United States Pharmaceuticals

Talphera Inc (TLPH)

Track

Talphera Inc. has seen no insider trading activity within the last three months. The most recent recorded transaction occurred on March 13, 2026, involving a planned purchase by the Chief Executive Officer. Prior to this, several executives executed buy orders throughout February 2026, reflecting historical patterns of leadership participation in equity acquisition.
Ticker: TLPH Exchange: NAS
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
2.5
Angotti Vincent J. CHIEF EXECUTIVE OFFICER Executive Director
Transaction date
Planned purchase
Price
311.23
Quantity 76,294 -3.1%
Value US$3,132,576
2.5
Angotti Vincent J. CHIEF EXECUTIVE OFFICER Executive Director
Transaction date
Purchase
Price
189.32
Quantity 29,320 -11.1%
Value US$3,155,556
2.5
Aslam Shakil Chief Medical Officer Officer
Transaction date
Purchase
Price
228.33
Quantity 95,758 -43.2%
Value US$236,422
2.3
Dasu Badri N Chief Engineering Officer Officer
Transaction date
Purchase
Price
0.81
Quantity 35,000 +84.9%
Value US$28,430
2.9
ASADORIAN RAFFI Chief Financial Officer Officer
Transaction date
Purchase
Price
0.81
Quantity 45,000 +97.3%
Value US$36,554
2.5
Angotti Vincent J. CHIEF EXECUTIVE OFFICER Executive Director
Transaction date
Purchase
Price
0.59
Quantity 213,310 +112.0%
Value US$125,000
2.5
Angotti Vincent J. CHIEF EXECUTIVE OFFICER Executive Director
Transaction date
Purchase
Price
0.64
Quantity 5,000 +2.5%
Value US$3,200
2.9
ASADORIAN RAFFI Officer Officer
Transaction date
Proposed sale
Price
0.69
Quantity 155
Value US$107
2.9
ASADORIAN RAFFI Chief Financial Officer Officer
Transaction date
Sale
Price
0.77
Quantity 155 -0.4%
Value US$119
2.5
Angotti Vincent J. CHIEF EXECUTIVE OFFICER Executive Director
Transaction date
Purchase
Price
0.73
Quantity 5,000 +2.5%
Value US$3,650
2.5
Angotti Vincent J. CHIEF EXECUTIVE OFFICER Executive Director
Transaction date
Planned purchase
Price
1.05
Quantity 7,260 +3.8%
Value US$7,598
2.5
Aslam Shakil Chief Medical Officer Officer
Transaction date
Purchase
Price
1.07
Quantity 5,000 +15.3%
Value US$5,357
2.5
Angotti Vincent J. CHIEF EXECUTIVE OFFICER Executive Director
Transaction date
Purchase
Price
1.08
Quantity 1,304 +0.7%
Value US$1,404
2.5
Aslam Shakil Chief Medical Officer Officer
Transaction date
Purchase
Price
0.98
Quantity 695 +2.2%
Value US$681
2.5
Angotti Vincent J. CHIEF EXECUTIVE OFFICER Executive Director
Transaction date
Purchase
Price
0.97
Quantity 4,570 +2.6%
Value US$4,438
2.5
Angotti Vincent J. CHIEF EXECUTIVE OFFICER Executive Director
Transaction date
Purchase
Price
0.97
Quantity 4,126 +2.4%
Value US$4,013
2.5
Angotti Vincent J. Chief Executive Officer Executive Director
Transaction date
Purchase
Price
0.73
Quantity 10,000 +10.9%
Value US$7,268
2.5
Angotti Vincent J. Chief Executive Officer Executive Director
Transaction date
Planned purchase
Price
0.80
Quantity 10,000 +12.2%
Value US$7,950
Palmer Pamela P Chief Medical Officer Executive Director
Transaction date
Planned sale
Price
1.09
Quantity 7,442 -19.5%
Value US$8,104
Palmer Pamela P Chief Medical Officer Executive Director
Transaction date
Planned sale
Price
1.17
Quantity 9,514 -19.9%
Value US$11,131
Palmer Pamela P Officer; Director Executive Director
Transaction date
