United States Biotechnology & Medical Research

Alnylam Pharmaceuticals Inc (ALNY)

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Over the past 90 days, Alnylam Pharmaceuticals Inc. insiders have exclusively engaged in selling activity, totaling approximately $2.29 million in transactions. Notable sales were conducted by Director David Pyott and Chief Human Resources Officer Melissa McLaughlin. These transactions occurred amid a 31% decline in stock price and following a recent earnings report that missed EPS expectations.
Ticker: ALNY Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
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Insider trades have triggered activity signals for Alnylam Pharmaceuticals Inc. Upgrade to see score, net flow, insiders and the full signal context.

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Top insiders
Trades
Planned sale 1 Jun 2026
Value US$3,787,316.27 | Price 35.03 | Shares 7,156 (-10.0%)
Planned sale 1 Jun 2026
Value US$141,331.50 | Price 420.25 | Shares 48,360 (-10.9%)
Planned sale 1 Jun 2026
Value US$366,441.14 | Price 299.87 | Shares 1,222 (-36.9%)
Planned sale 1 Jun 2026
Value US$351,219.25 | Price 298.91 | Shares 1,175 (-26.2%)
Planned sale 1 Jun 2026
Value US$274,190.91 | Price 297.71 | Shares 921 (-17.0%)
Proposed sale 1 Jun 2026
Value US$1,147,123.30 | Price 299.51 | Shares 3,830
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-06-03 2026-06-01 PlS Planned sale
3.0
PYOTT DAVID E I
Non-Executive Director
7,156 -10.0%
35.03
US$3,787,316 		7,156 -10.0% 35.03 US$3,787,316
2026-06-03 2026-06-01 PlS Planned sale
3.0
PYOTT DAVID E I
Non-Executive Director
48,360 -10.9%
420.25
US$141,331 		48,360 -10.9% 420.25 US$141,331
2026-06-03 2026-06-01 PlS Planned sale
3.0
PYOTT DAVID E I
Non-Executive Director
19,414 +39.9%
401.04
US$2,014,753 		19,414 +39.9% 401.04 US$2,014,753
2026-06-03 2026-06-01 PlS Planned sale
3.0
PYOTT DAVID E I
Non-Executive Director
1,175 -26.2%
298.91
US$351,219 		1,175 -26.2% 298.91 US$351,219
2026-06-03 2026-06-01 PlS Planned sale
3.0
PYOTT DAVID E I
Non-Executive Director
921 -17.0%
297.71
US$274,191 		921 -17.0% 297.71 US$274,191
2026-06-01 2026-06-01 PrS Proposed sale
3.0
PYOTT DAVID E I

Director

Non-Executive Director
3,830
299.51
US$1,147,123 		3,830 299.51 US$1,147,123
2026-04-07 2026-04-06 PlS Planned sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
199 -2.1%
333.94
US$66,454 		199 -2.1% 333.94 US$66,454
2026-04-07 2026-04-06 PlS Planned sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
293 -2.9%
331.89
US$97,244 		293 -2.9% 331.89 US$97,244
2026-04-07 2026-04-06 PlS Planned sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
829 -7.7%
330.46
US$273,951 		829 -7.7% 330.46 US$273,951
2026-04-07 2026-04-06 PlS Planned sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
909 -7.8%
329.76
US$299,752 		909 -7.8% 329.76 US$299,752
2026-04-07 2026-04-06 PlS Planned sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
56 -0.5%
320.14
US$17,928 		56 -0.5% 320.14 US$17,928
2026-04-06 2026-04-06 PrS Proposed sale
3.0
McLaughlin Melissa

