United States Biotechnology & Medical Research

Praxis Precision Medicines Inc (PRAX)

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Praxis Precision Medicines experienced significant insider trading activity recently, totaling over $10.8 million in sales. Director Jill DeSimone executed multiple planned divestments on June 24, 2026. These movements occurred following the company's August 2026 results financiers, where the firm outperformed earnings expectations by 20.3 percent despite a slight 90-day stock price decline.
Ticker: PRAX Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Praxis Precision Medicines Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
58.68
Quantity 91,477 +42.3%
Value US$3,910,075
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
222.44
Quantity 21,357 -19.5%
Value US$172,296
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
71.71
Quantity 81,857 -39.6%
Value US$1,166,922
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
312.83
Quantity 1,004 -16.8%
Value US$314,081
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
311.91
Quantity 2,854 -32.4%
Value US$890,203
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
310.89
Quantity 1,750 -16.6%
Value US$544,056
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
309.38
Quantity 999 -8.6%
Value US$309,074
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
308.24
Quantity 1,240 -9.7%
Value US$382,221
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
306.77
Quantity 683 -5.1%
Value US$209,522
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
305.31
Quantity 320 -2.3%
Value US$97,699
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
303.13
Quantity 120 -0.9%
Value US$36,375
1.6
DeSimone Jill Non-Executive Director
Transaction date
Planned sale
Price
301.44
Quantity 10 -0.1%
Value US$3,014
1.6
DeSimone Jill Director Non-Executive Director
Transaction date
Proposed sale
Price
311.32
Quantity 11,600
Value US$3,611,336
1.6
DeSimone Jill Director Non-Executive Director
Transaction date
Proposed sale
Price
311.32
Quantity 11,600
Value US$3,611,336
2.3
Nemiroff Alex General Counsel and Secretary Officer
Transaction date
Sale
Price
194.30
Quantity 9,100 -30.4%
Value US$1,768,130
2.3
Nemiroff Alex General Counsel and Secretary Officer
Transaction date
Sale
Price
193.23
Quantity 977 -3.2%
Value US$188,789
2.3
Nemiroff Alex General Counsel and Secretary Officer
Transaction date
Sale
Price
192.53
Quantity 13,339 -30.1%
Value US$2,568,198
2.3
Nemiroff Alex General Counsel and Secretary Officer
Transaction date
Sale
Price
190.86
Quantity 1,714 -3.7%
Value US$327,139
2.3
Mastrocola Lauren Principal Accounting Officer Officer
Transaction date
Sale
Price
192.71
Quantity 2,145 -17.0%
Value US$413,365
2.3
Mastrocola Lauren Principal Accounting Officer Officer
Transaction date
Sale
Price
191.96
Quantity 11,455 -47.6%
Value US$2,198,879
2.3
Nemiroff Alex Officer Officer
Transaction date
Proposed sale
Price
193.09
Quantity 25,130
Value US$4,852,249
2.3
Mastrocola Lauren Officer Officer
Transaction date
Proposed sale
Price
192.08
Quantity 13,600
Value US$2,612,239
2.3
Mastrocola Lauren Principal Accounting Officer Officer
Transaction date
Sale
Price
81.78
Quantity 5,188 -48.0%
Value US$424,318
2.3
