United States Biotechnology & Medical Research

Karyopharm Therapeutics Inc (KPTI)

Track

Over the past 90 days, Karyopharm Therapeutics Inc. insiders have exclusively engaged in selling activity, totaling $38,755.56 in net value across seven transactions. These sales involved six executives, including the CEO, following the company's May 14 earnings report. The stock has experienced a 24.9% price increase over the same period.
Ticker: KPTI Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Top insiders
Trades
Cheng Sohanya Roshan
EVP & Chief Commercial Officer
1 sale — total 3,078 USD
Sale 14 May 2026
Value US$4,490,846.80 | Price 228.41 | Shares 28,814
Sale 14 May 2026
Value US$4,552,114.88 | Price 251.22 | Shares 11,565
Sale 14 May 2026
Value US$3,828.50 | Price 9.50 | Shares 403
Sale 14 May 2026
Value US$3,876.00 | Price 9.50 | Shares 408
Sale 14 May 2026
Value US$20,928.50 | Price 9.50 | Shares 2,203
Sale 14 May 2026
Value US$503.50 | Price 9.50 | Shares 53
Sale 21 Apr 2026
Value US$4,014.06 | Price 8.94 | Shares 449
Sale 2 Mar 2026
Value US$5,259.91 | Price 9.41 | Shares 559
Sale 2 Mar 2026
Value US$33,177.90 | Price 9.41 | Shares 3,526
Sale 2 Mar 2026
Value US$43,321.34 | Price 9.41 | Shares 4,604
Sale 2 Mar 2026
Value US$47,668.53 | Price 9.41 | Shares 5,066
Sale 2 Mar 2026
Value US$116,310.83 | Price 9.41 | Shares 12,361
Sale 2 Mar 2026
Value US$47,997.86 | Price 9.41 | Shares 5,101
Sale 17 Feb 2026
Value US$3,262.14 | Price 8.63 | Shares 378
Sale 3 Feb 2026
Value US$10,243.80 | Price 6.30 | Shares 1,626
Sale 28 Jan 2026
Value US$351.50 | Price 7.03 | Shares 50
Sale 21 Jan 2026
Value US$1,579.40 | Price 5.96 | Shares 265
Sale 1 Oct 2025
Value US$2,279.15 | Price 6.30 | Shares 362
Sale 15 Sep 2025
Value US$8,082.51 | Price 6.43 | Shares 1,257
Sale 15 Sep 2025
Value US$2,623.44 | Price 6.43 | Shares 408
Sale 15 Sep 2025
Value US$147.89 | Price 6.43 | Shares 23
Sale 15 Sep 2025
Value US$1,504.62 | Price 6.43 | Shares 234
Sale 15 Sep 2025
Value US$2,578.43 | Price 6.43 | Shares 401
Sale 15 Sep 2025
Value US$2,089.75 | Price 6.43 | Shares 325
Sale 3 Sep 2025
Value US$81.36 | Price 6.78 | Shares 12
Sale 22 Jul 2025
Value US$952.00 | Price 4.00 | Shares 238
Sale 6 May 2025
Value US$1,680.32 | Price 7.12 | Shares 236
Sale 23 Apr 2025
Value US$2,585.23 | Price 6.17 | Shares 419
Sale 4 Apr 2025
Value US$916.30 | Price 3.74 | Shares 245
Sale 4 Mar 2025
Value US$3,591.59 | Price 6.29 | Shares 571
Sale 4 Mar 2025
Value US$21,669.05 | Price 6.29 | Shares 3,445
Sale 4 Mar 2025
Value US$22,316.92 | Price 6.29 | Shares 3,548
Sale 4 Mar 2025
Value US$73,555.26 | Price 6.29 | Shares 11,694
Sale 4 Mar 2025
Value US$22,562.23 | Price 6.29 | Shares 3,587
