DANSE EDWARD H

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2017-07-05	2017-07-05	Acucela Inc (4589)	S Sale	97,564 -28.0% 75.61 US$2,556,502	97,564 -28.0%	75.61	US$2,556,502
2017-06-02	2017-06-01	Acucela Inc (4589)	S Sale	74,403 +13.7% 117.50 US$2,313,910	74,403 +13.7%	117.50	US$2,313,910
2017-05-02	2017-05-01	Acucela Inc (4589)	S Sale	6,615 +13.9% 344.95 US$1,155,980	6,615 +13.9%	344.95	US$1,155,980
2017-03-02	2017-03-02	Acucela Inc (4589)	S Sale	1,250 -1.7% 7.72 US$9,650	1,250 -1.7%	7.72	US$9,650
2017-02-03	2017-02-02	Acucela Inc (4589)	S Sale	1,250 -1.6% 8.50 US$10,625	1,250 -1.6%	8.50	US$10,625
2017-01-06	2017-01-04	Acucela Inc (4589)	S Sale	1,270 -1.6% 8.58 US$10,897	1,270 -1.6%	8.58	US$10,897