|
2008-08-18 |
2008-08-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
33,496
-3.5%
227.39
US$821,312
|
33,496
-3.5%
|
227.39
|
US$821,312
|
|
|
2008-08-06 |
2008-08-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
95,647
-27.8%
435.09
US$2,087,386
|
95,647
-27.8%
|
435.09
|
US$2,087,386
|
|
|
2008-07-16 |
2008-07-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
91,324
+14.9%
53.21
US$51,004
|
91,324
+14.9%
|
53.21
|
US$51,004
|
|
|
2008-07-16 |
2008-07-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
681
-2.8%
3.05
US$2,077
|
681
-2.8%
|
3.05
|
US$2,077
|
|
|
2008-07-11 |
2008-07-11 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
7,000
+0.1%
3.07
US$21,489
|
7,000
+0.1%
|
3.07
|
US$21,489
|
|
|
2008-07-11 |
2008-07-11 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
2,000
+0.0%
3.07
US$6,140
|
2,000
+0.0%
|
3.07
|
US$6,140
|
|
|
2008-07-11 |
2008-07-11 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
3,500
+0.1%
3.07
US$10,744
|
3,500
+0.1%
|
3.07
|
US$10,744
|
|
|
2008-07-11 |
2008-07-10 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
236,000
+4.5%
3.03
US$715,033
|
236,000
+4.5%
|
3.03
|
US$715,033
|
|
|
2008-07-11 |
2008-07-10 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
68,000
+1.3%
3.03
US$206,026
|
68,000
+1.3%
|
3.03
|
US$206,026
|
|
|
2008-07-11 |
2008-07-10 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
99,200
+1.9%
3.03
US$300,556
|
99,200
+1.9%
|
3.03
|
US$300,556
|
|
|
2008-07-11 |
2008-07-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
468,000
+10.1%
3.04
US$1,423,422
|
468,000
+10.1%
|
3.04
|
US$1,423,422
|
|
|
2008-07-11 |
2008-07-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
135,000
+3.0%
3.04
US$410,602
|
135,000
+3.0%
|
3.04
|
US$410,602
|
|
|
2008-07-11 |
2008-07-09 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
197,300
+4.6%
3.04
US$600,088
|
197,300
+4.6%
|
3.04
|
US$600,088
|
|
|
2008-07-11 |
2008-07-08 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
48,000
+1.1%
2.99
US$143,707
|
48,000
+1.1%
|
2.99
|
US$143,707
|
|
|
2008-07-11 |
2008-07-08 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
14,000
+0.3%
2.99
US$41,915
|
14,000
+0.3%
|
2.99
|
US$41,915
|
|
|
2008-07-11 |
2008-07-08 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
20,100
+0.5%
2.99
US$60,177
|
20,100
+0.5%
|
2.99
|
US$60,177
|
|
|
2008-07-07 |
2008-07-07 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-3.1%
1.60
US$1,250
|
781
-3.1%
|
1.60
|
US$1,250
|
|
|
2008-06-20 |
2008-06-18 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
644,000
+18.1%
1.45
US$933,800
|
644,000
+18.1%
|
1.45
|
US$933,800
|
|
|
2008-06-20 |
2008-06-18 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
187,000
+5.5%
1.45
US$271,150
|
187,000
+5.5%
|
1.45
|
US$271,150
|
|
|
2008-06-20 |
2008-06-18 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
274,257
+8.8%
1.45
US$397,673
|
274,257
+8.8%
|
1.45
|
US$397,673
|
|
|
2008-06-17 |
2008-06-16 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
781
-3.3%
1.65
US$1,289
|
781
-3.3%
|
1.65
|
US$1,289
|
|
|
2008-06-06 |
2008-06-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-3.2%
1.35
US$1,054
|
781
-3.2%
|
1.35
|
US$1,054
|
|
|
2008-05-15 |
2008-05-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
781
-3.4%
1.45
US$1,132
|
781
-3.4%
|
1.45
|
US$1,132
|
|
|
2008-05-06 |
2008-05-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-3.3%
1.43
US$1,117
|
781
-3.3%
|
1.43
