Klassen Preston

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2025-06-04	2025-06-03	Regulus Therapeutics Inc (RGLS)	B Purchase	19,421 +36.5% 117.54 US$4,210,030	19,421 +36.5%	117.54	US$4,210,030
2025-01-15	2025-01-13	Regulus Therapeutics Inc (RGLS)	PlS Planned sale	12,783 -21.1% 312.56 US$1,599,442	12,783 -21.1%	312.56	US$1,599,442
2023-01-27	2023-01-26	Metacrine, Inc. (MTCR)	S Sale	18,579 -15.9% 467.25 US$1,041,828	18,579 -15.9%	467.25	US$1,041,828
2022-04-20	2022-04-19	Metacrine, Inc. (MTCR)	S Sale	1,173 -0.1% 0.51 US$593	1,173 -0.1%	0.51	US$593
2022-04-20	2022-04-19	Metacrine, Inc. (MTCR)	S Sale	43,575 -4.5% 0.50 US$21,879	43,575 -4.5%	0.50	US$21,879
2019-01-08	2019-01-08	Arena Pharmaceuticals Inc (ARNA)	PlS Planned sale	3,000 -100.0% 44.00 US$132,000	3,000 -100.0%	44.00	US$132,000
2019-01-08	2019-01-07	Arena Pharmaceuticals Inc (ARNA)	PlS Planned sale	400 -100.0% 42.32 US$16,927	400 -100.0%	42.32	US$16,927
2019-01-08	2019-01-07	Arena Pharmaceuticals Inc (ARNA)	PlS Planned sale	15,600 -97.5% 41.68 US$650,139	15,600 -97.5%	41.68	US$650,139