United States Biotechnology & Medical Research

Spruce Biosciences Inc (SPRB)

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Spruce Biosciences Inc. experienced recent insider trading activity on October 6, 2025, involving Parkman Healthcare Partners LLC. This entity executed multiple buy and sell orders on that date. Prior significant divestments occurred throughout March 2024 by Novo Holdings A/S. No further transactions have been recorded within the last three months.
Ticker: SPRB Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Spruce Biosciences Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
2.3
Novo Holdings A/S Large shareholder
Transaction date
Sale
Price
0.75
Quantity 465,021 -15.4%
Value US$350,951
2.3
Novo Holdings A/S Large shareholder
Transaction date
Sale
Price
0.73
Quantity 359,979 -10.7%
Value US$264,081
2.3
Novo Holdings A/S Large shareholder
Transaction date
Sale
Price
0.76
Quantity 593,000 -14.9%
Value US$447,715
2.3
Novo Holdings A/S Large shareholder
Transaction date
Sale
Price
0.77
Quantity 842,020 -17.5%
Value US$647,008
2.3
Novo Holdings A/S 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
0.81
Quantity 4,810,020
Value US$3,899,002
2.3
Novo Holdings A/S Large shareholder
Transaction date
Sale
Price
0.89
Quantity 1,912,316 -28.4%
Value US$1,698,902
2.3
Novo Holdings A/S 10% Stockholder Large shareholder
Transaction date
Proposed sale
Price
4.96
Quantity 1,912,316
Value US$9,485,087
2.3
O'Donnell Niall Non-Executive Director
Transaction date
Purchase
Price
3.17
Quantity 630,400 +90.6%
Value US$1,998,368
2.3
Novo Holdings A/S Large shareholder
Transaction date
Purchase
Price
3.17
Quantity 2,208,000 +48.9%
Value US$6,999,360
SIMPSON CAMILLA V Non-Executive Director
Transaction date
Planned sale
Price
15.29
Quantity 334 -100.0%
Value US$5,107
2.3
Novo Holdings A/S Large shareholder
Transaction date
Sale
Price
13.90
Quantity 475,000 -9.5%
Value US$6,602,500
SIMPSON CAMILLA V Non-Executive Director
Transaction date
Planned sale
Price
16.14
Quantity 14,045 -100.0%
Value US$226,664
1.5
Muralidhar Bali Non-Executive Director
Transaction date
Purchase
Price
15.00
Quantity 200,000 +12.6%
Value US$3,000,000
HANSSON JONAS Non-Executive Director
Transaction date
Purchase
Price
15.00
Quantity 250,000 +14.0%
Value US$3,750,000
HealthCap VIII, L.P. Former 10% Owner
Transaction date
Purchase
Price
15.00
Quantity 250,000 +14.0%
Value US$3,750,000
2.3
Novo Holdings A/S Large shareholder
Transaction date
Purchase
Price
15.00
Quantity 250,000 +5.3%
Value US$3,750,000
3.3
Omega Fund VI, L.P. Former 10% Owner
Transaction date
Purchase
Price
15.00
Quantity 250,000 +13.1%
Value US$3,750,000
2.3
O'Donnell Niall Non-Executive Director
Transaction date
Purchase
Price
15.00
Quantity 250,000 +56.1%
Value US$3,750,000
Chaya Moghrabi Dina Non-Executive Director
Transaction date
Purchase
Price
15.00
Quantity 250,000 +13.1%
Value US$3,750,000
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2025-10-15 2025-10-06 S Sale
Parkman Healthcare Partners LLC
Large shareholder
96,881 -47.3%
452.50
US$2,460,501 		96,881 -47.3% 452.50 US$2,460,501
2025-10-15 2025-10-06 S Sale
Parkman Healthcare Partners LLC
Large shareholder
47,862 +3.7%
108.43
US$2,196,654 		47,862 +3.7% 108.43 US$2,196,654
2025-10-15 2025-10-06 B Purchase
Parkman Healthcare Partners LLC
Large shareholder
77,762 -38.8%
293.76
US$4,118,734 		77,762 -38.8% 293.76 US$4,118,734
2025-10-08 2025-10-06 S Sale
Parkman Healthcare Partners LLC
Large shareholder
25 -2.3%
17.46
US$436 		25 -2.3% 17.46 US$436
2025-10-08 2025-10-06 S Sale
Parkman Healthcare Partners LLC
Large shareholder
232 -17.8%
19.33
US$4,484 		232 -17.8% 19.33 US$4,484
2025-10-08 2025-10-06 B Purchase
Parkman Healthcare Partners LLC
Large shareholder
256 +24.4%
17.91
US$4,585 		256 +24.4% 17.91 US$4,585
2024-03-25 2024-03-21 S Sale
2.3
Novo Holdings A/S
Large shareholder
465,021 -15.4%
0.75
US$350,951 		465,021 -15.4% 0.75 US$350,951
2024-03-20 2024-03-20 S Sale
2.3
Novo Holdings A/S
Large shareholder
359,979 -10.7%
0.73
US$264,081 		359,979 -10.7% 0.73 US$264,081
2024-03-20 2024-03-19 S Sale
2.3
Novo Holdings A/S
Large shareholder
593,000 -14.9%
0.76
US$447,715 		593,000 -14.9% 0.76 US$447,715
2024-03-20 2024-03-18 S Sale
2.3
Novo Holdings A/S
Large shareholder
842,020 -17.5%
0.77
US$647,008 		842,020 -17.5% 0.77 US$647,008
2024-03-18 2024-03-18 PrS Proposed sale
2.3
Novo Holdings A/S

