United States Biotechnology & Medical Research

Praxis Precision Medicines Inc (PRAX)

Track

Praxis Precision Medicines witnessed significant insider trading activity recently, totaling over $10.8 million in sales. Director Jill DeSimone executed fourteen planned and proposed divestments on June 24, 2026. These movements occurred following a positive earnings report, while the stock price maintains a strong position near its annual peak.
Ticker: PRAX Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Praxis Precision Medicines Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Top insiders
Trades
Planned sale 24 Jun 2026
Value US$3,910,074.83 | Price 58.68 | Shares 91,477 (+42.3%)
Planned sale 24 Jun 2026
Value US$172,296.41 | Price 222.44 | Shares 21,357 (-19.5%)
Planned sale 24 Jun 2026
Value US$158,086.15 | Price 313.66 | Shares 504 (-10.2%)
Planned sale 24 Jun 2026
Value US$314,081.32 | Price 312.83 | Shares 1,004 (-16.8%)
Planned sale 24 Jun 2026
Value US$890,202.56 | Price 311.91 | Shares 2,854 (-32.4%)
Planned sale 24 Jun 2026
Value US$544,055.75 | Price 310.89 | Shares 1,750 (-16.6%)
Planned sale 24 Jun 2026
Value US$309,073.62 | Price 309.38 | Shares 999 (-8.6%)
Planned sale 24 Jun 2026
Value US$382,221.32 | Price 308.24 | Shares 1,240 (-9.7%)
Planned sale 24 Jun 2026
Value US$209,521.86 | Price 306.77 | Shares 683 (-5.1%)
Planned sale 24 Jun 2026
Value US$97,699.20 | Price 305.31 | Shares 320 (-2.3%)
Planned sale 24 Jun 2026
Value US$36,375.24 | Price 303.13 | Shares 120 (-0.9%)
Planned sale 24 Jun 2026
Value US$3,014.40 | Price 301.44 | Shares 10 (-0.1%)
Proposed sale 24 Jun 2026
Value US$3,611,336.04 | Price 311.32 | Shares 11,600
Proposed sale 24 Jun 2026
Value US$3,611,336.04 | Price 311.32 | Shares 11,600
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
91,477 +42.3%
58.68
US$3,910,075 		91,477 +42.3% 58.68 US$3,910,075
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
21,357 -19.5%
222.44
US$172,296 		21,357 -19.5% 222.44 US$172,296
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
81,857 -39.6%
71.71
US$1,166,922 		81,857 -39.6% 71.71 US$1,166,922
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
1,004 -16.8%
312.83
US$314,081 		1,004 -16.8% 312.83 US$314,081
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
2,854 -32.4%
311.91
US$890,203 		2,854 -32.4% 311.91 US$890,203
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
1,750 -16.6%
310.89
US$544,056 		1,750 -16.6% 310.89 US$544,056
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
999 -8.6%
309.38
US$309,074 		999 -8.6% 309.38 US$309,074
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
1,240 -9.7%
308.24
US$382,221 		1,240 -9.7% 308.24 US$382,221
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
683 -5.1%
306.77
US$209,522 		683 -5.1% 306.77 US$209,522
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
320 -2.3%
305.31
US$97,699 		320 -2.3% 305.31 US$97,699
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
120 -0.9%
303.13
US$36,375 		120 -0.9% 303.13 US$36,375
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
10 -0.1%
301.44
US$3,014 		10 -0.1% 301.44 US$3,014
2026-06-24 2026-06-24 PrS Proposed sale
1.6
DeSimone Jill

Director

Non-Executive Director
11,600
311.32
US$3,611,336 		11,600 311.32 US$3,611,336
2026-06-24 2026-06-24 PrS Proposed sale
1.6
DeSimone Jill

