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United States Biotechnology & Medical Research

Alnylam Pharmaceuticals Inc (ALNY)

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Over the last 90 days, Alnylam Pharmaceuticals Inc. has seen significant insider selling, with a net value of -$519,014.14. A total of 21 transactions were recorded, all of which were sales. Notably, Director David E.I. Pyott and Chief Human Resources Officer Melissa McLaughlin were involved in multiple planned and proposed sales.
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Ticker: ALNY Exchange: NSM
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings
Top insiders
Trades
PYOTT DAVID E I
6 sales — total 1,647,123 USD
Planned sale 1 Jun 2026
Value US$3,787,316.27 | Price 35.03 | Shares 7,156
Planned sale 1 Jun 2026
Value US$141,331.50 | Price 420.25 | Shares 48,360
Planned sale 1 Jun 2026
Value US$100,000.00 | Price 299.87 | Shares 1,000
Planned sale 1 Jun 2026
Value US$100,000.00 | Price 298.91 | Shares 1,000
Planned sale 1 Jun 2026
Value US$100,000.00 | Price 297.71 | Shares 1,000
Proposed sale 1 Jun 2026
Value US$1,147,123.30 | Price 299.51 | Shares 3,830
Planned sale 6 Apr 2026
Value US$4,079,094.90 | Price 188.42 | Shares 74,017
Planned sale 6 Apr 2026
Value US$2,116,539.03 | Price 425.63 | Shares 41,192
Planned sale 6 Apr 2026
Value US$273,951.34 | Price 330.46 | Shares 829
Planned sale 6 Apr 2026
Value US$299,751.84 | Price 329.76 | Shares 909
Planned sale 6 Apr 2026
Value US$17,927.84 | Price 320.14 | Shares 56
Proposed sale 6 Apr 2026
Value US$731,748.60 | Price 320.10 | Shares 2,286
Sale 2 Apr 2026
Value US$2,603.92 | Price 325.49 | Shares 8
Sale 2 Apr 2026
Value US$26,214.84 | Price 323.64 | Shares 81
Sale 2 Apr 2026
Value US$79,100.70 | Price 322.86 | Shares 245
Sale 2 Apr 2026
Value US$72,047.36 | Price 321.64 | Shares 224
Sale 2 Apr 2026
Value US$47,131.14 | Price 320.62 | Shares 147
Sale 2 Apr 2026
Value US$27,493.34 | Price 319.69 | Shares 86
Sale 2 Apr 2026
Value US$66,560.23 | Price 318.47 | Shares 209
Sale 2 Apr 2026
Value US$113,960.96 | Price 317.44 | Shares 359
Sale 2 Apr 2026
Value US$83,901.65 | Price 316.61 | Shares 265
Planned sale 5 Mar 2026
Value US$163,040.00 | Price 326.08 | Shares 500
Planned sale 5 Mar 2026
Value US$165,540.90 | Price 324.59 | Shares 510
Planned sale 5 Mar 2026
Value US$239,427.00 | Price 323.55 | Shares 740
Planned sale 5 Mar 2026
Value US$210,803.82 | Price 322.33 | Shares 654
Proposed sale 5 Mar 2026
Value US$778,150.76 | Price 323.69 | Shares 2,404
Planned sale 5 Mar 2026
Value US$49,914.72 | Price 326.24 | Shares 153
Planned sale 5 Mar 2026
Value US$48,040.80 | Price 324.60 | Shares 148
Planned sale 5 Mar 2026
Value US$75,317.25 | Price 323.25 | Shares 233
Planned sale 5 Mar 2026
Value US$39,904.44 | Price 321.81 | Shares 124
Proposed sale 5 Mar 2026
Value US$212,988.02 | Price 323.69 | Shares 658
Sale 4 Mar 2026
Value US$86,302.55 | Price 325.67 | Shares 265
Sale 4 Mar 2026
Value US$112,083.60 | Price 324.88 | Shares 345
Sale 4 Mar 2026
Value US$315,096.32 | Price 323.84 | Shares 973
Sale 4 Mar 2026
Value US$143,416.44 | Price 323.01 | Shares 444
Sale 4 Mar 2026
Value US$118,429.76 | Price 321.82 | Shares 368
Sale 4 Mar 2026
Value US$87,901.94 | Price 320.81 | Shares 274
