United States Biotechnology & Medical Research

Shire-Nps Pharmaceuticals Inc (NPSP)

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Ticker: NPSP Exchange: NSQ
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• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Buy signal Sell signal Earnings
No insider activity signals detected

Insider trades have not triggered unusual activity signals for this company.

Top insiders
Trades
Abbreviations B: Buy, S: Sell, PP: Planned purchase, PlS: Planned sale, PrS: Proposed sale, O: Option / Other
Graf Susan E VP, Corp Development & Strateg Officer
Transaction date
Sale
Price
441.23
Quantity 65,771 +33.2%
Value US$1,609,078
Rogus Joseph J SVP, GTO & Supply Chain Mngmt Officer
Transaction date
Sale
Price
450.82
Quantity 8,953 -48.4%
Value US$2,468,411
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
369.98
Quantity 90,965 +15.0%
Value US$2,278,214
Rogus Joseph J SVP Gbl Tech Oper Sup Chn Mgt Officer
Transaction date
Planned sale
Price
35.00
Quantity 16,467 -45.0%
Value US$576,345
Selisker Rachel R Non-Executive Director
Transaction date
Planned sale
Price
34.59
Quantity 3,708 -33.4%
Value US$128,260
Selisker Rachel R Non-Executive Director
Transaction date
Planned sale
Price
34.50
Quantity 23,157 -70.1%
Value US$798,981
Selisker Rachel R Non-Executive Director
Transaction date
Planned sale
Price
34.50
Quantity 11,635 -54.0%
Value US$401,418
Rogus Joseph J SVP, Gbl Technical Operations Officer
Transaction date
Planned sale
Price
30.00
Quantity 26,782 -57.1%
Value US$803,540
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
30.01
Quantity 47,442 -39.5%
Value US$1,423,640
GRONINGER JAMES G Non-Executive Director
Transaction date
Planned sale
Price
37.70
Quantity 6,000 -37.6%
Value US$226,200
GEMAYEL GEORGES Non-Executive Director
Transaction date
Planned sale
Price
37.70
Quantity 6,188 -40.7%
Value US$233,288
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
35.01
Quantity 31,588 -34.8%
Value US$1,105,896
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
30.02
Quantity 37,874 -39.0%
Value US$1,136,977
GRONINGER JAMES G Non-Executive Director
Transaction date
Planned sale
Price
29.50
Quantity 3,000 -80.0%
Value US$88,500
STRATEMEIER ED SVP & General Counsel Officer
Transaction date
Planned sale
Price
25.17
Quantity 154,460 -78.5%
Value US$3,887,758
STRATEMEIER ED SVP & General Counsel Officer
Transaction date
Planned sale
Price
25.00
Quantity 50,972 -54.6%
Value US$1,274,300
STRATEMEIER ED SVP & General Counsel Officer
Transaction date
Planned sale
Price
25.00
Quantity 14,555 -25.6%
Value US$363,875
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
24.02
Quantity 60,311 -50.5%
Value US$1,448,387
Nader Francois President, CEO and Director Executive Director
Transaction date
Planned sale
Price
32.36
Quantity 43,458 -33.1%
Value US$1,406,118
Nader Francois President, CEO and Director Executive Director
Transaction date
Planned sale
Price
33.60
Quantity 6,497 -6.9%
Value US$218,299
Nader Francois President, CEO and Director Executive Director
Transaction date
Planned sale
Price
33.07
Quantity 143,503 -60.3%
Value US$4,745,644
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
30.05
Quantity 5,000 -7.8%
Value US$150,255
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
30.32
Quantity 12,000 -15.8%
Value US$363,840
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
30.15
Quantity 19,000 -20.0%
Value US$572,774
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
30.43
Quantity 14,000 -12.8%
Value US$426,006
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
28.65
Quantity 100 -0.2%
Value US$2,865
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
27.89
Quantity 49,900 -45.7%
Value US$1,391,711
Rogus Joseph J VP, Technical Operations Officer
Transaction date
Planned sale
Price
28.63
Quantity 4,300 -18.2%
Value US$123,127
Rogus Joseph J VP, Technical Operations Officer
Transaction date
Planned sale
Price
28.01
Quantity 21,012 -47.0%
Value US$588,454
GARCEAU ROGER SVP & CMO Officer
Transaction date
Planned sale
Price
25.18
Quantity 110,000 -63.2%
Value US$2,769,877
GRONINGER JAMES G Non-Executive Director
Transaction date
Planned sale
Price
23.21
Quantity 16,900 -81.8%
Value US$392,222
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
14.18
Quantity 45,150 -43.3%
Value US$640,001
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
14.00
Quantity 4,850 -7.6%
Value US$67,900
Nader Francois President, CEO and Director Executive Director
Transaction date
Planned sale
Price
11.68
Quantity 148,367 -40.6%
Value US$1,732,526
