|
2026-06-22 |
2026-06-17 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
92,768
+11.3%
37.72
US$1,798,599
|
92,768
+11.3%
|
37.72
|
US$1,798,599
|
|
|
2026-06-22 |
2026-06-17 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
7,890
+26.9%
206.71
US$4,620,809
|
7,890
+26.9%
|
206.71
|
US$4,620,809
|
|
|
2026-06-22 |
2026-06-17 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
73,815
-33.8%
34.20
US$450,444
|
73,815
-33.8%
|
34.20
|
US$450,444
|
|
|
2026-06-17 |
2026-06-17 |
PrS
Proposed sale
|
Officer
Officer
|
1,000
110.73
US$100,000
|
1,000
|
110.73
|
US$100,000
|
|
|
2026-05-22 |
2026-05-20 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
48
-100.0%
111.90
US$5,371
|
48
-100.0%
|
111.90
|
US$5,371
|
|
|
2026-05-22 |
2026-05-20 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
891
-94.9%
111.30
US$99,165
|
891
-94.9%
|
111.30
|
US$99,165
|
|
|
2026-05-22 |
2026-05-20 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
3,363
-78.2%
110.35
US$371,095
|
3,363
-78.2%
|
110.35
|
US$371,095
|
|
|
2026-05-20 |
2026-05-20 |
PrS
Proposed sale
|
Officer
Officer
|
4,302
110.56
US$475,631
|
4,302
|
110.56
|
US$475,631
|
|
|
2026-04-17 |
2026-04-15 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
100
-100.0%
130.33
US$13,033
|
100
-100.0%
|
130.33
|
US$13,033
|
|
|
2026-04-17 |
2026-04-15 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
639
-86.5%
129.17
US$82,539
|
639
-86.5%
|
129.17
|
US$82,539
|
|
|
2026-04-17 |
2026-04-15 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
561
-43.2%
128.23
US$71,940
|
561
-43.2%
|
128.23
|
US$71,940
|
|
|
2026-04-17 |
2026-04-15 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
1,500
-53.6%
127.13
US$190,688
|
1,500
-53.6%
|
127.13
|
US$190,688
|
|
|
2026-04-17 |
2026-04-15 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
1,502
-34.9%
125.96
US$189,199
|
1,502
-34.9%
|
125.96
|
US$189,199
|
|
|
2026-04-15 |
2026-04-15 |
PrS
Proposed sale
|
Officer
Officer
|
4,302
129.53
US$557,238
|
4,302
|
129.53
|
US$557,238
|
|
|
2026-04-01 |
2026-03-30 |
B
Purchase
|
Non-Executive Director
|
445
+0.2%
112.30
US$49,974
|
445
+0.2%
|
112.30
|
US$49,974
|
|
|
2026-03-20 |
2026-03-18 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
304
-100.0%
119.08
US$36,201
|
304
-100.0%
|
119.08
|
US$36,201
|
|
|
2026-03-20 |
2026-03-18 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
1,730
-85.1%
118.37
US$204,777
|
1,730
-85.1%
|
118.37
|
US$204,777
|
|
|
2026-03-20 |
2026-03-18 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
2,268
-52.7%
117.56
US$266,633
|
2,268
-52.7%
|
117.56
|
US$266,633
|
|
|
2026-03-18 |
2026-03-18 |
PrS
Proposed sale
|
Officer
Officer
|
4,302
120.80
US$519,681
|
4,302
|
120.80
|
US$519,681
|
|
|
2026-03-02 |
2026-02-27 |
B
Purchase
|
Non-Executive Director
|
2,400
+5.3%
125.00
US$300,000
|
2,400
+5.3%
|
125.00
|
US$300,000
|
|
|
2026-03-02 |
2026-02-27 |
B
Purchase
|
Non-Executive Director
|
4,000
+2.2%
125.00
US$500,000
|
4,000
+2.2%
|
125.00
|
US$500,000
|
|
|
2026-02-20 |
2026-02-18 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
1,276
-100.0%
79.97
US$102,035
|
1,276
-100.0%
|
79.97
|
US$102,035
|
|
|
2026-02-20 |
2026-02-18 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