Sale 4 Mar 2025
Value US$17,567.97 | Price 6.29 | Shares 2,793
Sale 18 Feb 2025
Value US$3,725.82 | Price 0.63 | Shares 5,914
Sale 4 Feb 2025
Value US$2,664.35 | Price 0.65 | Shares 4,099
Sale 6 Jan 2025
Value US$3,175.06 | Price 0.78 | Shares 4,055
Sale 4 Dec 2024
Value US$2,932.20 | Price 0.81 | Shares 3,620
Sale 5 Nov 2024
Value US$3,346.46 | Price 0.91 | Shares 3,675
Sale 4 Oct 2024
Value US$3,171.64 | Price 0.88 | Shares 3,607
Sale 4 Sep 2024
Value US$2,866.27 | Price 0.72 | Shares 3,971
Sale 4 Sep 2024
Value US$2,646.84 | Price 0.72 | Shares 3,667
Planned sale 4 Sep 2024
Value US$3,865.96 | Price 0.72 | Shares 5,356
Sale 4 Sep 2024
Value US$5,088.69 | Price 0.72 | Shares 7,050
Sale 6 Aug 2024
Value US$3,355.08 | Price 0.93 | Shares 3,608
Sale 30 Jul 2024
Value US$3,055.98 | Price 1.06 | Shares 2,883
Sale 5 Jul 2024
Value US$3,077.22 | Price 0.85 | Shares 3,616
Sale 7 Jun 2024
Value US$2,129.57 | Price 0.95 | Shares 2,240
Sale 7 Jun 2024
Value US$218,003.12 | Price 0.95 | Shares 229,308
Sale 6 Jun 2024
Value US$1,125.31 | Price 0.98 | Shares 1,145
Sale 6 Jun 2024
Value US$115,289.32 | Price 0.98 | Shares 117,307
Sale 5 Jun 2024
Value US$4,336.81 | Price 0.96 | Shares 4,526
Sale 5 Jun 2024
Value US$444,142.95 | Price 0.96 | Shares 463,518
Sale 4 Jun 2024
Value US$645.48 | Price 0.99 | Shares 652
Sale 4 Jun 2024
Value US$3,556.08 | Price 0.99 | Shares 3,592
Sale 4 Jun 2024
Value US$3,140.03 | Price 0.95 | Shares 3,298
Sale 4 Jun 2024
Value US$321,564.16 | Price 0.95 | Shares 337,742
Sale 3 Jun 2024
Value US$3,490.44 | Price 1.00 | Shares 3,488
Sale 3 Jun 2024
Value US$357,506.08 | Price 1.00 | Shares 357,256
Sale 31 May 2024
Value US$1,885.10 | Price 0.95 | Shares 1,976
Sale 31 May 2024
Value US$193,106.77 | Price 0.95 | Shares 202,418
Sale 6 May 2024
Value US$4,040.88 | Price 1.13 | Shares 3,576
Sale 6 May 2024
Value US$4,040.88 | Price 1.13 | Shares 3,576
Sale 22 Apr 2024
Value US$7,943.13 | Price 1.17 | Shares 6,789
Sale 4 Apr 2024
Value US$4,596.27 | Price 1.29 | Shares 3,563
Sale 5 Mar 2024
Value US$4,644.90 | Price 1.30 | Shares 3,573
Sale 1 Mar 2024
Value US$4,291.20 | Price 1.20 | Shares 3,576
Sale 1 Mar 2024
Value US$6,130.80 | Price 1.20 | Shares 5,109
Sale 1 Mar 2024
Value US$7,394.40 | Price 1.20 | Shares 6,162
Sale 1 Mar 2024
Value US$7,162.80 | Price 1.20 | Shares 5,969
Sale 1 Mar 2024
Value US$7,386.00 | Price 1.20 | Shares 6,155
Sale 1 Mar 2024
Value US$23,248.80 | Price 1.20 | Shares 19,374
Sale 29 Feb 2024
Value US$19,858.41 | Price 1.17 | Shares 16,973
Sale 29 Feb 2024
Value US$25,552.80 | Price 1.17 | Shares 21,840
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-05-15 2026-05-14 S Sale
3.7
Cheng Sohanya Roshan

