United States Biotechnology & Medical Research

Cabaletta Bio Inc (CABA)

Cabaletta Bio Inc experienced significant insider activity on January 21, 2026, when multiple executives and board members executed open-market purchases. These acquisitions involved various leadership figures, including the CEO and Chief Medical Officer. No further transactions have been reported since that date, marking a period of inactivity exceeding three months.
Ticker: CABA Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Cabaletta Bio Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
4.0
Simon Mark Non-Executive Director
Transaction date
Purchase
Price
31.09
Quantity 31,698 +34.7%
Value US$463,525
3.3
Chang David J. Chief Medical Officer Officer
Transaction date
Purchase
Price
333.54
Quantity 61,573 +0.6%
Value US$3,373,800
4.0
Binder Gwendolyn President, Science & Tech. Officer
Transaction date
Purchase
Price
315.77
Quantity 36,097 -42.5%
Value US$963,707
3.3
Gerard Michael General Counsel Officer
Transaction date
Purchase
Price
2.27
Quantity 6,600 New position
Value US$14,979
3.3
Gavel Steve Chief Commercial Officer Officer
Transaction date
Purchase
Price
2.27
Quantity 22,170 New position
Value US$50,215
3.7
Tomasello Shawn Non-Executive Director
Transaction date
Purchase
Price
2.21
Quantity 22,725 New position
Value US$50,322
4.0
Nichtberger Steven President & CEO Executive Director
Transaction date
Purchase
Price
2.24
Quantity 45,000 +4.6%
Value US$100,778
4.0
Bollard Catherine Non-Executive Director
Transaction date
Purchase
Price
2.27
Quantity 4,405 +440.5%
Value US$9,982
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
20.33
Quantity 700 -3.4%
Value US$14,229
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
19.54
Quantity 10,300 -33.2%
Value US$201,210
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
22.22
Quantity 3,132 -13.5%
Value US$69,593
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
21.76
Quantity 7,868 -25.4%
Value US$171,196
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
18.02
Quantity 7,458 -27.2%
Value US$134,405
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
17.39
Quantity 3,542 -11.4%
Value US$61,608
4.0
GWENDOLYN BINDER Officer Officer
Transaction date
Proposed sale
Price
17.96
Quantity 33,000
Value US$592,680
4.0
GWENDOLYN BINDER Officer Officer
Transaction date
Proposed sale
Price
13.46
Quantity 11,000
Value US$148,005
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
14.28
Quantity 408 -2.0%
Value US$5,825
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
13.32
Quantity 10,592 -34.2%
Value US$141,096
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
18.50
Quantity 700 -3.4%
Value US$12,950
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
17.50
Quantity 10,300 -33.2%
Value US$180,270
4.0
GWENDOLYN BINDER Officer Officer
Transaction date
Proposed sale
Price
18.65
Quantity 11,000
Value US$205,150
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
13.82
Quantity 300 -1.5%
Value US$4,147
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
13.41
Quantity 10,700 -34.5%
Value US$143,436
4.0
GWENDOLYN BINDER Officer Officer
Transaction date
Proposed sale
Price
12.68
Quantity 11,000
