|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
4,508
-5.5%
349.89
US$107,657
|
4,508
-5.5%
|
349.89
|
US$107,657
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
77,452
-36.0%
216.88
US$117,320
|
77,452
-36.0%
|
216.88
|
US$117,320
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
58,812
-1.0%
332.88
US$1,033,133
|
58,812
-1.0%
|
332.88
|
US$1,033,133
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
1,329
-0.1%
364.48
US$484,390
|
1,329
-0.1%
|
364.48
|
US$484,390
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
565
-0.0%
363.34
US$205,287
|
565
-0.0%
|
363.34
|
US$205,287
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
565
-0.0%
363.34
US$205,287
|
565
-0.0%
|
363.34
|
US$205,287
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
1,992
-0.2%
362.65
US$722,404
|
1,992
-0.2%
|
362.65
|
US$722,404
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
1,992
-0.2%
362.65
US$722,404
|
1,992
-0.2%
|
362.65
|
US$722,404
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
1,242
-0.1%
361.61
US$449,120
|
1,242
-0.1%
|
361.61
|
US$449,120
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
1,242
-0.1%
361.61
US$449,120
|
1,242
-0.1%
|
361.61
|
US$449,120
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
2,320
-0.2%
360.47
US$836,281
|
2,320
-0.2%
|
360.47
|
US$836,281
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
3,392
-0.3%
359.39
US$1,219,038
|
3,392
-0.3%
|
359.39
|
US$1,219,038
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
3,180
-0.2%
358.42
US$1,139,777
|
3,180
-0.2%
|
358.42
|
US$1,139,777
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
3,962
-0.3%
357.57
US$1,416,709
|
3,962
-0.3%
|
357.57
|
US$1,416,709
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
3,267
-0.2%
356.37
US$1,164,254
|
3,267
-0.2%
|
356.37
|
US$1,164,254
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
2,006
-0.2%
355.57
US$713,277
|
2,006
-0.2%
|
355.57
|
US$713,277
|
|
|
2026-09-04 |
2026-09-04 |
PlS
Planned sale
|
President, R&D
Executive Director
Large shareholder
|
520
-0.0%
354.54
US$184,361
|
520
-0.0%
|
354.54
|
US$184,361
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
405
-0.0%
366.56
US$148,455
|
405
-0.0%
|
366.56
|
US$148,455
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
405
-0.0%
366.56
US$148,455
|
405
-0.0%
|
366.56
|
US$148,455
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
847
-0.1%
365.42
US$309,508
|
847
-0.1%
|
365.42
|
US$309,508
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
847
-0.1%
365.42
US$309,508
|
847
-0.1%
|
365.42
|
US$309,508
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
1,358
-0.1%
364.48
US$494,963
|
1,358
-0.1%
|
364.48
|
US$494,963
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
1,358
-0.1%
364.48
US$494,963
|
1,358
-0.1%
|
364.48
|
US$494,963
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
573
-0.0%
363.34
US$208,195
|
573
-0.0%
|
363.34
|
US$208,195
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
2,010
-0.1%
362.65
US$728,927
|
2,010
-0.1%
|
362.65
|
US$728,927
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
1,214
-0.1%
361.61
US$438,993
|
1,214
-0.1%
|
361.61
|
US$438,993
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
2,266
-0.2%
360.46
US$816,809
|
2,266
-0.2%