Officer

Officer
2,286
320.10
US$731,749 		2,286 320.10 US$731,749
2026-04-07 2026-04-02 S Sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
8 -0.1%
325.49
US$2,604 		8 -0.1% 325.49 US$2,604
2026-04-07 2026-04-02 S Sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
81 -0.7%
323.64
US$26,215 		81 -0.7% 323.64 US$26,215
2026-04-07 2026-04-02 S Sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
245 -2.0%
322.86
US$79,101 		245 -2.0% 322.86 US$79,101
2026-04-07 2026-04-02 S Sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
224 -1.8%
321.64
US$72,047 		224 -1.8% 321.64 US$72,047
2026-04-07 2026-04-02 S Sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
147 -1.2%
320.62
US$47,131 		147 -1.2% 320.62 US$47,131
2026-04-07 2026-04-02 S Sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
86 -0.7%
319.69
US$27,493 		86 -0.7% 319.69 US$27,493
2026-04-07 2026-04-02 S Sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
209 -1.6%
318.47
US$66,560 		209 -1.6% 318.47 US$66,560
2026-04-07 2026-04-02 S Sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
359 -2.7%
317.44
US$113,961 		359 -2.7% 317.44 US$113,961
2026-04-07 2026-04-02 S Sale
3.0
McLaughlin Melissa

Chief Human Resources Officer

Officer
265 -2.0%
316.61
US$83,902 		265 -2.0% 316.61 US$83,902
2026-03-06 2026-03-05 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
500 -2.6%
326.08
US$163,040 		500 -2.6% 326.08 US$163,040
2026-03-06 2026-03-05 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
510 -2.6%
324.59
US$165,541 		510 -2.6% 324.59 US$165,541
2026-03-06 2026-03-05 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
740 -3.6%
323.55
US$239,427 		740 -3.6% 323.55 US$239,427
2026-03-06 2026-03-05 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
654 -3.1%
322.33
US$210,804 		654 -3.1% 322.33 US$210,804
2026-03-06 2026-03-05 PlS Planned sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
153 -0.7%
326.24
US$49,915 		153 -0.7% 326.24 US$49,915
2026-03-06 2026-03-05 PlS Planned sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
148 -0.7%
324.60
US$48,041 		148 -0.7% 324.60 US$48,041
2026-03-06 2026-03-05 PlS Planned sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
233 -1.1%
323.25
US$75,317 		233 -1.1% 323.25 US$75,317
2026-03-06 2026-03-05 PlS Planned sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
124 -0.6%
321.81
US$39,904 		124 -0.6% 321.81 US$39,904
2026-03-05 2026-03-05 PrS Proposed sale
3.4
Garg Pushkal

Officer

Officer
2,404
323.69
US$778,151 		2,404 323.69 US$778,151
2026-03-05 2026-03-05 PrS Proposed sale
3.4
Fitzgerald Kevin Joseph

Officer

Officer
658
323.69
US$212,988 		658 323.69 US$212,988
2026-03-06 2026-03-04 S Sale
3.5
Greenstreet Yvonne

Chief Executive Officer

Executive Director
265 -0.3%
325.67
US$86,303 		265 -0.3% 325.67 US$86,303
2026-03-06 2026-03-04 S Sale
3.5
Greenstreet Yvonne

Chief Executive Officer

Executive Director
345 -0.4%
324.88
US$112,084 		345 -0.4% 324.88 US$112,084
2026-03-06 2026-03-04 S Sale
3.5
Greenstreet Yvonne

Chief Executive Officer

Executive Director
973 -1.0%
323.84
US$315,096 		973 -1.0% 323.84 US$315,096
2026-03-06 2026-03-04 S Sale
3.5
Greenstreet Yvonne

Chief Executive Officer

Executive Director
444 -0.5%
323.01
US$143,416 		444 -0.5% 323.01 US$143,416
2026-03-06 2026-03-04 S Sale
3.5
Greenstreet Yvonne

Chief Executive Officer

Executive Director
368 -0.4%
321.82
US$118,430 		368 -0.4% 321.82 US$118,430
2026-03-06 2026-03-04 S Sale
3.5
Greenstreet Yvonne

Chief Executive Officer

Executive Director
274 -0.3%
320.81
US$87,902 		274 -0.3% 320.81 US$87,902
2026-03-06 2026-03-04 S Sale
3.5
Greenstreet Yvonne

Chief Executive Officer

Executive Director
129 -0.1%
320.01
US$41,281 		129 -0.1% 320.01 US$41,281
2026-03-06 2026-03-04 S Sale
3.5
Greenstreet Yvonne

