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United States Biotechnology & Medical Research

Design Therapeutics Inc (DSGN)

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The most recent insider trading activity occurred on November 18, 2025, with a proposed sale of 120,000 shares valued at $891,600. Prior to this, significant proposed sales were noted in November 2025 and August 2025. The last reported buy transaction was on March 25, 2024.
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Ticker: DSGN Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
Logos Global Master Fund LP
Director
1 sale — total 891,600 USD
Proposed sale 18 Nov 2025
Value US$3,517,949.25 | Price 225.96 | Shares 93,288
Proposed sale 14 Nov 2025
Value US$2,336,016.70 | Price 372.73 | Shares 6,472
Proposed sale 7 Nov 2025
Value US$2,851,050.00 | Price 6.87 | Shares 415,000
Sale 13 Aug 2025
Value US$1,142,541.75 | Price 5.25 | Shares 217,627
Sale 13 Aug 2025
Value US$1,811,250.00 | Price 5.25 | Shares 345,000
Proposed sale 13 Aug 2025
Value US$1,083,783.00 | Price 4.98 | Shares 217,627
Proposed sale 13 Aug 2025
Value US$1,718,100.00 | Price 4.98 | Shares 345,000
Sale 18 Dec 2024
Value US$23,863.62 | Price 6.27 | Shares 3,806
Sale 9 Aug 2024
Value US$3,463,214.50 | Price 4.25 | Shares 814,874
Proposed sale 9 Aug 2024
Value US$3,455,065.76 | Price 4.24 | Shares 814,874
Buy 25 Mar 2024
Value US$4,865.77 | Price 3.74 | Shares 1,300
Buy 25 Mar 2024
Value US$66,605.66 | Price 3.74 | Shares 17,809
Buy 22 Mar 2024
Value US$33,132.82 | Price 3.62 | Shares 9,156
Buy 29 Sep 2023
Value US$49,287.00 | Price 2.35 | Shares 21,000
Buy 29 Aug 2023
Value US$4,782,400.00 | Price 2.44 | Shares 1,960,000
Buy 29 Aug 2023
Value US$27,669.60 | Price 2.31 | Shares 12,000
Buy 28 Aug 2023
Value US$591,250.00 | Price 2.15 | Shares 275,000
Buy 20 Dec 2022
Value US$52,762.50 | Price 8.38 | Shares 6,300
Buy 20 Dec 2022
Value US$325,432.00 | Price 8.14 | Shares 40,000
Buy 20 Dec 2022
Value US$325,432.00 | Price 8.14 | Shares 40,000
Planned buy 19 Dec 2022
Value US$9,740.50 | Price 8.47 | Shares 1,150
Buy 19 Dec 2022
Value US$3,108,096.00 | Price 8.63 | Shares 360,000
Buy 19 Dec 2022
Value US$3,108,096.00 | Price 8.63 | Shares 360,000
Buy 16 Dec 2022
Value US$4,140,550.00 | Price 8.28 | Shares 500,000
Buy 16 Dec 2022
Value US$4,140,550.00 | Price 8.28 | Shares 500,000
Buy 9 Dec 2022
Value US$119,425.50 | Price 7.96 | Shares 15,000
Sale 22 Mar 2022
Value US$27,105.49 | Price 18.63 | Shares 1,455
Sale 21 Mar 2022
Value US$456,240.00 | Price 19.01 | Shares 24,000
Buy 21 Mar 2022
Value US$474,680.00 | Price 18.99 | Shares 25,000
Sale 18 Mar 2022
Value US$268,488.00 | Price 20.34 | Shares 13,200
Sale 18 Mar 2022
Value US$10,514,364.00 | Price 19.04 | Shares 552,225
Buy 31 Aug 2021
Value US$618,000.00 | Price 15.45 | Shares 40,000
Buy 30 Mar 2021
Value US$350,000.00 | Price 20.00 | Shares 17,500
Buy 30 Mar 2021
Value US$5,000,000.00 | Price 20.00 | Shares 250,000
Buy 30 Mar 2021
Value US$5,000,000.00 | Price 20.00 | Shares 250,000
Buy 30 Mar 2021
Value US$100,000.00 | Price 20.00 | Shares 5,000
Buy 30 Mar 2021
Value US$61,000.00 | Price 20.00 | Shares 3,050
Buy 30 Mar 2021
Value US$500,000.00 | Price 20.00 | Shares 25,000
Buy 30 Mar 2021
Value US$15,000,000.00 | Price 20.00 | Shares 750,000
Buy 30 Mar 2021
Value US$14,000,000.00 | Price 20.00 | Shares 700,000
Buy 30 Mar 2021
Value US$200,000.00 | Price 20.00 | Shares 10,000
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2025-11-18 2025-11-18 PrS Proposed sale
3.5
Logos Global Master Fund LP

