Gibson Neil W

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Activity signal Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other

Notification date	Transaction date	Company	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value
2014-12-01	2014-11-28	Regulus Therapeutics Inc (RGLS)	PlS Planned sale	67,957 -40.7% 473.87 US$490,268	67,957 -40.7%	473.87	US$490,268
2014-12-01	2014-11-28	Regulus Therapeutics Inc (RGLS)	PlS Planned sale	75,628 +23.1% 134.00 US$4,758,376	75,628 +23.1%	134.00	US$4,758,376
2014-10-24	2014-10-22	Regulus Therapeutics Inc (RGLS)	PlS Planned sale	8,681 +12.0% 393.93 US$4,309,297	8,681 +12.0%	393.93	US$4,309,297
2014-07-02	2014-07-01	Regulus Therapeutics Inc (RGLS)	PlS Planned sale	2,500 -3.0% 8.10 US$20,260	2,500 -3.0%	8.10	US$20,260
2014-06-18	2014-06-17	Regulus Therapeutics Inc (RGLS)	PlS Planned sale	5,000 -5.9% 8.05 US$40,227	5,000 -5.9%	8.05	US$40,227
2014-03-07	2014-03-06	Regulus Therapeutics Inc (RGLS)	PlS Planned sale	2,500 -3.0% 11.37 US$28,428	2,500 -3.0%	11.37	US$28,428
2014-02-07	2014-02-05	Regulus Therapeutics Inc (RGLS)	PlS Planned sale	17,500 -33.3% 8.38 US$146,706	17,500 -33.3%	8.38	US$146,706