|
360.46
|
US$816,809
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
3,357
-0.2%
359.39
US$1,206,459
|
3,357
-0.2%
|
359.39
|
US$1,206,459
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
3,143
-0.2%
358.42
US$1,126,508
|
3,143
-0.2%
|
358.42
|
US$1,126,508
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
3,981
-0.3%
357.57
US$1,423,501
|
3,981
-0.3%
|
357.57
|
US$1,423,501
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
3,297
-0.2%
356.37
US$1,174,948
|
3,297
-0.2%
|
356.37
|
US$1,174,948
|
|
|
2026-09-04 |
2026-09-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
2,029
-0.1%
355.57
US$721,455
|
2,029
-0.1%
|
355.57
|
US$721,455
|
|
|
2026-09-04 |
2026-09-04 |
PlS
Planned sale
|
President and CEO
Executive Director
Large shareholder
|
520
-0.0%
354.54
US$184,361
|
520
-0.0%
|
354.54
|
US$184,361
|
|
|
2026-09-04 |
2026-09-04 |
PrS
Proposed sale
|
Director; Officer; 10% Stockholder
Executive Director
Large shareholder
|
25,000
371.47
US$9,286,750
|
25,000
|
371.47
|
US$9,286,750
|
|
|
2026-09-04 |
2026-09-04 |
PrS
Proposed sale
|
Director; Officer; 10% Stockholder
Executive Director
Large shareholder
|
25,000
371.47
US$9,286,750
|
25,000
|
371.47
|
US$9,286,750
|
|
|
2026-08-14 |
2026-08-14 |
S
Sale
|
Non-Executive Director
|
40
-0.1%
333.23
US$13,329
|
40
-0.1%
|
333.23
|
US$13,329
|
|
|
2026-08-14 |
2026-08-14 |
S
Sale
|
Non-Executive Director
|
3,095
-5.8%
331.43
US$1,025,786
|
3,095
-5.8%
|
331.43
|
US$1,025,786
|
|
|
2026-08-14 |
2026-08-14 |
S
Sale
|
Non-Executive Director
|
4,896
-8.4%
330.36
US$1,617,422
|
4,896
-8.4%
|
330.36
|
US$1,617,422
|
|
|
2026-08-14 |
2026-08-14 |
S
Sale
|
Non-Executive Director
|
7,428
-11.3%
329.60
US$2,448,280
|
7,428
-11.3%
|
329.60
|
US$2,448,280
|
|
|
2026-08-14 |
2026-08-14 |
S
Sale
|
Non-Executive Director
|
1,687
-2.5%
328.52
US$554,205
|
1,687
-2.5%
|
328.52
|
US$554,205
|
|
|
2026-08-14 |
2026-08-14 |
S
Sale
|
Non-Executive Director
|
5,226
-7.2%
327.39
US$1,710,961
|
5,226
-7.2%
|
327.39
|
US$1,710,961
|
|
|
2026-08-14 |
2026-08-14 |
S
Sale
|
Non-Executive Director
|
2,287
-3.1%
326.60
US$746,941
|
2,287
-3.1%
|
326.60
|
US$746,941
|
|
|
2026-08-14 |
2026-08-14 |
S
Sale
|
Non-Executive Director
|
341
-0.5%
325.60
US$111,029
|
341
-0.5%
|
325.60
|
US$111,029
|
|
|
2026-08-14 |
2026-08-14 |
PrS
Proposed sale
|
Director
Non-Executive Director
|
25,000
332.27
US$8,306,750
|
25,000
|
332.27
|
US$8,306,750
|
|
|
2026-06-26 |
2026-06-25 |
PlS
Planned sale
|
EVP, General Counsel
Officer
|
1,000
-100.0%
347.27
US$347,270
|
1,000
-100.0%
|
347.27
|
US$347,270
|
|
|
2026-06-25 |
2026-06-25 |
PrS
Proposed sale
|
Officer
Officer
|
1,000
347.27
US$347,270
|
1,000
|
347.27
|
US$347,270
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
40
-0.0%
312.23
US$12,489
|
40
-0.0%
|
312.23
|
US$12,489
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
964
-0.1%
311.36
US$300,149
|
964
-0.1%
|
311.36
|
US$300,149
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
2,652
-0.2%
310.43
US$823,258
|
2,652
-0.2%
|
310.43
|
US$823,258
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
2,784
-0.2%
309.49
US$861,620
|
2,784
-0.2%
|
309.49
|
US$861,620
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
4,830
-0.3%
308.47
US$1,489,899
|
4,830
-0.3%
|
