United States Biotechnology & Medical Research

Design Therapeutics Inc (DSGN)

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Design Therapeutics Inc. experienced multiple proposed sales by Logos Global Master Fund LP throughout November 2025. These filings represent the most recent activity, with the latest occurring on November 18. Prior to this period, various directors and entities executed several sell orders during August 2025, reflecting a consistent pattern of divestment by key stakeholders.
Ticker: DSGN Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
3.5
Logos Global Master Fund LP Director Non-Executive Director
Transaction date
Proposed sale
Price
225.96
Quantity 93,288
Value US$3,517,949
3.5
Logos Global Master Fund LP Director Non-Executive Director
Transaction date
Proposed sale
Price
372.73
Quantity 6,472
Value US$2,336,017
3.5
Logos Global Master Fund LP Director Non-Executive Director
Transaction date
Proposed sale
Price
417.89
Quantity 35,628
Value US$2,449,742
2.8
William Arsani Non-Executive Director
Transaction date
Sale
Price
5.25
Quantity 217,627 -17.9%
Value US$1,142,542
2.8
William Arsani Non-Executive Director
Transaction date
Sale
Price
5.25
Quantity 345,000 -11.5%
Value US$1,811,250
Logos Opportunities Fund II LP Director Non-Executive Director
Transaction date
Proposed sale
Price
4.98
Quantity 217,627
Value US$1,083,783
3.5
Logos Global Master Fund LP Director Non-Executive Director
Transaction date
Proposed sale
Price
4.98
Quantity 345,000
Value US$1,718,100
3.2
Prasad Deepa Non-Executive Director
Transaction date
Sale
Price
6.27
Quantity 3,806 -16.0%
Value US$23,864
2.8
William Arsani Non-Executive Director
Transaction date
Sale
Price
4.25
Quantity 814,874 -100.0%
Value US$3,463,214
Logos SPV 1 LP Director Non-Executive Director
Transaction date
Proposed sale
Price
4.24
Quantity 814,874
Value US$3,455,066
1.5
Berger Heather A. Non-Executive Director
Transaction date
Purchase
Price
3.74
Quantity 1,300 +inf%
Value US$4,866
1.9
Schmid John P. Non-Executive Director
Transaction date
Purchase
Price
3.74
Quantity 17,809 +194.5%
Value US$66,606
1.9
Schmid John P. Non-Executive Director
Transaction date
Purchase
Price
3.62
Quantity 9,156 +inf%
Value US$33,133
2.2
LAPPE RODNEY W Non-Executive Director
Transaction date
Purchase
Price
2.35
Quantity 21,000 +18.7%
Value US$49,287
2.8
William Arsani Non-Executive Director
Transaction date
Purchase
Price
2.44
Quantity 1,960,000 +188.5%
Value US$4,782,400
3.2
Prasad Deepa Non-Executive Director
Transaction date
Purchase
Price
2.31
Quantity 12,000 +101.6%
Value US$27,670
2.8
William Arsani Non-Executive Director
Transaction date
Purchase
Price
2.15
Quantity 275,000 +35.9%
Value US$591,250
1.2
Siffert Joao MD President and CEO Executive Director
Transaction date
Purchase
Price
8.38
Quantity 6,300 +5.0%
Value US$52,762
3.1
George Simeon Non-Executive Director Large shareholder
Transaction date
Purchase
Price
8.14
Quantity 40,000 +0.6%
Value US$325,432
1.2
Siffert Joao MD President and CEO Executive Director
Transaction date
Planned purchase
Price
8.47
Quantity 1,150 +0.9%
Value US$9,740
3.1
George Simeon Non-Executive Director Large shareholder
Transaction date
Purchase
Price
8.63
Quantity 360,000 +5.9%
Value US$3,108,096
3.1
George Simeon Non-Executive Director Large shareholder
Transaction date
Purchase
Price
8.28
Quantity 500,000 +8.9%
Value US$4,140,550
2.2
LAPPE RODNEY W Non-Executive Director
Transaction date
Purchase
Price
7.96
Quantity 15,000 +15.5%
Value US$119,426
3.3
Xu Stella Non-Executive Director
Transaction date
Sale
Price
18.63
Quantity 1,455 -0.0%
Value US$27,105
3.3
Xu Stella Non-Executive Director
Transaction date
Sale
Price
19.01
Quantity 24,000 -0.6%
Value US$456,240
2.8
William Arsani Non-Executive Director
Transaction date
Purchase
Price
18.99
Quantity 25,000 +0.9%
Value US$474,680
3.3
Xu Stella Non-Executive Director
Transaction date
Sale
Price
20.34
Quantity 13,200 -0.3%
Value US$268,488
3.3
Xu Stella Non-Executive Director
Transaction date
Sale
Price
19.04
Quantity 552,225 -11.7%
Value US$10,514,364
2.8
William Arsani Non-Executive Director
Transaction date
Purchase
Price
15.45
Quantity 40,000 +1.5%
Value US$618,000
Thacker Justin Vice President, Finance Officer
Transaction date
Purchase
Price
20.00
Quantity 17,500 +inf%
Value US$350,000
3.1
George Simeon Non-Executive Director Large shareholder
Transaction date
Purchase
Price
20.00
Quantity 250,000 +4.6%
Value US$5,000,000
2.2
LAPPE RODNEY W Non-Executive Director
Transaction date
Purchase
Price
20.00
Quantity 5,000 +5.4%
Value US$100,000
Jeffries Sean Chief Operating Officer Officer
Transaction date
Purchase
Price
20.00
Quantity 3,050 +inf%
Value US$61,000
Shah Pratik Executive Chairperson Executive Director
Transaction date
Purchase
Price
20.00
Quantity 25,000 +inf%
Value US$500,000
2.8
William Arsani Non-Executive Director
Transaction date
Purchase
Price
20.00
Quantity 700,000 +34.4%
Value US$14,000,000
3.3
Xu Stella Non-Executive Director Large shareholder
Transaction date
Purchase
Price
20.00
Quantity 10,000 +0.2%
Value US$200,000
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2025-11-18 2025-11-18 PrS Proposed sale
3.5
Logos Global Master Fund LP