10% Stockholder

Large shareholder
4,810,020
0.81
US$3,899,002 		4,810,020 0.81 US$3,899,002
2024-03-18 2024-03-14 S Sale
2.3
Novo Holdings A/S
Large shareholder
1,912,316 -28.4%
0.89
US$1,698,902 		1,912,316 -28.4% 0.89 US$1,698,902
2024-03-14 2024-03-14 PrS Proposed sale
2.3
Novo Holdings A/S

10% Stockholder

Large shareholder
1,912,316
4.96
US$9,485,087 		1,912,316 4.96 US$9,485,087
2023-05-16 2023-02-16 B Purchase
2.3
O'Donnell Niall
Non-Executive Director
630,400 +90.6%
3.17
US$1,998,368 		630,400 +90.6% 3.17 US$1,998,368
2023-02-21 2023-02-16 B Purchase
2.3
Novo Holdings A/S
Large shareholder
2,208,000 +48.9%
3.17
US$6,999,360 		2,208,000 +48.9% 3.17 US$6,999,360
2021-05-21 2021-05-20 PlS Planned sale
SIMPSON CAMILLA V
Non-Executive Director
334 -100.0%
15.29
US$5,107 		334 -100.0% 15.29 US$5,107
2021-05-21 2021-05-19 S Sale
2.3
Novo Holdings A/S
Large shareholder
475,000 -9.5%
13.90
US$6,602,500 		475,000 -9.5% 13.90 US$6,602,500
2021-05-04 2021-04-30 PlS Planned sale
SIMPSON CAMILLA V
Non-Executive Director
14,045 -100.0%
16.14
US$226,664 		14,045 -100.0% 16.14 US$226,664
2020-10-16 2020-10-14 B Purchase
1.5
Muralidhar Bali
Non-Executive Director
200,000 +12.6%
15.00
US$3,000,000 		200,000 +12.6% 15.00 US$3,000,000
2020-10-16 2020-10-14 B Purchase
HANSSON JONAS
Non-Executive Director
250,000 +14.0%
15.00
US$3,750,000 		250,000 +14.0% 15.00 US$3,750,000
2020-10-16 2020-10-14 B Purchase
HealthCap VIII, L.P.

Former 10% Owner
250,000 +14.0%
15.00
US$3,750,000 		250,000 +14.0% 15.00 US$3,750,000
2020-10-16 2020-10-14 B Purchase
2.3
Novo Holdings A/S
Large shareholder
250,000 +5.3%
15.00
US$3,750,000 		250,000 +5.3% 15.00 US$3,750,000
2020-10-16 2020-10-14 B Purchase
1.3
RiverVest Venture Fund III, L.P.
Large shareholder
250,000 +13.2%
15.00
US$3,750,000 		250,000 +13.2% 15.00 US$3,750,000
2020-10-16 2020-10-14 B Purchase
3.3
Omega Fund VI, L.P.

Former 10% Owner
250,000 +13.1%
15.00
US$3,750,000 		250,000 +13.1% 15.00 US$3,750,000
2020-10-16 2020-10-14 B Purchase
2.3
O'Donnell Niall
Non-Executive Director
250,000 +56.1%
15.00
US$3,750,000 		250,000 +56.1% 15.00 US$3,750,000
2020-10-16 2020-10-14 B Purchase
Chaya Moghrabi Dina
Non-Executive Director
250,000 +13.1%
15.00
US$3,750,000 		250,000 +13.1% 15.00 US$3,750,000
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