308.47
|
US$1,489,899
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
11,461
-0.8%
307.68
US$3,526,293
|
11,461
-0.8%
|
307.68
|
US$3,526,293
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
589
-0.0%
306.33
US$180,429
|
589
-0.0%
|
306.33
|
US$180,429
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
544
-0.0%
304.81
US$165,817
|
544
-0.0%
|
304.81
|
US$165,817
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
176
-0.0%
303.17
US$53,358
|
176
-0.0%
|
303.17
|
US$53,358
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President and CEO
Executive Director
Large shareholder
|
640
-0.0%
302.24
US$193,431
|
640
-0.0%
|
302.24
|
US$193,431
|
|
|
2026-06-05 |
2026-06-04 |
PlS
Planned sale
|
President and CEO
Executive Director
Large shareholder
|
320
-0.0%
300.75
US$96,240
|
320
-0.0%
|
300.75
|
US$96,240
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
240
-0.0%
311.65
US$74,796
|
240
-0.0%
|
311.65
|
US$74,796
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
2,039
-0.1%
310.94
US$634,001
|
2,039
-0.1%
|
310.94
|
US$634,001
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
2,801
-0.2%
309.95
US$868,156
|
2,801
-0.2%
|
309.95
|
US$868,156
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
3,803
-0.3%
308.89
US$1,174,708
|
3,803
-0.3%
|
308.89
|
US$1,174,708
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
12,729
-0.9%
307.81
US$3,918,070
|
12,729
-0.9%
|
307.81
|
US$3,918,070
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
1,348
-0.1%
307.09
US$413,964
|
1,348
-0.1%
|
307.09
|
US$413,964
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
480
-0.0%
305.87
US$146,815
|
480
-0.0%
|
305.87
|
US$146,815
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
400
-0.0%
304.89
US$121,958
|
400
-0.0%
|
304.89
|
US$121,958
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
247
-0.0%
303.17
US$74,883
|
247
-0.0%
|
303.17
|
US$74,883
|
|
|
2026-06-05 |
2026-06-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
593
-0.0%
302.25
US$179,235
|
593
-0.0%
|
302.25
|
US$179,235
|
|
|
2026-06-05 |
2026-06-04 |
PlS
Planned sale
|
President, R&D
Executive Director
Large shareholder
|
320
-0.0%
300.75
US$96,240
|
320
-0.0%
|
300.75
|
US$96,240
|
|
|
2026-06-04 |
2026-06-04 |
PrS
Proposed sale
|
Director; Officer; 10% Stockholder
Executive Director
Large shareholder
|
25,000
301.82
US$7,545,500
|
25,000
|
301.82
|
US$7,545,500
|
|
|
2026-06-04 |
2026-06-04 |
PrS
Proposed sale
|
Director; Officer; 10% Stockholder
Executive Director
Large shareholder
|
25,000
301.82
US$7,545,500
|
25,000
|
301.82
|
US$7,545,500
|
|
|
2026-05-27 |
2026-05-26 |
PlS
Planned sale
|
EVP, General Counsel
Officer
|
642
-100.0%
302.03
US$193,903
|
642
-100.0%
|
302.03
|
US$193,903
|
|
|
2026-05-26 |
2026-05-26 |
PrS
Proposed sale
|
Officer
Officer
|
642
302.03
US$193,903
|
642
|
302.03
|
US$193,903
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
1,700
-0.1%
266.42
US$452,918
|
1,700
-0.1%
|
266.42
|
US$452,918
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
6,000
-0.4%
265.16
US$1,590,979
|
6,000
-0.4%
|
265.16
|
US$1,590,979
|
|
|
2026-03-06 |
2026-03-04 |
S
Sale
|
President, R&D
Executive Director
Large shareholder
|
4,852
-0.3%
264.64
US$1,284,019
|
4,852
-0.3%
|
264.64
|
US$1,284,019
|
|