Nemiroff Alex General Counsel and Secretary Officer
Transaction date
Sale
Price
80.20
Quantity 8,239 -44.4%
Value US$660,827
2.3
Mastrocola Lauren Officer Officer
Transaction date
Proposed sale
Price
81.77
Quantity 5,189
Value US$424,316
2.3
Nemiroff Alex Officer Officer
Transaction date
Proposed sale
Price
80.20
Quantity 8,240
Value US$660,832
1.6
DeSimone Jill Non-Executive Director
Transaction date
Purchase
Price
1.75
Quantity 14,500 +inf%
Value US$25,375
4.2
Souza Marcio Chief Executive Officer Executive Director
Transaction date
Purchase
Price
1.06
Quantity 10,000 +28.6%
Value US$10,587
3.7
MITCHELL DEAN J Non-Executive Director
Transaction date
Purchase
Price
0.84
Quantity 50,000 +200.0%
Value US$41,815
4.2
Souza Marcio Chief Executive Officer Executive Director
Transaction date
Purchase
Price
0.86
Quantity 35,002 +inf%
Value US$30,207
4.2
Souza Marcio Chief Executive Officer Executive Director
Transaction date
Purchase
Price
0.86
Quantity 35,000 +18.3%
Value US$30,160
2.3
Mastrocola Lauren Principal Accounting Officer Officer
Transaction date
Purchase
Price
1.93
Quantity 3,000 +10.6%
Value US$5,775
2.3
Nemiroff Alex General Counsel and Secretary Officer
Transaction date
Purchase
Price
1.63
Quantity 7,500 +23.6%
Value US$12,225
3.3
Kelly Timothy Edwin Chief Financial Officer Officer
Transaction date
Purchase
Price
1.77
Quantity 10,000 +32.8%
Value US$17,650
4.2
Souza Marcio Chief Executive Officer Executive Director
Transaction date
Purchase
Price
1.85
Quantity 27,000 +16.6%
Value US$49,888
3.7
MITCHELL DEAN J Non-Executive Director
Transaction date
Purchase
Price
1.81
Quantity 25,000 +inf%
Value US$45,188
4.2
Souza Marcio Chief Executive Officer Executive Director
Transaction date
Purchase
Price
26.08
Quantity 3,846 +18.7%
Value US$100,304
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
91,477 +42.3%
58.68
US$3,910,075 		91,477 +42.3% 58.68 US$3,910,075
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
21,357 -19.5%
222.44
US$172,296 		21,357 -19.5% 222.44 US$172,296
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
81,857 -39.6%
71.71
US$1,166,922 		81,857 -39.6% 71.71 US$1,166,922
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
1,004 -16.8%
312.83
US$314,081 		1,004 -16.8% 312.83 US$314,081
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
2,854 -32.4%
311.91
US$890,203 		2,854 -32.4% 311.91 US$890,203
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
1,750 -16.6%
310.89
US$544,056 		1,750 -16.6% 310.89 US$544,056
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
999 -8.6%
309.38
US$309,074 		999 -8.6% 309.38 US$309,074
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
1,240 -9.7%
308.24
US$382,221 		1,240 -9.7% 308.24 US$382,221
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
683 -5.1%
306.77
US$209,522 		683 -5.1% 306.77 US$209,522
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
320 -2.3%
305.31
US$97,699 		320 -2.3% 305.31 US$97,699
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
120 -0.9%
303.13
US$36,375 		120 -0.9% 303.13 US$36,375
2026-06-26 2026-06-24 PlS Planned sale
1.6
DeSimone Jill
Non-Executive Director
10 -0.1%
301.44
US$3,014 		10 -0.1% 301.44 US$3,014
2026-06-24 2026-06-24 PrS Proposed sale
1.6
DeSimone Jill

