United States Biotechnology & Medical Research

Spyre Therapeutics Inc (SYRE)

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Spyre Therapeutics Inc. experienced significant selling activity over the past ninety days, with executives offloading over 21 million dollars in stock. These transactions, primarily planned sales, occurred following a positive earnings report. Despite this divestment, the share price remains near its yearly highs, reflecting stable market performance for the healthcare firm.
Ticker: SYRE Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
King-Jones Heidy See Remarks Officer
Transaction date
Planned sale
Price
321.81
Quantity 43,155 -14.3%
Value US$1,295,564
King-Jones Heidy See Remarks Officer
Transaction date
Planned sale
Price
19.59
Quantity 46,051 +9.3%
Value US$4,394,407
King-Jones Heidy See Remarks Officer
Transaction date
Planned sale
Price
235.14
Quantity 60,531 -6.4%
Value US$2,184,429
King-Jones Heidy See Remarks Officer
Transaction date
Planned sale
Price
90.35
Quantity 1,000 -52.9%
Value US$100,000
King-Jones Heidy See Remarks Officer
Transaction date
Planned sale
Price
89.24
Quantity 1,000 -1.3%
Value US$100,000
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
93.91
Quantity 1,000 -0.0%
Value US$100,000
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
93.37
Quantity 1,000 -0.9%
Value US$100,000
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
92.31
Quantity 1,000 -0.7%
Value US$100,000
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
91.49
Quantity 1,000 -0.5%
Value US$100,000
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
90.10
Quantity 1,000 -0.5%
Value US$100,000
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
89.14
Quantity 1,000 -0.1%
Value US$100,000
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
93.57
Quantity 1,000 -0.3%
Value US$100,000
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
92.95
Quantity 1,000 -3.7%
Value US$100,000
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
91.92
Quantity 1,000 -2.5%
Value US$100,000
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
90.27
Quantity 1,000 -1.7%
Value US$100,000
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
89.07
Quantity 1,000 -0.7%
Value US$100,000
1.5
CAMERON TURTLE Director; Officer Executive Director
Transaction date
Proposed sale
Price
89.03
Quantity 1,000
Value US$100,000
HEIDY KING-JONES Officer Officer
Transaction date
Proposed sale
Price
89.03
Quantity 1,000
Value US$100,000
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Sale
Price
89.89
Quantity 1,000 -18.0%
Value US$100,000
1.9
SCOTT BURROWS Officer Officer
Transaction date
Proposed sale
Price
89.89
Quantity 1,000
Value US$100,000
King-Jones Heidy See Remarks Officer
Transaction date
Planned sale
Price
90.00
Quantity 400 -12.3%
Value US$36,000
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Sale
Price
89.35
Quantity 18,232 -18.6%
Value US$1,629,029
King-Jones Heidy See Remarks Officer
Transaction date
Planned sale
Price
89.38
Quantity 400 -12.3%
Value US$35,752
King-Jones Heidy See Remarks Officer
Transaction date
Planned sale
Price
88.17
Quantity 6,206 -65.7%
Value US$547,183
King-Jones Heidy See Remarks Officer
Transaction date
Planned sale
Price
87.20
Quantity 16,548 -63.6%
Value US$1,442,986
King-Jones Heidy See Remarks Officer
Transaction date
Planned sale
Price
86.40
Quantity 4,845 -15.7%
Value US$418,608
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
89.04
Quantity 200 -0.2%
Value US$17,808
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
88.03
Quantity 2,016 -2.0%
Value US$177,468
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
87.11
Quantity 4,384 -4.2%
Value US$381,890
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
86.25
Quantity 900 -0.9%
Value US$77,625
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
89.07
Quantity 400 -0.1%
Value US$35,628
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
88.06
Quantity 3,700 -0.7%
Value US$325,822
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
87.15
Quantity 8,400 -1.5%
Value US$732,060
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
86.36
Quantity 2,500 -0.4%
Value US$215,900
HEIDY KING-JONES Officer Officer
Transaction date
Proposed sale
Price
89.33
Quantity 46,665
Value US$4,168,584
2.3
Albers Jeffrey W. Non-Executive Director