Sale 4 Mar 2026
Value US$41,281.29 | Price 320.01 | Shares 129
Sale 4 Mar 2026
Value US$43,069.05 | Price 319.03 | Shares 135
Sale 4 Mar 2026
Value US$67,739.36 | Price 325.67 | Shares 208
Sale 4 Mar 2026
Value US$88,367.36 | Price 324.88 | Shares 272
Sale 4 Mar 2026
Value US$248,385.28 | Price 323.84 | Shares 767
Sale 4 Mar 2026
Value US$113,053.50 | Price 323.01 | Shares 350
Sale 4 Mar 2026
Value US$93,005.98 | Price 321.82 | Shares 289
Sale 4 Mar 2026
Value US$68,974.15 | Price 320.81 | Shares 215
Sale 4 Mar 2026
Value US$32,641.02 | Price 320.01 | Shares 102
Sale 4 Mar 2026
Value US$33,817.18 | Price 319.03 | Shares 106
Sale 4 Mar 2026
Value US$18,563.19 | Price 325.67 | Shares 57
Sale 4 Mar 2026
Value US$24,366.00 | Price 324.88 | Shares 75
Sale 4 Mar 2026
Value US$68,006.40 | Price 323.84 | Shares 210
Sale 4 Mar 2026
Value US$31,008.96 | Price 323.01 | Shares 96
Sale 4 Mar 2026
Value US$25,423.78 | Price 321.82 | Shares 79
Sale 4 Mar 2026
Value US$18,927.79 | Price 320.81 | Shares 59
Sale 4 Mar 2026
Value US$8,960.28 | Price 320.01 | Shares 28
Sale 4 Mar 2026
Value US$9,251.87 | Price 319.03 | Shares 29
Sale 4 Mar 2026
Value US$72,624.41 | Price 325.67 | Shares 223
Sale 4 Mar 2026
Value US$94,540.08 | Price 324.88 | Shares 291
Sale 4 Mar 2026
Value US$264,901.12 | Price 323.84 | Shares 818
Sale 4 Mar 2026
Value US$120,805.74 | Price 323.01 | Shares 374
Sale 4 Mar 2026
Value US$99,442.38 | Price 321.82 | Shares 309
Sale 4 Mar 2026
Value US$73,786.30 | Price 320.81 | Shares 230
Sale 4 Mar 2026
Value US$34,881.09 | Price 320.01 | Shares 109
Sale 4 Mar 2026
Value US$36,369.42 | Price 319.03 | Shares 114
Sale 4 Mar 2026
Value US$67,739.36 | Price 325.67 | Shares 208
Sale 4 Mar 2026
Value US$88,367.36 | Price 324.88 | Shares 272
Sale 4 Mar 2026
Value US$248,385.28 | Price 323.84 | Shares 767
Sale 4 Mar 2026
Value US$113,053.50 | Price 323.01 | Shares 350
Sale 4 Mar 2026
Value US$93,005.98 | Price 321.82 | Shares 289
Sale 4 Mar 2026
Value US$68,974.15 | Price 320.81 | Shares 215
Sale 4 Mar 2026
Value US$32,641.02 | Price 320.01 | Shares 102
Sale 4 Mar 2026
Value US$33,817.18 | Price 319.03 | Shares 106
Planned sale 3 Mar 2026
Value US$148,854.50 | Price 321.50 | Shares 463
Planned sale 3 Mar 2026
Value US$205,107.20 | Price 320.48 | Shares 640
Planned sale 3 Mar 2026
Value US$101,142.02 | Price 319.06 | Shares 317
Planned sale 3 Mar 2026
Value US$112,442.70 | Price 316.74 | Shares 355
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2026-06-03 2026-06-01 PlS Planned sale
3.0
PYOTT DAVID E I
Non-Executive Director
7,156 -10.0%
35.03
US$3,787,316 		7,156 -10.0% 35.03 US$3,787,316
2026-06-03 2026-06-01 PlS Planned sale
3.0
PYOTT DAVID E I
Non-Executive Director
48,360 -10.9%
420.25
US$141,331 		48,360 -10.9% 420.25 US$141,331
2026-06-03 2026-06-01 PlS Planned sale
3.0
PYOTT DAVID E I
Non-Executive Director
19,414 +39.9%
401.04
US$2,014,753 		19,414 +39.9% 401.04 US$2,014,753
2026-06-03 2026-06-01 PlS Planned sale
3.0
PYOTT DAVID E I
Non-Executive Director
1,000 -26.2%
298.91
US$100,000 		1,000 -26.2% 298.91 US$100,000
2026-06-03 2026-06-01 PlS Planned sale
3.0
PYOTT DAVID E I
Non-Executive Director
1,000 -17.0%
297.71
US$100,000 		1,000 -17.0% 297.71 US$100,000
2026-06-01 2026-06-01 PrS Proposed sale
3.0
PYOTT DAVID E I

