United States Biotechnology & Medical Research

Axsome Therapeutics Inc (AXSM)

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Over the past 90 days, Axsome Therapeutics Inc. insiders have executed 28 transactions, all of which were sales totaling approximately $82.86 million. Notable activity includes significant planned and proposed sales by CEO Herriot Tabuteau. These transactions follow the company's May 2026 results financiers, where the firm reported an EPS miss of 46.51%.
Ticker: AXSM Exchange: NMS
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Axsome Therapeutics Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Planned sale 6 Aug 2026
Value US$831,401.45 | Price 342.20 | Shares 34,742 (+14.8%)
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-08-07 2026-08-06 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
34,742 +14.8%
342.20
US$831,401 		34,742 +14.8% 342.20 US$831,401
2026-08-06 2026-08-06 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
72,217
157.53
US$2,249,264 		72,217 157.53 US$2,249,264
2026-08-07 2026-08-05 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
51,536 -26.4%
266.75
US$3,308,578 		51,536 -26.4% 266.75 US$3,308,578
2026-08-05 2026-08-05 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
1,000
212.85
US$100,000 		1,000 212.85 US$100,000
2026-07-01 2026-07-01 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
49,666 -87.3%
240.25
US$11,932,256 		49,666 -87.3% 240.25 US$11,932,256
2026-07-01 2026-07-01 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
49,666
240.66
US$11,952,620 		49,666 240.66 US$11,952,620
2026-06-11 2026-06-11 PlS Planned sale
2.4
JEFFS ROGER
Non-Executive Director
286 -0.5%
249.12
US$71,248 		286 -0.5% 249.12 US$71,248
2026-06-11 2026-06-11 PlS Planned sale
2.4
JEFFS ROGER
Non-Executive Director
286 -0.5%
249.12
US$71,248 		286 -0.5% 249.12 US$71,248
2026-06-11 2026-06-11 PlS Planned sale
2.4
JEFFS ROGER
Non-Executive Director
286 -0.5%
249.12
US$71,248 		286 -0.5% 249.12 US$71,248
2026-06-11 2026-06-11 PrS Proposed sale
2.4
JEFFS ROGER

Director

Non-Executive Director
286
249.12
US$71,248 		286 249.12 US$71,248
2026-06-11 2026-06-10 PlS Planned sale
2.4
JEFFS ROGER
Non-Executive Director
286 -0.5%
246.18
US$70,407 		286 -0.5% 246.18 US$70,407
2026-06-10 2026-06-10 PlS Planned sale
Mahony Susan
Non-Executive Director
300 -26.6%
246.18
US$73,854 		300 -26.6% 246.18 US$73,854
2026-06-10 2026-06-10 PlS Planned sale
3.5
Coleman Mark
Non-Executive Director
643 -2.1%
249.00
US$160,107 		643 -2.1% 249.00 US$160,107
2026-06-10 2026-06-10 PlS Planned sale
Mahony Susan
Non-Executive Director
300 -26.6%
246.18
US$73,854 		300 -26.6% 246.18 US$73,854
2026-06-10 2026-06-10 PlS Planned sale
3.5
Coleman Mark
Non-Executive Director
643 -2.1%
249.00
US$160,107 		643 -2.1% 249.00 US$160,107
2026-06-10 2026-06-10 PrS Proposed sale
3.5
Coleman Mark

Director

Non-Executive Director
643
249.00
US$160,109 		643 249.00 US$160,109
2026-06-10 2026-06-10 PrS Proposed sale
Mahony Susan

Director

Non-Executive Director
300
246.18
US$73,854 		300 246.18 US$73,854
2026-06-10 2026-06-10 PrS Proposed sale
2.4
JEFFS ROGER

Director

Non-Executive Director
286
246.18
US$70,407 		286 246.18 US$70,407
2026-06-10 2026-06-09 PlS Planned sale
Mahony Susan
Non-Executive Director
300 -21.0%
237.21
US$71,163 		300 -21.0% 237.21 US$71,163
2026-06-10 2026-06-09 PlS Planned sale
Mahony Susan
Non-Executive Director
300 -21.0%
237.21
US$71,163 		300 -21.0% 237.21 US$71,163
2026-06-09 2026-06-09 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
49,670 -87.3%
241.01
US$11,970,967 		49,670 -87.3% 241.01 US$11,970,967
2026-06-09 2026-06-09 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
49,670
245.64
US$12,200,939 		49,670 245.64 US$12,200,939
2026-06-09 2026-06-09 PlS Planned sale
3.9
Pizzie Nick