|
US$1,117
|
|
|
2008-04-16 |
2008-04-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
481
-2.2%
1.19
US$572
|
481
-2.2%
|
1.19
|
US$572
|
|
|
2008-04-16 |
2008-04-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
300
-1.4%
1.19
US$357
|
300
-1.4%
|
1.19
|
US$357
|
|
|
2008-04-08 |
2008-04-07 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
281
-1.3%
1.30
US$365
|
281
-1.3%
|
1.30
|
US$365
|
|
|
2008-04-08 |
2008-04-07 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
200
-0.9%
1.34
US$268
|
200
-0.9%
|
1.34
|
US$268
|
|
|
2008-04-08 |
2008-04-07 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
200
-0.9%
1.36
US$272
|
200
-0.9%
|
1.36
|
US$272
|
|
|
2008-04-08 |
2008-04-07 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
100
-0.4%
1.37
US$137
|
100
-0.4%
|
1.37
|
US$137
|
|
|
2008-03-18 |
2008-03-17 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
781
-3.7%
4.01
US$3,132
|
781
-3.7%
|
4.01
|
US$3,132
|
|
|
2008-03-05 |
2008-03-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-3.6%
4.05
US$3,163
|
781
-3.6%
|
4.05
|
US$3,163
|
|
|
2008-02-19 |
2008-02-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
781
-3.8%
4.05
US$3,163
|
781
-3.8%
|
4.05
|
US$3,163
|
|
|
2008-02-05 |
2008-02-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-3.7%
4.40
US$3,436
|
781
-3.7%
|
4.40
|
US$3,436
|
|
|
2008-01-16 |
2008-01-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
781
-4.0%
4.44
US$3,468
|
781
-4.0%
|
4.44
|
US$3,468
|
|
|
2008-01-07 |
2008-01-07 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-3.8%
5.15
US$4,022
|
781
-3.8%
|
5.15
|
US$4,022
|
|
|
2007-12-18 |
2007-12-17 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
781
-4.2%
4.75
US$3,710
|
781
-4.2%
|
4.75
|
US$3,710
|
|
|
2007-12-05 |
2007-12-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-4.0%
4.85
US$3,788
|
781
-4.0%
|
4.85
|
US$3,788
|
|
|
2007-11-16 |
2007-11-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
781
-4.3%
5.10
US$3,983
|
781
-4.3%
|
5.10
|
US$3,983
|
|
|
2007-11-05 |
2007-11-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-4.2%
6.50
US$5,076
|
781
-4.2%
|
6.50
|
US$5,076
|
|
|
2007-10-15 |
2007-10-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
400
-2.4%
6.43
US$2,572
|
400
-2.4%
|
6.43
|
US$2,572
|
|
|
2007-10-15 |
2007-10-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
200
-1.2%
6.42
US$1,284
|
200
-1.2%
|
6.42
|
US$1,284
|
|
|
2007-10-15 |
2007-10-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
181
-1.1%
6.41
US$1,160
|
181
-1.1%
|
6.41
|
US$1,160
|
|
|
2007-10-05 |
2007-10-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-4.3%
6.20
US$4,842
|
781
-4.3%
|
6.20
|
US$4,842
|
|
|
2007-09-17 |
2007-09-17 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
781
-4.8%
6.20
US$4,842
|
781
-4.8%
|
6.20
|
US$4,842
|
|
|
2007-09-05 |
2007-09-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
21
-0.1%
6.10
US$128
|
21
-0.1%
|
6.10
|
US$128
|
|
|
2007-09-05 |
2007-09-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
200
-1.2%
6.10
US$1,220
|
200
-1.2%
|
6.10
|
US$1,220
|
|
|
2007-09-05 |
2007-09-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
560
-3.3%
6.20
US$3,472
|
560
-3.3%
|
6.20
|
US$3,472
|
|
|
2007-08-16 |
2007-08-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
112
-0.7%
6.45
US$722
|
112
-0.7%
|
6.45
|
US$722
|
|
|
2007-08-16 |
2007-08-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
669
-4.3%
6.40
US$4,282