BESHAR LUKE M EVP & CFO Officer
Transaction date
Planned sale
Price
12.00
Quantity 50,000 -45.8%
Value US$600,220
Nader Francois President, CEO and Director Executive Director
Transaction date
Planned sale
Price
11.27
Quantity 150,000 -38.8%
Value US$1,689,840
Rogus Joseph J VP, Technical Operations Officer
Transaction date
Planned sale
Price
11.50
Quantity 48,015 -71.3%
Value US$552,172
Nader Francois President, CEO and Director Executive Director
Transaction date
Planned sale
Price
11.01
Quantity 150,000 -38.8%
Value US$1,650,795
Broom Colin MD Non-Executive Director
Transaction date
Planned sale
Price
8.74
Quantity 6,100 -40.1%
Value US$53,314
BONNEY MICHAEL W Non-Executive Director
Transaction date
Planned sale
Price
8.74
Quantity 5,325 -27.7%
Value US$46,540
GRONINGER JAMES G Non-Executive Director
Transaction date
Planned sale
Price
8.74
Quantity 5,325 -33.3%
Value US$46,540
TOMBROS PETER G Non-Executive Director
Transaction date
Planned sale
Price
8.74
Quantity 6,100 -14.6%
Value US$53,314
Selisker Rachel R Non-Executive Director
Transaction date
Planned sale
Price
8.74
Quantity 5,325 -35.0%
Value US$46,540
Melrose Glenn R SVP, Human Resources Officer
Transaction date
Purchase
Price
9.09
Quantity 11,000 +inf%
Value US$99,990
GARCEAU ROGER SVP & CMO Officer
Transaction date
Planned sale
Price
9.51
Quantity 140,625 -100.0%
Value US$1,337,119
BESHAR LUKE M SVP &CFO Officer
Transaction date
Planned sale
Price
10.00
Quantity 50,000 -100.0%
Value US$500,000
Nader Francois President, CEO and Director Executive Director
Transaction date
Sale
Price
3.37
Quantity 19,350 -11.4%
Value US$65,210
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Sale
Price
8.72
Quantity 166,000 -3.6%
Value US$1,447,088
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Sale
Price
8.72
Quantity 48,000 -1.0%
Value US$418,435
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Sale
Price
8.72
Quantity 69,200 -1.5%
Value US$603,244
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Sale
Price
8.55
Quantity 112,000 -2.3%
Value US$957,858
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Sale
Price
8.55
Quantity 32,000 -0.7%
Value US$273,674
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Sale
Price
8.55
Quantity 47,600 -1.0%
Value US$407,089
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.90
Quantity 2,000 +0.0%
Value US$7,800
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.90
Quantity 1,000 +0.0%
Value US$3,900
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.90
Quantity 400 +0.0%
Value US$1,560
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.80
Quantity 26,000 +0.5%
Value US$98,800
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.80
Quantity 8,000 +0.2%
Value US$30,400
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.80
Quantity 11,500 +0.2%
Value US$43,700
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.84
Quantity 58,000 +1.2%
Value US$222,981
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.84
Quantity 17,000 +0.4%
Value US$65,356
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.84
Quantity 25,000 +0.5%
Value US$96,112
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.77
Quantity 5,000 +0.1%
Value US$18,846
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.77
Quantity 1,000 +0.0%
Value US$3,769
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.77
Quantity 2,300 +0.0%
Value US$8,669
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.82
Quantity 23,000 +0.5%
Value US$87,860
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.82
Quantity 7,000 +0.1%
Value US$26,740
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.82
Quantity 8,600 +0.2%
Value US$32,852
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.71
Quantity 31,000 +0.7%
Value US$115,153
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.71
Quantity 9,000 +0.2%
Value US$33,431
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.71
Quantity 13,900 +0.3%
Value US$51,633
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.73
Quantity 73,000 +1.6%
Value US$271,925
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.73
Quantity 21,000 +0.5%
Value US$78,225
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.73
Quantity 32,000 +0.7%
Value US$119,200
BVF PARTNERS L P/IL Indirect Beneficial Owner Large shareholder
Transaction date
Purchase
Price
3.81
Quantity 85,000 +1.9%
Value US$323,510
Notification date Transaction date B/S Transaction type Insider and/or position Nb. shares
Price
Value 		Number of shares Price Value Details
2015-02-11 2015-02-10 S Sale Graf Susan E