Proposed sale
Price
1.17
Quantity 9,514
Value US$11,178
2.5
Angotti Vincent J. Chief Executive Officer Executive Director
Transaction date
Purchase
Price
0.22
Quantity 46,400 +4.8%
Value US$10,333
2.5
Angotti Vincent J. Chief Executive Officer Executive Director
Transaction date
Planned purchase
Price
1.33
Quantity 7,547 +1.6%
Value US$10,035
EDWARDS MARK G Non-Executive Director
Transaction date
Purchase
Price
1.78
Quantity 25,000 +11.4%
Value US$44,575
Angotti Vincent J. Chief Executive Officer Executive Director
Transaction date
Purchase
Price
1.79
Quantity 8,379 +3.1%
Value US$14,973
EDWARDS MARK G Non-Executive Director
Transaction date
Purchase
Price
2.17
Quantity 5,000 +2.3%
Value US$10,850
EDWARDS MARK G Non-Executive Director
Transaction date
Purchase
Price
2.20
Quantity 10,000 +4.9%
Value US$21,956
2.5
Angotti Vincent J. Chief Executive Officer Executive Director
Transaction date
Purchase
Price
2.31
Quantity 5,000 +1.9%
Value US$11,550
1.6
EDWARDS MARK G
Transaction date
Purchase
Price
2.99
Quantity 19,000 +10.5%
Value US$56,890
Palmer Pamela P Chief Medical Officer Executive Director
Transaction date
Planned purchase
Price
2.81
Quantity 840 +0.2%
Value US$2,360
Hamel Lawrence G Chief Development Officer
Transaction date
Planned purchase
Price
2.81
Quantity 3,682 +5.0%
Value US$10,346
2.9
ASADORIAN RAFFI Chief Financial Officer
Transaction date
Planned purchase
Price
2.81
Quantity 3,647 +3.0%
Value US$10,248
2.5
Angotti Vincent J. Chief Executive Officer Executive Director
Transaction date
Planned purchase
Price
2.81
Quantity 3,234 +1.3%
Value US$9,088
2.3
Dasu Badri N Chief Engineering Officer
Transaction date
Planned purchase
Price
2.81
Quantity 9,206 +8.8%
Value US$25,869
ASADORIAN RAFFI Chief Financial Officer Officer
Transaction date
Purchase
Price
2.78
Quantity 5,000 +10.6%
Value US$13,883
Angotti Vincent J. Chief Executive Officer Executive Director
Transaction date
Purchase
Price
2.78
Quantity 3,610 +7.1%
Value US$10,024
Angotti Vincent J. Chief Executive Officer Executive Director
Transaction date
Purchase
Price
2.99
Quantity 10,000 +24.4%
Value US$29,890
Palmer Pamela P Chief Medical Officer Executive Director
Transaction date
Purchase
Price
3.07
Quantity 16,000 +3.5%
Value US$49,120
EDWARDS MARK G Non-Executive Director
Transaction date
Purchase
Price
2.82
Quantity 20,700 +12.9%
Value US$58,376
ASADORIAN RAFFI Chief Financial Officer Officer
Transaction date
Purchase
Price
3.13
Quantity 5,000 +11.9%
Value US$15,646
Hamel Lawrence G Chief Development Officer Officer
Transaction date
Planned sale
Price
5.00
Quantity 5,216 -14.9%
Value US$26,080
Dasu Badri N Chief Engineering Officer Officer
Transaction date
Planned sale
Price
5.00
Quantity 28,351 -34.4%
Value US$141,755
Hamel Lawrence G Chief Development Officer Officer
Transaction date
Planned sale
Price
4.50
Quantity 6,953 -16.6%
Value US$31,288
EDWARDS MARK G Non-Executive Director
Transaction date
Purchase
Price
2.84
Quantity 5,300 +3.4%
Value US$15,063
Angotti Vincent J. Chief Executive Officer Executive Director
Transaction date
Planned purchase
Price
2.90
Quantity 10,000 +40.0%
Value US$28,950
ASADORIAN RAFFI Chief Financial Officer Officer
Transaction date
Purchase
Price
2.75
Quantity 5,000 +18.5%
Value US$13,725
