planned sale
|
Chief Scientific Officer
|
11,485
-100.0%
4.12
US$47,334
|
11,485
-100.0%
|
4.12
|
US$47,334
|
|
|
2019-02-26 |
2019-02-25 |
PlS
Planned sale
|
Chief Scientific Officer
Officer
|
11,485
-100.0%
4.25
US$48,853
|
11,485
-100.0%
|
4.25
|
US$48,853
|
|
|
2018-12-28 |
2018-12-26 |
PlS
Planned sale
|
Ettenberg Seth
Chief Scientific Officer
Officer
|
11,485
-100.0%
4.05
US$46,487
|
11,485
-100.0%
|
4.05
|
US$46,487
|
|
|
2018-11-26 |
2018-11-26 |
PlS
Planned sale
|
Ettenberg Seth
Chief Scientific Officer
Officer
|
11,485
-100.0%
7.00
US$80,444
|
11,485
-100.0%
|
7.00
|
US$80,444
|
|
|
2018-10-29 |
2018-10-25 |
PlS
Planned sale
|
Ettenberg Seth
Chief Scientific Officer
Officer
|
11,485
-100.0%
8.46
US$97,201
|
11,485
-100.0%
|
8.46
|
US$97,201
|
|
|
2018-09-26 |
2018-09-25 |
PlS
Planned sale
|
Ettenberg Seth
Chief Scientific Officer
Officer
|
11,485
-100.0%
12.47
US$143,181
|
11,485
-100.0%
|
12.47
|
US$143,181
|
|
|
2018-04-05 |
2018-04-03 |
B
Purchase
|
FMR LLC
See Remark 1
|
94,052
+26.3%
12.00
US$1,128,624
|
94,052
+26.3%
|
12.00
|
US$1,128,624
|
|
|
2018-04-03 |
2018-04-03 |
B
Purchase
|
Booth Bruce
Non-Executive Director
|
94,052
+2.9%
12.00
US$1,128,624
|
94,052
+2.9%
|
12.00
|
US$1,128,624
|
|
|
2018-04-03 |
2018-04-03 |
B
Purchase
|
Atlas Venture Fund IX, L.P.
Large shareholder
|
94,052
+2.9%
12.00
US$1,128,624
|
94,052
+2.9%
|
12.00
|
US$1,128,624
|
|
|
2018-04-03 |
2018-04-03 |
B
Purchase
|
Ratcliffe Liam
Non-Executive Director
|
275,000
+44.2%
12.00
US$3,300,000
|
275,000
+44.2%
|
12.00
|
US$3,300,000
|
|
|
2018-04-03 |
2018-04-03 |
B
Purchase
|
Ratcliffe Liam
Non-Executive Director
|
275,000
+44.2%
12.00
US$3,300,000
|
275,000
+44.2%
|
12.00
|
US$3,300,000
|
|