|
2026-06-26 |
2026-06-25 |
PlS
Planned sale
|
EVP, General Counsel
Officer
|
21,658
+5.1%
218.09
US$3,723,255
|
21,658
+5.1%
|
218.09
|
US$3,723,255
|
|
|
2026-06-25 |
2026-06-25 |
PrS
Proposed sale
|
Officer
Officer
|
13,695
50.85
US$4,271,128
|
13,695
|
50.85
|
US$4,271,128
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
33,132
+10.0%
442.32
US$2,386,275
|
33,132
+10.0%
|
442.32
|
US$2,386,275
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
964
-0.1%
311.36
US$300,149
|
964
-0.1%
|
311.36
|
US$300,149
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
2,652
-0.2%
310.43
US$823,258
|
2,652
-0.2%
|
310.43
|
US$823,258
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
2,784
-0.2%
309.49
US$861,620
|
2,784
-0.2%
|
309.49
|
US$861,620
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
4,830
-0.3%
308.47
US$1,489,899
|
4,830
-0.3%
|
308.47
|
US$1,489,899
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
11,461
-0.8%
307.68
US$3,526,293
|
11,461
-0.8%
|
307.68
|
US$3,526,293
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
589
-0.0%
306.33
US$180,429
|
589
-0.0%
|
306.33
|
US$180,429
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
544
-0.0%
304.81
US$165,817
|
544
-0.0%
|
304.81
|
US$165,817
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
176
-0.0%
303.17
US$53,358
|
176
-0.0%
|
303.17
|
US$53,358
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
640
-0.0%
302.24
US$193,431
|
640
-0.0%
|
302.24
|
US$193,431
|
|
|
2026-06-05 |
2026-06-04 |
PlS
Planned sale
|
President and CEO
Executive Director
Large shareholder
|
320
-0.0%
300.75
US$96,240
|
320
-0.0%
|
300.75
|
US$96,240
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
240
-0.0%
311.65
US$74,796
|
240
-0.0%
|
311.65
|
US$74,796
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
2,039
-0.1%
310.94
US$634,001
|
2,039
-0.1%
|
310.94
|
US$634,001
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
2,801
-0.2%
309.95
US$868,156
|
2,801
-0.2%
|
309.95
|
US$868,156
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
3,803
-0.3%
308.89
US$1,174,708
|
3,803
-0.3%
|
308.89
|
US$1,174,708
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
12,729
-0.9%
307.81
US$3,918,070
|
12,729
-0.9%
|
307.81
|
US$3,918,070
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
1,348
-0.1%
307.09
US$413,964
|
1,348
-0.1%
|
307.09
|
US$413,964
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
480
-0.0%
305.87
US$146,815
|
480
-0.0%
|
305.87
|
US$146,815
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
400
-0.0%
304.89
US$121,958
|
400
-0.0%
|
304.89
|
US$121,958
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
247
-0.0%
303.17
US$74,883
|
247
-0.0%
|
303.17
|
US$74,883
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
593
-0.0%
302.25
US$179,235
|
593
-0.0%
|
302.25
|
US$179,235
|
|
|
2026-06-05 |
2026-06-04 |
PlS
Planned sale
|
President, R&D
Executive Director
Large shareholder
|
320
-0.0%
300.75
US$96,240
|
320
-0.0%
|
300.75
|
US$96,240
|
|
|
2026-06-04 |
2026-06-04 |
PrS
Proposed sale
|
Director; Officer; 10% Stockholder
Executive Director
Large shareholder
|
25,000
301.82
US$7,545,500
|
25,000
|
301.82
|
US$7,545,500
|
|
|
2026-06-04 |
2026-06-04 |
PrS
Proposed sale
|
Director; Officer; 10% Stockholder
Executive Director
Large shareholder
|
25,000
301.82
US$7,545,500