Director

Non-Executive Director
3,830
299.51
US$1,147,123 		3,830 299.51 US$1,147,123
2026-04-07 2026-04-06 PlS Planned sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
199 -2.1%
333.94
US$66,454 		199 -2.1% 333.94 US$66,454
2026-04-07 2026-04-06 PlS Planned sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
293 -2.9%
331.89
US$97,244 		293 -2.9% 331.89 US$97,244
2026-04-07 2026-04-06 PlS Planned sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
829 -7.7%
330.46
US$273,951 		829 -7.7% 330.46 US$273,951
2026-04-07 2026-04-06 PlS Planned sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
909 -7.8%
329.76
US$299,752 		909 -7.8% 329.76 US$299,752
2026-04-07 2026-04-06 PlS Planned sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
56 -0.5%
320.14
US$17,928 		56 -0.5% 320.14 US$17,928
2026-04-06 2026-04-06 PrS Proposed sale
McLaughlin Melissa

Officer

Officer
2,286
320.10
US$731,749 		2,286 320.10 US$731,749
2026-04-07 2026-04-02 S Sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
8 -0.1%
325.49
US$2,604 		8 -0.1% 325.49 US$2,604
2026-04-07 2026-04-02 S Sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
81 -0.7%
323.64
US$26,215 		81 -0.7% 323.64 US$26,215
2026-04-07 2026-04-02 S Sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
245 -2.0%
322.86
US$79,101 		245 -2.0% 322.86 US$79,101
2026-04-07 2026-04-02 S Sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
224 -1.8%
321.64
US$72,047 		224 -1.8% 321.64 US$72,047
2026-04-07 2026-04-02 S Sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
147 -1.2%
320.62
US$47,131 		147 -1.2% 320.62 US$47,131
2026-04-07 2026-04-02 S Sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
86 -0.7%
319.69
US$27,493 		86 -0.7% 319.69 US$27,493
2026-04-07 2026-04-02 S Sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
209 -1.6%
318.47
US$66,560 		209 -1.6% 318.47 US$66,560
2026-04-07 2026-04-02 S Sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
359 -2.7%
317.44
US$113,961 		359 -2.7% 317.44 US$113,961
2026-04-07 2026-04-02 S Sale
McLaughlin Melissa

