Parkman Healthcare Partners LLC

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2025-10-15	2025-10-06	Spruce Biosciences Inc (SPRB)	S Sale	96,881 -47.3% 452.50 US$2,460,501	96,881 -47.3%	452.50	US$2,460,501
2025-10-15	2025-10-06	Spruce Biosciences Inc (SPRB)	S Sale	47,862 +3.7% 108.43 US$2,196,654	47,862 +3.7%	108.43	US$2,196,654
2025-10-15	2025-10-06	Spruce Biosciences Inc (SPRB)	B Purchase	77,762 -38.8% 293.76 US$4,118,734	77,762 -38.8%	293.76	US$4,118,734
2025-10-08	2025-10-06	Spruce Biosciences Inc (SPRB)	S Sale	25 -2.3% 17.46 US$436	25 -2.3%	17.46	US$436
2025-10-08	2025-10-06	Spruce Biosciences Inc (SPRB)	S Sale	232 -17.8% 19.33 US$4,484	232 -17.8%	19.33	US$4,484
2025-10-08	2025-10-06	Spruce Biosciences Inc (SPRB)	B Purchase	256 +24.4% 17.91 US$4,585	256 +24.4%	17.91	US$4,585