|
669
-4.3%
|
6.40
|
US$4,282
|
|
|
2007-08-07 |
2007-08-06 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
181
-1.1%
6.56
US$1,187
|
181
-1.1%
|
6.56
|
US$1,187
|
|
|
2007-08-07 |
2007-08-06 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
600
-3.7%
6.70
US$4,020
|
600
-3.7%
|
6.70
|
US$4,020
|
|
|
2007-07-16 |
2007-07-16 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
781
-5.3%
6.05
US$4,725
|
781
-5.3%
|
6.05
|
US$4,725
|
|
|
2007-07-09 |
2007-07-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-5.0%
5.33
US$4,163
|
781
-5.0%
|
5.33
|
US$4,163
|
|
|
2007-06-19 |
2007-06-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
100
-0.7%
5.18
US$518
|
100
-0.7%
|
5.18
|
US$518
|
|
|
2007-06-19 |
2007-06-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
100
-0.7%
5.15
US$515
|
100
-0.7%
|
5.15
|
US$515
|
|
|
2007-06-19 |
2007-06-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
581
-4.1%
5.11
US$2,969
|
581
-4.1%
|
5.11
|
US$2,969
|
|
|
2007-06-05 |
2007-06-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-5.3%
5.30
US$4,139
|
781
-5.3%
|
5.30
|
US$4,139
|
|
|
2007-05-16 |
2007-05-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
200
-1.6%
5.20
US$1,040
|
200
-1.6%
|
5.20
|
US$1,040
|
|
|
2007-05-16 |
2007-05-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
100
-0.8%
5.19
US$519
|
100
-0.8%
|
5.19
|
US$519
|
|
|
2007-05-16 |
2007-05-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
100
-0.8%
5.18
US$518
|
100
-0.8%
|
5.18
|
US$518
|
|
|
2007-05-16 |
2007-05-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
381
-2.9%
5.17
US$1,970
|
381
-2.9%
|
5.17
|
US$1,970
|
|
|
2007-05-08 |
2007-05-07 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
281
-2.1%
5.08
US$1,427
|
281
-2.1%
|
5.08
|
US$1,427
|
|
|
2007-05-08 |
2007-05-07 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
500
-3.6%
5.00
US$2,500
|
500
-3.6%
|
5.00
|
US$2,500
|
|
|
2007-04-17 |
2007-04-16 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
202
-1.7%
5.04
US$1,018
|
202
-1.7%
|
5.04
|
US$1,018
|
|
|
2007-04-17 |
2007-04-16 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
200
-1.7%
5.02
US$1,004
|
200
-1.7%
|
5.02
|
US$1,004
|
|
|
2007-04-17 |
2007-04-16 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
379
-3.0%
5.01
US$1,899
|
379
-3.0%
|
5.01
|
US$1,899
|
|
|
2007-04-05 |
2007-04-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-5.9%
4.61
US$3,600
|
781
-5.9%
|
4.61
|
US$3,600
|
|
|
2007-03-15 |
2007-03-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
100
-0.9%
5.53
US$553
|
100
-0.9%
|
5.53
|
US$553
|
|
|
2007-03-15 |
2007-03-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
681
-5.8%
5.53
US$3,766
|
681
-5.8%
|
5.53
|
US$3,766
|
|
|
2007-03-05 |
2007-03-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-6.2%
4.83
US$3,772
|
781
-6.2%
|
4.83
|
US$3,772
|
|
|
2007-02-15 |
2007-02-15 |
PlS
Planned sale
|
Reich Siegfried
VP, Drug Discovery
Officer
|
781
-7.1%
5.36
US$4,186
|
781
-7.1%
|
5.36
|
US$4,186
|
|
|
2007-02-05 |
2007-02-05 |
PlS
Planned sale
|
Myers W Todd
CFO
Officer
|
781
-6.7%
3.90
US$3,046
|
781
-6.7%
|
3.90
|
US$3,046
|
|
|
2007-01-16 |
2007-01-16 |
PlS
Planned sale
|
Reich Siegfried
Vice President, Drug Discovery
Officer
|
9,375
-50.0%
3.50
US$32,812
|
9,375
-50.0%
|
3.50
|
US$32,812
|
|
|
2007-01-08 |
2007-01-05 |
PlS
Planned sale
|
Myers W Todd
Chief Financial Officer
Officer
|
150
-1.5%
3.25
US$488
|
150
-1.5%
|
3.25
|
US$488
|
|