Chief Human Resources Officer

Officer
265 -2.0%
316.61
US$83,902 		265 -2.0% 316.61 US$83,902
2026-03-06 2026-03-05 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
500 -2.6%
326.08
US$163,040 		500 -2.6% 326.08 US$163,040
2026-03-06 2026-03-05 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
510 -2.6%
324.59
US$165,541 		510 -2.6% 324.59 US$165,541
2026-03-06 2026-03-05 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
740 -3.6%
323.55
US$239,427 		740 -3.6% 323.55 US$239,427
2026-03-06 2026-03-05 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
654 -3.1%
322.33
US$210,804 		654 -3.1% 322.33 US$210,804
2026-03-06 2026-03-05 PlS Planned sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
153 -0.7%
326.24
US$49,915 		153 -0.7% 326.24 US$49,915
2026-03-06 2026-03-05 PlS Planned sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
148 -0.7%
324.60
US$48,041 		148 -0.7% 324.60 US$48,041
2026-03-06 2026-03-05 PlS Planned sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
233 -1.1%
323.25
US$75,317 		233 -1.1% 323.25 US$75,317
2026-03-06 2026-03-05 PlS Planned sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
124 -0.6%
321.81
US$39,904 		124 -0.6% 321.81 US$39,904
2026-03-05 2026-03-05 PrS Proposed sale
3.4
Garg Pushkal

Officer

Officer
2,404
323.69
US$778,151 		2,404 323.69 US$778,151
2026-03-05 2026-03-05 PrS Proposed sale
3.4
Fitzgerald Kevin Joseph

Officer

Officer
658
323.69
US$212,988 		658 323.69 US$212,988
2026-03-06 2026-03-04 S Sale
3.4
Greenstreet Yvonne

Chief Executive Officer

Executive Director
265 -0.3%
325.67
US$86,303 		265 -0.3% 325.67 US$86,303
2026-03-06 2026-03-04 S Sale
3.4
Greenstreet Yvonne

Chief Executive Officer

Executive Director
345 -0.4%
324.88
US$112,084 		345 -0.4% 324.88 US$112,084
2026-03-06 2026-03-04 S Sale
3.4
Greenstreet Yvonne

Chief Executive Officer

Executive Director
973 -1.0%
323.84
US$315,096 		973 -1.0% 323.84 US$315,096
2026-03-06 2026-03-04 S Sale
3.4
Greenstreet Yvonne

Chief Executive Officer

Executive Director
444 -0.5%
323.01
US$143,416 		444 -0.5% 323.01 US$143,416
2026-03-06 2026-03-04 S Sale
3.4
Greenstreet Yvonne

Chief Executive Officer

Executive Director
368 -0.4%
321.82
US$118,430 		368 -0.4% 321.82 US$118,430
2026-03-06 2026-03-04 S Sale
3.4
Greenstreet Yvonne

Chief Executive Officer

Executive Director
274 -0.3%
320.81
US$87,902 		274 -0.3% 320.81 US$87,902
2026-03-06 2026-03-04 S Sale
3.4
Greenstreet Yvonne

Chief Executive Officer

Executive Director
129 -0.1%
320.01
US$41,281 		129 -0.1% 320.01 US$41,281
2026-03-06 2026-03-04 S Sale
3.4
Greenstreet Yvonne