Palmer Pamela P Chief Medical Officer Officer
Transaction date
Planned purchase
Price
2.75
Quantity 37,000 +8.8%
Value US$101,750
EDWARDS MARK G
Transaction date
Purchase
Price
3.35
Quantity 4,700 +3.1%
Value US$15,745
EDWARDS MARK G
Transaction date
Purchase
Price
3.30
Quantity 300 +0.2%
Value US$990
ASADORIAN RAFFI Chief Financial Officer Officer
Transaction date
Planned purchase
Price
3.18
Quantity 5,000 +22.7%
Value US$15,922
EDWARDS MARK G
Transaction date
Purchase
Price
1.90
Quantity 30,000 +25.0%
Value US$56,970
ASADORIAN RAFFI Chief Financial Officer
Transaction date
Purchase
Price
1.94
Quantity 5,000 +71.4%
Value US$9,710
Hamel Lawrence G Chief Development Officer
Transaction date
Planned sale
Price
5.29
Quantity 10,161 -19.5%
Value US$53,752
Hamel Lawrence G Chief Development Officer
Transaction date
Planned sale
Price
0.00
Quantity 13,827
Value US$0
ASADORIAN RAFFI Chief Financial Officer
Transaction date
Purchase
Price
3.24
Quantity 7,000 +inf%
Value US$22,705
EDWARDS MARK G
Transaction date
Purchase
Price
3.03
Quantity 4,800 +4.2%
Value US$14,520
Angotti Vincent J. Chief Executive Officer Executive Director
Transaction date
Purchase
Price
3.00
Quantity 15,000 +inf%
Value US$45,000
EDWARDS MARK G
Transaction date
Purchase
Price
2.90
Quantity 200 +0.2%
Value US$580
Palmer Pamela P Chief Medical Officer Executive Director
Transaction date
Planned purchase
Price
2.95
Quantity 10,000 +2.5%
Value US$29,487
PERCEPTIVE ADVISORS LLC Large shareholder
Transaction date
Sale
Price
2.40
Quantity 875,000 -16.2%
Value US$2,100,000
PERCEPTIVE ADVISORS LLC Large shareholder
Transaction date
Sale
Price
3.88
Quantity 97,200 -1.8%
Value US$377,117
PERCEPTIVE ADVISORS LLC Large shareholder
Transaction date
Sale
Price
3.96
Quantity 119,300 -2.1%
Value US$472,380
PERCEPTIVE ADVISORS LLC Large shareholder
Transaction date
Sale
Price
3.63
Quantity 115,923 -2.0%
Value US$420,511
PERCEPTIVE ADVISORS LLC Large shareholder
Transaction date
Sale
Price
3.73
Quantity 276,927 -4.6%
Value US$1,032,301
Rosen Howard B CEO Executive Director
Transaction date
Purchase
Price
3.26
Quantity 10,206 +25.6%
Value US$33,272
EDWARDS MARK G Non-Executive Director
Transaction date
Purchase
Price
3.05
Quantity 5,000 +4.5%
Value US$15,250
EDWARDS MARK G Non-Executive Director
Transaction date
Purchase
Price
3.15
Quantity 5,000 +4.8%
Value US$15,750
EDWARDS MARK G Non-Executive Director
Transaction date
Purchase
Price
3.25
Quantity 5,000 +5.0%
Value US$16,250
PERCEPTIVE ADVISORS LLC Large shareholder
Transaction date
Sale
Price
5.35
Quantity 42,300 -0.7%
Value US$226,132
PERCEPTIVE ADVISORS LLC Large shareholder
Transaction date
Sale
Price
5.36
Quantity 133,900 -2.2%
Value US$717,409
PERCEPTIVE ADVISORS LLC Large shareholder
Transaction date
Sale
Price
4.47
Quantity 17,100 -0.3%
Value US$76,365
PERCEPTIVE ADVISORS LLC Large shareholder
Transaction date
Sale
Price
4.62
Quantity 75,000 -1.2%
Value US$346,260
PERCEPTIVE ADVISORS LLC Large shareholder
Transaction date
Sale
Price
4.18
Quantity 310,000 -4.7%
Value US$1,294,777
EDWARDS MARK G Non-Executive Director
Transaction date
Purchase
Price
3.13
Quantity 40,000 +66.7%
Value US$125,116
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-03-25 2026-03-13 PP Planned purchase
2.5
Angotti Vincent J.