Director

Non-Executive Director
11,600
311.32
US$3,611,336 		11,600 311.32 US$3,611,336
2025-11-21 2025-11-20 S Sale
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
9,100 -30.4%
194.30
US$1,768,130 		9,100 -30.4% 194.30 US$1,768,130
2025-11-21 2025-11-20 S Sale
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
977 -3.2%
193.23
US$188,789 		977 -3.2% 193.23 US$188,789
2025-11-21 2025-11-20 S Sale
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
13,339 -30.1%
192.53
US$2,568,198 		13,339 -30.1% 192.53 US$2,568,198
2025-11-21 2025-11-20 S Sale
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
1,714 -3.7%
190.86
US$327,139 		1,714 -3.7% 190.86 US$327,139
2025-11-21 2025-11-20 S Sale
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
2,145 -17.0%
192.71
US$413,365 		2,145 -17.0% 192.71 US$413,365
2025-11-21 2025-11-20 S Sale
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
11,455 -47.6%
191.96
US$2,198,879 		11,455 -47.6% 191.96 US$2,198,879
2025-11-20 2025-11-20 PrS Proposed sale
2.4
Nemiroff Alex

Officer

Officer
25,130
193.09
US$4,852,249 		25,130 193.09 US$4,852,249
2025-11-20 2025-11-20 PrS Proposed sale
2.3
Mastrocola Lauren

Officer

Officer
13,600
192.08
US$2,612,239 		13,600 192.08 US$2,612,239
2024-11-15 2024-11-14 S Sale
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
5,188 -48.0%
81.78
US$424,318 		5,188 -48.0% 81.78 US$424,318
2024-11-15 2024-11-14 S Sale
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
8,239 -44.4%
80.20
US$660,827 		8,239 -44.4% 80.20 US$660,827
2024-11-14 2024-11-14 PrS Proposed sale
2.3
Mastrocola Lauren

Officer

Officer
5,189
81.77
US$424,316 		5,189 81.77 US$424,316
2024-11-14 2024-11-14 PrS Proposed sale
2.4
Nemiroff Alex

Officer

Officer
8,240
80.20
US$660,832 		8,240 80.20 US$660,832
2023-10-10 2023-10-05 B Purchase
1.6
DeSimone Jill
Non-Executive Director
14,500 +inf%
1.75
US$25,375 		14,500 +inf% 1.75 US$25,375
2023-06-27 2023-06-27 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
10,000 +28.6%
1.06
US$10,587 		10,000 +28.6% 1.06 US$10,587
2023-03-27 2023-03-24 B Purchase
3.7
MITCHELL DEAN J
Non-Executive Director
50,000 +200.0%
0.84
US$41,815 		50,000 +200.0% 0.84 US$41,815
2023-03-27 2023-03-23 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
35,002 +inf%
0.86
US$30,207 		35,002 +inf% 0.86 US$30,207
2023-03-27 2023-03-23 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
35,000 +18.3%
0.86
US$30,160 		35,000 +18.3% 0.86 US$30,160
2022-06-21 2022-06-16 B Purchase
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
3,000 +10.6%
1.93
US$5,775 		3,000 +10.6% 1.93 US$5,775
2022-06-14 2022-06-13 B Purchase
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
7,500 +23.6%
1.63
US$12,225 		7,500 +23.6% 1.63 US$12,225
2022-06-13 2022-06-09 B Purchase
3.3
Kelly Timothy Edwin

Chief Financial Officer

Officer
10,000 +32.8%
1.77
US$17,650 		10,000 +32.8% 1.77 US$17,650
2022-06-09 2022-06-08 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
27,000 +16.6%
1.85
US$49,888 		27,000 +16.6% 1.85 US$49,888
2022-06-09 2022-06-08 B Purchase
3.7
MITCHELL DEAN J
Non-Executive Director
25,000 +inf%
1.81
US$45,188 		25,000 +inf% 1.81 US$45,188
2021-10-08 2021-10-06 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
400,000 -100.0%
17.50
US$7,000,000 		400,000 -100.0% 17.50 US$7,000,000
2021-10-05 2021-10-05 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
23,946 -5.6%
19.15
US$458,566 		23,946 -5.6% 19.15 US$458,566
2021-10-05 2021-10-01 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
22,600 -5.1%
19.13
US$432,338 		22,600 -5.1% 19.13 US$432,338
2021-08-05 2021-08-03 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
22,300 -2.6%
14.99
US$334,277 		22,300 -2.6% 14.99 US$334,277
2020-11-10 2020-11-10 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
3,846 +18.7%
26.08
US$100,304 		3,846 +18.7% 26.08 US$100,304
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