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United States Biotechnology & Medical Research

Aprea Therapeutics Inc (APRE)

Track

The most recent insider trading activity occurred on January 30, 2026, with President/CEO Gilad Oren and SrVP/CFO John P. Hamill making purchases. Prior to this, significant buying activity was noted in October 2024, including a large purchase by Marc Duey. Overall, recent transactions show a pattern of insider buying.
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Ticker: APRE Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
Hamill John P.
SrVP/CFO/Prin Fin & Acct Ofcr
1 purchase — total 5,073 USD
Buy 30 Jan 2026
Value US$4,597,740.58 | Price 430.12 | Shares 34,073
Buy 30 Jan 2026
Value US$318,037.45 | Price 477.45 | Shares 79,843
Buy 10 Dec 2025
Value US$24,999.74 | Price 1.17 | Shares 21,459
Buy 10 Dec 2025
Value US$5,825.00 | Price 1.17 | Shares 5,000
Buy 3 Apr 2025
Value US$4,494.60 | Price 1.80 | Shares 2,497
Buy 3 Apr 2025
Value US$5,615.61 | Price 1.87 | Shares 3,003
Buy 23 Oct 2024
Value US$1,957.50 | Price 3.92 | Shares 500
Sale 18 Oct 2024
Value US$29,583.04 | Price 4.58 | Shares 6,462
Buy 16 Oct 2024
Value US$131,700.00 | Price 4.39 | Shares 30,000
Buy 15 Oct 2024
Value US$725.00 | Price 2.90 | Shares 250
Buy 14 Oct 2024
Value US$490.20 | Price 2.58 | Shares 190
Buy 14 Oct 2024
Value US$2,590.00 | Price 2.59 | Shares 1,000
Buy 11 Oct 2024
Value US$123.19 | Price 2.46 | Shares 50
Buy 11 Oct 2024
Value US$26,800.00 | Price 2.68 | Shares 10,000
Buy 10 Oct 2024
Value US$381.00 | Price 2.54 | Shares 150
Buy 10 Oct 2024
Value US$1,174.50 | Price 2.61 | Shares 450
Buy 13 Mar 2024
Value US$7,362.90 | Price 7.29 | Shares 1,010
Buy 13 Mar 2024
Value US$50,009.40 | Price 7.29 | Shares 6,860
Buy 13 Mar 2024
Value US$50,009.40 | Price 7.29 | Shares 6,860
Buy 13 Mar 2024
Value US$14,580.00 | Price 7.29 | Shares 2,000
Buy 7 Jun 2023
Value US$22,192.15 | Price 3.68 | Shares 6,029
Buy 6 Jun 2023
Value US$14,764.40 | Price 3.63 | Shares 4,068
Buy 18 May 2022
Value US$35,500.00 | Price 0.71 | Shares 50,000
Buy 18 May 2022
Value US$24,123.75 | Price 0.64 | Shares 37,500
Planned sale 28 Feb 2022
Value US$62,280.00 | Price 1.73 | Shares 36,000
Planned sale 1 Dec 2021
Value US$108,900.00 | Price 3.96 | Shares 27,500
Planned sale 1 Nov 2021
Value US$137,500.00 | Price 5.00 | Shares 27,500
Planned sale 1 Oct 2021
Value US$134,475.00 | Price 4.89 | Shares 27,500
Planned sale 1 Oct 2021
Value US$244,500.00 | Price 4.89 | Shares 50,000
Sale 28 Dec 2020
Value US$34,005.40 | Price 5.80 | Shares 5,863
Sale 28 Dec 2020
Value US$2,757,284.46 | Price 5.58 | Shares 494,137
Sale 5 Oct 2020
Value US$4,427,500.00 | Price 25.30 | Shares 175,000
Sale 7 Jul 2020
Value US$8,350,838.65 | Price 34.55 | Shares 241,703
Sale 16 Jun 2020
Value US$660,538.80 | Price 33.30 | Shares 19,836
Sale 16 Jun 2020
Value US$160,073.10 | Price 33.30 | Shares 4,807
Sale 16 Jun 2020
Value US$3,841,388.10 | Price 33.30 | Shares 115,357
Sale 16 Jun 2020
Value US$160,073.10 | Price 33.30 | Shares 4,807
Sale 16 Jun 2020
Value US$3,841,388.10 | Price 33.30 | Shares 115,357
Sale 11 Jun 2020
Value US$281,776.46 | Price 28.75 | Shares 9,800
Sale 11 Jun 2020
Value US$6,762,635.04 | Price 28.75 | Shares 235,200
Sale 11 Jun 2020
Value US$281,776.46 | Price 28.75 | Shares 9,800
Sale 11 Jun 2020
Value US$6,762,635.04 | Price 28.75 | Shares 235,200
Sale 19 May 2020
Value US$358,530.00 | Price 35.15 | Shares 10,200
Sale 19 May 2020
Value US$8,604,720.00 | Price 35.15 | Shares 244,800
Sale 19 May 2020
Value US$358,530.00 | Price 35.15 | Shares 10,200
Sale 19 May 2020
Value US$8,604,720.00 | Price 35.15 | Shares 244,800
Sale 13 Apr 2020
Value US$6,579,625.00 | Price 31.25 | Shares 210,548
Buy 7 Oct 2019
Value US$4,999,995.00 | Price 15.00 | Shares 333,333
Buy 7 Oct 2019
Value US$6,000,000.00 | Price 15.00 | Shares 400,000
Buy 7 Oct 2019
Value US$7,500.00 | Price 15.00 | Shares 500
Buy 7 Oct 2019
Value US$4,000,005.00 | Price 15.00 | Shares 266,667
Buy 7 Oct 2019
Value US$37,500.00 | Price 15.00 | Shares 2,500
Buy 7 Oct 2019
Value US$3,000.00 | Price 15.00 | Shares 200
Buy 7 Oct 2019
Value US$3,000.00 | Price 15.00 | Shares 200
Buy 7 Oct 2019
Value US$75,000.00 | Price 15.00 | Shares 5,000
Buy 7 Oct 2019
Value US$75,000.00 | Price 15.00 | Shares 5,000
Buy 7 Oct 2019
Value US$15,000.00 | Price 15.00 | Shares 1,000
Buy 7 Oct 2019
Value US$15,000.00 | Price 15.00 | Shares 1,000
Buy 7 Oct 2019
Value US$15,000.00 | Price 15.00 | Shares 1,000
Buy 7 Oct 2019
Value US$15,000.00 | Price 15.00 | Shares 1,000
Buy 7 Oct 2019
Value US$15,000.00 | Price 15.00 | Shares 1,000
Buy 7 Oct 2019
Value US$15,000.00 | Price 15.00 | Shares 1,000
Buy 7 Oct 2019
Value US$4,999,995.00 | Price 15.00 | Shares 333,333
Buy 7 Oct 2019
Value US$4,000,005.00 | Price 15.00 | Shares 266,667
Buy 7 Oct 2019
Value US$4,999,995.00 | Price 15.00 | Shares 333,333
Buy 7 Oct 2019
Value US$97,500.00 | Price 15.00 | Shares 6,500
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-02-02 2026-01-30 B Purchase
2.6
Hamill John P.