VP, Corp Development & Strateg

Officer
65,771 +33.2%
441.23
US$1,609,078 		65,771 +33.2% 441.23 US$1,609,078
2015-02-09 2015-02-05 S Sale Rogus Joseph J

SVP, GTO & Supply Chain Mngmt

Officer
8,953 -48.4%
450.82
US$2,468,411 		8,953 -48.4% 450.82 US$2,468,411
2014-12-19 2014-12-17 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
90,965 +15.0%
369.98
US$2,278,214 		90,965 +15.0% 369.98 US$2,278,214
2014-12-19 2014-12-17 PlS Planned sale Rogus Joseph J

SVP Gbl Tech Oper Sup Chn Mgt

Officer
16,467 -45.0%
35.00
US$576,345 		16,467 -45.0% 35.00 US$576,345
2014-12-19 2014-12-17 PlS Planned sale Selisker Rachel R Non-Executive Director
3,708 -33.4%
34.59
US$128,260 		3,708 -33.4% 34.59 US$128,260
2014-12-10 2014-12-08 PlS Planned sale Selisker Rachel R Non-Executive Director
23,157 -70.1%
34.50
US$798,981 		23,157 -70.1% 34.50 US$798,981
2014-12-02 2014-11-28 PlS Planned sale Selisker Rachel R Non-Executive Director
11,635 -54.0%
34.50
US$401,418 		11,635 -54.0% 34.50 US$401,418
2014-11-19 2014-11-17 PlS Planned sale Rogus Joseph J

SVP, Gbl Technical Operations

Officer
26,782 -57.1%
30.00
US$803,540 		26,782 -57.1% 30.00 US$803,540
2014-11-19 2014-11-17 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
47,442 -39.5%
30.01
US$1,423,640 		47,442 -39.5% 30.01 US$1,423,640
2014-02-14 2014-02-13 PlS Planned sale GRONINGER JAMES G Non-Executive Director
6,000 -37.6%
37.70
US$226,200 		6,000 -37.6% 37.70 US$226,200
2014-02-14 2014-02-13 PlS Planned sale GEMAYEL GEORGES Non-Executive Director
6,188 -40.7%
37.70
US$233,288 		6,188 -40.7% 37.70 US$233,288
2014-01-09 2014-01-08 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
31,588 -34.8%
35.01
US$1,105,896 		31,588 -34.8% 35.01 US$1,105,896
2013-12-30 2013-12-26 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
37,874 -39.0%
30.02
US$1,136,977 		37,874 -39.0% 30.02 US$1,136,977
2013-12-26 2013-12-23 PlS Planned sale GRONINGER JAMES G Non-Executive Director
3,000 -80.0%
29.50
US$88,500 		3,000 -80.0% 29.50 US$88,500
2013-12-19 2013-12-18 PlS Planned sale STRATEMEIER ED

SVP & General Counsel

Officer
154,460 -78.5%
25.17
US$3,887,758 		154,460 -78.5% 25.17 US$3,887,758
2013-12-19 2013-12-17 PlS Planned sale STRATEMEIER ED

SVP & General Counsel

Officer
50,972 -54.6%
25.00
US$1,274,300 		50,972 -54.6% 25.00 US$1,274,300
2013-12-18 2013-12-16 PlS Planned sale STRATEMEIER ED

SVP & General Counsel

Officer
14,555 -25.6%
25.00
US$363,875 		14,555 -25.6% 25.00 US$363,875
2013-12-16 2013-12-12 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
60,311 -50.5%
24.02
US$1,448,387 		60,311 -50.5% 24.02 US$1,448,387
2013-09-30 2013-09-27 PlS Planned sale Nader Francois

President, CEO and Director

Executive Director
43,458 -33.1%
32.36
US$1,406,118 		43,458 -33.1% 32.36 US$1,406,118
2013-09-30 2013-09-26 PlS Planned sale Nader Francois

President, CEO and Director

Executive Director
6,497 -6.9%
33.60
US$218,299 		6,497 -6.9% 33.60 US$218,299
2013-09-30 2013-09-26 PlS Planned sale Nader Francois