Director

Non-Executive Director
93,288
225.96
US$3,517,949 		93,288 225.96 US$3,517,949
2025-11-14 2025-11-14 PrS Proposed sale
3.5
Logos Global Master Fund LP

Director

Non-Executive Director
6,472
372.73
US$2,336,017 		6,472 372.73 US$2,336,017
2025-11-07 2025-11-07 PrS Proposed sale
3.5
Logos Global Master Fund LP

Director

Non-Executive Director
35,628
417.89
US$2,449,742 		35,628 417.89 US$2,449,742
2025-08-14 2025-08-13 S Sale
2.8
William Arsani
Non-Executive Director
217,627 -17.9%
5.25
US$1,142,542 		217,627 -17.9% 5.25 US$1,142,542
2025-08-14 2025-08-13 S Sale
2.8
William Arsani
Non-Executive Director
345,000 -11.5%
5.25
US$1,811,250 		345,000 -11.5% 5.25 US$1,811,250
2025-08-13 2025-08-13 PrS Proposed sale
Logos Opportunities Fund II LP

Director

Non-Executive Director
217,627
4.98
US$1,083,783 		217,627 4.98 US$1,083,783
2025-08-13 2025-08-13 PrS Proposed sale
3.5
Logos Global Master Fund LP

Director

Non-Executive Director
345,000
4.98
US$1,718,100 		345,000 4.98 US$1,718,100
2024-12-19 2024-12-18 S Sale
3.2
Prasad Deepa
Non-Executive Director
3,806 -16.0%
6.27
US$23,864 		3,806 -16.0% 6.27 US$23,864
2024-08-12 2024-08-09 S Sale
2.8
William Arsani
Non-Executive Director
814,874 -100.0%
4.25
US$3,463,214 		814,874 -100.0% 4.25 US$3,463,214
2024-08-09 2024-08-09 PrS Proposed sale
Logos SPV 1 LP

Director

Non-Executive Director
814,874
4.24
US$3,455,066 		814,874 4.24 US$3,455,066
2024-03-25 2024-03-25 B Purchase
1.5
Berger Heather A.
Non-Executive Director
1,300 +inf%
3.74
US$4,866 		1,300 +inf% 3.74 US$4,866
2024-03-25 2024-03-25 B Purchase
3.0
Schmid John P.
Non-Executive Director
17,809 +194.5%
3.74
US$66,606 		17,809 +194.5% 3.74 US$66,606
2024-03-25 2024-03-22 B Purchase
3.0
Schmid John P.
Non-Executive Director
9,156 +inf%
3.62
US$33,133 		9,156 +inf% 3.62 US$33,133
2023-10-02 2023-09-29 B Purchase
2.2
LAPPE RODNEY W
Non-Executive Director
21,000 +18.7%
2.35
US$49,287 		21,000 +18.7% 2.35 US$49,287
2023-08-30 2023-08-29 B Purchase
2.8
William Arsani
Non-Executive Director
1,960,000 +188.5%
2.44
US$4,782,400 		1,960,000 +188.5% 2.44 US$4,782,400
2023-08-30 2023-08-29 B Purchase
3.2
Prasad Deepa
Non-Executive Director
12,000 +101.6%
2.31
US$27,670 		12,000 +101.6% 2.31 US$27,670
2023-08-30 2023-08-28 B Purchase
2.8
William Arsani
Non-Executive Director
275,000 +35.9%
2.15
US$591,250 		275,000 +35.9% 2.15 US$591,250
2022-12-21 2022-12-20 B Purchase
1.2
Siffert Joao MD

President and CEO

Executive Director
6,300 +5.0%
8.38
US$52,762 		6,300 +5.0% 8.38 US$52,762
2022-12-20 2022-12-20 B Purchase
3.1
George Simeon
Non-Executive Director Large shareholder
40,000 +0.6%
8.14
US$325,432 		40,000 +0.6% 8.14 US$325,432
2022-12-20 2022-12-20 B Purchase
1.4
SR One Capital Fund I Aggregator LP
Large shareholder
40,000 +0.6%
8.14
US$325,432 		40,000 +0.6% 8.14 US$325,432
2022-12-21 2022-12-19 PP Planned purchase
1.2
Siffert Joao MD