SrVP/CFO/Prin Fin & Acct Ofcr

Officer
34,073 -47.8%
430.12
US$4,597,741 		34,073 -47.8% 430.12 US$4,597,741
2026-02-02 2026-01-30 B Purchase
2.2
Gilad Oren

President/CEO

Executive Director
79,843 +19.5%
477.45
US$318,037 		79,843 +19.5% 477.45 US$318,037
2025-12-11 2025-12-10 B Purchase
1.8
Duey Marc
Non-Executive Director
65,859 +21.4%
366.34
US$401,203 		65,859 +21.4% 366.34 US$401,203
2025-12-11 2025-12-10 B Purchase
2.6
Hamill John P.

SrVP/CFO/Prin Fin & Acct Ofcr

Officer
5,000 +22.0%
1.17
US$5,825 		5,000 +22.0% 1.17 US$5,825
2025-04-04 2025-04-03 B Purchase
2.2
Gilad Oren

President/CEO

Executive Director
2,497 +0.7%
1.80
US$4,495 		2,497 +0.7% 1.80 US$4,495
2025-04-04 2025-04-03 B Purchase
2.2
Gilad Oren

President/CEO

Executive Director
3,003 +0.9%
1.87
US$5,616 		3,003 +0.9% 1.87 US$5,616
2024-10-24 2024-10-23 B Purchase
2.2
Gilad Oren