3,026
-70.3%
79.16
US$239,529
|
3,026
-70.3%
|
79.16
|
US$239,529
|
|
|
2026-02-19 |
2026-02-18 |
PrS
Proposed sale
|
Officer
Officer
|
4,302
80.09
US$344,547
|
4,302
|
80.09
|
US$344,547
|
|
|
2026-02-18 |
2026-02-18 |
PrS
Proposed sale
|
Officer
Officer
|
4,301
80.09
US$344,467
|
4,301
|
80.09
|
US$344,467
|
|
|
2026-01-23 |
2026-01-21 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
3,749
-100.0%
97.94
US$367,177
|
3,749
-100.0%
|
97.94
|
US$367,177
|
|
|
2026-01-23 |
2026-01-21 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
553
-12.9%
95.49
US$52,806
|
553
-12.9%
|
95.49
|
US$52,806
|
|
|
2026-01-21 |
2026-01-21 |
PrS
Proposed sale
|
Officer
Officer
|
4,302
98.01
US$421,639
|
4,302
|
98.01
|
US$421,639
|
|
|
2025-12-19 |
2025-12-17 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
4,302
-100.0%
96.47
US$415,023
|
4,302
-100.0%
|
96.47
|
US$415,023
|
|
|
2025-12-17 |
2025-12-17 |
PrS
Proposed sale
|
Officer
Officer
|
4,302
96.81
US$416,477
|
4,302
|
96.81
|
US$416,477
|
|
|
2025-11-21 |
2025-11-19 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
2,802
-100.0%
86.51
US$242,388
|
2,802
-100.0%
|
86.51
|
US$242,388
|
|
|
2025-11-21 |
2025-11-19 |
PlS
Planned sale
|
Chief Operating Officer
Officer
|
1,500
-34.9%
85.72
US$128,577
|
1,500
-34.9%
|
85.72
|
US$128,577
|
|
|
2025-11-19 |
2025-11-19 |
PrS
Proposed sale
|
Officer
Officer
|
4,302
82.94
US$356,808
|
4,302
|
82.94
|
US$356,808
|
|
|
2025-04-10 |
2025-04-09 |
B
Purchase
|
Non-Executive Director
|
2,490
+22.6%
20.27
US$50,472
|
2,490
+22.6%
|
20.27
|
US$50,472
|
|
|
2025-04-10 |
2025-04-09 |
B
Purchase
|
Non-Executive Director
|
2,500
+1.4%
20.13
US$50,325
|
2,500
+1.4%
|
20.13
|
US$50,325
|
|
|
2024-12-19 |
2024-12-18 |
B
Purchase
|
Non-Executive Director
|
4,000
+2.3%
12.93
US$51,720
|
4,000
+2.3%
|
12.93
|
US$51,720
|
|
|
2024-08-12 |
2024-08-12 |
B
Purchase
|
Large shareholder
|
757
+5.3%
15.88
US$12,023
|
757
+5.3%
|
15.88
|
US$12,023
|
|
|
2024-08-12 |
2024-08-12 |
B
Purchase
|
Large shareholder
|
2,243
+1.8%
15.88
US$35,624
|
2,243
+1.8%
|
15.88
|
US$35,624
|
|
|
2024-08-12 |
2024-08-09 |
B
Purchase
|
Large shareholder
|
3,000
+2.4%
14.89
US$44,679
|
3,000
+2.4%
|
14.89
|
US$44,679
|
|
|
2023-05-30 |
2023-05-25 |
B
Purchase
|
Non-Executive Director
|
10,000
+100.0%
0.85
US$8,500
|
10,000
+100.0%
|
0.85
|
US$8,500
|
|
|
2022-05-16 |
2022-05-13 |
B
Purchase
|
Chief Medical Officer
Officer
|
6,000
+inf%
1.71
US$10,260
|
6,000
+inf%
|
1.71
|
US$10,260
|
|
|
2021-09-01 |
2021-08-30 |
S
Sale
|
Chief Development Officer
Officer
|
29,200
-86.3%
5.15
US$150,380
|
29,200
-86.3%
|
5.15
|
US$150,380
|
|
|
2021-09-01 |
2021-08-30 |
S
Sale
|
Chief Development Officer
Officer
|
9,200
-21.4%
5.00
US$46,000
|
9,200
-21.4%
|
5.00
|
US$46,000
|
|
|
2020-07-22 |
2020-07-21 |
S
Sale
|
Large shareholder
|
1,900,000
-34.1%
2.95
US$5,605,000
|
1,900,000
-34.1%
|
2.95
|
US$5,605,000
|
|
|
2019-09-10 |
2019-09-06 |
S
Sale
|
Large shareholder
|
1,128
-0.4%
4.50
US$5,075
|
1,128
-0.4%
|
4.50
|
US$5,075
|
|
|
2019-09-10 |
2019-09-06 |
S
Sale
|
Large shareholder
|
25,720
-1.1%
4.50
US$115,725
|
25,720
-1.1%
|
4.50
|
US$115,725
|
|
|
2019-09-10 |
2019-09-06 |
S
Sale
|