Chief Executive Officer

Executive Director
135 -0.1%
319.03
US$43,069 		135 -0.1% 319.03 US$43,069
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
208 -1.0%
325.67
US$67,739 		208 -1.0% 325.67 US$67,739
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
272 -1.3%
324.88
US$88,367 		272 -1.3% 324.88 US$88,367
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
767 -3.4%
323.84
US$248,385 		767 -3.4% 323.84 US$248,385
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
350 -1.5%
323.01
US$113,054 		350 -1.5% 323.01 US$113,054
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
289 -1.3%
321.82
US$93,006 		289 -1.3% 321.82 US$93,006
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
215 -0.9%
320.81
US$68,974 		215 -0.9% 320.81 US$68,974
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
102 -0.4%
320.01
US$32,641 		102 -0.4% 320.01 US$32,641
2026-03-06 2026-03-04 S Sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
106 -0.5%
319.03
US$33,817 		106 -0.5% 319.03 US$33,817
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
57 -0.3%
325.67
US$18,563 		57 -0.3% 325.67 US$18,563
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
75 -0.4%
324.88
US$24,366 		75 -0.4% 324.88 US$24,366
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
210 -1.0%
323.84
US$68,006 		210 -1.0% 323.84 US$68,006
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
96 -0.4%
323.01
US$31,009 		96 -0.4% 323.01 US$31,009
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
79 -0.4%
321.82
US$25,424 		79 -0.4% 321.82 US$25,424
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
59 -0.3%
320.81
US$18,928 		59 -0.3% 320.81 US$18,928
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
28 -0.1%
320.01
US$8,960 		28 -0.1% 320.01 US$8,960
2026-03-06 2026-03-04 S Sale
3.4
Fitzgerald Kevin Joseph

CSO & EVP, Head of Research

Officer
29 -0.1%
319.03
US$9,252 		29 -0.1% 319.03 US$9,252
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
223 -0.4%
325.67
US$72,624 		223 -0.4% 325.67 US$72,624
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
291 -0.5%
324.88
US$94,540 		291 -0.5% 324.88 US$94,540
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
818 -1.3%
323.84
US$264,901 		818 -1.3% 323.84 US$264,901
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
374 -0.6%
323.01
US$120,806 		374 -0.6% 323.01 US$120,806
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
309 -0.5%
321.82
US$99,442 		309 -0.5% 321.82 US$99,442
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
230 -0.4%
320.81
US$73,786 		230 -0.4% 320.81 US$73,786
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
109 -0.2%
320.01
US$34,881 		109 -0.2% 320.01 US$34,881
2026-03-06 2026-03-04 S Sale
3.5
Poulton Jeffrey V.

EVP, Chief Financial Officer

Officer
114 -0.2%
319.03
US$36,369 		114 -0.2% 319.03 US$36,369
2026-03-06 2026-03-04 S Sale
3.4
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
208 -0.6%
325.67
US$67,739 		208 -0.6% 325.67 US$67,739
2026-03-06 2026-03-04 S Sale
3.4
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
272 -0.8%
324.88
US$88,367 		272 -0.8% 324.88 US$88,367
2026-03-06 2026-03-04 S Sale
3.4
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
767 -2.2%
323.84
US$248,385 		767 -2.2% 323.84 US$248,385
2026-03-06 2026-03-04 S Sale
3.4
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
350 -1.0%
323.01
US$113,054 		350 -1.0% 323.01 US$113,054
2026-03-06 2026-03-04 S Sale
3.4
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
289 -0.8%
321.82
US$93,006 		289 -0.8% 321.82 US$93,006
2026-03-06 2026-03-04 S Sale
3.4
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
215 -0.6%
320.81
US$68,974 		215 -0.6% 320.81 US$68,974
2026-03-06 2026-03-04 S Sale
3.4
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
102 -0.3%
320.01
US$32,641 		102 -0.3% 320.01 US$32,641
2026-03-06 2026-03-04 S Sale
3.4
Tanguler Tolga

EVP, Chief Commercial Officer

Officer
106 -0.3%
319.03
US$33,817 		106 -0.3% 319.03 US$33,817
2026-03-04 2026-03-03 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
463 -1.9%
321.50
US$148,854 		463 -1.9% 321.50 US$148,854
2026-03-04 2026-03-03 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
640 -2.6%
320.48
US$205,107 		640 -2.6% 320.48 US$205,107
2026-03-04 2026-03-03 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
317 -1.3%
319.06
US$101,142 		317 -1.3% 319.06 US$101,142
2026-03-04 2026-03-03 PlS Planned sale
3.4
Garg Pushkal

EVP Chief R&D

Officer
355 -1.4%
316.74
US$112,443 		355 -1.4% 316.74 US$112,443
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