Value US$139,480
4.0
GWENDOLYN BINDER Officer Officer
Transaction date
Proposed sale
Price
13.98
Quantity 11,000
Value US$153,780
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
14.26
Quantity 2,815 -12.3%
Value US$40,143
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
13.67
Quantity 8,185 -26.4%
Value US$111,879
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
12.99
Quantity 11,000 -35.5%
Value US$142,925
4.0
GWENDOLYN BINDER Officer Officer
Transaction date
Proposed sale
Price
13.12
Quantity 11,000
Value US$144,320
4.0
GWENDOLYN BINDER Officer Officer
Transaction date
Proposed sale
Price
13.12
Quantity 11,000
Value US$144,320
4.0
GWENDOLYN BINDER Officer Officer
Transaction date
Proposed sale
Price
12.30
Quantity 22,000
Value US$270,600
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Planned sale
Price
11.81
Quantity 22,000 -52.4%
Value US$259,833
4.0
Nichtberger Steven President & CEO Executive Director
Transaction date
Purchase
Price
1.25
Quantity 8,127 +0.8%
Value US$10,152
4.0
Simon Mark Non-Executive Director
Transaction date
Purchase
Price
0.98
Quantity 7,000 New position
Value US$6,835
4.0
Simon Mark Non-Executive Director
Transaction date
Purchase
Price
0.98
Quantity 118,000 +650.4%
Value US$115,286
4.0
Bollard Catherine Non-Executive Director
Transaction date
Purchase
Price
0.99
Quantity 1,000 New position
Value US$994
4.0
Binder Gwendolyn See Remarks Officer
Transaction date
Purchase
Price
0.99
Quantity 20,000 New position
Value US$19,894
3.4
Marda Anup Chief Financial Officer Officer
Transaction date
Purchase
Price
0.99
Quantity 50,000 New position
Value US$49,620
4.0
Nichtberger Steven President & CEO Executive Director
Transaction date
Purchase
Price
0.99
Quantity 141,873 +17.0%
Value US$141,008
3.5
5AM Ventures V, L.P. Large shareholder
Transaction date
Sale
Price
13.00
Quantity 36,544 -9.9%
Value US$475,072
3.5
5AM Ventures V, L.P. Large shareholder
Transaction date
Sale
Price
13.00
Quantity 258,456 -13.0%
Value US$3,359,928
3.5
5AM Ventures V, L.P. Large shareholder
Transaction date
Sale
Price
13.00
Quantity 10,530 -2.8%
Value US$136,890
3.5
5AM Ventures V, L.P. Large shareholder
Transaction date
Sale
Price
13.00
Quantity 74,470 -2.8%
Value US$968,110
3.5
5AM Ventures V, L.P. Large shareholder
Transaction date
Sale
Price
13.00
Quantity 37,411 -9.0%
Value US$486,343
3.5
5AM Ventures V, L.P. Large shareholder
Transaction date
Sale
Price
13.00
Quantity 264,589 -9.0%
Value US$3,439,657
3.5
5AM Ventures V, L.P. Large shareholder
Transaction date
Sale
Price
14.75
Quantity 36,916 -8.1%
Value US$544,511
3.5
5AM Ventures V, L.P. Large shareholder
Transaction date
Sale
Price
14.75
Quantity 261,084 -8.1%
Value US$3,850,989
3.5
5AM Ventures V, L.P. Large shareholder
Transaction date
Purchase
Price
11.00
Quantity 454,545 New position
Value US$4,999,995
2.8
Flynn James E Large shareholder
Transaction date
Purchase
Price
11.00
Quantity 700,000 New position
Value US$7,700,000
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-01-21 2026-01-21 B Purchase
4.0
Simon Mark
Non-Executive Director
31,698 +34.7%
31.09
US$463,525 		31,698 +34.7% 31.09 US$463,525
2026-01-21 2026-01-21 B Purchase
3.3
Chang David J.