President/CEO

Executive Director
500 +0.2%
3.92
US$1,958 		500 +0.2% 3.92 US$1,958
2024-10-25 2024-10-18 S Sale
1.8
Duey Marc
Non-Executive Director
6,462 -2.7%
4.58
US$29,583 		6,462 -2.7% 4.58 US$29,583
2024-10-17 2024-10-16 B Purchase
1.8
Duey Marc
Non-Executive Director
30,000 +14.3%
4.39
US$131,700 		30,000 +14.3% 4.39 US$131,700
2024-10-16 2024-10-15 B Purchase
2.2
Gilad Oren

President/CEO

Executive Director
250 +0.1%
2.90
US$725 		250 +0.1% 2.90 US$725
2024-10-16 2024-10-14 B Purchase
1.8
Duey Marc
Non-Executive Director
190 +0.1%
2.58
US$490 		190 +0.1% 2.58 US$490
2024-10-15 2024-10-14 B Purchase
2.2
Gilad Oren

President/CEO

Executive Director
1,000 +0.3%
2.59
US$2,590 		1,000 +0.3% 2.59 US$2,590
2024-10-16 2024-10-11 B Purchase
2.6
Hamill John P.

SrVP/CFO/Prin Fin & Acct Ofcr

Officer
50 +0.3%
2.46
US$123 		50 +0.3% 2.46 US$123
2024-10-15 2024-10-11 B Purchase
2.9
Seizinger Bernd R.
Non-Executive Director
10,000 +28.8%
2.68
US$26,800 		10,000 +28.8% 2.68 US$26,800
2024-10-15 2024-10-10 B Purchase
2.2
Gilad Oren

President/CEO

Executive Director
150 +0.0%
2.54
US$381 		150 +0.0% 2.54 US$381
2024-10-15 2024-10-10 B Purchase
2.6
Hamill John P.

SrVP/CFO/Prin Fin & Acct Ofcr

Officer
450 +2.4%
2.61
US$1,174 		450 +2.4% 2.61 US$1,174
2024-03-14 2024-03-13 B Purchase
2.6
Hamill John P.

SrVP/CFO/Prin Fin & Acct Ofcr

Officer
1,010 +7.0%
7.29
US$7,363 		1,010 +7.0% 7.29 US$7,363
2024-03-14 2024-03-13 B Purchase
2.9
Seizinger Bernd R.
Non-Executive Director
6,860 +25.6%
7.29
US$50,009 		6,860 +25.6% 7.29 US$50,009
2024-03-14 2024-03-13 B Purchase
3.3
HENNEMAN JOHN B III
Non-Executive Director
6,860 +536.4%
7.29
US$50,009 		6,860 +536.4% 7.29 US$50,009
2024-03-14 2024-03-13 B Purchase
2.2
Gilad Oren

President, CEO

Executive Director
2,000 +0.6%
7.29
US$14,580 		2,000 +0.6% 7.29 US$14,580
2023-06-08 2023-06-07 B Purchase
2.9
Seizinger Bernd R.
Non-Executive Director
6,029 +29.7%
3.68
US$22,192 		6,029 +29.7% 3.68 US$22,192
2023-06-08 2023-06-06 B Purchase
2.9
Seizinger Bernd R.
Non-Executive Director
4,068 +25.1%
3.63
US$14,764 		4,068 +25.1% 3.63 US$14,764
2022-05-19 2022-05-18 B Purchase
2.9
Seizinger Bernd R.
Non-Executive Director
50,000 +18.6%
0.71
US$35,500 		50,000 +18.6% 0.71 US$35,500
2022-05-19 2022-05-18 B Purchase
2.2
SCHADE CHRISTIAN S

Chairman & CEO

Executive Director
37,500 +14.7%
0.64
US$24,124 		37,500 +14.7% 0.64 US$24,124
2022-03-01 2022-02-28 PlS Planned sale
Attar Eyal C.