CHIEF EXECUTIVE OFFICER

Executive Director
76,294 -3.1%
311.23
US$3,132,576 		76,294 -3.1% 311.23 US$3,132,576
2026-02-20 2026-02-12 B Purchase
2.5
Angotti Vincent J.

CHIEF EXECUTIVE OFFICER

Executive Director
29,320 -11.1%
189.32
US$3,155,556 		29,320 -11.1% 189.32 US$3,155,556
2026-02-20 2026-02-12 B Purchase
2.5
Aslam Shakil

Chief Medical Officer

Officer
95,758 -43.2%
228.33
US$236,422 		95,758 -43.2% 228.33 US$236,422
2026-02-20 2026-02-12 B Purchase
2.3
Dasu Badri N

Chief Engineering Officer

Officer
35,000 +84.9%
0.81
US$28,430 		35,000 +84.9% 0.81 US$28,430
2026-02-20 2026-02-12 B Purchase
2.9
ASADORIAN RAFFI

Chief Financial Officer

Officer
45,000 +97.3%
0.81
US$36,554 		45,000 +97.3% 0.81 US$36,554
2025-04-03 2025-04-02 B Purchase
2.5
Angotti Vincent J.

CHIEF EXECUTIVE OFFICER

Executive Director
213,310 +112.0%
0.59
US$125,000 		213,310 +112.0% 0.59 US$125,000
2024-12-06 2024-12-05 B Purchase
2.5
Angotti Vincent J.

CHIEF EXECUTIVE OFFICER

Executive Director
5,000 +2.5%
0.64
US$3,200 		5,000 +2.5% 0.64 US$3,200
2024-12-02 2024-12-02 PrS Proposed sale
2.9
ASADORIAN RAFFI

Officer

Officer
155
0.69
US$107 		155 0.69 US$107
2024-12-02 2024-12-02 S Sale
2.9
ASADORIAN RAFFI

Chief Financial Officer

Officer
155 -0.4%
0.77
US$119 		155 -0.4% 0.77 US$119
2024-12-02 2024-11-27 B Purchase
2.5
Angotti Vincent J.

CHIEF EXECUTIVE OFFICER

Executive Director
5,000 +2.5%
0.73
US$3,650 		5,000 +2.5% 0.73 US$3,650
2024-09-03 2024-08-30 PP Planned purchase
2.5
Angotti Vincent J.

CHIEF EXECUTIVE OFFICER

Executive Director
7,260 +3.8%
1.05
US$7,598 		7,260 +3.8% 1.05 US$7,598
2025-02-26 2024-06-14 B Purchase
2.5
Aslam Shakil

Chief Medical Officer

Officer
5,000 +15.3%
1.07
US$5,357 		5,000 +15.3% 1.07 US$5,357
2024-06-14 2024-06-14 B Purchase
2.5
Angotti Vincent J.

CHIEF EXECUTIVE OFFICER

Executive Director
1,304 +0.7%
1.08
US$1,404 		1,304 +0.7% 1.08 US$1,404
2025-02-26 2024-06-13 B Purchase
2.5
Aslam Shakil

Chief Medical Officer

Officer
695 +2.2%
0.98
US$681 		695 +2.2% 0.98 US$681
2024-06-14 2024-06-13 B Purchase
2.5
Angotti Vincent J.

CHIEF EXECUTIVE OFFICER

Executive Director
4,570 +2.6%
0.97
US$4,438 		4,570 +2.6% 0.97 US$4,438
2024-06-14 2024-06-12 B Purchase
2.5
Angotti Vincent J.

CHIEF EXECUTIVE OFFICER

Executive Director
4,126 +2.4%
0.97
US$4,013 		4,126 +2.4% 0.97 US$4,013
2023-12-14 2023-12-13 B Purchase
2.5
Angotti Vincent J.