Transaction date
Planned sale
Price
104.68
Quantity 10,000 -51.7%
Value US$1,046,800
2.3
Albers Jeffrey W. Non-Executive Director
Transaction date
Planned sale
Price
104.38
Quantity 8,000 -29.2%
Value US$835,040
2.3
Albers Jeffrey W. Non-Executive Director
Transaction date
Planned sale
Price
104.47
Quantity 5,000 -100.0%
Value US$522,350
2.3
SESSIONS, LLC Director Non-Executive Director
Transaction date
Proposed sale
Price
103.42
Quantity 18,000
Value US$1,861,560
2.3
JEFFREY ALBERS Director Non-Executive Director
Transaction date
Proposed sale
Price
103.42
Quantity 5,000
Value US$517,100
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
97.10
Quantity 100 -0.1%
Value US$9,710
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
96.30
Quantity 2,300 -2.3%
Value US$221,490
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
95.21
Quantity 5,100 -4.8%
Value US$485,571
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
97.46
Quantity 16 -0.0%
Value US$1,559
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
96.82
Quantity 1,392 -0.2%
Value US$134,773
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
95.93
Quantity 5,635 -1.0%
Value US$540,566
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
95.10
Quantity 7,157 -1.2%
Value US$680,631
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
93.97
Quantity 800 -0.1%
Value US$75,176
1.9
SCOTT BURROWS Officer Officer
Transaction date
Proposed sale
Price
98.33
Quantity 30,000
Value US$2,949,900
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
88.37
Quantity 1,725 -1.7%
Value US$152,438
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
87.55
Quantity 5,775 -5.5%
Value US$505,601
Sloan Sheldon Chief Medical Officer Officer
Transaction date
Planned sale
Price
88.34
Quantity 1,834 -100.0%
Value US$162,016
Sloan Sheldon Chief Medical Officer Officer
Transaction date
Planned sale
Price
87.52
Quantity 6,500 -78.0%
Value US$568,880
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
88.91
Quantity 590 -0.1%
Value US$52,457
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
88.12
Quantity 4,234 -0.7%
Value US$373,100
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
87.44
Quantity 10,176 -1.7%
Value US$889,789
1.5
CAMERON TURTLE Director; Officer Executive Director
Transaction date
Proposed sale
Price
88.78
Quantity 45,000
Value US$3,995,100
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Sale
Price
87.14
Quantity 10,000 -9.3%
Value US$871,400
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Sale
Price
87.12
Quantity 5,000 -4.4%
Value US$435,600
1.9
SCOTT BURROWS Officer Officer
Transaction date
Proposed sale
Price
87.13
Quantity 15,000
Value US$1,306,980
HENDERSON MICHAEL THOMAS Non-Executive Director
Transaction date
Planned sale
Price
100.00
Quantity 20,000 -22.6%
Value US$2,000,000
MICHAEL HENDERSON Director Non-Executive Director
Transaction date
Proposed sale
Price
88.34
Quantity 20,000
Value US$1,766,800
MICHAEL HENDERSON Director Non-Executive Director
Transaction date
Proposed sale
Price
88.34
Quantity 20,000
Value US$1,766,800
Sloan Sheldon Chief Medical Officer Officer
Transaction date
Planned sale
Price
75.00
Quantity 8,333 -100.0%
Value US$624,975
SHELDON SLOAN Officer Officer
Transaction date
Proposed sale
Price
69.16
Quantity 16,667
Value US$1,152,690
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
71.38
Quantity 3,294 -0.5%
Value US$235,126
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
70.50
Quantity 8,149 -1.3%
Value US$574,504
1.5
Turtle Cameron Chief Executive Officer Executive Director
Transaction date
Planned sale
Price
69.40
Quantity 3,557 -0.6%
Value US$246,856
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
72.06
Quantity 3,100 -3.1%
Value US$223,386
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
70.77
Quantity 2,599 -2.5%
Value US$183,931
1.9
Burrows Scott L Chief Financial Officer Officer
Transaction date
Planned sale
Price
69.75
Quantity 1,801 -1.7%
Value US$125,620
HENDERSON MICHAEL THOMAS Non-Executive Director
Transaction date
Planned sale
Price
75.35
Quantity 19,269 -17.9%
Value US$1,451,919
HENDERSON MICHAEL THOMAS Non-Executive Director
Transaction date
Planned sale
Price
74.76
Quantity 24,814 -18.7%
Value US$1,855,095
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-10-02 2026-10-01 PlS Planned sale
King-Jones Heidy