EVP & Chief Commercial Officer

Officer
28,814 +48.3%
228.41
US$4,490,847 		28,814 +48.3% 228.41 US$4,490,847
2026-05-15 2026-05-14 S Sale
3.7
Mano Michael

EVP, CLO&Secretary

Officer
11,565 +49.0%
251.22
US$4,552,115 		11,565 +49.0% 251.22 US$4,552,115
2026-05-15 2026-05-14 S Sale
3.8
Poulton Stuart

EVP, Chief Development Officer

Officer
63,663 +41.1%
110.76
US$2,715,759 		63,663 +41.1% 110.76 US$2,715,759
2026-05-15 2026-05-14 S Sale
3.9
Rangwala Reshma

EVP & Chief Medical Officer

Officer
408 -0.7%
9.50
US$3,876 		408 -0.7% 9.50 US$3,876
2026-05-15 2026-05-14 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
2,203 -0.8%
9.50
US$20,928 		2,203 -0.8% 9.50 US$20,928
2026-05-15 2026-05-14 S Sale
3.0
Abate Kristin

Chief Accounting Officer

Officer
53 -0.2%
9.50
US$504 		53 -0.2% 9.50 US$504
2026-04-22 2026-04-21 S Sale
3.9
Rangwala Reshma

EVP & Chief Medical Officer

Officer
449 -0.8%
8.94
US$4,014 		449 -0.8% 8.94 US$4,014
2026-03-03 2026-03-02 S Sale
3.0
Abate Kristin

Chief Accounting Officer

Officer
559 -2.5%
9.41
US$5,260 		559 -2.5% 9.41 US$5,260
2026-03-03 2026-03-02 S Sale
3.7
Mano Michael

EVP, CLO&Secretary

Officer
3,526 -3.6%
9.41
US$33,178 		3,526 -3.6% 9.41 US$33,178
2026-03-03 2026-03-02 S Sale
3.7
Cheng Sohanya Roshan

EVP & Chief Commercial Officer

Officer
4,604 -4.1%
9.41
US$43,321 		4,604 -4.1% 9.41 US$43,321
2026-03-03 2026-03-02 S Sale
3.9
Rangwala Reshma

EVP & Chief Medical Officer

Officer
5,066 -8.2%
9.41
US$47,669 		5,066 -8.2% 9.41 US$47,669
2026-03-03 2026-03-02 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
12,361 -4.4%
9.41
US$116,311 		12,361 -4.4% 9.41 US$116,311
2026-03-03 2026-03-02 S Sale
3.8
Poulton Stuart

EVP, Chief Development Officer

Officer
5,101 -5.1%
9.41
US$47,998 		5,101 -5.1% 9.41 US$47,998
2026-02-19 2026-02-17 S Sale
3.8
Poulton Stuart

EVP, Chief Development Officer

Officer
378 -0.4%
8.63
US$3,262 		378 -0.4% 8.63 US$3,262
2026-02-04 2026-02-03 S Sale
0.5
Macomber Lori

EVP, CFO & Treasurer

Officer
1,626 -1.9%
6.30
US$10,244 		1,626 -1.9% 6.30 US$10,244
2026-01-29 2026-01-28 S Sale
3.0
Abate Kristin

Chief Accounting Officer

Officer
50 -0.2%
7.03
US$352 		50 -0.2% 7.03 US$352
2026-01-22 2026-01-21 S Sale
3.0
Abate Kristin

Chief Accounting Officer

Officer
265 -1.2%
5.96
US$1,579 		265 -1.2% 5.96 US$1,579
2025-10-03 2025-10-01 S Sale
3.0
Abate Kristin

Chief Accounting Officer

Officer
362 -3.5%
6.30
US$2,279 		362 -3.5% 6.30 US$2,279
2025-09-16 2025-09-15 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
1,257 -1.5%
6.43
US$8,083 		1,257 -1.5% 6.43 US$8,083
2025-09-16 2025-09-15 S Sale
3.9
Rangwala Reshma

EVP & Chief Medical Officer

Officer
408 -1.4%
6.43
US$2,623 		408 -1.4% 6.43 US$2,623
2025-09-16 2025-09-15 S Sale
3.0
Abate Kristin

Chief Accounting Officer

Officer
23 -0.2%
6.43
US$148 		23 -0.2% 6.43 US$148
2025-09-16 2025-09-15 S Sale
3.7
Mano Michael

SVP, General Counsel&Secretary

Officer
234 -1.1%
6.43
US$1,505 		234 -1.1% 6.43 US$1,505
2025-09-16 2025-09-15 S Sale
3.8
Poulton Stuart

EVP, Chief Development Officer

Officer
401 -1.4%
6.43
US$2,578 		401 -1.4% 6.43 US$2,578
2025-09-16 2025-09-15 S Sale
3.7
Cheng Sohanya Roshan

EVP & Chief Commercial Officer

Officer
325 -0.9%
6.43
US$2,090 		325 -0.9% 6.43 US$2,090
2025-09-04 2025-09-03 S Sale
3.0
Abate Kristin

Chief Accounting Officer

Officer
12 -0.1%
6.78
US$81 		12 -0.1% 6.78 US$81
2025-07-23 2025-07-22 S Sale
3.0
Abate Kristin

