|
2013-10-16 |
2013-06-24 |
B
Purchase
|
Foresite Capital Management I, LLC
Large shareholder
|
15,037
-33.7%
126.46
US$271,477
|
15,037
-33.7%
|
126.46
|
US$271,477
|
|
|
2013-10-16 |
2013-06-14 |
B
Purchase
|
Foresite Capital Management I, LLC
Large shareholder
|
39,914
-10.9%
349.33
US$732,869
|
39,914
-10.9%
|
349.33
|
US$732,869
|
|
|
2013-10-16 |
2013-06-12 |
B
Purchase
|
Foresite Capital Management I, LLC
Large shareholder
|
88,039
-8.0%
407.13
US$4,560,400
|
88,039
-8.0%
|
407.13
|
US$4,560,400
|
|
|
2013-10-16 |
2013-06-03 |
B
Purchase
|
Foresite Capital Management I, LLC
Large shareholder
|
10,000
+0.5%
6.99
US$69,908
|
10,000
+0.5%
|
6.99
|
US$69,908
|
|
|
2013-05-24 |
2013-05-23 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
120
+0.9%
6.99
US$839
|
120
+0.9%
|
6.99
|
US$839
|
|
|
2013-05-24 |
2013-05-23 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
12,380
+0.8%
6.99
US$86,528
|
12,380
+0.8%
|
6.99
|
US$86,528
|
|
|
2013-05-24 |
2013-05-23 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
120
+0.9%
6.99
US$839
|
120
+0.9%
|
6.99
|
US$839
|
|
|
2013-05-24 |
2013-05-23 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
12,380
+0.8%
6.99
US$86,528
|
12,380
+0.8%
|
6.99
|
US$86,528
|
|
|
2013-10-16 |
2013-05-22 |
B
Purchase
|
Foresite Capital Management I, LLC
Large shareholder
|
5,005
+0.2%
6.74
US$33,729
|
5,005
+0.2%
|
6.74
|
US$33,729
|
|
|
2013-05-24 |
2013-05-22 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
200
+1.5%
6.86
US$1,372
|
200
+1.5%
|
6.86
|
US$1,372
|
|
|
2013-05-24 |
2013-05-22 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
200
+1.5%
6.86
US$1,372
|
200
+1.5%
|
6.86
|
US$1,372
|
|
|
2013-05-24 |
2013-05-22 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
21,100
+1.5%
6.86
US$144,767
|
21,100
+1.5%
|
6.86
|
US$144,767
|
|
|
2013-05-24 |
2013-05-22 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
21,100
+1.5%
6.86
US$144,767
|
21,100
+1.5%
|
6.86
|
US$144,767
|
|
|
2013-10-16 |
2013-05-21 |
B
Purchase
|
Foresite Capital Management I, LLC
Large shareholder
|
1,811
+0.1%
6.84
US$12,380
|
1,811
+0.1%
|
6.84
|
US$12,380
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
80
+0.6%
6.90
US$552
|
80
+0.6%
|
6.90
|
US$552
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
8,020
+0.6%
6.90
US$55,314
|
8,020
+0.6%
|
6.90
|
US$55,314
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
590
+4.5%
8.00
US$4,720
|
590
+4.5%
|
8.00
|
US$4,720
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
61,910
+4.5%
8.00
US$495,280
|
61,910
+4.5%
|
8.00
|
US$495,280
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
5,653
+76.1%
8.00
US$45,224
|
5,653
+76.1%
|
8.00
|
US$45,224
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
593,618
+76.1%
8.00
US$4,748,944
|
593,618
+76.1%
|
8.00
|
US$4,748,944
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
80
+0.6%
6.90
US$552
|
80
+0.6%
|
6.90
|
US$552
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
8,020
+0.6%
6.90
US$55,314
|
8,020
+0.6%
|
6.90
|
US$55,314
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
590
+4.5%
8.00
US$4,720
|
590
+4.5%
|
8.00
|
US$4,720
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
61,910
+4.5%
8.00
US$495,280
|
61,910
+4.5%
|
8.00
|
US$495,280
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
5,653
+76.1%
8.00
US$45,224
|
5,653
+76.1%
|
8.00
|
US$45,224
|
|
|
2013-05-22 |
2013-05-21 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
593,618
+76.1%
8.00
US$4,748,944
|
593,618
+76.1%
|
8.00
|
US$4,748,944
|
|
|
2013-05-21 |
2013-05-21 |
B
Purchase
|
ELMS STEVE
Non-Executive Director
|
423,635
+37.7%
8.00
US$3,389,080
|
423,635
+37.7%
|
8.00
|
US$3,389,080
|
|
|
2013-05-21 |
2013-05-21 |
B
Purchase
|
Marchington Allan P
Non-Executive Director
|
431,527
+48.2%
8.00
US$3,452,216
|
431,527
+48.2%
|
8.00
|
US$3,452,216
|
|
|
2013-05-21 |
2013-05-21 |
B
Purchase
|
FLEMING STANDISH
Non-Executive Director
|
263,301
+37.5%
8.00
US$2,106,408
|
263,301
+37.5%
|
8.00
|
US$2,106,408
|
|
|
2013-10-16 |
2013-05-20 |
B
Purchase
|
Foresite Capital Management I, LLC
Large shareholder
|
8,120
+0.4%
6.90
US$56,048
|
8,120
+0.4%
|
6.90
|
US$56,048
|
|
|
2013-05-22 |
2013-05-20 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
100
+5000.0%
6.78
US$678
|
100
+5000.0%
|
6.78
|
US$678
|
|
|
2013-05-22 |
2013-05-20 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
100
+5000.0%
6.78
US$678
|
100
+5000.0%
|
6.78
|
US$678
|
|
|
2013-05-22 |
2013-05-20 |
B
Purchase
|
Bonita David P
Non-Executive Director
Large shareholder
|
10,500
+3420.2%
6.78
US$71,162
|
10,500
+3420.2%
|
6.78
|
US$71,162
|
|
|
2013-05-22 |
2013-05-20 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
10,500
+3420.2%
6.78
US$71,162
|
10,500
+3420.2%
|
6.78
|
US$71,162
|
|
|
2013-10-16 |
2013-05-17 |
B
Purchase
|
Foresite Capital Management I, LLC
Large shareholder
|
36,616
+1.8%
6.77
US$247,953
|
36,616
+1.8%
|
6.77
|
US$247,953
|
|