|
2008-08-06 |
2008-08-06 |
B
Purchase
|
Bengal Acquisition Inc.
See Footnote (1)
Large shareholder
|
18,635
-32.0%
437.84
US$4,207,035
|
18,635
-32.0%
|
437.84
|
US$4,207,035
|
|
|
2008-08-05 |
2008-08-05 |
B
Purchase
|
Stiefel Laboratories, Inc.
See footnote (1)(2)
Large shareholder
|
75,410
-40.1%
414.03
US$3,672,996
|
75,410
-40.1%
|
414.03
|
US$3,672,996
|
|
|
2006-11-14 |
2006-11-13 |
B
Purchase
|
ERICKSON EDWARD L
Non-Executive Director
|
70,382
-18.2%
277.64
US$4,387,336
|
70,382
-18.2%
|
277.64
|
US$4,387,336
|
|
|
2006-11-14 |
2006-11-13 |
B
Purchase
|
ERICKSON EDWARD L
Non-Executive Director
|
100
+11.1%
7.26
US$726
|
100
+11.1%
|
7.26
|
US$726
|
|
|
2006-11-14 |
2006-11-13 |
B
Purchase
|
ERICKSON EDWARD L
Non-Executive Director
|
300
+50.0%
7.25
US$2,175
|
300
+50.0%
|
7.25
|
US$2,175
|
|
|
2006-11-14 |
2006-11-13 |
B
Purchase
|
ERICKSON EDWARD L
Non-Executive Director
|
600
+inf%
7.23
US$4,338
|
600
+inf%
|
7.23
|
US$4,338
|
|
|
2006-09-27 |
2006-09-27 |
B
Purchase
|
Jacey Charles F Jr
Non-Executive Director
|
300
+100.0%
6.40
US$1,920
|
300
+100.0%
|
6.40
|
US$1,920
|
|
|
2006-08-10 |
2006-08-09 |
B
Purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
1,000
+10.0%
5.44
US$5,437
|
1,000
+10.0%
|
5.44
|
US$5,437
|
|
|
2006-08-10 |
2006-08-09 |
PP
Planned purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
600
+0.1%
5.44
US$3,262
|
600
+0.1%
|
5.44
|
US$3,262
|
|
|
2006-08-10 |
2006-08-09 |
B
Purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
400
+0.1%
5.42
US$2,168
|
400
+0.1%
|
5.42
|
US$2,168
|
|
|
2006-06-16 |
2006-06-16 |
B
Purchase
|
CAMPBELL ROBERT E
Non-Executive Director
|
3,000
+100.0%
5.92
US$17,751
|
3,000
+100.0%
|
5.92
|
US$17,751
|
|
|
2006-05-19 |
2006-05-19 |
B
Purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
4,000
+100.0%
6.17
US$24,680
|
4,000
+100.0%
|
6.17
|
US$24,680
|
|
|
2006-05-19 |
2006-05-19 |
B
Purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
1,000
+0.2%
6.17
US$6,166
|
1,000
+0.2%
|
6.17
|
US$6,166
|
|
|
2006-03-15 |
2006-03-15 |
PP
Planned purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
1,300
+0.3%
9.25
US$12,022
|
1,300
+0.3%
|
9.25
|
US$12,022
|
|
|
2006-03-15 |
2006-03-15 |
B
Purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
700
+0.1%
9.25
US$6,475
|
700
+0.1%
|
9.25
|
US$6,475
|
|
|
2006-03-06 |
2006-03-06 |
B
Purchase
|
CAMPBELL ROBERT E
Non-Executive Director
|
1,000
+50.0%
9.97
US$9,970
|
1,000
+50.0%
|
9.97
|
US$9,970
|
|
|
2005-03-14 |
2005-03-11 |
B
Purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
200
+5.3%
14.47
US$2,894
|
200
+5.3%
|
14.47
|
US$2,894
|
|
|
2005-03-14 |
2005-03-11 |
B
Purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
1,300
+52.0%
14.34
US$18,642
|
1,300
+52.0%
|
14.34
|
US$18,642
|
|
|
2005-03-14 |
2005-03-11 |
PP