See Remarks

Officer
43,155 -14.3%
321.81
US$1,295,564 		43,155 -14.3% 321.81 US$1,295,564
2026-10-02 2026-10-01 PlS Planned sale
King-Jones Heidy

See Remarks

Officer
46,051 +9.3%
19.59
US$4,394,407 		46,051 +9.3% 19.59 US$4,394,407
2026-10-02 2026-10-01 PlS Planned sale
King-Jones Heidy

See Remarks

Officer
60,531 -6.4%
235.14
US$2,184,429 		60,531 -6.4% 235.14 US$2,184,429
2026-10-02 2026-10-01 PlS Planned sale
King-Jones Heidy

See Remarks

Officer
1,000 -52.9%
90.35
US$100,000 		1,000 -52.9% 90.35 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
King-Jones Heidy

See Remarks

Officer
1,000 -1.3%
89.24
US$100,000 		1,000 -1.3% 89.24 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
1,000 -0.0%
93.91
US$100,000 		1,000 -0.0% 93.91 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
1,000 -0.9%
93.37
US$100,000 		1,000 -0.9% 93.37 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
1,000 -0.7%
92.31
US$100,000 		1,000 -0.7% 92.31 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
1,000 -0.5%
91.49
US$100,000 		1,000 -0.5% 91.49 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
1,000 -0.5%
90.10
US$100,000 		1,000 -0.5% 90.10 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
1,000 -0.1%
89.14
US$100,000 		1,000 -0.1% 89.14 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
1,000 -0.3%
93.57
US$100,000 		1,000 -0.3% 93.57 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
1,000 -3.7%
92.95
US$100,000 		1,000 -3.7% 92.95 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
1,000 -2.5%
91.92
US$100,000 		1,000 -2.5% 91.92 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
1,000 -1.7%
90.27
US$100,000 		1,000 -1.7% 90.27 US$100,000
2026-10-02 2026-10-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
1,000 -0.7%
89.07
US$100,000 		1,000 -0.7% 89.07 US$100,000
2026-10-01 2026-10-01 PrS Proposed sale
1.5
CAMERON TURTLE

Director; Officer

Executive Director
1,000
89.03
US$100,000 		1,000 89.03 US$100,000
2026-10-01 2026-10-01 PrS Proposed sale
HEIDY KING-JONES

Officer

Officer
1,000
89.03
US$100,000 		1,000 89.03 US$100,000
2026-10-02 2026-09-30 S Sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
1,000 -18.0%
89.89
US$100,000 		1,000 -18.0% 89.89 US$100,000
2026-09-30 2026-09-30 PrS Proposed sale
1.9
SCOTT BURROWS

Officer

Officer
1,000
89.89
US$100,000 		1,000 89.89 US$100,000
2026-09-03 2026-09-02 PlS Planned sale
King-Jones Heidy

See Remarks

Officer
400 -12.3%
90.00
US$36,000 		400 -12.3% 90.00 US$36,000
2026-09-03 2026-09-02 S Sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
18,232 -18.6%
89.35
US$1,629,029 		18,232 -18.6% 89.35 US$1,629,029
2026-09-03 2026-09-01 PlS Planned sale
King-Jones Heidy

See Remarks

Officer
400 -12.3%
89.38
US$35,752 		400 -12.3% 89.38 US$35,752
2026-09-03 2026-09-01 PlS Planned sale
King-Jones Heidy

See Remarks

Officer
6,206 -65.7%
88.17
US$547,183 		6,206 -65.7% 88.17 US$547,183
2026-09-03 2026-09-01 PlS Planned sale
King-Jones Heidy

See Remarks

Officer
16,548 -63.6%
87.20
US$1,442,986 		16,548 -63.6% 87.20 US$1,442,986
2026-09-03 2026-09-01 PlS Planned sale
King-Jones Heidy