President and CEO

Executive Director
1,150 +0.9%
8.47
US$9,740 		1,150 +0.9% 8.47 US$9,740
2022-12-20 2022-12-19 B Purchase
3.1
George Simeon
Non-Executive Director Large shareholder
360,000 +5.9%
8.63
US$3,108,096 		360,000 +5.9% 8.63 US$3,108,096
2022-12-20 2022-12-19 B Purchase
1.4
SR One Capital Fund I Aggregator LP
Large shareholder
360,000 +5.9%
8.63
US$3,108,096 		360,000 +5.9% 8.63 US$3,108,096
2022-12-20 2022-12-16 B Purchase
3.1
George Simeon
Non-Executive Director Large shareholder
500,000 +8.9%
8.28
US$4,140,550 		500,000 +8.9% 8.28 US$4,140,550
2022-12-20 2022-12-16 B Purchase
1.4
SR One Capital Fund I Aggregator LP
Large shareholder
500,000 +8.9%
8.28
US$4,140,550 		500,000 +8.9% 8.28 US$4,140,550
2022-12-12 2022-12-09 B Purchase
2.2
LAPPE RODNEY W
Non-Executive Director
15,000 +15.5%
7.96
US$119,426 		15,000 +15.5% 7.96 US$119,426
2022-03-22 2022-03-22 S Sale
3.3
Xu Stella
Non-Executive Director
1,455 -0.0%
18.63
US$27,105 		1,455 -0.0% 18.63 US$27,105
2022-03-22 2022-03-21 S Sale
3.3
Xu Stella
Non-Executive Director
24,000 -0.6%
19.01
US$456,240 		24,000 -0.6% 19.01 US$456,240
2022-03-22 2022-03-21 B Purchase
2.8
William Arsani
Non-Executive Director
25,000 +0.9%
18.99
US$474,680 		25,000 +0.9% 18.99 US$474,680
2022-03-22 2022-03-18 S Sale
3.3
Xu Stella
Non-Executive Director
13,200 -0.3%
20.34
US$268,488 		13,200 -0.3% 20.34 US$268,488
2022-03-22 2022-03-18 S Sale
3.3
Xu Stella
Non-Executive Director
552,225 -11.7%
19.04
US$10,514,364 		552,225 -11.7% 19.04 US$10,514,364
2021-09-02 2021-08-31 B Purchase
2.8
William Arsani
Non-Executive Director
40,000 +1.5%
15.45
US$618,000 		40,000 +1.5% 15.45 US$618,000
2021-04-01 2021-03-30 B Purchase
Thacker Justin

Vice President, Finance

Officer
17,500 +inf%
20.00
US$350,000 		17,500 +inf% 20.00 US$350,000
2021-04-01 2021-03-30 B Purchase
1.4
SR One Capital Fund I Aggregator LP
Large shareholder
250,000 +4.6%
20.00
US$5,000,000 		250,000 +4.6% 20.00 US$5,000,000
2021-04-01 2021-03-30 B Purchase
3.1
George Simeon
Non-Executive Director Large shareholder
250,000 +4.6%
20.00
US$5,000,000 		250,000 +4.6% 20.00 US$5,000,000
2021-04-01 2021-03-30 B Purchase
2.2
LAPPE RODNEY W
Non-Executive Director
5,000 +5.4%
20.00
US$100,000 		5,000 +5.4% 20.00 US$100,000
2021-04-01 2021-03-30 B Purchase
Jeffries Sean

Chief Operating Officer

Officer
3,050 +inf%
20.00
US$61,000 		3,050 +inf% 20.00 US$61,000
2021-04-01 2021-03-30 B Purchase
Shah Pratik

Executive Chairperson

Executive Director
25,000 +inf%
20.00
US$500,000 		25,000 +inf% 20.00 US$500,000
2021-04-01 2021-03-30 B Purchase
3.8
Cormorant Asset Management, LP
750,000 +17.2%
20.00
US$15,000,000 		750,000 +17.2% 20.00 US$15,000,000
2021-04-01 2021-03-30 B Purchase
2.8
William Arsani
Non-Executive Director
700,000 +34.4%
20.00
US$14,000,000 		700,000 +34.4% 20.00 US$14,000,000
2021-04-01 2021-03-30 B Purchase
3.3
Xu Stella
Non-Executive Director Large shareholder
10,000 +0.2%
20.00
US$200,000 		10,000 +0.2% 20.00 US$200,000
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