Planned purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
100
+0.0%
14.80
US$1,480
|
100
+0.0%
|
14.80
|
US$1,480
|
|
|
2005-03-14 |
2005-03-11 |
B
Purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
100
+0.0%
14.79
US$1,479
|
100
+0.0%
|
14.79
|
US$1,479
|
|
|
2005-03-14 |
2005-03-11 |
B
Purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
100
+0.0%
14.78
US$1,478
|
100
+0.0%
|
14.78
|
US$1,478
|
|
|
2005-03-14 |
2005-03-11 |
B
Purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
1,200
+0.2%
14.77
US$17,724
|
1,200
+0.2%
|
14.77
|
US$17,724
|
|
|
2005-03-09 |
2005-03-08 |
PP
Planned purchase
|
VANLENT ANNE
Exec. V.P., CFO and Treasurer
Officer
|
2,000
+1.8%
14.47
US$28,930
|
2,000
+1.8%
|
14.47
|
US$28,930
|
|
|
2005-03-03 |
2005-02-15 |
S
Sale
|
SIMON NICHOLAS J III
Non-Executive Director
|
384,236
-16.5%
19.50
US$7,492,602
|
384,236
-16.5%
|
19.50
|
US$7,492,602
|
|
|
2005-03-03 |
2005-02-15 |
S
Sale
|
EVNIN LUKE
See Remarks
|
384,236
-16.5%
19.50
US$7,492,602
|
384,236
-16.5%
|
19.50
|
US$7,492,602
|
|
|
2005-03-03 |
2005-02-15 |
S
Sale
|
MPM BIOVENTURES III QP LP
See Remarks
|
384,236
-16.5%
19.50
US$7,492,602
|
384,236
-16.5%
|
19.50
|
US$7,492,602
|
|
|
2005-02-17 |
2005-02-15 |
S
Sale
|
AKKARAJU SRINIVAS
Non-Executive Director
|
380,497
-16.4%
18.33
US$6,974,510
|
380,497
-16.4%
|
18.33
|
US$6,974,510
|
|
|
2005-02-17 |
2005-02-15 |
S
Sale
|
JP MORGAN PARTNERS BHCA LP
Large shareholder
|
3,682
-16.4%
18.33
US$67,491
|
3,682
-16.4%
|
18.33
|
US$67,491
|
|
|
2005-02-17 |
2005-02-15 |
S
Sale
|
JP MORGAN PARTNERS BHCA LP
Large shareholder
|
9,068
-16.4%
18.33
US$166,216
|
9,068
-16.4%
|
18.33
|
US$166,216
|
|
|
2005-02-17 |
2005-02-15 |
S
Sale
|
JP MORGAN PARTNERS BHCA LP
Large shareholder
|
33,018
-16.4%
18.33
US$605,220
|
33,018
-16.4%
|
18.33
|
US$605,220
|
|
|
2005-02-17 |
2005-02-15 |
S
Sale
|
JP MORGAN PARTNERS BHCA LP
Large shareholder
|
65,168
-16.4%
18.33
US$1,194,529
|
65,168
-16.4%
|
18.33
|
US$1,194,529
|
|
|
2005-02-17 |
2005-02-15 |
S
Sale
|
JP MORGAN PARTNERS BHCA LP
Large shareholder
|
380,497
-16.4%
18.33
US$6,974,510
|
380,497
-16.4%
|
18.33
|
US$6,974,510
|
|
|
2005-02-17 |
2005-02-15 |
S
Sale
|
PERSEUS SOROS BIOPHARMACEUTICAL FUND LP
See footnote (2)
|
430,004
-15.6%
19.50
US$8,385,078
|
430,004
-15.6%
|
19.50
|
US$8,385,078
|
|
|
2005-02-15 |
2005-02-15 |
S
Sale
|
JOHNSON & JOHNSON
Large shareholder
|
694,327
-15.6%
19.50
US$13,539,376
|
694,327
-15.6%
|
19.50
|
US$13,539,376
|
|
|
2005-01-04 |
2004-12-30 |
B
Purchase
|
JP MORGAN PARTNERS BHCA LP
Large shareholder
|
147,134
+inf%
7.94
US$1,168,244
|
147,134
+inf%
|
7.94
|
US$1,168,244
|
|
|
2005-01-04 |
2004-12-30 |
S
Sale
|
JP MORGAN PARTNERS BHCA LP
Large shareholder
|
147,134
-6.0%
7.94
US$1,168,244
|
147,134
-6.0%
|
7.94
|
US$1,168,244
|
|
|
2004-12-30 |