Large shareholder
|
23,152
-1.0%
4.50
US$104,170
|
23,152
-1.0%
|
4.50
|
US$104,170
|
|
|
2018-09-17 |
2018-09-14 |
B
Purchase
|
KIRITSY CHRISTOPHER P
|
5,000
+100.0%
5.11
US$25,525
|
5,000
+100.0%
|
5.11
|
US$25,525
|
|
|
2018-05-16 |
2018-05-15 |
B
Purchase
|
GERAGHTY JAMES A
|
10,000
+100.0%
5.75
US$57,500
|
10,000
+100.0%
|
5.75
|
US$57,500
|
|
|
2018-05-02 |
2018-04-30 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
10,400
-21.1%
6.35
US$66,040
|
10,400
-21.1%
|
6.35
|
US$66,040
|
|
|
2018-05-02 |
2018-04-30 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
989,600
-18.0%
6.35
US$6,283,960
|
989,600
-18.0%
|
6.35
|
US$6,283,960
|
|
|
2018-02-15 |
2018-02-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
75
-0.2%
8.98
US$674
|
75
-0.2%
|
8.98
|
US$674
|
|
|
2018-02-15 |
2018-02-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
7,822
-0.1%
8.98
US$70,242
|
7,822
-0.1%
|
8.98
|
US$70,242
|
|
|
2018-01-04 |
2018-01-03 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
16,128
-24.7%
7.35
US$118,541
|
16,128
-24.7%
|
7.35
|
US$118,541
|
|
|
2018-01-04 |
2018-01-03 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
1,693,492
-23.5%
7.35
US$12,447,166
|
1,693,492
-23.5%
|
7.35
|
US$12,447,166
|
|
|
2017-12-20 |
2017-12-18 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
1,392
-2.1%
5.70
US$7,934
|
1,392
-2.1%
|
5.70
|
US$7,934
|
|
|
2017-12-20 |
2017-12-18 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
146,243
-2.0%
5.70
US$833,585
|
146,243
-2.0%
|
5.70
|
US$833,585
|
|
|
2017-08-17 |
2017-08-17 |
B
Purchase
|
GERAGHTY JAMES A
|
10,000
+inf%
4.82
US$48,200
|
10,000
+inf%
|
4.82
|
US$48,200
|
|
|
2017-08-17 |
2017-08-17 |
B
Purchase
|
Reine Allan
See Remarks
|
20,000
+44.4%
4.89
US$97,800
|
20,000
+44.4%
|
4.89
|
US$97,800
|
|
|
2017-08-17 |
2017-08-16 |
B
Purchase
|
Reine Allan
See Remarks
|
45,000
+inf%
4.79
US$215,550
|
45,000
+inf%
|
4.79
|
US$215,550
|
|
|
2016-06-15 |
2016-06-14 |
B
Purchase
|
Matis Louis
SVP, Chief Development Officer
Officer
|
7,915
+379.6%
1.71
US$13,535
|
7,915
+379.6%
|
1.71
|
US$13,535
|
|
|
2016-06-15 |
2016-06-13 |
B
Purchase
|
Matis Louis
SVP, Chief Development Officer
Officer
|
2,085
+inf%
1.68
US$3,503
|
2,085
+inf%
|
1.68
|
US$3,503
|
|
|
2016-06-15 |
2016-06-13 |
B
Purchase
|
Yoder Stephen S.
President and CEO
Executive Director
|
6,000
+inf%
1.68
US$10,080
|
6,000
+inf%
|
1.68
|
US$10,080
|
|
|
2016-06-15 |
2016-06-13 |
B
Purchase
|
DEPTULA-HICKS DARLENE M
SVP, Chief Financial Officer
Officer
|
5,000
+inf%
1.66
US$8,300
|
5,000
+inf%
|
1.66
|
US$8,300
|
|
|
2015-07-08 |
2015-07-06 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
4,717
+7.8%
2.75
US$12,972
|
4,717
+7.8%
|
2.75
|
US$12,972
|
|
|
2015-07-08 |
2015-07-06 |
B
Purchase
|
Khuong Chau Quang
Non-Executive Director
Large shareholder
|
4,717
+7.8%
2.75
US$12,972
|
4,717
+7.8%
|
2.75
|
US$12,972
|
|
|
2015-07-08 |
2015-07-06 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
495,283
+7.4%
2.75
US$1,362,028
|
495,283
+7.4%
|
2.75
|
US$1,362,028
|
|
|
2015-07-08 |
2015-07-06 |
B
Purchase
|
Khuong Chau Quang
Non-Executive Director
Large shareholder
|
495,283
+7.4%
2.75
US$1,362,028
|
495,283
+7.4%
|
2.75
|
US$1,362,028
|
|