Director

Non-Executive Director
93,288
225.96
US$3,517,949 		93,288 225.96 US$3,517,949
2025-11-14 2025-11-14 PrS Proposed sale
3.5
Logos Global Master Fund LP

Director

Non-Executive Director
6,472
372.73
US$2,336,017 		6,472 372.73 US$2,336,017
2025-11-07 2025-11-07 PrS Proposed sale
3.5
Logos Global Master Fund LP

Director

Non-Executive Director
35,628
417.89
US$2,449,742 		35,628 417.89 US$2,449,742
2025-08-14 2025-08-13 S Sale
2.8
William Arsani
Non-Executive Director
217,627 -17.9%
5.25
US$1,142,542 		217,627 -17.9% 5.25 US$1,142,542
2025-08-14 2025-08-13 S Sale
2.8
William Arsani
Non-Executive Director
345,000 -11.5%
5.25
US$1,811,250 		345,000 -11.5% 5.25 US$1,811,250
2025-08-13 2025-08-13 PrS Proposed sale
Logos Opportunities Fund II LP

Director

Non-Executive Director
217,627
4.98
US$1,083,783 		217,627 4.98 US$1,083,783
2025-08-13 2025-08-13 PrS Proposed sale
3.5
Logos Global Master Fund LP

Director

Non-Executive Director
345,000
4.98
US$1,718,100 		345,000 4.98 US$1,718,100
2024-12-19 2024-12-18 S Sale
3.2
Prasad Deepa
Non-Executive Director
3,806 -16.0%
6.27
US$23,864 		3,806 -16.0% 6.27 US$23,864
2024-08-12 2024-08-09 S Sale
2.8
William Arsani
Non-Executive Director
814,874 -100.0%
4.25
US$3,463,214 		814,874 -100.0% 4.25 US$3,463,214
2024-08-09 2024-08-09 PrS Proposed sale
Logos SPV 1 LP

Director

Non-Executive Director
814,874
4.24
US$3,455,066 		814,874 4.24 US$3,455,066
2024-03-25 2024-03-25 B Purchase
1.5
Berger Heather A.
Non-Executive Director
1,300 +inf%
3.74
US$4,866 		1,300 +inf% 3.74 US$4,866
2024-03-25 2024-03-25 B Purchase
1.9
Schmid John P.
Non-Executive Director
17,809 +194.5%
3.74
US$66,606 		17,809 +194.5% 3.74 US$66,606
2024-03-25 2024-03-22 B Purchase
1.9
Schmid John P.
Non-Executive Director
9,156 +inf%
3.62
US$33,133 		9,156 +inf% 3.62 US$33,133
2023-10-02 2023-09-29 B Purchase
2.2
LAPPE RODNEY W
Non-Executive Director
21,000 +18.7%
2.35
US$49,287 		21,000 +18.7% 2.35 US$49,287
2023-08-30 2023-08-29 B Purchase
2.8
William Arsani
Non-Executive Director
1,960,000 +188.5%
2.44
US$4,782,400 		1,960,000 +188.5% 2.44 US$4,782,400
2023-08-30 2023-08-29 B Purchase
3.2
Prasad Deepa
Non-Executive Director
12,000 +101.6%
2.31
US$27,670 		12,000 +101.6% 2.31 US$27,670
2023-08-30 2023-08-28 B Purchase
2.8
William Arsani
Non-Executive Director
275,000 +35.9%
2.15
US$591,250 		275,000 +35.9% 2.15 US$591,250
2022-12-21 2022-12-20 B Purchase
1.2
Siffert Joao MD