2004-12-30 |
PlS
Planned sale
|
BRISTOW ALBERT
General Counsel and Secretary
Officer
|
500
-85.0%
16.25
US$8,125
|
500
-85.0%
|
16.25
|
US$8,125
|
|
|
2004-12-30 |
2004-12-29 |
PlS
Planned sale
|
BRISTOW ALBERT
General Counsel and Secretary
Officer
|
500
-85.0%
16.38
US$8,190
|
500
-85.0%
|
16.38
|
US$8,190
|
|
|
2004-12-30 |
2004-12-29 |
PlS
Planned sale
|
BRISTOW ALBERT
General Counsel and Secretary
Officer
|
1,000
-63.0%
16.35
US$16,350
|
1,000
-63.0%
|
16.35
|
US$16,350
|
|
|
2004-12-30 |
2004-12-29 |
PlS
Planned sale
|
BRISTOW ALBERT
General Counsel and Secretary
Officer
|
500
-23.9%
16.33
US$8,165
|
500
-23.9%
|
16.33
|
US$8,165
|
|
|
2004-12-30 |
2004-12-29 |
PlS
Planned sale
|
BRISTOW ALBERT
General Counsel and Secretary
Officer
|
500
-19.3%
16.32
US$8,160
|
500
-19.3%
|
16.32
|
US$8,160
|
|
|
2004-12-28 |
2004-12-28 |
B
Purchase
|
CAMPBELL ROBERT E
Non-Executive Director
|
2,000
+inf%
16.25
US$32,500
|
2,000
+inf%
|
16.25
|
US$32,500
|
|
|
2004-12-22 |
2004-12-20 |
S
Sale
|
MPM BIOVENTURES III QP LP
Large shareholder
|
10,000
-0.4%
17.90
US$179,001
|
10,000
-0.4%
|
17.90
|
US$179,001
|
|
|
2004-12-22 |
2004-12-20 |
S
Sale
|
SIMON NICHOLAS J III
Non-Executive Director
Large shareholder
|
10,000
-0.4%
17.90
US$179,001
|
10,000
-0.4%
|
17.90
|
US$179,001
|
|
|
2004-12-22 |
2004-12-20 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
10,000
-0.4%
17.90
US$179,001
|
10,000
-0.4%
|
17.90
|
US$179,001
|
|
|
2004-08-18 |
2004-08-17 |
B
Purchase
|
VANLENT ANNE
Exec. V.P., CFO and Treasurer
Officer
|
1,000
+inf%
10.18
US$10,180
|
1,000
+inf%
|
10.18
|
US$10,180
|
|
|
2004-08-16 |
2004-08-13 |
B
Purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
1,500
+150.0%
10.70
US$16,050
|
1,500
+150.0%
|
10.70
|
US$16,050
|
|
|
2004-08-16 |
2004-08-13 |
PP
Planned purchase
|
CAUWENBERGH GEERT
Chief Executive Officer
Executive Director
|
1,000
+0.2%
10.16
US$10,160
|
1,000
+0.2%
|
10.16
|
US$10,160
|
|
|
2004-05-06 |
2004-05-04 |
B
Purchase
|
Chief Executive Officer
Executive Director
|
1,000
+inf%
15.00
US$15,000
|
1,000
+inf%
|
15.00
|
US$15,000
|
|
|
2004-05-06 |
2004-05-04 |
B
Purchase
|
Chief Executive Officer
Executive Director
|
1,000
+inf%
15.00
US$15,000
|
1,000
+inf%
|
15.00
|
US$15,000
|
|
|
2004-05-06 |
2004-05-04 |
B
Purchase
|
Chief Executive Officer
Executive Director
|
1,000
+inf%
15.00
US$15,000
|
1,000
+inf%
|
15.00
|
US$15,000
|
|
|
2004-05-05 |
2004-05-04 |
B
Purchase
|
Large shareholder
|
200,000
+9.3%
15.00
US$3,000,000
|
200,000
+9.3%
|
15.00
|
US$3,000,000
|
|
|
2004-05-05 |
2004-05-04 |
B
Purchase
|
Large shareholder
|
200,000
+9.3%
15.00
US$3,000,000
|
200,000
+9.3%
|
15.00
|
US$3,000,000
|
|
|
2004-05-05 |
2004-05-04 |
B
Purchase
|
Large shareholder
|
200,000
+9.3%
15.00
US$3,000,000
|
200,000
+9.3%
|
15.00
|
US$3,000,000
|
|