SVP, Chief Medical Officer

Officer
36,000 -43.4%
1.73
US$62,280 		36,000 -43.4% 1.73 US$62,280
2021-12-03 2021-12-01 PlS Planned sale
Korbel Gregory Alan

SVP, Chief Business Officer

Officer
27,500 -61.6%
3.96
US$108,900 		27,500 -61.6% 3.96 US$108,900
2021-11-03 2021-11-01 PlS Planned sale
Korbel Gregory Alan

SVP, Chief Business Officer

Officer
27,500 -61.6%
5.00
US$137,500 		27,500 -61.6% 5.00 US$137,500
2021-10-05 2021-10-01 PlS Planned sale
Korbel Gregory Alan

SVP, Chief Business Officer

Officer
27,500 -61.6%
4.89
US$134,475 		27,500 -61.6% 4.89 US$134,475
2021-10-05 2021-10-01 PlS Planned sale
Abrahmsen Lars B.

SVP, Chief Scientific Officer

Officer
50,000 -72.5%
4.89
US$244,500 		50,000 -72.5% 4.89 US$244,500
2021-02-16 2020-12-28 S Sale
3.2
Redmile Group, LLC
Large shareholder
5,863 -0.3%
5.80
US$34,005 		5,863 -0.3% 5.80 US$34,005
2021-02-16 2020-12-28 S Sale
3.2
Redmile Group, LLC
Large shareholder
494,137 -21.8%
5.58
US$2,757,284 		494,137 -21.8% 5.58 US$2,757,284
2020-10-07 2020-10-05 S Sale
3.6
5AM Ventures IV, L.P.

Former 10% holder
175,000 -55.8%
25.30
US$4,427,500 		175,000 -55.8% 25.30 US$4,427,500
2020-07-07 2020-07-07 S Sale
3.2
KDev Investments AB
Large shareholder
241,703 -10.8%
34.55
US$8,350,839 		241,703 -10.8% 34.55 US$8,350,839
2020-06-18 2020-06-16 S Sale
3.6
5AM Ventures IV, L.P.
Large shareholder
19,836 -6.0%
33.30
US$660,539 		19,836 -6.0% 33.30 US$660,539
2020-06-18 2020-06-16 S Sale
3.6
5AM Ventures IV, L.P.
Large shareholder
4,807 -6.0%
33.30
US$160,073 		4,807 -6.0% 33.30 US$160,073
2020-06-18 2020-06-16 S Sale
3.1
ROCKLAGE SCOTT M
Non-Executive Director Large shareholder
4,807 -6.0%
33.30
US$160,073 		4,807 -6.0% 33.30 US$160,073
2020-06-18 2020-06-16 S Sale
3.6
5AM Ventures IV, L.P.
Large shareholder
115,357 -6.0%
33.30
US$3,841,388 		115,357 -6.0% 33.30 US$3,841,388
2020-06-18 2020-06-16 S Sale
3.1
ROCKLAGE SCOTT M
Non-Executive Director Large shareholder
115,357 -6.0%
33.30
US$3,841,388 		115,357 -6.0% 33.30 US$3,841,388
2020-06-15 2020-06-11 S Sale
3.6
5AM Ventures IV, L.P.
Large shareholder
9,800 -10.8%
28.75
US$281,776 		9,800 -10.8% 28.75 US$281,776
2020-06-15 2020-06-11 S Sale
3.1
ROCKLAGE SCOTT M
Non-Executive Director Large shareholder
9,800 -10.8%
28.75
US$281,776 		9,800 -10.8% 28.75 US$281,776
2020-06-15 2020-06-11 S Sale
3.1
ROCKLAGE SCOTT M
Non-Executive Director Large shareholder
235,200 -10.8%
28.75
US$6,762,635 		235,200 -10.8% 28.75 US$6,762,635
2020-06-15 2020-06-11 S Sale
3.6
5AM Ventures IV, L.P.
Large shareholder
235,200 -10.8%
28.75
US$6,762,635 		235,200 -10.8% 28.75 US$6,762,635
2020-05-21 2020-05-19 S Sale
3.1
ROCKLAGE SCOTT M
Non-Executive Director
10,200 -10.1%
35.15
US$358,530 		10,200 -10.1% 35.15 US$358,530
2020-05-21 2020-05-19 S Sale
3.6
5AM Ventures IV, L.P.
Large shareholder
10,200 -10.1%
35.15
US$358,530 		10,200 -10.1% 35.15 US$358,530
2020-05-21 2020-05-19 S Sale
3.6
5AM Ventures IV, L.P.
Large shareholder
244,800 -10.1%
35.15
US$8,604,720 		244,800 -10.1% 35.15 US$8,604,720
2020-05-21 2020-05-19 S Sale
3.1
ROCKLAGE SCOTT M
Non-Executive Director
244,800 -10.1%
35.15
US$8,604,720 		244,800 -10.1% 35.15 US$8,604,720
2020-04-15 2020-04-13 S Sale
3.2
KDev Investments AB
Large shareholder
210,548 -8.6%
31.25
US$6,579,625 		210,548 -8.6% 31.25 US$6,579,625
2019-10-09 2019-10-07 B Purchase
3.6
5AM Ventures IV, L.P.
Large shareholder
333,333 +inf%
15.00
US$4,999,995 		333,333 +inf% 15.00 US$4,999,995
2019-10-08 2019-10-07 B Purchase
3.2
Redmile Group, LLC
Large shareholder
400,000 +21.4%
15.00
US$6,000,000 		400,000 +21.4% 15.00 US$6,000,000
2019-10-07 2019-10-07 B Purchase
Korbel Gregory Alan

