Spruce Biosciences Inc (SPRB)

Healthcare Pharmaceuticals & Medical Research Biotechnology & Medical Research

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Ticker: SPRB Exchange: NSM

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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PS: Planned sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Insider and/or position	Nb. shares Price Value	Number of shares	Price	Total value	Details
2024-03-25	2024-03-21	S Sale	Novo Holdings A/S Large shareholder	465,021 -15.4% 0.75 350,951 USD	465,021 -15.4%	0.75	350,951 USD
2024-03-20	2024-03-20	S Sale	Novo Holdings A/S Large shareholder	359,979 -10.7% 0.73 264,081 USD	359,979 -10.7%	0.73	264,081 USD
2024-03-20	2024-03-19	S Sale	Novo Holdings A/S Large shareholder	593,000 -14.9% 0.76 447,715 USD	593,000 -14.9%	0.76	447,715 USD
2024-03-20	2024-03-18	S Sale	Novo Holdings A/S Large shareholder	842,020 -17.5% 0.77 647,008 USD	842,020 -17.5%	0.77	647,008 USD
2024-03-18	2024-03-14	S Sale	Novo Holdings A/S Large shareholder	1,912,316 -28.4% 0.89 1,698,902 USD	1,912,316 -28.4%	0.89	1,698,902 USD
2023-05-16	2023-02-16	B Purchase	O'Donnell Niall Non-Executive Director	630,400 +90.6% 3.17 1,998,368 USD	630,400 +90.6%	3.17	1,998,368 USD
2023-02-21	2023-02-16	B Purchase	Novo Holdings A/S Large shareholder	2,208,000 +48.9% 3.17 6,999,360 USD	2,208,000 +48.9%	3.17	6,999,360 USD
2021-05-21	2021-05-20	PS Planned sale	SIMPSON CAMILLA V Non-Executive Director	334 -100.0% 15.29 5,107 USD	334 -100.0%	15.29	5,107 USD
2021-05-21	2021-05-19	S Sale	Novo Holdings A/S Large shareholder	475,000 -9.5% 13.90 6,602,500 USD	475,000 -9.5%	13.90	6,602,500 USD
2021-05-04	2021-04-30	PS Planned sale	SIMPSON CAMILLA V Non-Executive Director	14,045 -100.0% 16.14 226,664 USD	14,045 -100.0%	16.14	226,664 USD
2020-10-16	2020-10-14	B Purchase	Muralidhar Bali Non-Executive Director	200,000 +12.6% 15.00 3,000,000 USD	200,000 +12.6%	15.00	3,000,000 USD
2020-10-16	2020-10-14	B Purchase	HANSSON JONAS Non-Executive Director	250,000 +14.0% 15.00 3,750,000 USD	250,000 +14.0%	15.00	3,750,000 USD
2020-10-16	2020-10-14	B Purchase	HealthCap VIII, L.P. Former 10% Owner	250,000 +14.0% 15.00 3,750,000 USD	250,000 +14.0%	15.00	3,750,000 USD
2020-10-16	2020-10-14	B Purchase	Novo Holdings A/S Large shareholder	250,000 +5.3% 15.00 3,750,000 USD	250,000 +5.3%	15.00	3,750,000 USD
2020-10-16	2020-10-14	B Purchase	RiverVest Venture Fund III, L.P. Large shareholder	250,000 +13.2% 15.00 3,750,000 USD	250,000 +13.2%	15.00	3,750,000 USD
2020-10-16	2020-10-14	B Purchase	Omega Fund VI, L.P. Former 10% Owner	250,000 +13.1% 15.00 3,750,000 USD	250,000 +13.1%	15.00	3,750,000 USD
2020-10-16	2020-10-14	B Purchase	O'Donnell Niall Non-Executive Director	250,000 +56.1% 15.00 3,750,000 USD	250,000 +56.1%	15.00	3,750,000 USD
2020-10-16	2020-10-14	B Purchase	Chaya Moghrabi Dina Non-Executive Director	250,000 +13.1% 15.00 3,750,000 USD	250,000 +13.1%	15.00	3,750,000 USD