President, CEO and Director

Executive Director
143,503 -60.3%
33.07
US$4,745,644 		143,503 -60.3% 33.07 US$4,745,644
2013-09-24 2013-09-20 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
5,000 -7.8%
30.05
US$150,255 		5,000 -7.8% 30.05 US$150,255
2013-09-24 2013-09-20 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
12,000 -15.8%
30.32
US$363,840 		12,000 -15.8% 30.32 US$363,840
2013-09-24 2013-09-20 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
19,000 -20.0%
30.15
US$572,774 		19,000 -20.0% 30.15 US$572,774
2013-09-24 2013-09-20 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
14,000 -12.8%
30.43
US$426,006 		14,000 -12.8% 30.43 US$426,006
2013-09-17 2013-09-16 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
100 -0.2%
28.65
US$2,865 		100 -0.2% 28.65 US$2,865
2013-09-17 2013-09-16 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
49,900 -45.7%
27.89
US$1,391,711 		49,900 -45.7% 27.89 US$1,391,711
2013-09-17 2013-09-16 PlS Planned sale Rogus Joseph J

VP, Technical Operations

Officer
4,300 -18.2%
28.63
US$123,127 		4,300 -18.2% 28.63 US$123,127
2013-09-17 2013-09-16 PlS Planned sale Rogus Joseph J

VP, Technical Operations

Officer
21,012 -47.0%
28.01
US$588,454 		21,012 -47.0% 28.01 US$588,454
2013-09-04 2013-08-30 PlS Planned sale GARCEAU ROGER

SVP & CMO

Officer
110,000 -63.2%
25.18
US$2,769,877 		110,000 -63.2% 25.18 US$2,769,877
2013-08-22 2013-08-20 PlS Planned sale GRONINGER JAMES G Non-Executive Director
16,900 -81.8%
23.21
US$392,222 		16,900 -81.8% 23.21 US$392,222
2013-05-13 2013-05-09 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
45,150 -43.3%
14.18
US$640,001 		45,150 -43.3% 14.18 US$640,001
2013-05-01 2013-04-29 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
4,850 -7.6%
14.00
US$67,900 		4,850 -7.6% 14.00 US$67,900
2013-04-10 2013-04-10 PlS Planned sale Nader Francois

President, CEO and Director

Executive Director
148,367 -40.6%
11.68
US$1,732,526 		148,367 -40.6% 11.68 US$1,732,526
2013-04-10 2013-04-10 PlS Planned sale BESHAR LUKE M

EVP & CFO

Officer
50,000 -45.8%
12.00
US$600,220 		50,000 -45.8% 12.00 US$600,220
2013-04-10 2013-04-09 PlS Planned sale Nader Francois

President, CEO and Director

Executive Director
150,000 -38.8%
11.27
US$1,689,840 		150,000 -38.8% 11.27 US$1,689,840
2013-04-10 2013-04-09 PlS Planned sale Rogus Joseph J

VP, Technical Operations

Officer
48,015 -71.3%
11.50
US$552,172 		48,015 -71.3% 11.50 US$552,172
2013-04-10 2013-04-08 PlS Planned sale Nader Francois

President, CEO and Director

Executive Director
150,000 -38.8%
11.01
US$1,650,795 		150,000 -38.8% 11.01 US$1,650,795
2013-02-11 2013-02-07 PlS Planned sale Broom Colin MD Non-Executive Director
6,100 -40.1%
8.74
US$53,314 		6,100 -40.1% 8.74 US$53,314
2013-02-11 2013-02-07 PlS Planned sale BONNEY MICHAEL W Non-Executive Director
5,325 -27.7%
8.74
US$46,540 		5,325 -27.7% 8.74 US$46,540
2013-02-11 2013-02-07 PlS Planned sale GRONINGER JAMES G Non-Executive Director
5,325 -33.3%
8.74
US$46,540 		5,325 -33.3% 8.74 US$46,540
2013-02-11 2013-02-07 PlS Planned sale TOMBROS PETER G Non-Executive Director
6,100 -14.6%
8.74
US$53,314 		6,100 -14.6% 8.74 US$53,314
2013-02-11 2013-02-07 PlS Planned sale Selisker Rachel R Non-Executive Director
5,325 -35.0%
8.74
US$46,540 		5,325 -35.0% 8.74 US$46,540
2012-11-19 2012-11-15 B Purchase Melrose Glenn R

SVP, Human Resources

Officer
11,000 +inf%
9.09
US$99,990 		11,000 +inf% 9.09 US$99,990
2012-10-05 2012-10-03 PlS Planned sale GARCEAU ROGER

SVP & CMO

Officer
140,625 -100.0%
9.51
US$1,337,119 		140,625 -100.0% 9.51 US$1,337,119
2011-02-02 2011-01-31 PlS Planned sale BESHAR LUKE M

