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United States Biotechnology & Medical Research

Praxis Precision Medicines Inc (PRAX)

Track

The most recent insider trading activity occurred on November 20, 2025, with significant sell transactions reported by Alex Nemiroff and Lauren Mastrocola. These sales, including proposed sales, represent substantial value. Earlier transactions in November 2024 also showed sell activity from these individuals. Prior to these, buy transactions were noted in October 2023 and June 2023.
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Ticker: PRAX Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
DeSimone Jill
Director
2 sales — total 200,000 USD
Proposed sale 24 Jun 2026
Value US$1,951,983.72 | Price 340.77 | Shares 46,719
Proposed sale 24 Jun 2026
Value US$3,802,910.46 | Price 434.39 | Shares 3,818
Sale 20 Nov 2025
Value US$490,737.03 | Price 85.54 | Shares 11,345
Sale 20 Nov 2025
Value US$1,155,703.34 | Price 430.07 | Shares 9,131
Sale 20 Nov 2025
Value US$2,568,197.69 | Price 192.53 | Shares 13,339
Sale 20 Nov 2025
Value US$327,139.18 | Price 190.86 | Shares 1,714
Proposed sale 20 Nov 2025
Value US$4,852,249.43 | Price 193.09 | Shares 25,130
Sale 20 Nov 2025
Value US$413,365.10 | Price 192.71 | Shares 2,145
Sale 20 Nov 2025
Value US$2,198,878.89 | Price 191.96 | Shares 11,455
Proposed sale 20 Nov 2025
Value US$2,612,238.86 | Price 192.08 | Shares 13,600
Sale 14 Nov 2024
Value US$424,318.34 | Price 81.78 | Shares 5,188
Proposed sale 14 Nov 2024
Value US$424,316.34 | Price 81.77 | Shares 5,189
Sale 14 Nov 2024
Value US$660,827.46 | Price 80.20 | Shares 8,239
Proposed sale 14 Nov 2024
Value US$660,831.71 | Price 80.20 | Shares 8,240
Buy 5 Oct 2023
Value US$25,375.00 | Price 1.75 | Shares 14,500
Buy 27 Jun 2023
Value US$10,587.00 | Price 1.06 | Shares 10,000
Buy 24 Mar 2023
Value US$41,815.00 | Price 0.84 | Shares 50,000
Buy 23 Mar 2023
Value US$30,206.51 | Price 0.86 | Shares 35,002
Buy 23 Mar 2023
Value US$30,159.50 | Price 0.86 | Shares 35,000
Buy 16 Jun 2022
Value US$5,775.00 | Price 1.93 | Shares 3,000
Buy 13 Jun 2022
Value US$12,225.00 | Price 1.63 | Shares 7,500
Buy 9 Jun 2022
Value US$17,650.00 | Price 1.77 | Shares 10,000
Buy 8 Jun 2022
Value US$49,887.90 | Price 1.85 | Shares 27,000
Buy 8 Jun 2022
Value US$45,187.50 | Price 1.81 | Shares 25,000
Sale 6 Oct 2021
Value US$7,000,000.00 | Price 17.50 | Shares 400,000
Sale 5 Oct 2021
Value US$458,565.90 | Price 19.15 | Shares 23,946
Sale 1 Oct 2021
Value US$432,338.00 | Price 19.13 | Shares 22,600
Sale 3 Aug 2021
Value US$334,277.00 | Price 14.99 | Shares 22,300
Buy 10 Nov 2020
Value US$100,303.68 | Price 26.08 | Shares 3,846
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-06-24 2026-06-24 PrS Proposed sale
1.6
DeSimone Jill

Director

Non-Executive Director
46,719
340.77
US$1,951,984 		46,719 340.77 US$1,951,984
2026-06-24 2026-06-24 PrS Proposed sale
1.6
DeSimone Jill