President and CEO

Executive Director
6,300 +5.0%
8.38
US$52,762 		6,300 +5.0% 8.38 US$52,762
2022-12-20 2022-12-20 B Purchase
3.1
George Simeon
Non-Executive Director Large shareholder
40,000 +0.6%
8.14
US$325,432 		40,000 +0.6% 8.14 US$325,432
2022-12-20 2022-12-20 B Purchase
1.4
SR One Capital Fund I Aggregator LP
Large shareholder
40,000 +0.6%
8.14
US$325,432 		40,000 +0.6% 8.14 US$325,432
2022-12-21 2022-12-19 PP Planned purchase
1.2
Siffert Joao MD

President and CEO

Executive Director
1,150 +0.9%
8.47
US$9,740 		1,150 +0.9% 8.47 US$9,740
2022-12-20 2022-12-19 B Purchase
3.1
George Simeon
Non-Executive Director Large shareholder
360,000 +5.9%
8.63
US$3,108,096 		360,000 +5.9% 8.63 US$3,108,096
2022-12-20 2022-12-19 B Purchase
1.4
SR One Capital Fund I Aggregator LP
Large shareholder
360,000 +5.9%
8.63
US$3,108,096 		360,000 +5.9% 8.63 US$3,108,096
2022-12-20 2022-12-16 B Purchase
3.1
George Simeon
Non-Executive Director Large shareholder
500,000 +8.9%
8.28
US$4,140,550 		500,000 +8.9% 8.28 US$4,140,550
2022-12-20 2022-12-16 B Purchase
1.4
SR One Capital Fund I Aggregator LP
Large shareholder
500,000 +8.9%
8.28
US$4,140,550 		500,000 +8.9% 8.28 US$4,140,550
2022-12-12 2022-12-09 B Purchase
2.2
LAPPE RODNEY W
Non-Executive Director
15,000 +15.5%
7.96
US$119,426 		15,000 +15.5% 7.96 US$119,426
2022-03-22 2022-03-22 S Sale
3.3
Xu Stella
Non-Executive Director
1,455 -0.0%
18.63
US$27,105 		1,455 -0.0% 18.63 US$27,105
2022-03-22 2022-03-21 S Sale
3.3
Xu Stella
Non-Executive Director
24,000 -0.6%
19.01
US$456,240 		24,000 -0.6% 19.01 US$456,240
2022-03-22 2022-03-21 B Purchase
2.8
William Arsani
Non-Executive Director
25,000 +0.9%
18.99
US$474,680 		25,000 +0.9% 18.99 US$474,680
2022-03-22 2022-03-18 S Sale
3.3
Xu Stella
Non-Executive Director
13,200 -0.3%
20.34
US$268,488 		13,200 -0.3% 20.34 US$268,488
2022-03-22 2022-03-18 S Sale
3.3
Xu Stella
Non-Executive Director
552,225 -11.7%
19.04
US$10,514,364 		552,225 -11.7% 19.04 US$10,514,364
2021-09-02 2021-08-31 B Purchase
2.8
William Arsani
Non-Executive Director
40,000 +1.5%
15.45
US$618,000 		40,000 +1.5% 15.45 US$618,000
2021-04-01 2021-03-30 B Purchase
Thacker Justin

Vice President, Finance

Officer
17,500 +inf%
20.00
US$350,000 		17,500 +inf% 20.00 US$350,000
2021-04-01 2021-03-30 B Purchase
1.4
SR One Capital Fund I Aggregator LP
Large shareholder
250,000 +4.6%
20.00
US$5,000,000 		250,000 +4.6% 20.00 US$5,000,000
2021-04-01 2021-03-30 B Purchase
3.1
George Simeon
Non-Executive Director Large shareholder
250,000 +4.6%
20.00
US$5,000,000 		250,000 +4.6% 20.00 US$5,000,000
2021-04-01 2021-03-30 B Purchase
2.2
LAPPE RODNEY W
Non-Executive Director
5,000 +5.4%
20.00
US$100,000 		5,000 +5.4% 20.00 US$100,000
2021-04-01 2021-03-30 B Purchase
Jeffries Sean

Chief Operating Officer

Officer
3,050 +inf%
20.00
US$61,000 		3,050 +inf% 20.00 US$61,000
2021-04-01 2021-03-30 B Purchase
Shah Pratik

Executive Chairperson

Executive Director
25,000 +inf%
20.00
US$500,000 		25,000 +inf% 20.00 US$500,000
2021-04-01 2021-03-30 B Purchase
3.7
Cormorant Asset Management, LP
750,000 +17.2%
20.00
US$15,000,000 		750,000 +17.2% 20.00 US$15,000,000
2021-04-01 2021-03-30 B Purchase
2.8
William Arsani
Non-Executive Director
700,000 +34.4%
20.00
US$14,000,000 		700,000 +34.4% 20.00 US$14,000,000
2021-04-01 2021-03-30 B Purchase
3.3
Xu Stella
Non-Executive Director Large shareholder
10,000 +0.2%
20.00
US$200,000 		10,000 +0.2% 20.00 US$200,000
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