Chief Accounting Officer

Officer
238 -2.5%
4.00
US$952 		238 -2.5% 4.00 US$952
2025-05-07 2025-05-06 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
236 -0.3%
7.12
US$1,680 		236 -0.3% 7.12 US$1,680
2025-04-24 2025-04-23 S Sale
3.9
Rangwala Reshma

EVP & Chief Medical Officer

Officer
419 -1.4%
6.17
US$2,585 		419 -1.4% 6.17 US$2,585
2025-04-07 2025-04-04 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
245 -0.3%
3.74
US$916 		245 -0.3% 3.74 US$916
2025-03-06 2025-03-04 S Sale
3.0
Abate Kristin

Chief Accounting Officer

Officer
571 -5.6%
6.29
US$3,592 		571 -5.6% 6.29 US$3,592
2025-03-06 2025-03-04 S Sale
3.7
Cheng Sohanya Roshan

EVP & Chief Commercial Officer

Officer
3,445 -9.1%
6.29
US$21,669 		3,445 -9.1% 6.29 US$21,669
2025-03-06 2025-03-04 S Sale
3.8
Poulton Stuart

EVP, Chief Development Officer

Officer
3,548 -11.5%
6.29
US$22,317 		3,548 -11.5% 6.29 US$22,317
2025-03-06 2025-03-04 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
11,694 -12.4%
6.29
US$73,555 		11,694 -12.4% 6.29 US$73,555
2025-03-06 2025-03-04 S Sale
3.9
Rangwala Reshma

EVP & Chief Medical Officer

Officer
3,587 -10.9%
6.29
US$22,562 		3,587 -10.9% 6.29 US$22,562
2025-03-06 2025-03-04 S Sale
3.7
Mano Michael

SVP, General Counsel&Secretary

Officer
2,793 -11.7%
6.29
US$17,568 		2,793 -11.7% 6.29 US$17,568
2025-02-19 2025-02-18 S Sale
3.8
Poulton Stuart

EVP, Chief Development Officer

Officer
5,914 -1.8%
0.63
US$3,726 		5,914 -1.8% 0.63 US$3,726
2025-02-05 2025-02-04 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
4,099 -0.4%
0.65
US$2,664 		4,099 -0.4% 0.65 US$2,664
2025-01-07 2025-01-06 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
4,055 -0.4%
0.78
US$3,175 		4,055 -0.4% 0.78 US$3,175
2024-12-05 2024-12-04 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
3,620 -0.3%
0.81
US$2,932 		3,620 -0.3% 0.81 US$2,932
2024-11-06 2024-11-05 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
3,675 -0.3%
0.91
US$3,346 		3,675 -0.3% 0.91 US$3,346
2024-10-07 2024-10-04 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
3,607 -0.3%
0.88
US$3,172 		3,607 -0.3% 0.88 US$3,172
2024-09-05 2024-09-04 S Sale
3.7
Mano Michael

SVP, General Counsel&Secretary

Officer
3,971 -1.4%
0.72
US$2,866 		3,971 -1.4% 0.72 US$2,866
2024-09-05 2024-09-04 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
3,667 -0.3%
0.72
US$2,647 		3,667 -0.3% 0.72 US$2,647
2024-09-05 2024-09-04 PlS Planned sale
3.7
Cheng Sohanya Roshan

EVP & Chief Commercial Officer

Officer
5,356 -1.3%
0.72
US$3,866 		5,356 -1.3% 0.72 US$3,866
2024-09-05 2024-09-04 S Sale
4.0
Mason Michael

EVP, CFO & Treasurer

Officer
7,050 -1.8%
0.72
US$5,089 		7,050 -1.8% 0.72 US$5,089
2024-08-08 2024-08-06 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
3,608 -0.3%
0.93
US$3,355 		3,608 -0.3% 0.93 US$3,355
2024-07-31 2024-07-30 S Sale
3.8
Poulton Stuart

EVP, Chief Development Officer

Officer
2,883 -0.9%
1.06
US$3,056 		2,883 -0.9% 1.06 US$3,056
2024-07-09 2024-07-05 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
3,616 -0.3%
0.85
US$3,077 		3,616 -0.3% 0.85 US$3,077
2024-06-07 2024-06-07 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
2,240 -100.0%
0.95
US$2,130 		2,240 -100.0% 0.95 US$2,130
2024-06-07 2024-06-07 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
229,308 -100.0%
0.95
US$218,003 		229,308 -100.0% 0.95 US$218,003
2024-06-07 2024-06-06 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
1,145 -33.8%
0.98
US$1,125 		1,145 -33.8% 0.98 US$1,125
2024-06-07 2024-06-06 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
117,307 -33.8%
0.98
US$115,289 		117,307 -33.8% 0.98 US$115,289
2024-06-07 2024-06-05 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
4,526 -57.2%
0.96
US$4,337 		4,526 -57.2% 0.96 US$4,337
2024-06-07 2024-06-05 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
463,518 -57.2%
0.96
US$444,143 		463,518 -57.2% 0.96 US$444,143
2024-06-06 2024-06-04 S Sale
4.0
Mason Michael