See Remarks

Officer
4,845 -15.7%
86.40
US$418,608 		4,845 -15.7% 86.40 US$418,608
2026-09-03 2026-09-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
200 -0.2%
89.04
US$17,808 		200 -0.2% 89.04 US$17,808
2026-09-03 2026-09-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
2,016 -2.0%
88.03
US$177,468 		2,016 -2.0% 88.03 US$177,468
2026-09-03 2026-09-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
4,384 -4.2%
87.11
US$381,890 		4,384 -4.2% 87.11 US$381,890
2026-09-03 2026-09-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
900 -0.9%
86.25
US$77,625 		900 -0.9% 86.25 US$77,625
2026-09-03 2026-09-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
400 -0.1%
89.07
US$35,628 		400 -0.1% 89.07 US$35,628
2026-09-03 2026-09-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
3,700 -0.7%
88.06
US$325,822 		3,700 -0.7% 88.06 US$325,822
2026-09-03 2026-09-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
8,400 -1.5%
87.15
US$732,060 		8,400 -1.5% 87.15 US$732,060
2026-09-03 2026-09-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
2,500 -0.4%
86.36
US$215,900 		2,500 -0.4% 86.36 US$215,900
2026-09-01 2026-09-01 PrS Proposed sale
HEIDY KING-JONES

Officer

Officer
46,665
89.33
US$4,168,584 		46,665 89.33 US$4,168,584
2026-08-10 2026-08-07 PlS Planned sale
2.3
Albers Jeffrey W.
Non-Executive Director
10,000 -51.7%
104.68
US$1,046,800 		10,000 -51.7% 104.68 US$1,046,800
2026-08-10 2026-08-07 PlS Planned sale
2.3
Albers Jeffrey W.
Non-Executive Director
8,000 -29.2%
104.38
US$835,040 		8,000 -29.2% 104.38 US$835,040
2026-08-10 2026-08-07 PlS Planned sale
2.3
Albers Jeffrey W.
Non-Executive Director
5,000 -100.0%
104.47
US$522,350 		5,000 -100.0% 104.47 US$522,350
2026-08-07 2026-08-07 PrS Proposed sale
2.3
SESSIONS, LLC

Director

Non-Executive Director
18,000
103.42
US$1,861,560 		18,000 103.42 US$1,861,560
2026-08-07 2026-08-07 PrS Proposed sale
2.3
JEFFREY ALBERS

Director

Non-Executive Director
5,000
103.42
US$517,100 		5,000 103.42 US$517,100
2026-08-05 2026-08-03 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
100 -0.1%
97.10
US$9,710 		100 -0.1% 97.10 US$9,710
2026-08-05 2026-08-03 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
2,300 -2.3%
96.30
US$221,490 		2,300 -2.3% 96.30 US$221,490
2026-08-05 2026-08-03 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
5,100 -4.8%
95.21
US$485,571 		5,100 -4.8% 95.21 US$485,571
2026-08-05 2026-08-03 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
16 -0.0%
97.46
US$1,559 		16 -0.0% 97.46 US$1,559
2026-08-05 2026-08-03 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
1,392 -0.2%
96.82
US$134,773 		1,392 -0.2% 96.82 US$134,773
2026-08-05 2026-08-03 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
5,635 -1.0%
95.93
US$540,566 		5,635 -1.0% 95.93 US$540,566
2026-08-05 2026-08-03 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
7,157 -1.2%
95.10
US$680,631 		7,157 -1.2% 95.10 US$680,631
2026-08-05 2026-08-03 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
800 -0.1%
93.97
US$75,176 		800 -0.1% 93.97 US$75,176
2026-08-03 2026-08-03 PrS Proposed sale
1.9
SCOTT BURROWS

Officer

Officer
30,000
98.33
US$2,949,900 		30,000 98.33 US$2,949,900
2026-07-02 2026-07-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
1,725 -1.7%
88.37
US$152,438 		1,725 -1.7% 88.37 US$152,438
2026-07-02 2026-07-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
5,775 -5.5%
87.55
US$505,601 		5,775 -5.5% 87.55 US$505,601
2026-07-02 2026-07-01 PlS Planned sale
Sloan Sheldon

Chief Medical Officer

Officer
1,834 -100.0%
88.34
US$162,016 		1,834 -100.0% 88.34 US$162,016
2026-07-02 2026-07-01 PlS Planned sale
Sloan Sheldon