Director

Non-Executive Director
3,818
434.39
US$3,802,910 		3,818 434.39 US$3,802,910
2025-11-21 2025-11-20 S Sale
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
11,345 -6.9%
85.54
US$490,737 		11,345 -6.9% 85.54 US$490,737
2025-11-21 2025-11-20 S Sale
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
977 -3.2%
193.23
US$188,789 		977 -3.2% 193.23 US$188,789
2025-11-21 2025-11-20 S Sale
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
13,339 -30.1%
192.53
US$2,568,198 		13,339 -30.1% 192.53 US$2,568,198
2025-11-21 2025-11-20 S Sale
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
1,714 -3.7%
190.86
US$327,139 		1,714 -3.7% 190.86 US$327,139
2025-11-21 2025-11-20 S Sale
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
2,145 -17.0%
192.71
US$413,365 		2,145 -17.0% 192.71 US$413,365
2025-11-21 2025-11-20 S Sale
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
11,455 -47.6%
191.96
US$2,198,879 		11,455 -47.6% 191.96 US$2,198,879
2025-11-20 2025-11-20 PrS Proposed sale
2.4
Nemiroff Alex

Officer

Officer
25,130
193.09
US$4,852,249 		25,130 193.09 US$4,852,249
2025-11-20 2025-11-20 PrS Proposed sale
2.3
Mastrocola Lauren

Officer

Officer
13,600
192.08
US$2,612,239 		13,600 192.08 US$2,612,239
2024-11-15 2024-11-14 S Sale
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
5,188 -48.0%
81.78
US$424,318 		5,188 -48.0% 81.78 US$424,318
2024-11-15 2024-11-14 S Sale
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
8,239 -44.4%
80.20
US$660,827 		8,239 -44.4% 80.20 US$660,827
2024-11-14 2024-11-14 PrS Proposed sale
2.3
Mastrocola Lauren

Officer

Officer
5,189
81.77
US$424,316 		5,189 81.77 US$424,316
2024-11-14 2024-11-14 PrS Proposed sale
2.4
Nemiroff Alex

Officer

Officer
8,240
80.20
US$660,832 		8,240 80.20 US$660,832
2023-10-10 2023-10-05 B Purchase
1.6
DeSimone Jill
Non-Executive Director
14,500 +inf%
1.75
US$25,375 		14,500 +inf% 1.75 US$25,375
2023-06-27 2023-06-27 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
10,000 +28.6%
1.06
US$10,587 		10,000 +28.6% 1.06 US$10,587
2023-03-27 2023-03-24 B Purchase
3.7
MITCHELL DEAN J
Non-Executive Director
50,000 +200.0%
0.84
US$41,815 		50,000 +200.0% 0.84 US$41,815
2023-03-27 2023-03-23 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
35,002 +inf%
0.86
US$30,207 		35,002 +inf% 0.86 US$30,207
2023-03-27 2023-03-23 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
35,000 +18.3%
0.86
US$30,160 		35,000 +18.3% 0.86 US$30,160
2022-06-21 2022-06-16 B Purchase
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
3,000 +10.6%
1.93
US$5,775 		3,000 +10.6% 1.93 US$5,775
2022-06-14 2022-06-13 B Purchase
2.4
Nemiroff Alex

General Counsel and Secretary

Officer
7,500 +23.6%
1.63
US$12,225 		7,500 +23.6% 1.63 US$12,225
2022-06-13 2022-06-09 B Purchase
3.3
Kelly Timothy Edwin

Chief Financial Officer

Officer
10,000 +32.8%
1.77
US$17,650 		10,000 +32.8% 1.77 US$17,650
2022-06-09 2022-06-08 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
27,000 +16.6%
1.85
US$49,888 		27,000 +16.6% 1.85 US$49,888
2022-06-09 2022-06-08 B Purchase
3.7
MITCHELL DEAN J
Non-Executive Director
25,000 +inf%
1.81
US$45,188 		25,000 +inf% 1.81 US$45,188
2021-10-08 2021-10-06 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
400,000 -100.0%
17.50
US$7,000,000 		400,000 -100.0% 17.50 US$7,000,000
2021-10-05 2021-10-05 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
23,946 -5.6%
19.15
US$458,566 		23,946 -5.6% 19.15 US$458,566
2021-10-05 2021-10-01 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
22,600 -5.1%
19.13
US$432,338 		22,600 -5.1% 19.13 US$432,338
2021-08-05 2021-08-03 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
22,300 -2.6%
14.99
US$334,277 		22,300 -2.6% 14.99 US$334,277
2020-11-10 2020-11-10 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
3,846 +18.7%
26.08
US$100,304 		3,846 +18.7% 26.08 US$100,304
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