Director

Non-Executive Director
11,600
311.32
US$3,611,336 		11,600 311.32 US$3,611,336
2026-06-24 2026-06-24 PrS Proposed sale
1.6
DeSimone Jill

Director

Non-Executive Director
11,600
311.32
US$3,611,336 		11,600 311.32 US$3,611,336
2025-11-21 2025-11-20 S Sale
2.3
Nemiroff Alex

General Counsel and Secretary

Officer
9,100 -30.4%
194.30
US$1,768,130 		9,100 -30.4% 194.30 US$1,768,130
2025-11-21 2025-11-20 S Sale
2.3
Nemiroff Alex

General Counsel and Secretary

Officer
977 -3.2%
193.23
US$188,789 		977 -3.2% 193.23 US$188,789
2025-11-21 2025-11-20 S Sale
2.3
Nemiroff Alex

General Counsel and Secretary

Officer
13,339 -30.1%
192.53
US$2,568,198 		13,339 -30.1% 192.53 US$2,568,198
2025-11-21 2025-11-20 S Sale
2.3
Nemiroff Alex

General Counsel and Secretary

Officer
1,714 -3.7%
190.86
US$327,139 		1,714 -3.7% 190.86 US$327,139
2025-11-21 2025-11-20 S Sale
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
2,145 -17.0%
192.71
US$413,365 		2,145 -17.0% 192.71 US$413,365
2025-11-21 2025-11-20 S Sale
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
11,455 -47.6%
191.96
US$2,198,879 		11,455 -47.6% 191.96 US$2,198,879
2025-11-20 2025-11-20 PrS Proposed sale
2.3
Nemiroff Alex

Officer

Officer
25,130
193.09
US$4,852,249 		25,130 193.09 US$4,852,249
2025-11-20 2025-11-20 PrS Proposed sale
2.3
Mastrocola Lauren

Officer

Officer
13,600
192.08
US$2,612,239 		13,600 192.08 US$2,612,239
2024-11-15 2024-11-14 S Sale
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
5,188 -48.0%
81.78
US$424,318 		5,188 -48.0% 81.78 US$424,318
2024-11-15 2024-11-14 S Sale
2.3
Nemiroff Alex

General Counsel and Secretary

Officer
8,239 -44.4%
80.20
US$660,827 		8,239 -44.4% 80.20 US$660,827
2024-11-14 2024-11-14 PrS Proposed sale
2.3
Mastrocola Lauren

Officer

Officer
5,189
81.77
US$424,316 		5,189 81.77 US$424,316
2024-11-14 2024-11-14 PrS Proposed sale
2.3
Nemiroff Alex

Officer

Officer
8,240
80.20
US$660,832 		8,240 80.20 US$660,832
2023-10-10 2023-10-05 B Purchase
1.6
DeSimone Jill
Non-Executive Director
14,500 +inf%
1.75
US$25,375 		14,500 +inf% 1.75 US$25,375
2023-06-27 2023-06-27 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
10,000 +28.6%
1.06
US$10,587 		10,000 +28.6% 1.06 US$10,587
2023-03-27 2023-03-24 B Purchase
3.7
MITCHELL DEAN J
Non-Executive Director
50,000 +200.0%
0.84
US$41,815 		50,000 +200.0% 0.84 US$41,815
2023-03-27 2023-03-23 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
35,002 +inf%
0.86
US$30,207 		35,002 +inf% 0.86 US$30,207
2023-03-27 2023-03-23 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
35,000 +18.3%
0.86
US$30,160 		35,000 +18.3% 0.86 US$30,160
2022-06-21 2022-06-16 B Purchase
2.3
Mastrocola Lauren

Principal Accounting Officer

Officer
3,000 +10.6%
1.93
US$5,775 		3,000 +10.6% 1.93 US$5,775
2022-06-14 2022-06-13 B Purchase
2.3
Nemiroff Alex

General Counsel and Secretary

Officer
7,500 +23.6%
1.63
US$12,225 		7,500 +23.6% 1.63 US$12,225
2022-06-13 2022-06-09 B Purchase
3.3
Kelly Timothy Edwin

Chief Financial Officer

Officer
10,000 +32.8%
1.77
US$17,650 		10,000 +32.8% 1.77 US$17,650
2022-06-09 2022-06-08 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
27,000 +16.6%
1.85
US$49,888 		27,000 +16.6% 1.85 US$49,888
2022-06-09 2022-06-08 B Purchase
3.7
MITCHELL DEAN J
Non-Executive Director
25,000 +inf%
1.81
US$45,188 		25,000 +inf% 1.81 US$45,188
2021-10-08 2021-10-06 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
400,000 -100.0%
17.50
US$7,000,000 		400,000 -100.0% 17.50 US$7,000,000
2021-10-05 2021-10-05 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
23,946 -5.6%
19.15
US$458,566 		23,946 -5.6% 19.15 US$458,566
2021-10-05 2021-10-01 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
22,600 -5.1%
19.13
US$432,338 		22,600 -5.1% 19.13 US$432,338
2021-08-05 2021-08-03 S Sale
2.0
BSOF Parallel Master Fund L.P.
Large shareholder
22,300 -2.6%
14.99
US$334,277 		22,300 -2.6% 14.99 US$334,277
2020-11-10 2020-11-10 B Purchase
4.2
Souza Marcio

Chief Executive Officer

Executive Director
3,846 +18.7%
26.08
US$100,304 		3,846 +18.7% 26.08 US$100,304
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