Chief Executive Officer

Executive Director
135 -0.1%
319.03
US$43,069 		135 -0.1% 319.03 US$43,069
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
208 -1.0%
325.67
US$67,739 		208 -1.0% 325.67 US$67,739
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
272 -1.3%
324.88
US$88,367 		272 -1.3% 324.88 US$88,367
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
767 -3.4%
323.84
US$248,385 		767 -3.4% 323.84 US$248,385
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
350 -1.5%
323.01
US$113,054 		350 -1.5% 323.01 US$113,054
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
289 -1.3%
321.82
US$93,006 		289 -1.3% 321.82 US$93,006
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
215 -0.9%
320.81
US$68,974 		215 -0.9% 320.81 US$68,974
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
102 -0.4%
320.01
US$32,641 		102 -0.4% 320.01 US$32,641
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
106 -0.5%
319.03
US$33,817 		106 -0.5% 319.03 US$33,817
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
57 -0.3%
325.67
US$18,563 		57 -0.3% 325.67 US$18,563
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
75 -0.4%
324.88
US$24,366 		75 -0.4% 324.88 US$24,366
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
210 -1.0%
323.84
US$68,006 		210 -1.0% 323.84 US$68,006
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
96 -0.4%
323.01
US$31,009 		96 -0.4% 323.01 US$31,009
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
79 -0.4%
321.82
US$25,424 		79 -0.4% 321.82 US$25,424
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
59 -0.3%
320.81
US$18,928 		59 -0.3% 320.81 US$18,928
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
28 -0.1%
320.01
US$8,960 		28 -0.1% 320.01 US$8,960
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
29 -0.1%
319.03
US$9,252 		29 -0.1% 319.03 US$9,252
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
223 -0.4%
325.67
US$72,624 		223 -0.4% 325.67 US$72,624
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
291 -0.5%
324.88
US$94,540 		291 -0.5% 324.88 US$94,540
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
818 -1.3%
323.84
US$264,901 		818 -1.3% 323.84 US$264,901
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
374 -0.6%
323.01
US$120,806 		374 -0.6% 323.01 US$120,806
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
309 -0.5%
321.82
US$99,442 		309 -0.5% 321.82 US$99,442
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
230 -0.4%
320.81
US$73,786 		230 -0.4% 320.81 US$73,786
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
109 -0.2%
320.01
US$34,881 		109 -0.2% 320.01 US$34,881
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
114 -0.2%
319.03
US$36,369 		114 -0.2% 319.03 US$36,369
2026-03-06 2026-03-04 S Sale
3.5
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
208 -0.6%
325.67
US$67,739 		208 -0.6% 325.67 US$67,739
2026-03-06 2026-03-04 S Sale
3.5
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
272 -0.8%
324.88
US$88,367 		272 -0.8% 324.88 US$88,367
2026-03-06 2026-03-04 S Sale
3.5
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
767 -2.2%
323.84
US$248,385 		767 -2.2% 323.84 US$248,385
2026-03-06 2026-03-04 S Sale
3.5
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
350 -1.0%
323.01
US$113,054 		350 -1.0% 323.01 US$113,054
2026-03-06 2026-03-04 S Sale
3.5
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
289 -0.8%
321.82
US$93,006 		289 -0.8% 321.82 US$93,006
2026-03-06 2026-03-04 S Sale
3.5
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
215 -0.6%
320.81
US$68,974 		215 -0.6% 320.81 US$68,974
2026-03-06 2026-03-04 S Sale
3.5
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
102 -0.3%
320.01
US$32,641 		102 -0.3% 320.01 US$32,641
2026-03-06 2026-03-04 S Sale
3.5
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
106 -0.3%
319.03
US$33,817 		106 -0.3% 319.03 US$33,817
2026-03-04 2026-03-03 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
463 -1.9%
321.50
US$148,854 		463 -1.9% 321.50 US$148,854
2026-03-04 2026-03-03 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
640 -2.6%
320.48
US$205,107 		640 -2.6% 320.48 US$205,107
2026-03-04 2026-03-03 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
317 -1.3%
319.06
US$101,142 		317 -1.3% 319.06 US$101,142
2026-03-04 2026-03-03 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
355 -1.4%
316.74
US$112,443 		355 -1.4% 316.74 US$112,443
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