|
25,000
|
301.82
|
US$7,545,500
|
|
|
2026-05-27 |
2026-05-26 |
PlS
Planned sale
|
EVP, General Counsel
Officer
|
642
-100.0%
302.03
US$193,903
|
642
-100.0%
|
302.03
|
US$193,903
|
|
|
2026-05-26 |
2026-05-26 |
PrS
Proposed sale
|
Officer
Officer
|
642
302.03
US$193,903
|
642
|
302.03
|
US$193,903
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
1,700
-0.1%
266.42
US$452,918
|
1,700
-0.1%
|
266.42
|
US$452,918
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
6,000
-0.4%
265.16
US$1,590,979
|
6,000
-0.4%
|
265.16
|
US$1,590,979
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
4,852
-0.3%
264.64
US$1,284,019
|
4,852
-0.3%
|
264.64
|
US$1,284,019
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
2,248
-0.2%
263.58
US$592,535
|
2,248
-0.2%
|
263.58
|
US$592,535
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
1,938
-0.1%
262.35
US$508,430
|
1,938
-0.1%
|
262.35
|
US$508,430
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
2,931
-0.2%
261.41
US$766,198
|
2,931
-0.2%
|
261.41
|
US$766,198
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
3,667
-0.3%
260.37
US$954,762
|
3,667
-0.3%
|
260.37
|
US$954,762
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
668
-0.0%
259.61
US$173,419
|
668
-0.0%
|
259.61
|
US$173,419
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
589
-0.0%
258.54
US$152,280
|
589
-0.0%
|
258.54
|
US$152,280
|
|
|
2026-03-06 |
2026-03-04 |
PlS
Planned sale
|
President, R&D
Executive Director
Large shareholder
|
407
-0.0%
257.32
US$104,729
|
407
-0.0%
|
257.32
|
US$104,729
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
920
-0.1%
266.56
US$245,231
|
920
-0.1%
|
266.56
|
US$245,231
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
2,439
-0.2%
265.59
US$647,773
|
2,439
-0.2%
|
265.59
|
US$647,773
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
8,798
-0.6%
264.85
US$2,330,151
|
8,798
-0.6%
|
264.85
|
US$2,330,151
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
2,043
-0.1%
263.70
US$538,741
|
2,043
-0.1%
|
263.70
|
US$538,741
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
2,380
-0.2%
262.44
US$624,619
|
2,380
-0.2%
|
262.44
|
US$624,619
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
2,962
-0.2%
261.41
US$774,289
|
2,962
-0.2%
|
261.41
|
US$774,289
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
3,128
-0.2%
260.49
US$814,802
|
3,128
-0.2%
|
260.49
|
US$814,802
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
1,377
-0.1%
259.87
US$357,838
|
1,377
-0.1%
|
259.87
|
US$357,838
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
470
-0.0%
258.38
US$121,438
|
470
-0.0%
|
258.38
|
US$121,438
|
|
|
2026-03-06 |
2026-03-04 |
PlS
Planned sale
|
President and CEO
Executive Director
Large shareholder
|
483
-0.0%
257.31
US$124,282
|
483
-0.0%
|
257.31
|
US$124,282
|
|
|
2026-03-04 |
2026-03-04 |
PrS
Proposed sale
|
Director; Officer; 10% Stockholder
Executive Director
Large shareholder
|
25,000
263.80
US$6,595,000
|
25,000
|
263.80
|
US$6,595,000
|
|
|
2026-03-04 |
2026-03-04 |
PrS
Proposed sale
|
Director; Officer; 10% Stockholder
Executive Director
Large shareholder
|
25,000
263.80
US$6,595,000
|
25,000
|
263.80
|
US$6,595,000
|
|
|
2026-03-03 |
2026-03-02 |
PlS
Planned sale
|
Chief Accounting Officer
Officer
|
750
-3.2%
267.60
US$200,700
|
750
-3.2%
|
267.60
|
US$200,700
|
|
|