VP of Business Dev't
500 +inf%
15.00
US$7,500 		500 +inf% 15.00 US$7,500
2019-10-07 2019-10-07 B Purchase
0.6
HealthCap VII, L.P.
Large shareholder
266,667 +12.7%
15.00
US$4,000,005 		266,667 +12.7% 15.00 US$4,000,005
2019-10-07 2019-10-07 B Purchase
Coiante Scott M

SVP, Chief Financial Officer
2,500 +inf%
15.00
US$37,500 		2,500 +inf% 15.00 US$37,500
2019-10-07 2019-10-07 B Purchase
Attar Eyal C.

SVP, Chief Medical Officer
200 +inf%
15.00
US$3,000 		200 +inf% 15.00 US$3,000
2019-10-07 2019-10-07 B Purchase
Attar Eyal C.

SVP, Chief Medical Officer
200 +inf%
15.00
US$3,000 		200 +inf% 15.00 US$3,000
2019-10-07 2019-10-07 B Purchase
3.3
HENNEMAN JOHN B III
5,000 +inf%
15.00
US$75,000 		5,000 +inf% 15.00 US$75,000
2019-10-07 2019-10-07 B Purchase
2.2
SCHADE CHRISTIAN S

President & CEO
5,000 +inf%
15.00
US$75,000 		5,000 +inf% 15.00 US$75,000
2019-10-07 2019-10-07 B Purchase
2.2
SCHADE CHRISTIAN S

President & CEO
1,000 +inf%
15.00
US$15,000 		1,000 +inf% 15.00 US$15,000
2019-10-07 2019-10-07 B Purchase
2.2
SCHADE CHRISTIAN S

President & CEO
1,000 +inf%
15.00
US$15,000 		1,000 +inf% 15.00 US$15,000
2019-10-07 2019-10-07 B Purchase
2.2
SCHADE CHRISTIAN S

President & CEO
1,000 +inf%
15.00
US$15,000 		1,000 +inf% 15.00 US$15,000
2019-10-07 2019-10-07 B Purchase
2.2
SCHADE CHRISTIAN S

President & CEO
1,000 +inf%
15.00
US$15,000 		1,000 +inf% 15.00 US$15,000
2019-10-07 2019-10-07 B Purchase
2.2
SCHADE CHRISTIAN S

President & CEO
1,000 +inf%
15.00
US$15,000 		1,000 +inf% 15.00 US$15,000
2019-10-07 2019-10-07 B Purchase
2.2
SCHADE CHRISTIAN S

President & CEO
1,000 +inf%
15.00
US$15,000 		1,000 +inf% 15.00 US$15,000
2019-10-07 2019-10-07 B Purchase
Versant V Luxco S.a r.l.
333,333 +inf%
15.00
US$4,999,995 		333,333 +inf% 15.00 US$4,999,995
2019-10-07 2019-10-07 B Purchase
0.6
Christenson Johan
266,667 +12.7%
15.00
US$4,000,005 		266,667 +12.7% 15.00 US$4,000,005
2019-10-07 2019-10-07 B Purchase
0.9
Versant Vantage I, L.P.
333,333 +inf%
15.00
US$4,999,995 		333,333 +inf% 15.00 US$4,999,995
2019-10-07 2019-10-07 B Purchase
Magni Guido
6,500 +inf%
15.00
US$97,500 		6,500 +inf% 15.00 US$97,500
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