Shire Human Genetic Therapies, Inc.

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2020-06-05	2020-06-03	Translate Bio Inc (TBIO)	S Sale	63,500 -3.8% 330.32 US$1,796,663	63,500 -3.8%	330.32	US$1,796,663
2020-06-03	2020-06-02	Translate Bio Inc (TBIO)	S Sale	81,848 +13.8% 174.13 US$1,493,923	81,848 +13.8%	174.13	US$1,493,923
2020-06-03	2020-06-02	Translate Bio Inc (TBIO)	S Sale	13,593 -46.0% 313.46 US$314,212	13,593 -46.0%	313.46	US$314,212
2020-06-03	2020-06-01	Translate Bio Inc (TBIO)	S Sale	1,400 -0.0% 20.53 US$28,742	1,400 -0.0%	20.53	US$28,742
2020-06-03	2020-06-01	Translate Bio Inc (TBIO)	S Sale	107,072 -1.5% 19.85 US$2,125,379	107,072 -1.5%	19.85	US$2,125,379