|
2004-04-21 |
2004-04-20 |
S
Sale
|
XMARK ASSET MANAGEMENT LLC
Large shareholder
|
3,923
-9.3%
40.79
US$2,453,187
|
3,923
-9.3%
|
40.79
|
US$2,453,187
|
|
|
2004-06-17 |
2004-04-19 |
S
Sale
|
FLEMING JONATHAN
Non-Executive Director
Large shareholder
|
20,033
+16.0%
423.46
US$4,869,384
|
20,033
+16.0%
|
423.46
|
US$4,869,384
|
|
|
2004-06-17 |
2004-04-19 |
B
Purchase
|
FLEMING JONATHAN
Non-Executive Director
Large shareholder
|
23,390
-34.8%
307.84
US$559,597
|
23,390
-34.8%
|
307.84
|
US$559,597
|
|
|
2004-06-17 |
2004-04-19 |
S
Sale
|
OXFORD BIOSCIENCE PARTNERS IV LP
Large shareholder
|
8,696,548
-100.0%
0.75
US$6,522,411
|
8,696,548
-100.0%
|
0.75
|
US$6,522,411
|
|
|
2004-06-17 |
2004-04-19 |
B
Purchase
|
OXFORD BIOSCIENCE PARTNERS IV LP
Large shareholder
|
11,595,397
+80.1%
0.75
US$8,696,548
|
11,595,397
+80.1%
|
0.75
|
US$8,696,548
|
|
|
2004-04-19 |
2004-04-15 |
S
Sale
|
XMARK ASSET MANAGEMENT LLC
Large shareholder
|
16,430
-0.8%
0.95
US$15,561
|
16,430
-0.8%
|
0.95
|
US$15,561
|
|
|
2004-06-17 |
2004-04-14 |
S
Sale
|
FLEMING JONATHAN
Non-Executive Director
Large shareholder
|
3,900,348
-100.0%
0.75
US$2,925,261
|
3,900,348
-100.0%
|
0.75
|
US$2,925,261
|
|
|
2004-06-17 |
2004-04-14 |
B
Purchase
|
FLEMING JONATHAN
Non-Executive Director
Large shareholder
|
5,200,464
+55.2%
0.75
US$3,900,348
|
5,200,464
+55.2%
|
0.75
|
US$3,900,348
|
|
|
2004-06-17 |
2004-04-14 |
B
Purchase
|
FLEMING JONATHAN
Non-Executive Director
Large shareholder
|
2,933,334
+45.3%
0.75
US$2,200,000
|
2,933,334
+45.3%
|
0.75
|
US$2,200,000
|
|
|
2004-06-17 |
2004-04-14 |
S
Sale
|
OXFORD BIOSCIENCE PARTNERS IV LP
Large shareholder
|
3,861,602
-100.0%
0.75
US$2,896,201
|
3,861,602
-100.0%
|
0.75
|
US$2,896,201
|
|
|
2004-06-17 |
2004-04-14 |
B
Purchase
|
OXFORD BIOSCIENCE PARTNERS IV LP
Large shareholder
|
5,148,802
+55.2%
0.75
US$3,861,602
|
5,148,802
+55.2%
|
0.75
|
US$3,861,602
|
|
|
2004-06-17 |
2004-04-14 |
B
Purchase
|
OXFORD BIOSCIENCE PARTNERS IV LP
Large shareholder
|
2,904,195
+45.3%
0.75
US$2,178,146
|
2,904,195
+45.3%
|
0.75
|
US$2,178,146
|
|
|
2004-04-15 |
2004-04-14 |
S
Sale
|
XMARK ASSET MANAGEMENT LLC
Large shareholder
|
96,900
-4.3%
1.16
US$112,171
|
96,900
-4.3%
|
1.16
|
US$112,171
|
|
|
2004-01-29 |
2004-01-27 |
S
Sale
|
XMARK ASSET MANAGEMENT LLC
Large shareholder
|
56,325
-2.4%
1.11
US$62,521
|
56,325
-2.4%
|
1.11
|
US$62,521
|
|
|
2004-01-27 |
2004-01-26 |
S
Sale
|
XMARK ASSET MANAGEMENT LLC
Large shareholder
|
13,375
-0.6%
1.23
US$16,451
|
13,375
-0.6%
|
1.23
|
US$16,451
|
|
|
2004-01-22 |
2004-01-21 |
S
Sale
|
XMARK ASSET MANAGEMENT LLC
Large shareholder
|
11,300
-0.5%
1.23
US$13,899
|
11,300
-0.5%
|
1.23
|
US$13,899
|
|
|
2004-01-14 |
2004-01-09 |
S
Sale
|
XMARK ASSET MANAGEMENT LLC
Large shareholder
|
26,400
-1.1%
1.44
US$37,910
|
26,400
-1.1%
|
1.44
|
US$37,910
|
|
|
2004-01-14 |
2004-01-08 |
S
Sale
|
XMARK ASSET MANAGEMENT LLC
Large shareholder
|
82,600
-3.4%
1.48
US$122,108
|
82,600
-3.4%
|
1.48
|
US$122,108
|
|
|
2004-01-14 |
2003-09-02 |
B
Purchase
|
XMARK ASSET MANAGEMENT LLC
Large shareholder
|
26,248
+1.1%
1.00
US$26,248
|
26,248
+1.1%
|
1.00
|
US$26,248
|
|
|
2004-01-14 |
2003-08-01 |
B
Purchase
|
XMARK ASSET MANAGEMENT LLC
Large shareholder
|
82,977
+3.5%
1.00
US$82,977
|
82,977
+3.5%
|
1.00
|
US$82,977
|
|