Chief Financial Officer

Officer
33,000 -43.5%
240.09
US$7,922,970 		33,000 -43.5% 240.09 US$7,922,970
2026-06-09 2026-06-09 PrS Proposed sale
Mahony Susan

Director

Non-Executive Director
300
237.21
US$71,163 		300 237.21 US$71,163
2026-06-09 2026-06-09 PrS Proposed sale
3.9
Pizzie Nick

Officer

Officer
33,000
240.09
US$7,923,002 		33,000 240.09 US$7,923,002
2026-06-02 2026-06-02 PlS Planned sale
3.5
Coleman Mark
Non-Executive Director
5,537 -15.8%
223.39
US$1,236,910 		5,537 -15.8% 223.39 US$1,236,910
2026-06-02 2026-06-02 PrS Proposed sale
3.5
Coleman Mark

Director

Non-Executive Director
5,537
223.39
US$1,236,885 		5,537 223.39 US$1,236,885
2026-06-02 2026-06-01 PlS Planned sale
3.5
Coleman Mark
Non-Executive Director
6,000 -14.6%
230.30
US$1,381,800 		6,000 -14.6% 230.30 US$1,381,800
2026-06-01 2026-06-01 PrS Proposed sale
3.5
Coleman Mark

Director

Non-Executive Director
6,000
230.30
US$1,381,798 		6,000 230.30 US$1,381,798
2026-06-02 2026-05-29 PlS Planned sale
3.5
Coleman Mark
Non-Executive Director
6,000 -12.7%
233.46
US$1,400,760 		6,000 -12.7% 233.46 US$1,400,760
2026-05-29 2026-05-29 PrS Proposed sale
3.5
Coleman Mark

Director

Non-Executive Director
6,000
233.46
US$1,400,783 		6,000 233.46 US$1,400,783
2026-05-05 2026-05-05 PlS Planned sale
0.7
Jacobson Mark L.

Chief Operating Officer

Officer
233 -100.0%
228.18
US$53,166 		233 -100.0% 228.18 US$53,166
2026-05-05 2026-05-05 PrS Proposed sale
0.7
Mark Jacobson

Officer

Officer
233
223.06
US$51,973 		233 223.06 US$51,973
2026-05-05 2026-05-04 PlS Planned sale
0.7
Jacobson Mark L.

Chief Operating Officer

Officer
4,517 -100.0%
227.94
US$1,029,605 		4,517 -100.0% 227.94 US$1,029,605
2026-05-05 2026-05-04 PrS Proposed sale
0.7
Mark Jacobson

Officer

Officer
4,517
223.70
US$1,010,453 		4,517 223.70 US$1,010,453
2026-05-04 2026-05-04 PrS Proposed sale
0.7
Mark Jacobson

Officer

Officer
4,517
223.70
US$1,010,453 		4,517 223.70 US$1,010,453
2026-04-23 2026-04-22 PlS Planned sale
Maizel Ari

Chief Commercial Officer

Officer
7,500 -100.0%
182.42
US$1,368,150 		7,500 -100.0% 182.42 US$1,368,150
2026-04-22 2026-04-22 PrS Proposed sale
Maizel Ari

Officer

Officer
7,500
182.42
US$1,368,151 		7,500 182.42 US$1,368,151
2026-02-27 2026-02-26 PlS Planned sale
3.5
Coleman Mark
Non-Executive Director
25,000 -34.7%
161.11
US$4,027,750 		25,000 -34.7% 161.11 US$4,027,750
2026-02-27 2026-02-26 PlS Planned sale
0.7
Jacobson Mark L.

Chief Operating Officer

Officer
35,378 -100.0%
161.88
US$5,726,991 		35,378 -100.0% 161.88 US$5,726,991
2026-02-26 2026-02-26 PrS Proposed sale
0.7
Mark Jacobson

Officer

Officer
35,378
163.19
US$5,773,336 		35,378 163.19 US$5,773,336
2026-02-26 2026-02-26 PrS Proposed sale
3.5
Coleman Mark

Director

Non-Executive Director
25,000
161.11
US$4,027,636 		25,000 161.11 US$4,027,636
2026-02-02 2026-02-02 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
32,410
185.88
US$6,024,371 		32,410 185.88 US$6,024,371
2026-02-02 2026-02-02 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
32,410 -81.8%
185.60
US$6,015,296 		32,410 -81.8% 185.60 US$6,015,296
2026-01-23 2026-01-22 PlS Planned sale
3.9
Pizzie Nick

Chief Financial Officer

Officer
12,000 -22.0%
187.92
US$2,255,040 		12,000 -22.0% 187.92 US$2,255,040
2026-01-22 2026-01-22 PrS Proposed sale
3.9
Pizzie Nick

