RA CAPITAL MANAGEMENT, LLC Large shareholder Transaction date 11 Dec 2018 Notification date 13 Dec 2018 Purchase Price 230.17 Quantity 5,298 -14.6% Value US$1,514,349 Comments Filing More details Fewer details
Kolchinsky Peter Non-Executive Director Large shareholder Transaction date 11 Dec 2018 Notification date 13 Dec 2018 Purchase Price 263.71 Quantity 90,248 -23.4% Value US$4,377,109 Comments Filing More details Fewer details
ORBIMED ADVISORS LLC Non-Executive Director Large shareholder Transaction date 11 Dec 2018 Notification date 13 Dec 2018 Purchase Price 256.02 Quantity 26,557 +7.8% Value US$3,974,782 Comments Filing More details Fewer details
Thompson Peter A. Non-Executive Director Large shareholder Transaction date 11 Dec 2018 Notification date 13 Dec 2018 Purchase Price 11.00 Quantity 1,363,636 +34.5% Value US$14,999,996 Comments Filing More details Fewer details
Reardon Tighe ·Acting Chief Financial Officer Officer Transaction date 11 Dec 2018 Notification date 13 Dec 2018 Purchase Price 11.00 Quantity 545,455 +48.0% Value US$6,000,005 Comments Filing More details Fewer details
Lichter Jay Non-Executive Director Large shareholder Transaction date 11 Dec 2018 Notification date 13 Dec 2018 Purchase Price 11.00 Quantity 545,455 +48.0% Value US$6,000,005 Comments Filing More details Fewer details
Avalon Ventures X, L.P. Large shareholder Transaction date 11 Dec 2018 Notification date 13 Dec 2018 Purchase Price 11.00 Quantity 545,455 +48.0% Value US$6,000,005 Comments Filing More details Fewer details