Chief Executive Officer

Executive Director
10,000 +10.9%
0.73
US$7,268 		10,000 +10.9% 0.73 US$7,268
2023-09-11 2023-09-11 PP Planned purchase
2.5
Angotti Vincent J.

Chief Executive Officer

Executive Director
10,000 +12.2%
0.80
US$7,950 		10,000 +12.2% 0.80 US$7,950
2023-08-25 2023-08-25 PrS Proposed sale
Pamela Palmer, Trustee of the Pamela P Palmer Revocable Trust DTD 10/17/2014

Officer

Officer
7,450
1.10
US$8,195 		7,450 1.10 US$8,195
2023-08-25 2023-08-25 PlS Planned sale
Palmer Pamela P

Chief Medical Officer

Executive Director
7,442 -19.5%
1.09
US$8,104 		7,442 -19.5% 1.09 US$8,104
2023-08-25 2023-08-24 PlS Planned sale
Palmer Pamela P

Chief Medical Officer

Executive Director
9,514 -19.9%
1.17
US$11,131 		9,514 -19.9% 1.17 US$11,131
2023-08-24 2023-08-24 PrS Proposed sale
Palmer Pamela P

Officer; Director

Executive Director
9,514
1.17
US$11,178 		9,514 1.17 US$11,178
2022-06-08 2022-06-07 B Purchase
2.5
Angotti Vincent J.

Chief Executive Officer

Executive Director
46,400 +4.8%
0.22
US$10,333 		46,400 +4.8% 0.22 US$10,333
2020-06-15 2020-06-15 PP Planned purchase
2.5
Angotti Vincent J.

Chief Executive Officer

Executive Director
7,547 +1.6%
1.33
US$10,035 		7,547 +1.6% 1.33 US$10,035
2019-11-12 2019-11-12 B Purchase EDWARDS MARK G Non-Executive Director
25,000 +11.4%
1.78
US$44,575 		25,000 +11.4% 1.78 US$44,575
2019-11-12 2019-11-11 B Purchase Angotti Vincent J.

Chief Executive Officer

Executive Director
8,379 +3.1%
1.79
US$14,973 		8,379 +3.1% 1.79 US$14,973
2019-08-26 2019-08-26 B Purchase EDWARDS MARK G Non-Executive Director
5,000 +2.3%
2.17
US$10,850 		5,000 +2.3% 2.17 US$10,850
2019-08-26 2019-08-23 B Purchase EDWARDS MARK G Non-Executive Director
10,000 +4.9%
2.20
US$21,956 		10,000 +4.9% 2.20 US$21,956
2019-06-06 2019-06-05 B Purchase
2.5
Angotti Vincent J.

Chief Executive Officer

Executive Director
5,000 +1.9%
2.31
US$11,550 		5,000 +1.9% 2.31 US$11,550
2019-03-12 2019-03-12 B Purchase
1.6
EDWARDS MARK G
19,000 +10.5%
2.99
US$56,890 		19,000 +10.5% 2.99 US$56,890
2019-03-04 2019-02-28 PP Planned purchase
Palmer Pamela P

Chief Medical Officer

Executive Director
840 +0.2%
2.81
US$2,360 		840 +0.2% 2.81 US$2,360
2019-03-04 2019-02-28 PP Planned purchase
Hamel Lawrence G

Chief Development Officer
3,682 +5.0%
2.81
US$10,346 		3,682 +5.0% 2.81 US$10,346
2019-03-04 2019-02-28 PP Planned purchase
2.9
ASADORIAN RAFFI

Chief Financial Officer
3,647 +3.0%
2.81
US$10,248 		3,647 +3.0% 2.81 US$10,248
2019-03-04 2019-02-28 PP Planned purchase
2.5
Angotti Vincent J.

Chief Executive Officer

Executive Director
3,234 +1.3%
2.81
US$9,088 		3,234 +1.3% 2.81 US$9,088
2019-03-04 2019-02-28 PP Planned purchase
2.3
Dasu Badri N

Chief Engineering Officer
9,206 +8.8%
2.81
US$25,869 		9,206 +8.8% 2.81 US$25,869
2018-12-17 2018-12-14 B Purchase ASADORIAN RAFFI

Chief Financial Officer

Officer
5,000 +10.6%
2.78
US$13,883 		5,000 +10.6% 2.78 US$13,883
2018-12-17 2018-12-14 B Purchase Angotti Vincent J.