EVP, CFO & Treasurer

Officer
652 -0.2%
0.99
US$645 		652 -0.2% 0.99 US$645
2024-06-06 2024-06-04 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
3,592 -0.3%
0.99
US$3,556 		3,592 -0.3% 0.99 US$3,556
2024-06-04 2024-06-04 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
3,298 -29.4%
0.95
US$3,140 		3,298 -29.4% 0.95 US$3,140
2024-06-04 2024-06-04 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
337,742 -29.4%
0.95
US$321,564 		337,742 -29.4% 0.95 US$321,564
2024-06-04 2024-06-03 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
3,488 -23.7%
1.00
US$3,490 		3,488 -23.7% 1.00 US$3,490
2024-06-04 2024-06-03 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
357,256 -23.7%
1.00
US$357,506 		357,256 -23.7% 1.00 US$357,506
2024-06-04 2024-05-31 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
1,976 -11.9%
0.95
US$1,885 		1,976 -11.9% 0.95 US$1,885
2024-06-04 2024-05-31 S Sale
4.0
PAKIANATHAN DEEPIKA
Non-Executive Director
202,418 -11.9%
0.95
US$193,107 		202,418 -11.9% 0.95 US$193,107
2024-05-07 2024-05-06 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
3,576 -0.3%
1.13
US$4,041 		3,576 -0.3% 1.13 US$4,041
2024-05-07 2024-05-06 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
3,576 -0.3%
1.13
US$4,041 		3,576 -0.3% 1.13 US$4,041
2024-04-23 2024-04-22 S Sale
3.9
Rangwala Reshma

EVP & Chief Medical Officer

Officer
6,789 -1.9%
1.17
US$7,943 		6,789 -1.9% 1.17 US$7,943
2024-04-05 2024-04-04 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
3,563 -0.3%
1.29
US$4,596 		3,563 -0.3% 1.29 US$4,596
2024-03-06 2024-03-05 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
3,573 -0.3%
1.30
US$4,645 		3,573 -0.3% 1.30 US$4,645
2024-03-04 2024-03-01 S Sale
3.7
Mano Michael

SVP, General Counsel&Secretary

Officer
3,576 -1.3%
1.20
US$4,291 		3,576 -1.3% 1.20 US$4,291
2024-03-04 2024-03-01 S Sale
3.7
Cheng Sohanya Roshan

EVP & Chief Commercial Officer

Officer
5,109 -1.3%
1.20
US$6,131 		5,109 -1.3% 1.20 US$6,131
2024-03-04 2024-03-01 S Sale
4.0
Mason Michael

EVP, CFO & Treasurer

Officer
6,162 -1.5%
1.20
US$7,394 		6,162 -1.5% 1.20 US$7,394
2024-03-04 2024-03-01 S Sale
3.9
Rangwala Reshma

EVP & Chief Medical Officer

Officer
5,969 -1.7%
1.20
US$7,163 		5,969 -1.7% 1.20 US$7,163
2024-03-04 2024-03-01 S Sale
3.8
Poulton Stuart

EVP, Chief Development Officer

Officer
6,155 -1.8%
1.20
US$7,386 		6,155 -1.8% 1.20 US$7,386
2024-03-04 2024-03-01 S Sale
3.9
Paulson Richard A.

President and CEO

Executive Director
19,374 -1.6%
1.20
US$23,249 		19,374 -1.6% 1.20 US$23,249
2024-03-04 2024-02-29 S Sale
3.7
Mano Michael

SVP, General Counsel&Secretary

Officer
16,973 -5.7%
1.17
US$19,858 		16,973 -5.7% 1.17 US$19,858
2024-03-04 2024-02-29 S Sale
3.7
Cheng Sohanya Roshan

EVP & Chief Commercial Officer

Officer
21,840 -5.2%
1.17
US$25,553 		21,840 -5.2% 1.17 US$25,553
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