Chief Medical Officer

Officer
61,573 +0.6%
333.54
US$3,373,800 		61,573 +0.6% 333.54 US$3,373,800
2026-01-21 2026-01-21 B Purchase
4.0
Binder Gwendolyn

President, Science & Tech.

Officer
36,097 -42.5%
315.77
US$963,707 		36,097 -42.5% 315.77 US$963,707
2026-01-21 2026-01-21 B Purchase
3.3
Gerard Michael

General Counsel

Officer
6,600 New position
2.27
US$14,979 		6,600 New position 2.27 US$14,979
2026-01-21 2026-01-21 B Purchase
3.3
Gavel Steve

Chief Commercial Officer

Officer
22,170 New position
2.27
US$50,215 		22,170 New position 2.27 US$50,215
2026-01-21 2026-01-21 B Purchase
3.7
Tomasello Shawn
Non-Executive Director
22,725 New position
2.21
US$50,322 		22,725 New position 2.21 US$50,322
2026-01-21 2026-01-21 B Purchase
4.0
Nichtberger Steven

President & CEO

Executive Director
45,000 +4.6%
2.24
US$100,778 		45,000 +4.6% 2.24 US$100,778
2026-01-21 2026-01-21 B Purchase
4.0
Bollard Catherine
Non-Executive Director
4,405 +440.5%
2.27
US$9,982 		4,405 +440.5% 2.27 US$9,982
2024-01-19 2024-01-19 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
700 -3.4%
20.33
US$14,229 		700 -3.4% 20.33 US$14,229
2024-01-19 2024-01-19 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
10,300 -33.2%
19.54
US$201,210 		10,300 -33.2% 19.54 US$201,210
2023-12-19 2023-12-19 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
3,132 -13.5%
22.22
US$69,593 		3,132 -13.5% 22.22 US$69,593
2023-12-19 2023-12-19 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
7,868 -25.4%
21.76
US$171,196 		7,868 -25.4% 21.76 US$171,196
2023-11-21 2023-11-20 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
7,458 -27.2%
18.02
US$134,405 		7,458 -27.2% 18.02 US$134,405
2023-11-21 2023-11-20 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
3,542 -11.4%
17.39
US$61,608 		3,542 -11.4% 17.39 US$61,608
2023-11-20 2023-11-20 PrS Proposed sale
4.0
GWENDOLYN BINDER

Officer

Officer
33,000
17.96
US$592,680 		33,000 17.96 US$592,680
2023-10-19 2023-10-19 PrS Proposed sale
4.0
GWENDOLYN BINDER

Officer

Officer
11,000
13.46
US$148,005 		11,000 13.46 US$148,005
2023-10-19 2023-10-19 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
408 -2.0%
14.28
US$5,825 		408 -2.0% 14.28 US$5,825
2023-10-19 2023-10-19 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
10,592 -34.2%
13.32
US$141,096 		10,592 -34.2% 13.32 US$141,096
2023-09-20 2023-09-19 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
700 -3.4%
18.50
US$12,950 		700 -3.4% 18.50 US$12,950
2023-09-20 2023-09-19 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
10,300 -33.2%
17.50
US$180,270 		10,300 -33.2% 17.50 US$180,270
2023-09-19 2023-09-19 PrS Proposed sale
4.0
GWENDOLYN BINDER

Officer

Officer
11,000
18.65
US$205,150 		11,000 18.65 US$205,150
2023-08-22 2023-08-21 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
300 -1.5%
13.82
US$4,147 		300 -1.5% 13.82 US$4,147
2023-08-22 2023-08-21 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
10,700 -34.5%
13.41
US$143,436 		10,700 -34.5% 13.41 US$143,436
2023-08-21 2023-08-21 PrS Proposed sale
4.0
GWENDOLYN BINDER

Officer

Officer
11,000
12.68
US$139,480 		11,000 12.68 US$139,480
2023-07-19 2023-07-19 PrS Proposed sale
4.0
GWENDOLYN BINDER

Officer

Officer
11,000
13.98
US$153,780 		11,000 13.98 US$153,780
2023-07-19 2023-07-19 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
2,815 -12.3%
14.26
US$40,143 		2,815 -12.3% 14.26 US$40,143
2023-07-19 2023-07-19 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
8,185 -26.4%
13.67
US$111,879 		8,185 -26.4% 13.67 US$111,879
2023-06-21 2023-06-20 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
11,000 -35.5%
12.99
US$142,925 		11,000 -35.5% 12.99 US$142,925
2023-06-20 2023-06-20 PrS Proposed sale
4.0
GWENDOLYN BINDER

Officer

Officer
11,000
13.12
US$144,320 		11,000 13.12 US$144,320
2023-06-20 2023-06-20 PrS Proposed sale
4.0
GWENDOLYN BINDER

Officer

Officer
11,000
13.12
US$144,320 		11,000 13.12 US$144,320
2023-05-19 2023-05-19 PrS Proposed sale
4.0
GWENDOLYN BINDER