Chief Executive Officer

Executive Director
3,610 +7.1%
2.78
US$10,024 		3,610 +7.1% 2.78 US$10,024
2018-12-12 2018-12-12 B Purchase Angotti Vincent J.

Chief Executive Officer

Executive Director
10,000 +24.4%
2.99
US$29,890 		10,000 +24.4% 2.99 US$29,890
2018-11-19 2018-11-19 B Purchase Palmer Pamela P

Chief Medical Officer

Executive Director
16,000 +3.5%
3.07
US$49,120 		16,000 +3.5% 3.07 US$49,120
2018-11-15 2018-11-15 B Purchase EDWARDS MARK G Non-Executive Director
20,700 +12.9%
2.82
US$58,376 		20,700 +12.9% 2.82 US$58,376
2018-11-13 2018-11-13 B Purchase ASADORIAN RAFFI

Chief Financial Officer

Officer
5,000 +11.9%
3.13
US$15,646 		5,000 +11.9% 3.13 US$15,646
2018-10-16 2018-10-15 PlS Planned sale Hamel Lawrence G

Chief Development Officer

Officer
5,216 -14.9%
5.00
US$26,080 		5,216 -14.9% 5.00 US$26,080
2018-10-16 2018-10-15 PlS Planned sale Dasu Badri N

Chief Engineering Officer

Officer
28,351 -34.4%
5.00
US$141,755 		28,351 -34.4% 5.00 US$141,755
2018-09-26 2018-09-24 PlS Planned sale Hamel Lawrence G

Chief Development Officer

Officer
6,953 -16.6%
4.50
US$31,288 		6,953 -16.6% 4.50 US$31,288
2018-08-08 2018-08-07 B Purchase EDWARDS MARK G Non-Executive Director
5,300 +3.4%
2.84
US$15,063 		5,300 +3.4% 2.84 US$15,063
2018-08-07 2018-08-07 PP Planned purchase Angotti Vincent J.

Chief Executive Officer

Executive Director
10,000 +40.0%
2.90
US$28,950 		10,000 +40.0% 2.90 US$28,950
2018-08-06 2018-08-06 B Purchase ASADORIAN RAFFI

Chief Financial Officer

Officer
5,000 +18.5%
2.75
US$13,725 		5,000 +18.5% 2.75 US$13,725
2018-08-06 2018-08-06 PP Planned purchase Palmer Pamela P

Chief Medical Officer

Officer
37,000 +8.8%
2.75
US$101,750 		37,000 +8.8% 2.75 US$101,750
2018-06-05 2018-06-05 B Purchase EDWARDS MARK G
4,700 +3.1%
3.35
US$15,745 		4,700 +3.1% 3.35 US$15,745
2018-06-05 2018-06-01 B Purchase EDWARDS MARK G
300 +0.2%
3.30
US$990 		300 +0.2% 3.30 US$990
2018-05-29 2018-05-25 PP Planned purchase ASADORIAN RAFFI

Chief Financial Officer

Officer
5,000 +22.7%
3.18
US$15,922 		5,000 +22.7% 3.18 US$15,922
2017-11-15 2017-11-14 B Purchase EDWARDS MARK G
30,000 +25.0%
1.90
US$56,970 		30,000 +25.0% 1.90 US$56,970
2017-11-14 2017-11-13 B Purchase ASADORIAN RAFFI

Chief Financial Officer
5,000 +71.4%
1.94
US$9,710 		5,000 +71.4% 1.94 US$9,710
2017-10-03 2017-10-02 PlS Planned sale Hamel Lawrence G

Chief Development Officer
10,161 -19.5%
5.29
US$53,752 		10,161 -19.5% 5.29 US$53,752
2017-09-27 2017-09-25 PlS Planned sale Hamel Lawrence G

Chief Development Officer
13,827
0.00
US$0 		13,827 0.00 US$0
2017-09-11 2017-09-11 B Purchase ASADORIAN RAFFI

Chief Financial Officer
7,000 +inf%
3.24
US$22,705 		7,000 +inf% 3.24 US$22,705
2017-08-24 2017-08-24 B Purchase EDWARDS MARK G
4,800 +4.2%
3.03
US$14,520 		4,800 +4.2% 3.03 US$14,520
2017-08-24 2017-08-24 B Purchase Angotti Vincent J.