2026-03-02 |
2026-03-02 |
PrS
Proposed sale
|
Officer
Officer
|
750
267.60
US$200,700
|
750
|
267.60
|
US$200,700
|
|
|
2026-03-03 |
2026-02-27 |
PlS
Planned sale
|
Non-Executive Director
|
2,373
-3.1%
276.17
US$655,343
|
2,373
-3.1%
|
276.17
|
US$655,343
|
|
|
2026-03-03 |
2026-02-27 |
PlS
Planned sale
|
Non-Executive Director
|
9,430
-11.1%
275.45
US$2,597,481
|
9,430
-11.1%
|
275.45
|
US$2,597,481
|
|
|
2026-02-27 |
2026-02-27 |
PrS
Proposed sale
|
Director
Non-Executive Director
|
11,803
275.59
US$3,252,824
|
11,803
|
275.59
|
US$3,252,824
|
|
|
2026-02-26 |
2026-02-26 |
PlS
Planned sale
|
Non-Executive Director
|
2,638
-3.0%
276.32
US$728,919
|
2,638
-3.0%
|
276.32
|
US$728,919
|
|
|
2026-02-26 |
2026-02-26 |
PlS
Planned sale
|
Non-Executive Director
|
5,103
-5.5%
275.28
US$1,404,760
|
5,103
-5.5%
|
275.28
|
US$1,404,760
|
|
|
2026-02-26 |
2026-02-26 |
PrS
Proposed sale
|
Director
Non-Executive Director
|
7,741
275.63
US$2,133,680
|
7,741
|
275.63
|
US$2,133,680
|
|
|
2026-02-26 |
2026-02-25 |
PlS
Planned sale
|
Non-Executive Director
|
700
-0.7%
275.00
US$192,500
|
700
-0.7%
|
275.00
|
US$192,500
|
|
|
2026-02-25 |
2026-02-25 |
PrS
Proposed sale
|
Director
Non-Executive Director
|
700
275.00
US$192,500
|
700
|
275.00
|
US$192,500
|
|
|
2026-02-26 |
2026-02-24 |
PlS
Planned sale
|
Non-Executive Director
|
2,425
-2.5%
274.90
US$666,627
|
2,425
-2.5%
|
274.90
|
US$666,627
|
|
|
2026-02-26 |
2026-02-24 |
PlS
Planned sale
|
Non-Executive Director
|
930
-1.0%
269.50
US$250,636
|
930
-1.0%
|
269.50
|
US$250,636
|
|
|
2026-02-26 |
2026-02-24 |
PlS
Planned sale
|
Non-Executive Director
|
1,674
-1.7%
268.67
US$449,747
|
1,674
-1.7%
|
268.67
|
US$449,747
|
|
|
2026-02-26 |
2026-02-24 |
PlS
Planned sale
|
Non-Executive Director
|
1,891
-1.9%
267.37
US$505,597
|
1,891
-1.9%
|
267.37
|
US$505,597
|
|
|
2026-02-26 |
2026-02-24 |
PlS
Planned sale
|
Non-Executive Director
|
4,339
-4.1%
266.62
US$1,156,879
|
4,339
-4.1%
|
266.62
|
US$1,156,879
|
|
|
2026-02-26 |
2026-02-24 |
PlS
Planned sale
|
Non-Executive Director
|
1,604
-1.5%
265.54
US$425,919
|
1,604
-1.5%
|
265.54
|
US$425,919
|
|
|
2026-02-26 |
2026-02-24 |
PlS
Planned sale
|
Non-Executive Director
|
900
-0.8%
264.60
US$238,136
|
900
-0.8%
|
264.60
|
US$238,136
|
|
|
2026-02-26 |
2026-02-24 |
PlS
Planned sale
|
Non-Executive Director
|
62
-0.1%
263.05
US$16,309
|
62
-0.1%
|
263.05
|
US$16,309
|
|
|
2026-02-26 |
2026-02-24 |
S
Sale
|
Non-Executive Director
|
373
-100.0%
271.09
US$101,118
|
373
-100.0%
|
271.09
|
US$101,118
|
|
|
2026-02-26 |
2026-02-24 |
S
Sale
|
Non-Executive Director
|
370
-49.8%
269.83
US$99,836
|
370
-49.8%
|
269.83
|
US$99,836
|
|
|
2026-02-26 |
2026-02-24 |
S
Sale
|
Non-Executive Director
|
3,963
-84.2%
268.97
US$1,065,924
|
3,963
-84.2%
|
268.97
|
US$1,065,924
|
|
|
2026-02-26 |
2026-02-24 |
S
Sale
|
Non-Executive Director
|
6,671
-58.6%
268.04
US$1,788,079
|
6,671
-58.6%
|
268.04
|
US$1,788,079
|
|
|
2026-02-26 |
2026-02-24 |
S
Sale
|
Non-Executive Director
|
11,673
-50.6%
266.97
US$3,116,310
|
11,673
-50.6%
|
266.97
|
US$3,116,310
|
|
|
2026-02-26 |
2026-02-24 |
S
Sale
|
Non-Executive Director
|
8,986
-28.0%
266.18
US$2,391,885
|
8,986
-28.0%
|
266.18
|
US$2,391,885
|
|
|
2026-02-26 |
2026-02-24 |
S
Sale
|
Non-Executive Director
|
3,557
-10.0%
265.08
US$942,878
|
3,557
-10.0%
|
265.08
|
US$942,878
|
|