SVP &CFO

Officer
50,000 -100.0%
10.00
US$500,000 		50,000 -100.0% 10.00 US$500,000
2010-04-02 2010-02-03 S Sale Nader Francois

President, CEO and Director

Executive Director
19,350 -11.4%
3.37
US$65,210 		19,350 -11.4% 3.37 US$65,210
2008-09-23 2008-09-22 S Sale BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
166,000 -3.6%
8.72
US$1,447,088 		166,000 -3.6% 8.72 US$1,447,088
2008-09-23 2008-09-22 S Sale BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
48,000 -1.0%
8.72
US$418,435 		48,000 -1.0% 8.72 US$418,435
2008-09-23 2008-09-22 S Sale BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
69,200 -1.5%
8.72
US$603,244 		69,200 -1.5% 8.72 US$603,244
2008-09-23 2008-09-19 S Sale BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
112,000 -2.3%
8.55
US$957,858 		112,000 -2.3% 8.55 US$957,858
2008-09-23 2008-09-19 S Sale BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
32,000 -0.7%
8.55
US$273,674 		32,000 -0.7% 8.55 US$273,674
2008-09-23 2008-09-19 S Sale BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
47,600 -1.0%
8.55
US$407,089 		47,600 -1.0% 8.55 US$407,089
2008-03-20 2008-03-19 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
2,000 +0.0%
3.90
US$7,800 		2,000 +0.0% 3.90 US$7,800
2008-03-20 2008-03-19 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
1,000 +0.0%
3.90
US$3,900 		1,000 +0.0% 3.90 US$3,900
2008-03-20 2008-03-19 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
400 +0.0%
3.90
US$1,560 		400 +0.0% 3.90 US$1,560
2008-03-19 2008-03-17 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
26,000 +0.5%
3.80
US$98,800 		26,000 +0.5% 3.80 US$98,800
2008-03-19 2008-03-17 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
8,000 +0.2%
3.80
US$30,400 		8,000 +0.2% 3.80 US$30,400
2008-03-19 2008-03-17 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
11,500 +0.2%
3.80
US$43,700 		11,500 +0.2% 3.80 US$43,700
2008-03-17 2008-03-14 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
58,000 +1.2%
3.84
US$222,981 		58,000 +1.2% 3.84 US$222,981
2008-03-17 2008-03-14 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
17,000 +0.4%
3.84
US$65,356 		17,000 +0.4% 3.84 US$65,356
2008-03-17 2008-03-14 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
25,000 +0.5%
3.84
US$96,112 		25,000 +0.5% 3.84 US$96,112
2008-03-17 2008-03-13 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
5,000 +0.1%
3.77
US$18,846 		5,000 +0.1% 3.77 US$18,846
2008-03-17 2008-03-13 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
1,000 +0.0%
3.77
US$3,769 		1,000 +0.0% 3.77 US$3,769
2008-03-17 2008-03-13 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
2,300 +0.0%
3.77
US$8,669 		2,300 +0.0% 3.77 US$8,669
2008-03-13 2008-03-12 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
23,000 +0.5%
3.82
US$87,860 		23,000 +0.5% 3.82 US$87,860
2008-03-13 2008-03-12 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
7,000 +0.1%
3.82
US$26,740 		7,000 +0.1% 3.82 US$26,740
2008-03-13 2008-03-12 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
8,600 +0.2%
3.82
US$32,852 		8,600 +0.2% 3.82 US$32,852
2008-03-13 2008-03-11 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
31,000 +0.7%
3.71
US$115,153 		31,000 +0.7% 3.71 US$115,153
2008-03-13 2008-03-11 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
9,000 +0.2%
3.71
US$33,431 		9,000 +0.2% 3.71 US$33,431
2008-03-13 2008-03-11 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
13,900 +0.3%
3.71
US$51,633 		13,900 +0.3% 3.71 US$51,633
2008-03-11 2008-03-10 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
73,000 +1.6%
3.73
US$271,925 		73,000 +1.6% 3.73 US$271,925
2008-03-11 2008-03-10 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
21,000 +0.5%
3.73
US$78,225 		21,000 +0.5% 3.73 US$78,225
2008-03-11 2008-03-10 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
32,000 +0.7%
3.73
US$119,200 		32,000 +0.7% 3.73 US$119,200
2008-03-11 2008-03-07 B Purchase BVF PARTNERS L P/IL

Indirect Beneficial Owner

Large shareholder
85,000 +1.9%
3.81
US$323,510 		85,000 +1.9% 3.81 US$323,510
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