Chief Executive Officer

Executive Director
15,000 +inf%
3.00
US$45,000 		15,000 +inf% 3.00 US$45,000
2017-08-24 2017-08-22 B Purchase EDWARDS MARK G
200 +0.2%
2.90
US$580 		200 +0.2% 2.90 US$580
2017-08-22 2017-08-22 PP Planned purchase Palmer Pamela P

Chief Medical Officer

Executive Director
10,000 +2.5%
2.95
US$29,487 		10,000 +2.5% 2.95 US$29,487
2017-06-21 2017-06-19 S Sale PERCEPTIVE ADVISORS LLC Large shareholder
875,000 -16.2%
2.40
US$2,100,000 		875,000 -16.2% 2.40 US$2,100,000
2016-09-30 2016-09-29 S Sale PERCEPTIVE ADVISORS LLC Large shareholder
97,200 -1.8%
3.88
US$377,117 		97,200 -1.8% 3.88 US$377,117
2016-09-30 2016-09-28 S Sale PERCEPTIVE ADVISORS LLC Large shareholder
119,300 -2.1%
3.96
US$472,380 		119,300 -2.1% 3.96 US$472,380
2016-09-16 2016-09-15 S Sale PERCEPTIVE ADVISORS LLC Large shareholder
115,923 -2.0%
3.63
US$420,511 		115,923 -2.0% 3.63 US$420,511
2016-09-16 2016-09-15 S Sale PERCEPTIVE ADVISORS LLC Large shareholder
276,927 -4.6%
3.73
US$1,032,301 		276,927 -4.6% 3.73 US$1,032,301
2016-05-16 2016-05-13 B Purchase Rosen Howard B

CEO

Executive Director
10,206 +25.6%
3.26
US$33,272 		10,206 +25.6% 3.26 US$33,272
2016-05-12 2016-05-12 B Purchase EDWARDS MARK G Non-Executive Director
5,000 +4.5%
3.05
US$15,250 		5,000 +4.5% 3.05 US$15,250
2016-05-12 2016-05-11 B Purchase EDWARDS MARK G Non-Executive Director
5,000 +4.8%
3.15
US$15,750 		5,000 +4.8% 3.15 US$15,750
2016-05-12 2016-05-10 B Purchase EDWARDS MARK G Non-Executive Director
5,000 +5.0%
3.25
US$16,250 		5,000 +5.0% 3.25 US$16,250
2015-11-19 2015-11-18 S Sale PERCEPTIVE ADVISORS LLC Large shareholder
42,300 -0.7%
5.35
US$226,132 		42,300 -0.7% 5.35 US$226,132
2015-11-19 2015-11-17 S Sale PERCEPTIVE ADVISORS LLC Large shareholder
133,900 -2.2%
5.36
US$717,409 		133,900 -2.2% 5.36 US$717,409
2015-11-09 2015-11-06 S Sale PERCEPTIVE ADVISORS LLC Large shareholder
17,100 -0.3%
4.47
US$76,365 		17,100 -0.3% 4.47 US$76,365
2015-11-09 2015-11-05 S Sale PERCEPTIVE ADVISORS LLC Large shareholder
75,000 -1.2%
4.62
US$346,260 		75,000 -1.2% 4.62 US$346,260
2015-09-11 2015-09-09 S Sale PERCEPTIVE ADVISORS LLC Large shareholder
310,000 -4.7%
4.18
US$1,294,777 		310,000 -4.7% 4.18 US$1,294,777
2015-05-07 2015-05-07 B Purchase EDWARDS MARK G Non-Executive Director
40,000 +66.7%
3.13
US$125,116 		40,000 +66.7% 3.13 US$125,116
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