Officer

Officer
22,000
12.30
US$270,600 		22,000 12.30 US$270,600
2023-05-19 2023-05-19 PlS Planned sale
4.0
Binder Gwendolyn

See Remarks

Officer
22,000 -52.4%
11.81
US$259,833 		22,000 -52.4% 11.81 US$259,833
2022-10-19 2022-10-19 B Purchase
4.0
Nichtberger Steven

President & CEO

Executive Director
8,127 +0.8%
1.25
US$10,152 		8,127 +0.8% 1.25 US$10,152
2022-10-18 2022-10-18 B Purchase
4.0
Simon Mark
Non-Executive Director
7,000 New position
0.98
US$6,835 		7,000 New position 0.98 US$6,835
2022-10-18 2022-10-18 B Purchase
4.0
Simon Mark
Non-Executive Director
118,000 +650.4%
0.98
US$115,286 		118,000 +650.4% 0.98 US$115,286
2022-10-18 2022-10-18 B Purchase
4.0
Bollard Catherine
Non-Executive Director
1,000 New position
0.99
US$994 		1,000 New position 0.99 US$994
2022-10-18 2022-10-18 B Purchase
4.0
Binder Gwendolyn

See Remarks

Officer
20,000 New position
0.99
US$19,894 		20,000 New position 0.99 US$19,894
2022-10-18 2022-10-18 B Purchase
3.4
Marda Anup

Chief Financial Officer

Officer
50,000 New position
0.99
US$49,620 		50,000 New position 0.99 US$49,620
2022-10-18 2022-10-18 B Purchase
4.0
Nichtberger Steven

President & CEO

Executive Director
141,873 +17.0%
0.99
US$141,008 		141,873 +17.0% 0.99 US$141,008
2021-11-03 2021-11-01 S Sale
3.5
5AM Ventures V, L.P.
Large shareholder
36,544 -9.9%
13.00
US$475,072 		36,544 -9.9% 13.00 US$475,072
2021-11-03 2021-11-01 S Sale
3.5
5AM Ventures V, L.P.
Large shareholder
258,456 -13.0%
13.00
US$3,359,928 		258,456 -13.0% 13.00 US$3,359,928
2021-01-12 2021-01-12 S Sale
3.5
5AM Ventures V, L.P.
Large shareholder
10,530 -2.8%
13.00
US$136,890 		10,530 -2.8% 13.00 US$136,890
2021-01-12 2021-01-12 S Sale
3.5
5AM Ventures V, L.P.
Large shareholder
74,470 -2.8%
13.00
US$968,110 		74,470 -2.8% 13.00 US$968,110
2021-01-12 2021-01-08 S Sale
3.5
5AM Ventures V, L.P.
Large shareholder
37,411 -9.0%
13.00
US$486,343 		37,411 -9.0% 13.00 US$486,343
2021-01-12 2021-01-08 S Sale
3.5
5AM Ventures V, L.P.
Large shareholder
264,589 -9.0%
13.00
US$3,439,657 		264,589 -9.0% 13.00 US$3,439,657
2020-12-14 2020-12-10 S Sale
3.5
5AM Ventures V, L.P.
Large shareholder
36,916 -8.1%
14.75
US$544,511 		36,916 -8.1% 14.75 US$544,511
2020-12-14 2020-12-10 S Sale
3.5
5AM Ventures V, L.P.
Large shareholder
261,084 -8.1%
14.75
US$3,850,989 		261,084 -8.1% 14.75 US$3,850,989
2019-10-31 2019-10-29 B Purchase
3.5
5AM Ventures V, L.P.
Large shareholder
454,545 New position
11.00
US$4,999,995 		454,545 New position 11.00 US$4,999,995
2019-10-30 2019-10-29 B Purchase
2.8
Flynn James E
Large shareholder
700,000 New position
11.00
US$7,700,000 		700,000 New position 11.00 US$7,700,000
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