Patterson Joshua F.

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2020-09-24	2020-09-22	Akcea Therapeutics Inc (AKCA)	S Sale	96,251 -37.7% 363.91 US$3,360,114	96,251 -37.7%	363.91	US$3,360,114
2020-07-20	2020-07-17	Akcea Therapeutics Inc (AKCA)	S Sale	72,753 +25.7% 18.12 US$2,253,525	72,753 +25.7%	18.12	US$2,253,525
2020-03-25	2020-03-23	Akcea Therapeutics Inc (AKCA)	S Sale	84,185 -48.5% 474.60 US$1,169,351	84,185 -48.5%	474.60	US$1,169,351