Officer

Officer
12,000
187.92
US$2,254,989 		12,000 187.92 US$2,254,989
2026-01-23 2026-01-21 PlS Planned sale
Maizel Ari

Chief Commercial Officer

Officer
7,500 -100.0%
184.44
US$1,383,300 		7,500 -100.0% 184.44 US$1,383,300
2026-01-21 2026-01-21 PrS Proposed sale
Maizel Ari

Officer

Officer
7,500
184.44
US$1,383,327 		7,500 184.44 US$1,383,327
2026-01-07 2026-01-07 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
31,261
170.69
US$5,335,940 		31,261 170.69 US$5,335,940
2026-01-07 2026-01-07 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
31,261 -81.2%
170.38
US$5,326,249 		31,261 -81.2% 170.38 US$5,326,249
2026-01-07 2026-01-06 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
29,450 -80.3%
172.33
US$5,075,118 		29,450 -80.3% 172.33 US$5,075,118
2026-01-06 2026-01-06 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
29,450
171.88
US$5,061,866 		29,450 171.88 US$5,061,866
2026-01-07 2026-01-05 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
78,703 -91.6%
171.28
US$13,480,250 		78,703 -91.6% 171.28 US$13,480,250
2026-01-05 2026-01-05 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
78,703
171.49
US$13,496,777 		78,703 171.49 US$13,496,777
2026-01-02 2025-12-31 PlS Planned sale
2.9
Saad Mark E
Non-Executive Director
31,346 -75.8%
165.18
US$5,177,732 		31,346 -75.8% 165.18 US$5,177,732
2026-01-02 2025-12-31 PlS Planned sale
2.9
Saad Mark E
Non-Executive Director
6,231 -38.4%
165.18
US$1,029,237 		6,231 -38.4% 165.18 US$1,029,237
2025-12-04 2025-12-04 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
10,558
148.04
US$1,563,006 		10,558 148.04 US$1,563,006
2025-12-04 2025-12-04 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
10,558 -59.4%
148.18
US$1,564,484 		10,558 -59.4% 148.18 US$1,564,484
2025-12-04 2025-12-03 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
20,163 -73.6%
146.94
US$2,962,751 		20,163 -73.6% 146.94 US$2,962,751
2025-12-03 2025-12-03 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
20,163
147.81
US$2,980,293 		20,163 147.81 US$2,980,293
2025-12-04 2025-12-02 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
49,252 -87.2%
144.59
US$7,121,347 		49,252 -87.2% 144.59 US$7,121,347
2025-12-02 2025-12-02 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
49,252
142.09
US$6,998,217 		49,252 142.09 US$6,998,217
2025-11-05 2025-11-05 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
21,775
135.69
US$2,954,650 		21,775 135.69 US$2,954,650
2025-11-05 2025-11-05 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
21,775 -75.1%
134.49
US$2,928,520 		21,775 -75.1% 134.49 US$2,928,520
2025-11-05 2025-11-04 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
50,459 -87.5%
133.79
US$6,750,910 		50,459 -87.5% 133.79 US$6,750,910
2025-11-04 2025-11-04 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
50,459
134.93
US$6,808,433 		50,459 134.93 US$6,808,433
2025-11-05 2025-11-03 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
91,705 -92.7%
132.34
US$12,136,240 		91,705 -92.7% 132.34 US$12,136,240
2025-11-03 2025-11-03 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
91,705
135.75
US$12,448,954 		91,705 135.75 US$12,448,954
2025-10-08 2025-10-08 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
12,774
118.71
US$1,516,402 		12,774 118.71 US$1,516,402
2025-10-08 2025-10-08 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
12,774 -63.9%
118.84
US$1,518,062 		12,774 -63.9% 118.84 US$1,518,062
2025-10-08 2025-10-07 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
13,390 -64.9%
118.77
US$1,590,330 		13,390 -64.9% 118.77 US$1,590,330
2025-10-07 2025-10-07 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
13,390
118.64
US$1,588,590 		13,390 118.64 US$1,588,590
2025-10-08 2025-10-06 PlS Planned sale
TABUTEAU HERRIOT

Chief Executive Officer

Executive Director Large shareholder
19,220 -72.7%
120.17
US$2,309,667 		19,220 -72.7% 120.17 US$2,309,667
2025-10-06 2025-10-06 PrS Proposed sale
Herriot Tabuteau

Officer

Officer
19,220
119.94
US$2,305,247 		19,220 119.94 US$2,305,247
2025-09-22 2025-09-22 PrS Proposed sale
0.7
Jacobson Mark L.

Officer

Officer
10,000
115.96
US$1,159,571 		10,000 115.96 US$1,159,571
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