Chief Medical Officer

Officer
6,500 -78.0%
87.52
US$568,880 		6,500 -78.0% 87.52 US$568,880
2026-07-02 2026-07-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
590 -0.1%
88.91
US$52,457 		590 -0.1% 88.91 US$52,457
2026-07-02 2026-07-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
4,234 -0.7%
88.12
US$373,100 		4,234 -0.7% 88.12 US$373,100
2026-07-02 2026-07-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
10,176 -1.7%
87.44
US$889,789 		10,176 -1.7% 87.44 US$889,789
2026-07-01 2026-07-01 PrS Proposed sale
1.5
CAMERON TURTLE

Director; Officer

Executive Director
45,000
88.78
US$3,995,100 		45,000 88.78 US$3,995,100
2026-06-26 2026-06-25 S Sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
10,000 -9.3%
87.14
US$871,400 		10,000 -9.3% 87.14 US$871,400
2026-06-26 2026-06-25 S Sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
5,000 -4.4%
87.12
US$435,600 		5,000 -4.4% 87.12 US$435,600
2026-06-25 2026-06-25 PrS Proposed sale
1.9
SCOTT BURROWS

Officer

Officer
15,000
87.13
US$1,306,980 		15,000 87.13 US$1,306,980
2026-06-23 2026-06-23 PrS Proposed sale
3.3
Fairmount Healthcare Fund II L.P.

Director

Non-Executive Director
4,684,781
85.31
US$399,658,667 		4,684,781 85.31 US$399,658,667
2026-06-23 2026-06-23 S Sale
3.3
Fairmount Funds Management LLC
Non-Executive Director
4,684,781 -100.0%
85.31
US$399,658,667 		4,684,781 -100.0% 85.31 US$399,658,667
2026-06-23 2026-06-22 PlS Planned sale
HENDERSON MICHAEL THOMAS
Non-Executive Director
20,000 -22.6%
100.00
US$2,000,000 		20,000 -22.6% 100.00 US$2,000,000
2026-06-22 2026-06-22 PrS Proposed sale
MICHAEL HENDERSON

Director

Non-Executive Director
20,000
88.34
US$1,766,800 		20,000 88.34 US$1,766,800
2026-06-22 2026-06-22 PrS Proposed sale
MICHAEL HENDERSON

Director

Non-Executive Director
20,000
88.34
US$1,766,800 		20,000 88.34 US$1,766,800
2026-06-03 2026-06-03 PlS Planned sale
Sloan Sheldon

Chief Medical Officer

Officer
8,333 -100.0%
75.00
US$624,975 		8,333 -100.0% 75.00 US$624,975
2026-06-03 2026-06-03 PrS Proposed sale
SHELDON SLOAN

Officer

Officer
16,667
69.16
US$1,152,690 		16,667 69.16 US$1,152,690
2026-06-03 2026-06-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
3,294 -0.5%
71.38
US$235,126 		3,294 -0.5% 71.38 US$235,126
2026-06-03 2026-06-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
8,149 -1.3%
70.50
US$574,504 		8,149 -1.3% 70.50 US$574,504
2026-06-03 2026-06-01 PlS Planned sale
1.5
Turtle Cameron

Chief Executive Officer

Executive Director
3,557 -0.6%
69.40
US$246,856 		3,557 -0.6% 69.40 US$246,856
2026-06-03 2026-06-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
3,100 -3.1%
72.06
US$223,386 		3,100 -3.1% 72.06 US$223,386
2026-06-03 2026-06-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
2,599 -2.5%
70.77
US$183,931 		2,599 -2.5% 70.77 US$183,931
2026-06-03 2026-06-01 PlS Planned sale
1.9
Burrows Scott L

Chief Financial Officer

Officer
1,801 -1.7%
69.75
US$125,620 		1,801 -1.7% 69.75 US$125,620
2026-05-08 2026-05-08 PlS Planned sale
HENDERSON MICHAEL THOMAS
Non-Executive Director
19,269 -17.9%
75.35
US$1,451,919 		19,269 -17.9% 75.35 US$1,451,919
2026-05-08 2026-05-08 PlS Planned sale
HENDERSON MICHAEL THOMAS
Non-Executive Director
24,814 -18.7%
74.76
US$1,855,095 		24,814 -18.7% 74.76 US$1,855,095
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